Clinical trials: Anesthesia, Local
Breast Cancer
Continuous Serrates Plane Block in Axillary Dissection
Patients undergone to axillary dissection during breast surgery with a PECS I, II block will be randomized to receive either a serratus plane continuous local anesthetic infusion through a multiple hole catheter or nothing.
- Trial name
- NCT03992859
- Testing
- Continuous serratus plane block
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Intracranial Pressure Increase
Comparison of ONSD and rSO2 Measurements Between General and Spinal Anesthesia in C-Section
General anesthesia and regional anesthesia can be chosen in cesarean operations. Endotracheal intubation and mechanical ventilation are components of general anesthesia.
- Trial name
- NCT04446013
- Testing
- Optic Nerve Sheath Diameter Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Transversus Abdominis Plane Block
Bupivacaine Pharmacokinetics Following TAP Block
The aims of this study are to determine population PK parameters of bupivacaine in children following TAP block using a population-based PK approach, and to evaluate the influence of patient covariates on drug disposition.
- Trial name
- NCT02015182
- Testing
- Blood sample for bupivicaine pharmacokinetics
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Pain, Injection
Does Pre-injection Local Anesthesia Affect Experienced Pain During Intra-articular Hip Injections.
Intra-articular hip injections are commonly used for diagnostic and therapeutic purposes but are often associated with patient anxiety and fear.
- Conditions
- Pain, Injection, Prevention, Assessment
- Trial name
- NCT06760559
- Testing
- Intra-articular corticosteroid injection
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Lower Eyelid Bags
The Effect of Inhalation Aromatherapy on Intraoperative Fear in Patients Undergoing Lower Blepharoplasty Under Local Anesthesia: A Randomized Controlled Trial
This study is a single-center, randomized, controlled, open-label clinical trial designed to evaluate the intervention effect of inhaled aromatherapy on intraoperative fear in patients undergoing lower blepharoplasty (eyelid bag…
- Trial name
- NCT07766902
- Testing
- inhaled aromatherapy
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Infection
PReclude Infection EVEnts With No Prophylaxis Transperineal Biopsy
Approximately one million transrectal prostate biopsies are performed annually in the U.S., and the risk of post- biopsy infection is increasing due to greater antibiotic resistance of rectal flora.
- Trial name
- PREVENT (NCT04843566)
- Testing
- Transperineal MRI-guided prostate biopsy, Transrectal MRI-guided prostate biopsy, Antibiotic (prophylaxis)
- Where
- 10 sites in United States
- Volunteers
- 687 people
- Sponsor
- Weill Medical College of Cornell University
Anesthesia, Local, Postoperative Pain
Comparison of Lateral and Medial Approaches to Costoclavicular Brachial Plexus Block in Pediatrics
In upper extremity surgeries, the brachial plexus block can be performed with different techniques at various levels depending on the proximal and distal level of the surgery.
- Trial name
- NCT04786756
- Testing
- Bupivacaine 0.25% Injectable Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Carpal Tunnel, Carpal Tunnel Syndrome
Comparing Superficial vs. Deep Local Anesthetic Infiltration to Improve Patient Experience During Carpal Tunnel Release
Hypothesis: When comparing superficial infiltration of local anesthetic to superficial and deep infiltration of local anesthetic in the setting of carpal tunnel release, the null hypothesis is that there will be no significant…
- Trial name
- NCT04201652
- Testing
- Superficial local anesthetic infiltration, Deep local anesthetic infiltration
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- University of Saskatchewan
Ankle Fractures
Local Multimodal Injection Versus Regional Anesthesia in Controlling Pain for Treating Rotational Ankle Fractures
The investigators plan to evaluate the efficacy in reducing post-operative pain between local multimodal analgesia as compared to regional anesthesia in rotational ankle fractures.
- Trial name
- NCT05019638
- Testing
- Regional anesthesia group, Local multimodal analgesia group
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Utah
Intensive Care Unit
Regional Anaesthesia in Intensive Care Unit
Pain is a major problem in Intensive Care Unit (ICU). Adequate pain management not only means decreasing the pain intensity, but also improving the functionality and allowing the early mobilization that is a prerequisite for…
- Trial name
- Week'ALR (NCT05131633)
- Where
- 19 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Anesthesia, Local, Anesthesia
Regional Anesthesia in Pediatric Orthopaedic Patients
To identify the benefits from regional anesthesia use as pain management in the pediatric population by delineating the differences in efficacy of continuous nerve blockade versus single-shot techniques after pediatric…
- Conditions
- Anesthesia, Local, Anesthesia, Orthopedic Disorder
- Trial name
- NCT04669145
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ochsner Health System
Pain
S-Caine™ Peel (Skin Numbing Cream) to Treat Pain During Non-Ablative Facial Laser Resurfacing in Adults
Lasers are used for non-ablative resurfacing of facial rhytides, atrophic scars, and a variety of epidermal and dermal lesions. Pain associated with the non-ablative laser treatment has been described as moderate to severe.
- Trial name
- NCT00110747
- Testing
- S-Caine™ Peel (lidocaine and tetracaine topical cream 7%/7%)
- Where
- 3 sites in United States
- Volunteers
- 54 people
- Sponsor
- ZARS Pharma Inc.
Local Anesthetic Efficacy
Efficacy of Differents Anaesthetics in Mandibular Third Molar Germectomy
Aim: To compare the clinical efficacy of local anaesthetics with articaine 4% or mepivacaine 2% (both with epinephrine 1:100.000) using different anaesthetic techniques to perform germectomy of lower third molars and to assess…
- Trial name
- NCT04465149
- Testing
- Third Molar Germectomy
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Pain, Postoperative, Hernia, Ventral
An Open-label Safety and Pharmacokinetic Study of INL-001 in Adults Following Various Open Soft-Tissue Surgeries
This is a multicenter, Phase 3, open-label, safety, tolerability, and characterization of pharmacokinetics study of the INL 001 (bupivacaine HCl) implant, at 300 mg, in patients following various soft-tissue surgeries: open…
- Conditions
- Pain, Postoperative, Hernia, Ventral, Abdominoplasty, Hysterectomy
- Trial name
- NCT04785638
- Testing
- INL-001 (bupivacaine hydrochloride) implant
- Where
- 8 sites in United States
- Volunteers
- 100 people
- Sponsor
- Innocoll
Distal Upper Limb Surgeries
Comparative Study of Subcoracoid Tunnel Block Versus Costoclavicular Block
The purpose of this study is to compare the analgesic outcomes (time to first analgesic request, total amount of analgesic consumption, and pain scores) following the ultrasound-guided subcoracoid tunnel block or costoclavicular…
- Trial name
- NCT07305584
- Testing
- subcoracoid tunnel block, Costoclavicular block
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Zagazig University
Local Anesthesia
Effect of Lidocaine With Magnesium Sulfate on the Success of the Inferior Alveolar Nerve Block
68 healthy patients pulpitis and requiring root canal therapy are selected. . Sampling was done in a simple and non-experimental way from a dental clinic in Isfahan, and then the samples were randomly assigned to one of the two…
- Trial name
- NCT03262857
- Testing
- use of magnesium sulfate with lidocaine in inferior alveolar nerve block
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Rebound Pain
Local Anesthetic Concentration and Rebound Pain
The rebound pain after nerve block could interfere with patient's recovery and rehabilitation. It is not known how local anesthetic concentrations affect rebound pain.
- Trial name
- NCT04457557
- Testing
- Reduced concentration of local anesthetic (ropivacaine), Usual concentration of local anesthetic (ropivacaine)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Ajou University School of Medicine
Neck Pain, Radiculopathy, Cervical
Repeated Transforaminal Anesthetic Injections With or Without Glucocorticoid in Patients With Cervical Radiculopathy
The main objective is to evaluate pain and muscle strength in the upper extremities after treatment with cervical transforaminal injection of glucocorticoid vs.
- Conditions
- Neck Pain, Radiculopathy, Cervical, Cervical Foraminal Stenosis, Cervical Disc Disease
- Trial name
- NCT03541681
- Testing
- Glucocorticoid Injections, Anesthetic Injections
- Sponsor
- Region Skane
Spinal Anesthesia, Nursing
The Effect of Local Dry Heat Applıcatıon and Half Shower on The Development of Urinary Retentıon and Paın
Urinary retention is defined as the inability to empty the bladder spontaneously even though the bladder is full. Although urinary retention is seen in two forms as acute and chronic, acute urinary retention is defined by the…
- Conditions
- Spinal Anesthesia, Nursing, Bladder Retention, Dry Heat Application
- Trial name
- NCT05580289
- Testing
- half-shower and hot pack
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Duzce University
Hysterectomy, Postoperative Pain
Postoperative Analgesic Effectiveness of the Modified Thoracoabdominal Nerve Block Through a Perichondrial Approach in Total Laparoscopic Hysterectomy
This single-center retrospective cohort study evaluated the effect of the modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA) on postoperative analgesia in patients undergoing elective total…
- Trial name
- MTAPA-TLH (NCT07740252)
- Testing
- Modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Namik Kemal University