Clinical trials: Anesthesia Effectiveness
Anesthesia
Comparison of the Total Dose and Efficacy of Two Lidocaine Concentrations Needed for Cutaneous Surgery Local Anesthesia
The purpose of the study will be to demonstrate whether Mohs micrographic surgery can be performed with a lower total dose of local anesthesia (and greater patient safety) when using 0.5% lidocaine with 1:200,000 epinephrine…
- Trial name
- NCT00594542
- Testing
- lidocaine
- Volunteers
- 149 people
- Sponsor
- University of Pennsylvania
Acute Pain, Chronic Post Operative Pain
Understanding the Acute Pain Phenotype in Patients Undergoing Surgery
The goal of this observational study is to learn about how regional anesthesia (numbing medication) affects pain in patients with different psychosocial phenotypes such as different levels of concern about pain, sleep issues, and…
- Conditions
- Acute Pain, Chronic Post Operative Pain, Opioid Use
- Trial name
- NCT06466941
- Testing
- regional anesthesia, no regional anesthesia, acute pain consultation
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Brigham and Women's Hospital
Dental Education, Inferior Alveolar Nerve Block
Virtual Reality Training for Inferior Alveolar Nerve Block in Dental Students
This randomized controlled study aims to evaluate the effectiveness of virtual reality simulator-based training in teaching the inferior alveolar nerve block (IANB) technique to third-year dental students.
- Trial name
- VR-IANB (NCT07653854)
- Testing
- SIMtoCARE Virtual Reality Simulator, Conventional Training
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Konya Necmettin Erbakan Üniversitesi
Anesthesia
Experimental Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 Anesthetic Spray in Normal Volunteers
The purpose of this study is to determine if the topical application to cheek tissue of the combination of benzocaine and tetracaine has a longer duration of local anesthetic activity than benzocaine alone.
- Trial name
- NCT02908620
- Testing
- One spray CTY-5339-A, One spray CTY-5339-CB, Two sprays CTY-5339-A
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cetylite Industries
Shivering, Post-Spinal Shivering
Efficacy of Intravenous Midazolam-Ketamine Combination Versus Placebo for Prevention of Post-Spinal Shivering in Elective Cesarean Section
Spinal anesthesia is the preferred anesthetic method for elective cesarean deliveries, but it frequently causes post-spinal shivering.
- Conditions
- Shivering, Post-Spinal Shivering, Hypothermia, Cesarean Section
- Trial name
- NCT07855523
- Testing
- Midazolam and Ketamine, 0.9% Sodium Chloride
- Volunteers
- 120 people
- Sponsor
- Assiut University
Post Operative Pain, Bradycardia
Postoperative Analgesic Effectiveness of Bupivacaine With and Without Dexmedetomidine in Patients With Abdominal Surgery
Abdominal surgeries are major surgical procedures that are performed at any teaching hospital. Pain control is major concern in the intra-operative as well as post-operative period in these patients.
- Conditions
- Post Operative Pain, Bradycardia, Hypotension, Nausea
- Trial name
- NCT06531603
- Testing
- bupivacaine wound infilteration, Bupivacaine plus dexmedetomidine wound infilteration
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Sahiwal medical college sahiwal
Anesthesia, Postoperative Pain
Lateral QL Block vs Intrathecal Morphine for Cesarean Section
Effective postoperative analgesia after cesarean delivery is essential for maternal recovery, early mobilization, breastfeeding, and maternal-infant bonding.
- Conditions
- Anesthesia, Postoperative Pain, Regional Anesthesia
- Trial name
- NCT07712783
- Testing
- Lateral Quadratus Lumborum Block, ıv morphine PCA, Intrathecal morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Ondokuz Mayıs University
Pregnancy, Cesarean Section, Spinal Anesthesia
The Effectiveness of Binaural Beats on Midazolam Requirement During Cesarean Section With Spinal Anesthesia
Spinal anesthesia is preferred for cesarean section in many institutions due to concerns regarding the potential effects of general anesthetic agents on the fetus.
- Trial name
- NCT07386054
- Testing
- binaural beats, Midazolam
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Cough, Anesthesia
Efficacy of Alkalinized Lidocaine in the Endotracheal Tube Cuff on the Incidence of Coughing During Emergence
This study is designed to compare the efficacy of endotracheal tube cuffs pre-filled with alkalinized lidocaine on the: incidence of coughing during emergence of general anesthesia time needed for emergence following a…
- Trial name
- NCT01715688
- Testing
- Alkalinized lidocaine, Saline
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Secretion Removal Above ETT Cuff
Evaluation of Above the Cuff Suctioning During General Anesthesia
The aim of this prospective, randomized, pilot study is compare ease of tracheal intubation, amount of microaspiration and efficacy of secretion removal using three FDA (Food and Drug Administration)-cleared endotracheal tubes…
- Trial name
- NCT01386879
- Testing
- methylene blue
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Dexamethasone, Magnesium Sulphate
Dexamethasone Versus Magnesium Sulphate as an Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block for Postoperative Analgesia in Elective Caesarean Section Under Spinal Anesthesia
This study aims to compare the efficacy of adding dexamethasone and magnesium sulfate as an adjuvant to bupivacaine in bilateral erector spinae block in postoperative pain control in patients undergoing caesarean section under…
- Conditions
- Dexamethasone, Magnesium Sulphate, Adjuvant, Ultrasound
- Trial name
- NCT07139522
- Testing
- Bupivacaine, Dexamethasone, Magnesium sulphate
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Cairo University
Hypotension, Spinal Anesthesia
Prophylactic Ondansetron for Preventing Spinal Anesthesia-Induced Hypotension in Elective Cesarean Section
Spinal anesthesia is the preferred technique for elective cesarean section, but it frequently causes maternal hypotension due to sympathetic blockade and the Bezold-Jarisch reflex, which can threaten both mother and baby.
- Conditions
- Hypotension, Spinal Anesthesia, Cesarean Section
- Trial name
- NCT07886151
- Testing
- Ondansetron
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Headache Disorders, Central Nervous System Diseases
Is Sphenopalatine Ganglion Block Treatment Effective on Postspinal Headaches
This study evaluates effect of sphenopalatine ganglion block in post dural puncture headache. Half of participants will receive standard supportive treatment and other half of patients will be performed sphenopalatine ganglion…
- Trial name
- SPG (NCT03512977)
- Testing
- sphenopalatine ganglion block, conservative treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Derince Training and Research Hospital
Anesthesia, Deep Sedation
Intranasal Dexmedetomidine Sedation at Dose of 2 mcg/kg Versus 4 mcg/kg in Children Undergoing MRI
This study aimed to compare the effectiveness of intranasal Dexmedetomidine sedation at Dose of 2 mcg/kg and 4 mcg/kg in Children Undergoing MRI at Cipto Mangunkusumo Hospital
- Conditions
- Anesthesia, Deep Sedation, Magnetic Resonance Imaging, Pediatric ALL
- Trial name
- NCT05091151
- Testing
- Intranasal dexmedetomidine at dose of 2 mcg/kg and 4 mcg/kg
- Where
- Indonesia
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Local Anesthesia, Dental Implants
Comparison of Anesthetic Efficacy and Safety Between Inferior Alveolar Nerve Block and the Infiltrative Technique for the Treatment of Peri-implant Diseases in Posterior Mandibular Implants
This triple-blind randomized clinical trial aims to compare the anesthetic efficacy and safety of two local anesthesia techniques for the surgical treatment of peri-implantitis in posterior mandibular implants: inferior alveolar…
- Conditions
- Local Anesthesia, Dental Implants, Periimplantitis
- Trial name
- NCT07590037
- Testing
- Comparison of anesthetic efficacy and safety between nerve block and infiltrative technique for periimplantitis surgical treatment in poosterior mandibular implants
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Intraoperative Bleeding in Lumbar Spine Surgery, Postoperative Pain in Lumbar Spine Surgery
Efficacy of Periarticular Vasoconstrictor Infiltration (PVI) in Reducing Bleeding and Postoperative Pain in Lumbar Fusion Surgery
This retrospective observational study evaluates the efficacy of periarticular vasoconstrictor infiltration (PVI) in reducing intraoperative bleeding and postoperative pain in adult patients undergoing lumbar fusion surgery at…
- Trial name
- NCT07530237
- Testing
- Periarticular Vasoconstrictor Infiltration
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Colorectal Cancer
Xenon Combined With Intraoperative Thoracic Epidural Analgesia
This is a monocentric study in 2 steps: A safety part to assess the feasibility of using Xenon in association with a thoracic epidural analgesia (TEA) with a sequential recruitment of 3, 6 or 9 patients according to predefined…
- Trial name
- NCT01696630
- Testing
- Xenon, Desflurane
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Centre Leon Berard
Interstitial Cystitis
Evaluate The Effectiveness Of Fospropofol (Lusedra®) For Induction Of Anesthesia
Interstitial cystitis is a condition where a defect in the protective lining of the bladder causes the urinary symptoms such as urgency, frequency and pain/burning on urination.
- Trial name
- NCT01378754
- Testing
- Fospropofol (Lusedra®) 6.5, Fospropofol (Lusedra®) 10, Fospropofol (Lusedra®) 12
- Sponsor
- Grace Shih, MD
Pain, Post Operative, Regional Anesthesia
Pain Reduction in Maxillomandibular Surgery Using Maxillary and Mandibular Nerve Blocks
Maxillo-mandibular osteotomy is a painful surgery which requires mostly opioids use. Recent studies on maxillary and mandibular nerve blocks have suggested benefit in maxillo-facial surgery but have been poorly investigated in…
- Trial name
- ECHOMAX (NCT05351151)
- Testing
- bilateral ultra-sound guided maxillary and mandibular nerve blocks, Infiltration of Lidocaine 1%
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Toulouse
Molar Incisor Hypomineralization
Local Anesthesia in Molar Teeth With Molar Incisor Hypomineralization
To compare responses to electrical pulp test (EPT) and cold test among molar incisor hypomineralization (MIH)-effected and not MIH-effected carious teeth before and after administration of local anesthesia for caries removal.
- Trial name
- NCT04061096
- Testing
- Evaluation of cold test, Evaluation of electrical pulp test, Evaluation of pain during the treatment
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Didem Sakaryali
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