Clinical trials: Anesthesia, Intravenous
Anesthesia
Automatic Control of Total Intravenous Anesthesia (ACTIVA)
This study concerns the clinical evaluation of a closed loop control system for the automatic administration of anesthetic drugs in TIVA (Total Intra Venous Anesthesia).
- Trial name
- ACTIVA (NCT04432974)
- Testing
- Automatic closed-loop anesthesia
- Where
- Italy
- Volunteers
- 139 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Delayed Emergence From Anesthesia
Recovery Profile Comparison Between Remifentanil-propofol or Desflurane Anesthesia Monitored With Bispectral Index.
Bispectral monitoring anesthesia with remifentanil-desflurane has a better post-operative recovery than remifentanil-propofol.
- Trial name
- NCT02631525
- Testing
- Desflurane, Propofol
- Volunteers
- 40 people
- Sponsor
- Federal University of Minas Gerais
Adjuvants, Anesthesia
Effects of Dexmedetomidine Target Controlled Infusion on Patient State Index Values and Electroencephalographic Spectrum During Total Intravenous Anesthesia With Propofol
Dexmedetomidine Target Controlled infusion (TCI, Dyck model) effects on Neuromonitoring during Total Intravenous Anesthesia (TIVA) with Propofol and Remifentanil TCI (Eleveld model) has not been investigate yet.
- Trial name
- NCT07259460
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Padova
Hypertension, Hemodynamic Response
Dexmedetomidine in Attenuation of Haemodynamic Response to Laryngoscopy in Controlled Hypertensive Patients
This randomized control trial, which was carried out at Sindh Institute of Urology and Transplantation (SIUT), used a non-probability consecutive sampling technique for six months from January 1, 2025, to June 30, 2025.
- Conditions
- Hypertension, Hemodynamic Response, Anesthesia
- Trial name
- NCT07557680
- Testing
- Dexmedetomidine, Normal Saline
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Sindh Institute of Urology and Transplantation
Idiopathic Scoliosis
Anesthesia During Neurophysiologic Monitoring in Scoliosis Patients
When patients have spinal surgery, electrodes are placed on the body to measure motor evoked potentials (MEP) and somatosensory evoked potentials (SSEP).
- Trial name
- NCT01549873
- Testing
- propofol, Desflurane
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Nationwide Children's Hospital
Bladder Tumors, Spinal Anesthesia
Magnesium vs. Dexmedetomidine in TURBT Under Spinal Anesthesia
This randomized controlled trial evaluated the effects of intraoperative intravenous magnesium sulfate versus dexmedetomidine on postoperative pain, analgesic consumption, hemodynamic stability, and respiratory function in…
- Conditions
- Bladder Tumors, Spinal Anesthesia, Postoperative Pain, Magnesium Sulfate
- Trial name
- TURBT (NCT07445451)
- Testing
- magnesium sulfate, Dexmedetomidine, Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Total Intravenous Anaesthesia, Eleveld Model, Obes
Prospective Validation Of The Eleveld TCI Model For Propofol In The Malaysian Obese Population
This is a prospective single blinded randomized trial to validate the 2014 published and widely used Eleveld TCI model which is a universal model suitable for use in all age groups and is suitable for all patients even in the…
- Trial name
- NCT05885100
- Testing
- Eleveld Model
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Postoperative Nausea and Vomiting
Dexamethasone for the Prevention of Post-operative Nausea and Vomiting in Patients Undergoing Cesarean Sections
Patients who present for scheduled (non-emergent) cesarean section will be given either intravenous dexamethasone or placebo prior to receiving a duramorph containing spinal anesthetic.
- Trial name
- NCT01734161
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Anaesthesia
Effect of Language and Confusion on Pain During Peripheral Intravenous Catheterization (KTHYPE)
The purpose of this study is to compare three communications during peripheral intravenous catheterization and measure pain patient: one hypnotic, confusion (HYPNOSIS), an other with negative connotation (NOCEBO) and at least…
- Trial name
- KTHYPE (NCT02662322)
- Testing
- Hypnotic communication, negative connotation communication, neutral connotation communication
- Where
- 3 sites in Belgium, France
- Volunteers
- 294 people
- Sponsor
- Rennes University Hospital
Anesthesia, Intravenous
Comparison of Recovery Profile After TIVA Between Remimazolam With Flumazenil and Propofol
This prospective, randomized, single-blinded study is designed to compare the recovery profile between propofol-based total intravenous anesthesia (TIVA) and remimazolam-based TIVA in patients undergoing thyroidectomy.
