Clinical trials: Anesthesia, General
Emergence From Anesthesia, Mechanical Ventilation
Controlled Ventilation During Anesthetic Emergence
Absolutely - for a ClinicalTrials.gov-style Brief Summary, I'd keep it simple and patient-friendly like your example: The goal of this clinical trial is to learn whether maintaining controlled mechanical ventilation during…
- Trial name
- NCT07853547
- Testing
- Controlled/Full-Support Mechanical Ventilation During Emergence
- Where
- Saudi Arabia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz Medical City
Spinal Fusion Acquired, Spinal Stenosis
Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion
Major lumbar spine surgery causes inflammation, soreness and swelling that can delay discharge from the hospital. Dexmedetomidine (DEX) has been shown to have anti-inflammatory effects.
- Conditions
- Spinal Fusion Acquired, Spinal Stenosis, Lesions of Lumbosacral Intervertebral Disc, Spinal Diseases
- Trial name
- DEXREDLOS (NCT00808665)
- Testing
- Dexmedetomidine, 0.9% Saline
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Vanderbilt University Medical Center
Airway Complication of Anaesthesia, Laryngeal Mask Airway Removal
The Application of Lidocaine Cream on Oral Secretions of LMA Removal During the Recovery Period in Ophthalmic Surgical Patients Under General Anesthesia
The application of lidocaine cream on oral secretions of LMA removal during the recovery period in ophthalmic surgical patients under general anesthesia: a randomized controlled trial
- Conditions
- Airway Complication of Anaesthesia, Laryngeal Mask Airway Removal, Anesthesia Emergence, Secretion; Excess, Salivation
- Trial name
- LICOS (NCT06967064)
- Testing
- lidocaine cream
- Sponsor
- Sun Yat-sen University
Elective Surgery of Short Duration (Less Than 2 hr) Undergoing General Anesthesia Using Supraglottic Airway
The Comparison of the Clinical Efficacy Between I-gel and LMA-Supreme, the Two Most Recently Developed Supraglottic Airway Devices, in Infants
Although the safety and efficacy of the I gel in children has been shown in several large observational studies, There is no study about comparison of the clinical efficacy between I-gel and LMA-Supreme , in particular sizes 1…
- Trial name
- NCT01863316
- Testing
- I gel, LMA Supreme
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
General Anesthesia, Hypotension on Induction
Ultrasonographic Predictors of Hypotension After Induction
The purpose of the study is to evaluate the predictive value of the inferior vena cava collapsibility index and caval aorta index for detecting hypotension after induction of general anesthesia.
- Trial name
- NCT05239234
- Testing
- Inferior vena cava-Aorta diameter index
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Antalya Training and Research Hospital
Reversing Vecuronium-Induced Neuromuscular Blockade in Patients Undergoing General Anesthesia Surgery, Reversing Rocuronium-Induced Neuromuscular Blockade in Patients Undergoing General Anesthesia Surgery
A Dose-Finding Study of Amogammadex Sodium for Reversing Vecuronium and Rocuronium-Induced Neuromuscular Blockade
Background context: Amogammadex sodium has completed Phase I-III clinical studies in China for reversal of rocuronium-induced blockade. No clinical studies have yet been conducted for vecuronium-induced blockade.
- Trial name
- NCT07595393
- Testing
- Rocuronium (0.6mg/kg), vecuronium bromide (0.1mg/kg)
- Volunteers
- 64 people
- Sponsor
- Amckaus PTY LTD.
Prostate Cancer
The Effect of Combined General/Epidural Anesthesia Versus General Anesthesia on Diaphragmatic Function
The aim of this study was to investigate whether robot assisted laparoscopic radical prostatectomy give rise to the impairment of diaphragmatic function postoperatively, and whether combined general/epidural anesthesia could…
- Trial name
- NCT01547416
- Testing
- epidural 250mL of 0.2% ropivacaine and 2 μg/mL of fentanyl, 5 mL/hr continuous infusion and 0.5 mL bolus dose, no epidural drug administered
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Hernia Repair, Orchiopexy
Postoperative Pain Relief in Children: Comparing Caudal Bupivacaine Alone Versus Bupivacaine With Dexmedetomidine for Infra-Umbilical Surgeries Under General Anesthesia
This study is being done to find out which medicine combination provides better pain relief after surgery in children. Children who are having surgery below the belly button (called infra-umbilical surgery) will receive general…
- Conditions
- Hernia Repair, Orchiopexy, Hypospadias
- Trial name
- NCT07121764
- Testing
- Bupivacaine %0.25 (isobaric), Dexmedetomidine & Bupivacaine.
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Allama Iqbal Teaching Hospital
Eye Diseases
Correlation Between Exhaled Propofol Concentration With Plasma Concentration in Children
Children due for elective eye surgery in propofol based anesthesia will be kept at steady state propofol infusion for maintenance, ventilation via endotracheal tube.
- Trial name
- NCT04150432
- Testing
- Edmon
- Where
- Norway
- Volunteers
- 32 people
- Sponsor
- Oslo University Hospital
Vasopressor Agents, Endarterectomy, Carotid
Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Artery Surgery
This will be a prospective, randomized, double-blinded, cross-over clinical trial to compare the effects of phenylephrine or norepinephrine on cardiac function during carotid artery surgery in patients under general anesthesia.
- Conditions
- Vasopressor Agents, Endarterectomy, Carotid, Echocardiography, Transesophageal
- Trial name
- NCT00294606
- Testing
- Comparison of Effects of Phenylephrine and Norepinephrine
- Where
- Canada
- Volunteers
- 86 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Ear Deformities, Acquired
The Effect of General Anesthesia on the Middle Ear Pressure
The investigators aimed to examine the effect of sevoflurane and desflurane, agents used in patients who do not have any ear pathology and undergo surgery under general anesthesia, on the MEP.
- Trial name
- NCT03100604
- Testing
- desflurane,, Sevoflurane
- Volunteers
- 50 people
- Sponsor
- Trakya University
Parkinson's Disease (PD)
A General Anesthesia Regimen for DBS Surgery in Patients With PD
Patients who meet the enrollment criteria and voluntarily join this study will be admitted to the operating room on the day of surgery, and will receive endotracheal intubation under general anesthesia.
- Trial name
- GADBS (NCT06658132)
- Testing
- 0.5~1ug/kg/min remifentanil combined with 0.2~0.5mg/kg/h esketamine for the physiological testing phase of DBS surgery.
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Anesthesia, General, Hemodynamics
Observation on Administration of Propofol at Different Titration Endpoints
Propofol has a rapid onset and short duration of action, making it widely used for induction of general anesthesia. However, its prominent drawback is circulatory depression.
- Trial name
- OAPDTE (NCT06685198)
- Testing
- Titrated administration of propofol to an OAA/S score of 1 as the endpoint, Titrated administration of propofol to an OAA/S score of 2 as the endpoint, Titrated administration of propofol to a BIS value ≤ 60 as the endpoint
- Where
- China
- Volunteers
- 258 people
- Sponsor
- SanQing Jin
Teeth, Impacted, Tooth-loss
The Influence of Sedation and General Anesthesia to Patients' Psycho-emotional State Undergoing Wisdom Teeth Extraction
The aim of the study is to evaluate, wheather the sedation or general anesthesia in third molar extractions influence the patient's psycho-emotional status.
- Conditions
- Teeth, Impacted, Tooth-loss, Anxiety, Fear
- Trial name
- NCT04259463
- Testing
- Third molars extraction
- Where
- Lithuania
- Volunteers
- 53 people
- Sponsor
- Inesa Astramskaitė
Ischemic Stroke, Anesthesia
The Effect of Sedoanalgesia and General Anaesthesia on Early Neurological Recovery in Acute Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy
The hypothesis of this study is that sedoanalgesia will provide better early neurological recovery than general anaesthesia in acute ischaemic stroke patients undergoing endovascular thrombectomy and to investigate the…
- Conditions
- Ischemic Stroke, Anesthesia, Neurologic Symptoms
- Trial name
- NCT06183567
- Testing
- Sedoanalgesia, general anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Umraniye Education and Research Hospital
Delirium, Anesthesia Emergence, Delirium
The Efficacy of Oral Melatonin in Preventing Postoperative Delirium for Patients Undergoing Orthopedic Surgery Under General Anesthesia
Postoperative delirium is a complication that should not be underestimated. As it elaborates many complications that could be avoided when an accurate assessment of the risk factors and interventional measures are taken…
- Trial name
- NCT05236907
- Testing
- Melatonin, No intervention, Midazolam
- Where
- 2 sites in Iraq
- Volunteers
- 36 people
- Sponsor
- University of Baghdad
General Anesthesia, Intraoperative Monitoring
Equivalent MAC in General Anesthesia
This observational study aims to evaluate the clinical applicability of the Equivalent Minimum Alveolar Concentration (eMAC) parameter during general anesthesia.
- Conditions
- General Anesthesia, Intraoperative Monitoring, Anesthetic Depth
- Trial name
- NCT07197567
- Testing
- Sevoflurane + Remifentanil, Sevoflurane + Propofol + Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sakarya University
Breast Cancer, General Anaesthesia
Effect of Rocuronium on BIS Values
Aim of this trial is to define if Trend of Four (TOF) values after a bolus of rocuronium is correlated with Bispectral Index BIS values during standard general anaesthesia for breast surgery.
- Trial name
- NCT05681611
- Testing
- Rocuronium
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- University of Padova
Post Induction Hypotension, Elderly
Ciprofol Titrated Induction in Reducing Post-induction Hypotension in Geriatric Patients
Geriatric patients undergoing general anesthesia face a significant challenge, with the induction phase contributing to 50% of hypotensive events.
- Trial name
- CTIH (NCT06258967)
- Testing
- ciprofol, propofol
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
General Surgery
Serum Neurofilament Light (NFL) in Surgery Under General Anaesthesia (GA) Compared to Surgery With Hypno-analgesia (Hyp)
Experimental studies have shown that inhalational anesthetics may be neurotoxic by for example causing amyloid beta deposition. Otherwise a pre-clinical study reported an increase in tau phosphorylation with the use of propofol.
- Trial name
- NCT04500236
- Testing
- General anesthesia, Hypno-analgesia
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain