Clinical trials: Anesthesia, Inhalation
Respiratory Aspiration of Gastric Content
AuraGainTM and I-Gel® Laryngeal Masks in General Anesthesia for Laparoscopic Cholecystectomy
The standard procedure used for airway control in general anesthesia for LC (laparoscopic cholecystectomy) is endotracheal intubation (EI).
- Trial name
- AILMALC (NCT02925598)
- Testing
- I-gel LMA insertion, AuraGain LMA insertion, ETT insertion
- Volunteers
- 114 people
- Sponsor
- Adiyaman University Research Hospital
Adult Patients Undergoing Elective Surgery With General Anesthesia and LMA Insertion
Comparison Between Lidocaine Inhalation and Intravenous Dexamethasone in Reducing Pain After Laryngeal Mask Insertion
This study aimed to compare the efficacy between lidocaine inhalation vs intravenous dexamethasone to reduce pain after laryngeal mask insertion
- Trial name
- NCT03139591
- Testing
- lidocaine inhalation; intravenous dexamethasone
- Where
- Indonesia
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Premature Birth, Sedation During Labor and Delivery; Complications, Pulmonary
Magnesium for Neonatal Neuroprotection and Mothers
Magnesium is a treatment for mothers to protect brains of babies born early. This study investigates combined effects of magnesium and spinal or epidural anesthesia on mothers having cesareans.
- Conditions
- Premature Birth, Sedation During Labor and Delivery; Complications, Pulmonary, Respiratory Depression
- Trial name
- MnMs (NCT01482078)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
The Patients Who Underwent General Anesthesia
Comparison of Esophageal and Tracheal Temperature in the Patients Using Breathing Circuit With Heated Wire Humidifier
When using a breathing circuit with heated wire humidifier, investigators will check if the temperature measured by the thermometer of the endotracheal tube is more than 0.25 degrees apart from the temperature measured by the…
- Trial name
- NCT04817943
- Testing
- Non applicable
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Pusan National University Yangsan Hospital
Anesthesia
Power Spectral Analysis of EEG During Equi-MAC Inhalation Anesthesia
The purpose of this clinical trial is to compare hypnotic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using power spectral analysis of the electroencephalogram.
- Trial name
- NCT02872389
- Testing
- Sevoflurane, Desflurane
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Kangbuk Samsung Hospital
Frail Elderly Syndrome
Home-based Prehabilitation for Elderly Patients
As a consequence of the increasing life expectancy hospitals are seeing a growing number of elderly patients undergoing elective surgery.
- Trial name
- TRAilty (NCT03964363)
- Testing
- Unsupervised home-based physical prehabilitation
- Where
- 3 sites in Germany
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Effect of a Neuromuscular Block on Ventilation
Influence of Neuromuscular Block on Mask Ventilation
Difficult mask ventilation might lead to a life-threatening situation, if endotracheal intubation is also impossible and neuromuscular blocking agents (NMBA) inhibit spontaneous ventilation.
- Trial name
- NCT01849211
- Testing
- rocuronium
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Kreiskrankenhaus Dormagen
Pleural Neoplasms, Aspiration, Respiratory
Local Anesthesia Versus Combined Local Anesthesia With Single Dose Analgesia on Pain Control During Thoracic Ultrasound Guided Procedures
This study aims to evaluate the efficacy of single dose analgesia in combination with local anesthesia to control pain during Trans Ultrasound guided procedures.
- Conditions
- Pleural Neoplasms, Aspiration, Respiratory, Pleural Effusion, Lung Neoplasms
- Trial name
- NCT05121233
- Testing
- Diclofenac
- Volunteers
- 100 people
- Sponsor
- Assiut University
Hypoxemia During Surgery, Hypoxia
Evaluation of the Effect of Sevoflurane and Propofol Hypotensive Anesthesia on Blood Antioxidant Levels and HIF 1 Levels
The aim of this study to evaluate the patients who underwent controlled hypotensive anesthesia under standardized depth of anesthesia with total intravenous anesthesia or inhalation anesthesia; preoperative and 30. ,60. ,120.
- Trial name
- NCT04246567
- Testing
- Mean Blood Pressure (MBP), Add to 0.5 mcg / kg fentanyl.