- Trial name
- NCT05047939
- Testing
- remimazolam-based TIVA, propofol-based TIVA
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Sevoflurane, Lidocaine
Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy
This study will be conducted to evaluate the effects of different anesthetic modalities [sevoflurane with or without intraoperative lidocaine infusion and Propofol total intravenous anesthesia (TIVA)] on intracranial pressure…
- Conditions
- Sevoflurane, Lidocaine, Propofol, Intracranial Pressure
- Trial name
- NCT07062367
- Testing
- Propofol, Sevoflurane plus lidocaine infusion, Sevoflurane
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Myocardial Ischemia
Optimization of Cardioprotection in Diabetic Patients Undergoing Cardiac Surgery
This study evaluates the myocardial protection against perioperative ischemia comparing two standard anesthetic regimes in diabetic patients undergoing elective cardiac surgery.
- Trial name
- OPT (NCT02407626)
- Testing
- Propofol, Sevoflurane
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- Triemli Hospital
Anesthesia, Cardiac Surgery
Oral and Intravenous Methadone for Analgesia in Cardiac Surgery
The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac…
- Trial name
- NCT06720415
- Testing
- Oral methadone, immediately prior to transport, Intravenous methadone
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Spinal (Fusion) Surgery, Total Intravenous Anesthesia
Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider
This randomized prospective study aims to compare the effects of two target-controlled infusion models, the Schnider and Eleveld models, on anesthetic depth and hemodynamic responses during anesthesia induction in adult patients…
- Conditions
- Spinal (Fusion) Surgery, Total Intravenous Anesthesia, Target Controlled Infusion of Propofol, Anesthesia Depth Monitoring
- Trial name
- NCT07586189
- Testing
- TCI Propofol Injection Models- Eleveld, TCI Propofol Injection Schnider
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Insomnia, Digestive Endoscopy
Changes in Rimazolen Dosage in Patients With Insomnia Under Intravenous Anesthesia
To compare the dosage requirement of rimazolen under intravenous anesthesia between patients with insomnia and those with normal sleep pattern.
- Trial name
- NCT07028190
- Testing
- No interventions, it is a observational study
- Where
- China
- Volunteers
- 840 people
- Sponsor
- Beijing Tiantan Hospital
Total Abdominal Hysterectomy
S Ketamine Use in Total Abdominal Hysterectomy
This study investigates the effect of low dose S+ketamine compared to placebo on cumulative morphine consumption at 24 hours in women undergoing open abdominal hysterectomy with remifentanil-propofol target controlled infusion.
- Trial name
- SKET (NCT02543385)
- Testing
- S Ketamine
- Sponsor
- KK Women's and Children's Hospital
Healthy Participants Study, General Anesthesia
Safety, Pharmacokinetics, and Pharmacodynamics of Continuous KL0011034 Infusion in Healthy Chinese Adults
This Phase 1 study will evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of continuous intravenous infusion of KL0011034 Injection in healthy Chinese adults.
- Trial name
- NCT07841626
- Testing
- KL0011034 Injection, Propofol Injectable Emulsion
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Anesthesia, Pediatrics, Surgery
Comparative Study of Superficial Cervical Plexus Block and Nerve of Arnold Block and Incidence of PONV for Inner Ear Surgery
The investigators would like to compare the therapeutic and cost effectiveness of established therapies for postoperative nausea and vomiting to regional nerve blocks of the head and neck area an intervention known for analgesia…
- Trial name
- NCT02724033
- Testing
- regional nerve block, Antiemetic
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Indiana University
Anesthesia, Intravenous
Target Effect-site Concentration of Remifentanil in Transperineal Prostate Puncture
The research about the target effect-site concentration of remifentanil, inhibiting stress reaction of the perineal prostate puncture when Dexmedetomidine being continuous pumping
- Trial name
- NCT03428191
- Testing
- Remifentanyl+Dexmedetomidine
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese Medical Association
Postoperative Recovery, Inhalation Anesthesia
Effect of Combined Intravenous-Inhalational Anesthesia (CIVIA) on Postoperative Recovery Patterns.
This study was planned as a single-center, prospective, randomized trial. Adult patients undergoing elective spinal surgery lasting longer than three hours, performed in a neurosurgery operating room, will be evaluated.
- Conditions
- Postoperative Recovery, Inhalation Anesthesia, Total Intravenous Anesthesia
- Trial name
- NCT07123870
- Testing
- Sevofluorane, Desflurane, Total Intravenous Anesthesia(TIVA)
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Kocaeli City Hospital