Clinical trials: Anemia in Pregnancy
End Stage Renal Disease
Less Frequency Hemodialysis and COVID-19
Facing the unusual situation imposed by the coronavirus disease, the aim of this study is to evaluate the risk and effects of less frequent hemodialysis on prevalent patients
- Trial name
- NCT04374058
- Testing
- less-frequency hemodialysis
- Where
- Argentina
- Volunteers
- 50 people
- Sponsor
- Dialisis Madariaga
Iron Deficiency Anemia of Pregnancy
Daily vs Intermittent Iron Therapy in Pregnancy
This is a randomized non inferiority trial to evaluate the response to iron therapy in the standard daily vs. intermittent (three-four times a week on nonconsecutive days) groups by using hematological markers (hemoglobin…
- Trial name
- NCT03706638
- Testing
- Ferrous Sulfate
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- UConn Health
Atypical Hemolytic Uremic Syndrome
Evaluate Long-term Safety, Tolerability and Efficacy of Iptacopan in Study Participants With aHUS
This is a multicenter, single arm, open-label, extension study to evaluate the long-term safety, tolerability, and efficacy of iptacopan in participants with aHUS.
- Trial name
- NCT05795140
- Testing
- Iptcaopan 200 mg
- Where
- 9 sites in Brazil, China and 4 more
- Volunteers
- 65 people
- Sponsor
- Novartis Pharmaceuticals
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Abnormal Uterine Bleeding
Role of Blood Management in Perioperative Outcomes
There is currently limited information regarding the role of blood management in the benign gynecologic population and specifically, in patients who are scheduled to undergo surgery for fibroids and/or abnormal uterine bleeding.
- Trial name
- NCT04475497
- Testing
- Blood management, Usual care
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- The Cleveland Clinic
Iron-Deficiency Anemia, Inflammation
Ferumoxytol for Iron-Deficiency Anemia in Chronic Kidney Disease and Peritoneal Dialysis Patients
The purpose of this study is to investigate the efficacy of ferumoxytol for the repletion of iron stores and correction of iron deficiency anaemia in patients with severe chronic kidney disease or end-stage chronic kidney disease…
- Conditions
- Iron-Deficiency Anemia, Inflammation, Oxidative Stress
- Trial name
- NCT01942460
- Testing
- Ferumoxytol
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Georges Ouellet
Anemia Ferropenic, Risk of Hemoconcentration (Iron Levels >130g/L)
Effectiveness of Adaptation of the Dose of Iron Supplementation in Pregnancy on Maternal-child Health. (ECLIPSES)
Currently, there is no consensus regarding iron supplementation dose that is most beneficial for maternal and offspring health during gestation. This deficit, or excess, of iron prejudices the mother-child wellbeing.
- Trial name
- (ECLIPSES) (NCT03196882)
- Testing
- 40mg/day of iron, 20mg/day of iron, 80mg/day of iron
- Where
- 2 sites in Spain
- Volunteers
- 704 people, healthy volunteers welcome
- Sponsor
- Victoria Arija Val
Thrombotic Microangiopathies, Hemolytic Uremic Syndrome, Atypical
Complement Prospective Evaluation of Thrombotic Microangiopathy on Endothelium
Thrombotic microangiopathy (TMA) is a severe and life-threatening condition, often affecting the kidneys and brain. It can occur on the background of various clinical conditions.
- Conditions
- Thrombotic Microangiopathies, Hemolytic Uremic Syndrome, Atypical, Hemolytic-Uremic Syndrome
- Trial name
- COMPETE (NCT04745195)
- Where
- Netherlands
- Volunteers
- 42 people
- Sponsor
- Maastricht University Medical Center
Renal Anemia
Neocytolysis in the Treatment of Renal Anemia With Erythropoieses Stimulating Agents (ESA)
The purpose of this study is to gain information on reticulocyte neocytolysis in patients treated with ESA with regard to different types of ESA.
- Trial name
- NCT01306409
- Testing
- cera, darbepoetin, epoetin-beta, ESA
- Where
- Switzerland
- Volunteers
- 9 people
- Sponsor
- University Hospital, Basel, Switzerland
Hypothermia, Hemorrhage, Postpartum
Complications Associated With Intraoperative Hypothermia.
Maintaining intraoperative normothermia and temperature measurement is a marker of quality of care. We know that intraoperative hypothermia is associated with an increased risk of cardiovascular events, infection of the surgical…
- Conditions
- Hypothermia, Hemorrhage, Postpartum, Infection Surgical Wound, Transfusion-dependent Anemia
- Trial name
- NCT05203016
- Testing
- Hipotermia/Normotermia
- Where
- Spain
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Pregnancy Complications, Anemia, Iron Deficiency
Eradication of H-pylori in Pregnancy and Its Effect on Iron Replacement Therapy?
the effect of eradication of H-pylori in pregnant patients with iron deficiency anemia on the level of hemoglobin after iron therapy.
- Conditions
- Pregnancy Complications, Anemia, Iron Deficiency, H Pylori Infection
- Trial name
- NCT03347513
- Testing
- triple attack therapy, Ferrous(II)-glycine-sulphate complex 567.7 mg capsules
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Anemia in Incident Dialysis Patients
Safety and Efficacy Study of Roxadustat (FG-4592) for the Treatment of Anemia in End-Stage Renal Disease (ESRD) Newly Initiated Dialysis Participants
The purpose of this study is to determine whether roxadustat is safe and effective in the treatment of anemia in participants who have just begun dialysis treatment for ESRD.
- Trial name
- Himalayas (NCT02052310)
- Testing
- Roxadustat, Epoetin Alfa
- Where
- 113 sites in United States, Argentina and 13 more
- Volunteers
- 1,043 people
- Sponsor
- Kyntra Bio
Hemolytic-Uremic Syndrome
Efficacy of INM004 in Children With STEC-HUS
The objectives of this study are to evaluate the efficacy, safety, and pharmacokinetics of INM004 in pediatric patients with Hemolytic Uremic Syndrome associated to infection by Shiga toxin-producing Escherichia coli (STEC-HUS).
- Trial name
- NCT06389474
- Testing
- INM004
- Where
- 52 sites in Argentina, Belgium and 7 more
- Volunteers
- 220 people
- Sponsor
- Inmunova S.A.
Kidney Failure, Chronic, Malnutrition-Inflammation Syndrome
Roxadustat's Effect on Heart, Nutrition, and Inflammation in Hemodialysis Patients
Patients with kidney failure who require hemodialysis often suffer from anemia (low red blood cell count), heart and blood vessel problems, and a condition involving poor nutrition, inflammation, and hardening of the arteries…
- Conditions
- Kidney Failure, Chronic, Malnutrition-Inflammation Syndrome, Anemia in End Stage Renal Disease, Cardiovascular Diseases (CVD)
- Trial name
- ROXA-HD-MIA (NCT06903559)
- Testing
- Roxadustat, Conventional Anemia Management
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Mansoura University
Anaemia
Anemia Studies in CKD: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat- Iron (ASCEND: Fe)
Daprodustat administration has the potential, by virtue of increasing hypoxia-inducible factor (HIF) levels, to increase oral iron absorption and incorporation into hemoglobin (Hgb).
- Trial name
- NCT03457701
- Testing
- Daprodustat, rhEPO, Ferrous sulfate containing the stable iron isotope (57Fe)
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- GlaxoSmithKline
Anemia, Heart Failure
An Evaluation of the Causes of Anemia in Patients With Heart Failure
Anemia is frequent in patients with heart failure. Few studies have clearly addressed the causes of anemia in patients with HF. The purpose of this study is to evaluate differences in blood concentrations of various substances…
- Conditions
- Anemia, Heart Failure, Chronic Renal Failure
- Trial name
- ANCHOR (NCT00834691)
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- Montreal Heart Institute
Atypical Hemolytic Uremic Syndrome
Eculizumab to Cemdisiran Switch in aHUS
Atypical Hemolytic Uremic Syndrome (aHUS) is a rare, lifethreatening, chronic disease of complement-mediated thrombotic microangiopathy (TMA) characterized by acute onset of renal impairment, thrombocytopenia, and…
- Trial name
- DANCE (NCT03999840)
- Testing
- cemdisiran
- Where
- Italy
- Sponsor
- Mario Negri Institute for Pharmacological Research
Anemia in Chronic Kidney Disease Patients Not on Dialysis
ASP1517 Phase 2 Clinical Trial - Double-Blind Study of ASP1517 for the Treatment of Anemia in Chronic Kidney Disease Patients Not on Dialysis-
This study is to evaluate the safety and the dose-response of ASP1517 in the treatment of anemia in non-dialysis Chronic Kidney Disease (CKD) patients when ASP1517 is applied intermittently.
- Trial name
- NCT01964196
- Testing
- ASP1517
- Where
- 7 sites in Japan
- Volunteers
- 107 people
- Sponsor
- Astellas Pharma Inc
End Stage Renal Disease, Renal Anemia
Assessment of an Anemia Model Predictive Controller for Anemia Management in Hemodialysis Patients
The purpose of this randomized, controlled pilot study is to evaluate the performance of this novel Anemia Controller (vis-à-vis standard of care) for anemia management in hemodialysis patients.
- Conditions
- End Stage Renal Disease, Renal Anemia, Chronic Kidney Diseases
- Trial name
- NCT04360902
- Testing
- Anemia Controller
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Renal Research Institute
Anemia, Multiple Myeloma
The Effect of Epoetin Alfa on the Anemia of Patients With Selected Cancers Receiving Chemotherapy
The purpose of this study is to evaluate the safety and effectiveness of epoetin alfa versus placebo in reducing or preventing the need for transfusions in anemic patients with cancer receiving chemotherapy, and to investigate…
- Conditions
- Anemia, Multiple Myeloma, Lymphoma, Breast Cancer
- Trial name
- NCT00270166
- Testing
- epoetin alfa
- Volunteers
- 201 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.