Clinical trials: Anesthesia Complication
Emergence Agitation
Effect of Lollipop on Emergence Delirium in Pediatric Patients Undergoing General Anesthesia
This study aims to evaluate the effectiveness of lollipop administration after surgery in reducing emergence agitation in pediatric patients undergoing anesthesia with sevoflurane at RS Ngoerah.
- Trial name
- LOLLIPOP-ED (NCT07571707)
- Testing
- Lollipop
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Udayana University
Endometriosis; Peritoneum, Postoperative Pain
LTAP Block in Endometriosis Surgery - a Randomised Controlled Double-blind Trial
The purpose of this study is to compare the efficacy and safety of laparoscopically inserted transversus abdominis plane block (LTAP) in comparison to local wound analgesia in laparoscopic surgery due to suspected or diagnosed…
- Trial name
- NCT04735770
- Testing
- Postoperative pain management: LTAP block or local wound anesthesia with levobupivacaine
- Where
- Finland
- Volunteers
- 46 people
- Sponsor
- Oulu University Hospital
Biomarkers, Coronary Artery Bypass Surgery
Dynamics of microRNA Expression and Systemic Inflammatory Response in POCD After Cardiac Surgery
Postoperative cognitive decline (POCD) is one of the most common complications after cardiac surgery. It is characterized by impaired memory, attention, and executive functions and can have long-term consequences.
- Conditions
- Biomarkers, Coronary Artery Bypass Surgery, Interleukin-6, MicroRNAs
- Trial name
- NCT07231731
- Where
- Croatia
- Volunteers
- 48 people
- Sponsor
- Osijek University Hospital
Surgery-Complications, Anesthesia Complication
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major…
- Conditions
- Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia
- Trial name
- THRIVE (NCT05991453)
- Testing
- Anesthetic technique Propofol TIVA, Anesthetic technique inhaled agent
- Where
- 24 sites in United States
- Volunteers
- 13,000 people
- Sponsor
- Washington University School of Medicine
Pain Threshold, Surgery
The Effect of Remifentanil on the Objectively Measured Pressure Pain Threshold
It is a clinical study investigating the relationship between objectively measured pain threshold and the need for escalating doses of remifentanyl opioids. This study is expected to include approximately 40 participants.
- Conditions
- Pain Threshold, Surgery, Postoperative Pain, Intravenous Anesthesia
- Trial name
- NCT07568405
- Testing
- Pressure pain theshold measured under remifentanil (ultiva®) infusion, Postoperative PCA IV morphine (Sterop®) consumption and adverse events history
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Université Libre de Bruxelles
Sedative Adverse Reaction
Effect of Sedation on Pulmonary Aeration in Children
Pediatric sedation is an anesthesiological technique with a good safety profile, but various complications might ensure, especially from the respiratory point of view.
- Trial name
- LunSed (NCT03392012)
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- IRCCS San Raffaele
Postoperative Pain, Acute, Regional Anesthesia
Comparation of Bilateral and Unilateral Erector Spinae Plane Block
Although laparoscopic cholecystectomy is a minimally invasive surgery with many advantages, it is one of the operations with high postoperative pain scores. Opioids are frequently used to prevent postoperative pain.
- Conditions
- Postoperative Pain, Acute, Regional Anesthesia, Multimodal Analgesia
- Trial name
- NCT05152602
- Testing
- Bilateral Erector spinae plane block, Unilateral Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Ankara City Hospital Bilkent
General Anesthesia, Ventilator-Induced Lung Injuries
Prevention of Postoperative Respiratory Complications
Given the huge number of patients mechanically ventilated during general anaesthesia, optimizing alveolar recruitment by limiting pulmonary and systemic aggression is a key objective for further progress in perioperative patient…
- Conditions
- General Anesthesia, Ventilator-Induced Lung Injuries, Postoperative Respiratory Complications
- Trial name
- RAMAGE (NCT06899295)
- Testing
- Continuous measurement of esophageal pressure Peso (cmH2O), Measurement of impedance variation with each respiratory cycle (EIT), Z in ohm, Measurement of regional respiratory compliance (EIT), Ohm/cmH2O
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Opioid Use, Pain, Postoperative
Outcome of Multimodal Anesthesia Bern
In the context of the ongoing opioid crisis in the USA and Europe, reducing perioperative opioid use is a growing priority. Multimodal anesthesia (MMA) offers a patient-centered alternative to opioid-free anesthesia, combining…
- Conditions
- Opioid Use, Pain, Postoperative, Postoperative Complications, Postoperative Nausea
- Trial name
- NCT06985069
- Testing
- General anesthesia applying multimodal anesthesia, General anesthesia using conventional opioid-based regimen
- Where
- Switzerland
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Postoperative Complications, Hip Fracture
A Trial To Assess Risk of Delirium in Older Adults Undergoing Hip Fracture Surgery With Spinal or General Anesthesia
This pilot project will address the gaps in knowledge regarding the effect of anesthetic technique on the risk of delirium through an adequately-powered trial employing standardized regimens for treatment and outcome assessment…
- Conditions
- Postoperative Complications, Hip Fracture, Delirium
- Trial name
- NCT02190903
- Testing
- General endotracheal anesthesia, Regional (spinal) Anesthesia
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pennsylvania
Respiratory Complications Due to Anesthesia
A Comparison of Controlled Ventilation With the V60 Non-Invasive Ventilator vs. Traditional Mask Ventilation
The purpose of this study is to determine whether an experienced anesthesia provider can adequately and/or easily mask ventilate an anesthetized patient with a commercial non-invasive ventilator device.
- Trial name
- NCT02623270
- Testing
- Noninvasive Ventilator, V60 (Philips), Manual Bag
- Volunteers
- 20 people
- Sponsor
- University of Utah
Postoperative Pain
Postoperative Discomfort After Dental General Anesthesia
The aim of this prospective, randomised, controlled clinical trial was to compare immediate postoperative discomfort, emergence delirium and recovery time of the patients intubated using either laryngeal mask airway or…
- Trial name
- NCT03197753
- Testing
- Laryngeal mask airway, Nasotracheal intubation
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Breast Cancer
Opioid-Free Versus Opioid-Based Anesthesia in Modified Radical Mastectomy
This randomized controlled trial compares opioid-free anesthesia combined with pectoral nerve block (PECS I and II) with opioid-based anesthesia in patients undergoing modified radical mastectomy.
- Trial name
- NCT07798895
- Testing
- Pectoral Nerve Block (PECS I and II), Dexmedetomidine, Fentanyl
- Where
- Indonesia
- Volunteers
- 28 people
- Sponsor
- Muhammad Fiqhi Amiruddin
Cognition Disorders
Effect of Depth of Total Intravenous Anesthesia Using Propofol on Postoperative Cognitive Dysfunction
The purpose of this study is to investigate whether the depth of anesthesia with propofol affects the incidence of early postoperative cognitive dysfunction
- Trial name
- NCT01708837
- Testing
- Propofol
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xiangya Hospital of Central South University
Obstructive Jaundice, ERCP
Determinants of Technical Success and Safety in Therapeutic ERCP for Obstructive Jaundice
compare the impact of type of anesthesia on ERCP including technical success, rate of complications, peri procedural safety, patient and endoscopist satisfaction in adult patients with obstructive jaundice
- Conditions
- Obstructive Jaundice, ERCP, Anesthesia Complication, Anesthesia Effectiveness
- Trial name
- ERCP (NCT07563569)
- Testing
- ERCP
- Volunteers
- 100 people
- Sponsor
- Sohag University
Regional Anesthesia Morbidity, Postoperative Pain
Retrolaminar Thoracic Paravertebral Block
This clinical study will be conducted on female patients admitted to The General Surgery Department of Tanta Faculty of Medicine for a period of 9 months.
- Trial name
- NCT04162951
- Testing
- Ordinary approach paravertebral block, Retrolaminar paravertebral block
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Tanta University
Surgery, Anesthesia, Local
Block of the Sphenopalatine Nerve Ganglion for Postoperative Analgesia
Transsphenoidal surgery is considered safe and effective and is currently the procedure of choice for the removal of intrasellar lesions.
- Conditions
- Surgery, Anesthesia, Local, Postoperative Pain
- Trial name
- NCT04339231
- Testing
- sphenopalatine ganglion block
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Awareness, Anesthesia, Obstetric Anesthesia Problems
Direct REporting of Awareness in MaternitY Patients
DREAMY is a prospective, multi-centre observational cohort study using a mixed methods approach to provide quantitative and qualitative data on accidental awareness under general anaesthesia (AAGA) in obstetric surgery patients.
- Trial name
- DREAMY (NCT03100396)
- Where
- United Kingdom
- Volunteers
- 3,100 people
- Sponsor
- St George's, University of London
Nephrolithotomy, Percutaneous, Anesthetics, Local
Efficiency of Erector Spinae Plane Block For Patients Undergoing Percutaneous Nephrolithotomy
Investigators' goal is to determine whether Erector Spinae Plane Block would provide a better analgesia, help mobilization and early discharge or increase satisfaction for patients undergoing Percutaneous Nephrolithotomy(PNL).
- Conditions
- Nephrolithotomy, Percutaneous, Anesthetics, Local, Nerve Block, Erector Spinae Plane Block
- Trial name
- NCT03652103
- Testing
- Ultrasound Guided Erector Spinae Plane Block Catheterisation, Bupivacaine 0.25% Injectable Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bozyaka Training and Research Hospital
Postoperative Pain, Laparotomy
M-TAPA vs RSB in Midline Abdominal Incision Laparotomy
The aim is to compare the postoperative analgesic effects of Modified ThoracoAbdominal nerve block through Perichondrial Approach (M-TAPA) versus Rectus Sheath Block (RSB) in patients undergoing laparotomy with midline abdominal…
- Trial name
- NCT07233629
- Testing
- Modified thoracoabdominal nerve block through perichondrial approach (M-TAPA), Rectus Sheath Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cumhuriyet University