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bezmialem Vakif University
Oxygen Consumption, Sevoflurane
Oxygen Consumption and Sevoflurane Uptake Based on Physiological Dead Space Estimation
In this study, the investigators will evaluate whether the delivered fraction of oxygen (O2) and sevoflurane administered through a a closed circuit and calculated on the basis of the estimations of O2 consumption (VO2) and…
- Conditions
- Oxygen Consumption, Sevoflurane, Anesthetics, Inhalation, Surgery
- Trial name
- NCT05511584
- Testing
- VO2 estimation, SEVOup estimation
- Where
- Spain
- Volunteers
- 17 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Valve Disease, Heart, CABG
Nonintubated Anesthesia for Adult Cardiac Surgery With Cardiopulmonary Bypass
The goal of this prospective, multicenter, randomized clinical trial is to learn whether a nonintubated supraglottic airway anesthesia strategy with early restoration of spontaneous breathing can reduce postoperative pulmonary…
- Trial name
- NIA-Heart (NCT07744009)
- Testing
- Nonintubated Anesthesia Group, Conventional Anesthesia Group
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Atelectasis
Effects of Spontaneous Breathing Activity on Atelectasis Formation During General Anaesthesia
Atelectasis and redistribution of ventilation towards non-dependent lung zones are a common side effects of general anesthesia. Spontaneous breathing activity (SBA) during mechanical ventilation may avoid or reduce atelectasis…
- Trial name
- SBAFGA (NCT01073917)
- Testing
- Spontaneous Breathing, Pressure Controlled Ventilation, Pressure Support Ventilation
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technische Universität Dresden
Drug Interactions, Anesthesia, Conduction
Interaction of Sevoflurane Propofol and Remifentanil in Anesthesia for Laparoscopic Surgery
Recently a new model for the interaction of sevoflurane propofol and remifentanil was developed. The potency of any combination of the three drugs is defined as probability that a subject tolerates laryngoscopy without movement…
- Trial name
- SPRV (NCT02457442)
- Testing
- Propofol and Remifentanil, Sevoflurane and Remifentanil, SPR 1
- Where
- Switzerland
- Volunteers
- 172 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Anesthesia Intubation Complication, Cardiovascular Complication
Induction of Anesthesia With Sevoflurane Preserving Spontaneous Breathing: Cardiorespiratory Effects.
Airway management is of outmost importance in the perioperative period. One of the main questions while making a plan for airway management is whether spontaneous ventilation should be maintained or not.
- Conditions
- Anesthesia Intubation Complication, Cardiovascular Complication, Intubation
- Trial name
- NCT04802122
- Testing
- Sevoflurane inhalant product, Propofol Fresenius
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aristotle University Of Thessaloniki
Pulmonary Aspiration of Gastric Contents
A Multicentre Preoperative Fasting Audit
The new European Society of Anaesthesiology and Intensive Care (ESAIC) preoperative fasting guideline recommends a one hour minimum fasting time for clear fluids.
- Trial name
- EUROFAST (NCT05519969)
- Where
- Sweden
- Volunteers
- 307,162 people
- Sponsor
- Uppsala University
Pregnancy
Changes in Ventilation Inhomogeneity and Respiratory Function Following Elective Caesarean Section Under Regional Anaesthesia
Pregnancy is associated with physiological changes affecting the cardiorespiratory system as a consequence of an increase in both cardiac output and intra-abdominal pressure.
- Trial name
- VIRCA (NCT02714556)
- Testing
- Physiologic measures of lung function
- Where
- Switzerland
- Sponsor
- Walid HABRE
Child, Only, Inhalation; Vapor
Cerebral and Peripheral Near Infrared Spectroscopy Monitoring in Low and High Flow Anaesthesia in Pediatric
To investigate the effects of non-invasive cerebral and peripheral NIRS monitoring and low and high flow sevoflurane anaesthesia on cerebral and peripheral NIRS in paediatric patients.
- Conditions
- Child, Only, Inhalation; Vapor, Anesthesia, Cerebral Oxygenation
- Trial name
- NCT06320743
- Testing
- NIRS ,Ventilation parameters, Oxygen concentration
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Ankara City Hospital Bilkent
Adverse Effect of Other General Anesthetics, Anesthesia Intubation Complication
Comparison of Tapered- vs. Cylindrical-shaped Tube Cuffs Pressure Alteration With Nitrous Oxide
When using nitrous oxide for general anesthesia, nitrous oxide diffusion induces intracuff hyperinflation of the endotracheal tube.
- Conditions
- Adverse Effect of Other General Anesthetics, Anesthesia Intubation Complication, Inhalation of Nitrous Oxide, Trachea
- Trial name
- NCT01812915
- Testing
- Cylindrical-shape cuff ETT (Group C), Tapered-shape cuff ETT (Group T)
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- DongGuk University
Patients With Suspected Non-small Cell Lung Cancer (NSCLC) at Clinical Stage T1
Anesthesia Comparison in Early-stage Small NSCLC: A Multicenter RCT
This study is a prospective, randomized, controlled study, which intends to enroll patients with suspected early-stage NSCLC (non-small cell lung cancer) with a diameter of ≤ 3 cm as research subjects.
- Trial name
- NCT07327736
- Testing
- Non-intubated video-assisted thoracic surgery with spontaneous breathing (NIVATS)
- Volunteers
- 410 people
- Sponsor
- Tang-Du Hospital
Airway Complication of Anaesthesia, Healthy
The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects
The investigators hypothesize that propofol, when compared to sevoflurane, causes the upper airway to collapse more easily and causes less activity in the tongue muscle.
- Trial name
- NCT01557920
- Testing
- Propofol, Sevoflurane
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital