Clinical trials: Anemia, Sickle Cell
Sickle Cell Disease
Nonmyeloablative Conditioning for Mismatched Hematopoietic Stem Cell Transplantation for Severe Sickle Cell Disease
The aim of this study is to evaluate the overall safety and feasibility of using haploidentical or one antigen mismatch unrelated hematopoietic stem cell transplant (HSCT) for adult patients with severe sickle cell disease (SCD)…
- Trial name
- NCT02678143
- Testing
- Alemtuzumab, Cyclophosphamide, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Washington University School of Medicine
Sickle Cell Disease
Phase 1 Study of Zoledronic Acid in Sickle Cell Disease
The long-term goal of this study is to learn if Zoledronic Acid can prevent or reduce pain in sickle cell disease. The goal of this study is to learn about the safety of Zoledronic Acid in persons with sickle cell disease who…
- Trial name
- NCT00639392
- Testing
- Zoledronic Acid
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Sickle Cell Disease, Cerebral Stroke
Cerebral Oxygen Metabolism in Children
The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life.
- Trial name
- COMIC (NCT04157179)
- Testing
- Carbon Dioxide
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Sickle Cell Anemia
Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil
The investigators would like to study the endothelial function in sickle cell patients without pulmonary hypertension in an in vivo method during a steady state condition before and after sildenafil treatment for 1 month, and to…
- Trial name
- NCT00937144
- Testing
- Viagra (Sildenafil)
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Sickle Cell Disease
A Stress and Pain Self-management m-Health App for Adult Outpatients With Sickle Cell Disease
Our long-term goal is to reduce stress and improve sickle cell disease (SCD) pain control with less opioid use through an intervention with self-management relaxation/distraction exercises (RDE), named You Cope, We Support…
- Trial name
- NCT04484272
- Testing
- Self-monitoring of pain, stress, and opioid use + alerts/reminders + use of YCWS. [three video banks of RDE + Support])., Self-monitoring of pain, stress, and opioid use + alerts/reminders.
- Where
- United States
- Volunteers
- 239 people
- Sponsor
- University of Florida
Sickle Cell Disease
Pharmacokinetics and Pharmacodynamics of Rifaximin Novel Formulations in Patients With Sickle Cell Disease
This is a randomized, double-blind, placebo-controlled study in sickle cell disease participants with a history of Vaso-occlusive Crises (VOCs).
- Trial name
- NCT05098028
- Testing
- Low Dose Rifaximin ER, Low Dose Rifaximin DER, High Dose Rifaximin ER
- Where
- 8 sites in United States, Canada and 1 more
- Volunteers
- 44 people
- Sponsor
- Bausch Health Americas, Inc.
Acute Respiratory Distress Syndrome
Sigh Ventilation to Increase Ventilator-Free Days in Victims of Trauma at Risk for Acute Respiratory Distress Syndrome
A randomized, concurrent controlled trial to assess if adding sigh breaths to usual invasive mechanical ventilation of victims of trauma who are at risk of developing ARDS will decrease the number of days they require invasive…
- Trial name
- SiVent (NCT02582957)
- Testing
- Sigh breaths
- Where
- 15 sites in United States
- Volunteers
- 524 people
- Sponsor
- University of Minnesota
Sickle Cell Disease
Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease
Background: Sickle Cell Disease (SCD) causes blood cells form a crescent shape. It is caused by a genetic mutation in the hemoglobin gene.
- Trial name
- NCT05170412
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Sickle Cell Disease
Integrative Training Program for Pediatric Sickle Cell Pain
This research aims to answer the question: does a group training program specifically for teens with chronic sickle cell disease (SCD) pain that teaches skills to strengthen the mind and body help improve everyday functioning and…
- Trial name
- I-STRONG SCD (NCT06691867)
- Testing
- I-STRONG, Enhanced Usual Care (EUC)
- Where
- 4 sites in United States
- Volunteers
- 155 people
- Sponsor
- Emory University
Sickle Cell, Sickle Cell Disease
Sickle Cell, Pain and Mediterranean Diet
The goal of this study is to compare pain levels in individuals with Sickle Cell Disease while following the Mediterranean Diet to pain levels while following their usual diet.
- Conditions
- Sickle Cell, Sickle Cell Disease, Sickle Cell Disease Without Crisis, Mediterranean Diet
- Trial name
- MedSCP (NCT06886477)
- Testing
- Mediterranean Diet, Usual Diet
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Illinois at Chicago
Sickle Cell Anemia, Pulmonary Hypertension
Exercise-induced Pulmonary Hypertension in Patients With Sickle-cell Anemia
Pulmonary hypertension (PH) at rest is a risk factor for death in patients with sickle-cell anemia (SCA). Exercise echocardiography (EE) can detect latent PH.
- Trial name
- NCT00948012
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Leukemia in Remission
Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer
This phase II trial studies how well fludarabine phosphate, cyclophosphamide, total body irradiation, and donor stem cell transplant work in treating patients with blood cancer.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Leukemia in Remission, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
- Trial name
- NCT03333486
- Testing
- Cyclophosphamide, Fludarabine Phosphate, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Roswell Park Cancer Institute
Sickle Cell Disease
PK Study of Ticagrelor in Children Aged Less Than 24 Months, With Sickle Cell Disease (HESTIA4)
The purpose of this Phase I study is to investigate the pharmacokinetic properties of ticagrelor in pediatric patients from 0 to less than 24 months with sickle cell disease.
- Trial name
- HESTIA4 (NCT03492931)
- Testing
- Ticagrelor
- Where
- 8 sites in Belgium, Italy and 4 more
- Volunteers
- 21 people
- Sponsor
- AstraZeneca
Sickle Cell Disease
Hydroxyurea in the Treatment of Sickle Cell Disease
This is a retrospective cohort study of Sickle Cell Disease (SCD) patients attending 32 treatment centers across Italy. The aim of this study will be to report the Italian experience with the use of hydroxyurea in a large cohort…
- Trial name
- NCT02709681
- Testing
- Physician standard-of-care in SCD patients
- Where
- 30 sites in Italy
- Volunteers
- 628 people
- Sponsor
- Società Italiana Talassemie ed Emoglobinopatie
Sickle Cell Disease, Vaso-occlusive Pain Episode
Intravenous L-Citrulline for Vaso-occlusive Pain Episode in Sickle Cell Disease
The goal of this clinical trial is to learn if intravenous citrulline works to treat acute pain in hospitalized patients with sickle cell disease. It will also learn about the safety of intravenous citrulline.
- Trial name
- NCT06635902
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Suvankar Majumdar
Thalassemia, Sickle Cell Disease
Cerebrovascular Reserve and White Matter Disease in Patients with Chronic Anemia
This is primarily an observational trial in patients with chronic anemia syndromes (sickle cell disease and thalassemia) and control subjects.
- Conditions
- Thalassemia, Sickle Cell Disease, Healthy Controls
- Trial name
- CVR (NCT03715972)
- Testing
- Hydroxyurea, Acetazolamide
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Sickle Cell Disease
Sickle Cell Anemia and Cerebral Microcirculation : Multimodal Exploration
The aim of this study is to evaluate determinants of cerebral oxygenation and perfusion at the microcirculatory level in children with sickle cell anemia (SCA) using combined novel investigational tools: Arterial Spin Labeling…
- Trial name
- DREAM² (NCT02909283)
- Testing
- Physical exams and blood analyzes
- Where
- 2 sites in France
- Volunteers
- 64 people
- Sponsor
- Imagine Institute
Anemia, Sickle Cell
Quality of Life of Children With Sickle Cell Disease Who Are Getting Chronic Transfusions With a Lifeport
This study is being done to see what impact having a Lifeport device has on quality of life for children with sickle cell who are getting chronic transfusions, from the child's perspective.
- Trial name
- NCT00246077
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Children's Mercy Hospital Kansas City
Sickle Cell Trait
Effect of Exercise on Biomarkers in SCT
This study measures the effect of exercise on a variety of biomarkers in blood and urine selected to evaluate the physiological pathways of hemolysis, myolysis, thrombosis, inflammation, and renal function in subjects with sickle…
- Trial name
- NCT04273022
- Testing
- Exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Sickle Cell Disease, Respiration Disorders
Sleep Respiratory Disorders Evaluation in Sickle Cell Disease Children
In Sickle cell disease children, sleep respiratory abnormalities are risk factors for vaso-occlusive complications, as well as cerebral vasculopathy.
- Trial name
- SOMMEDREP (NCT01565954)
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris