Clinical trials: Anesthesia Management
Surgery, Anesthesia, Endotracheal
The Videolaryngoscopy in Small Infants
Complications related to infant (≤ 1 year) airway management are under-appreciated because of few rigorous and targeted studies.
- Trial name
- VISI (NCT03396432)
- Testing
- Video Laryngoscopy for ET placement, Direct Laryngoscopy for ET Placement
- Where
- 5 sites in United States, Australia
- Volunteers
- 566 people
- Sponsor
- Children's Hospital of Philadelphia
Anesthesia, Surgery
Association Between Clinical Effect of Continuous Morphine Administration After Surgery and Pharmacogenetics
Identification of the genetic polymorphisms that could be correlated either with a better clinical response or with a major predisposition of patients to develop tolerance and/or side effects to the treatment with morphine.
- Trial name
- NCT01233219
- Testing
- morphine chlorhydrate
- Where
- Italy
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Primary Total Knee Arthroplasty
Quadriblock Versus "IPACK + Femoral Triangle Block + Obturator Nerve Block" in Total Knee Arthroplasty
Total knee arthroplasty (TKA) is one of the most common orthopedic surgical procedure and is associated with severe pain in the immediate postoperative period, thus limiting early recovery.
- Trial name
- QuITO (NCT04499716)
- Testing
- IPACK, Femoral triangle block, Obturator nerve block
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Clinique Medipole Garonne
Postoperative Pain
COMPARISON OF INTRAOPERATIVE LOCAL ANESTHETIC APPLICATIONS IN POSTOPERATIVE PAIN MANAGEMENT IN LAPAROSCOPIC CHOLECYSTECTOMY PATIENTS
Since 1987, laparoscopic cholecystectomy has become the standard procedure for gallbladder stones and lesions. Complications due to improvements in laparoscopy and increased surgical experience have decreased day by day, but…
- Trial name
- NCT03790007
- Testing
- Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 3 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Anaesthesia, Airway Management
Randomised Controlled Trial of Intubation, Comparing Pentax AWS Against Macintosh Laryngoscope.
A randomised controlled trial of intubation by inexperienced anaesthetists, comparing the The Pentax Airway Scope AWS-S100 Rigid Video Laryngoscope(Pentax AWS) and the Macintosh Laryngoscope.
- Conditions
- Anaesthesia, Airway Management, Videolaryngoscopy
- Trial name
- PAWS (NCT01029756)
- Testing
- Macintosh Laryngoscope, Pentax AWS Videolaryngoscope
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- NHS Grampian
Hip Surgery, Postoperative Pain Management
Comparison of Intermittent Bolus vs. Continuous Infusion PENG Block for Postoperative Pain in Hip Surgery
This retrospective study evaluates the effects of two different administration methods of the Pericapsular Nerve Group (PENG) Block on postoperative pain control, opioid consumption, and recovery in patients undergoing hip…
- Conditions
- Hip Surgery, Postoperative Pain Management, Pericapsular Nerve Group Block (PENG Block), Regional Anesthesia
- Trial name
- ICPENG (NCT06834243)
- Testing
- Intermittent Bolus PENG Block, Continuous Infusion PENG Block
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Onur Baran
Lacerations, Wound Repair
Pain Experience Using Lidocaine Adrenaline Tetracaine (LAT) Gel Versus Lidocaine Infiltration for Laceration Repair in Adults
This prospective comparative study evaluates pain experience in adult patients undergoing laceration repair in the emergency department using either topical lidocaine-adrenaline-tetracaine (LAT) gel or lidocaine infiltration as…
- Conditions
- Lacerations, Wound Repair, Acute Traumatic Wounds, Pain Management
- Trial name
- NCT07480135
- Testing
- Lidocaine-Adrenaline-Tetracaine (LAT) Gel, Lidocaine infiltration
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- Vrije Universiteit Brussel
Anesthesia
Administration of Dexmedetomidine Guided by Entropy/SPI Reduce
Dexmedetomidine, a selective alpha2-adrenergic agonist is known to reduce propofol and opioid requirements due to its sedative and analgesic properties.
- Trial name
- NCT02818621
- Testing
- Group Dex (dexmedetomidine)
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Gangnam Severance Hospital
Abdominal Muscles/Ultrasonography, Adult
Medial Versus Traditional Approach to US-guided TAP Blocks for Open Inguinal Hernia Repair
Pain relief after open inguinal hernia repair could be improved by administration of TAP block or ilioinguinal/iliohypogastric nerve block. It is unclear which one works better.
- Conditions
- Abdominal Muscles/Ultrasonography, Adult, Ambulatory Surgical Procedures, Anesthetics, Local/Administration & Dosage
- Trial name
- NCT01589796
- Testing
- TAP block
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Stamford Anesthesiology Services, PC
Post Operative Pain, Regional Anesthesia Morbidity
Does ESP Block Reduce Pain and Opiates Consumption After Surgery
The patients will be randomly assigned to standard therapy or standard therapy+ESP nerve block. After surgery pain level and narcotic consumption will be measured, and vital signs and side effects will bo monitored for up to 72…
- Conditions
- Post Operative Pain, Regional Anesthesia Morbidity, Opioid-Related Disorders, Chronic Pain
- Trial name
- NCT05512897
- Testing
- erector spinea plane block
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Michael Dubilet MD
Periprocedural Complication
Periprocedural Direct Oral Anticoagulant Management
Direct oral anticoagulants (DOAC) are a new drug group that has been approved for chronic anticoagulation of patients in atrial fibrillation or suffering acute thrombosis, between others.
- Trial name
- RA-ACOD (NCT03182218)
- Testing
- Direct oral anticoagulant
- Where
- 30 sites in Spain
- Volunteers
- 1,100 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Therapy Animals, Dental Anxiety
Do Therapy Dogs Improve Behavior and Reduce Anxiety in Pediatric Dental Patients?
The goal of this clinical trial is to assess whether the presence of a certified therapy dog during dental procedures that require an injection reduces anxiety and improves behavior in pediatric dental patients.
- Conditions
- Therapy Animals, Dental Anxiety, Child Behavior, Anesthesia, Local
- Trial name
- NCT06057090
- Testing
- Therapy Dog
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Vertebral Compression, Vertebra Compression Fracture
Basivertebral Nerve Block During Vertebral Augmentation: An Alternative Approach to Intraprocedural Pain Management
The goal of this study is to assess the efficacy of lidocaine basivertebral nerve block as intraprocedural anesthesia during vertebral augmentation procedures.
- Conditions
- Vertebral Compression, Vertebra Compression Fracture, Vertebral Fracture
- Trial name
- NCT04774029
- Testing
- Basivertebral nerve block, Lidocaine induced basivertebral nerve block
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwell Health
Postoperative Cognitive Dysfunction, Orthopedic Procedures
Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery
This study aims to compare two medications, Remimazolam and Midazolam, used for sedation during orthopedic surgeries performed under regional anesthesia.
- Conditions
- Postoperative Cognitive Dysfunction, Orthopedic Procedures, Postoperative Pain Management, Hip Fracture
- Trial name
- REMIND-ORTHO (NCT07113483)
- Testing
- Midazolam, REMIMAZOLAM BESYLATE 2.5 Mg in 1 mL INTRAVENOUS INJECTION, POWDER, LYOPHILIZED, for SOLUTION [BYFAVO]
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Romanian Society for Enteral and Parenteral Nutrition
Mechanical Ventilation Complication
Airway Management in Thoracic Anesthesia in Italy
The aim of this study is to evaluate the positioning time and the malpositioning rate of DLTs and BBs, the degree of difficulty perceived in device positioning, the use of bronchoscopy (BRO), and the quality of lung collapse…
- Trial name
- AIRTHOR (NCT02361983)
- Testing
- Double lumen tube, Bronchial blocker
- Where
- Italy
- Volunteers
- 2,225 people
- Sponsor
- Azienda Ospedaliera S. Maria della Misericordia
General Anesthesia
Cerebral Perfusion Variation During Blood Pressure Changes Under General Anesthesia
The risk associated with arterial hypotension during general anesthesia for surgery has been demonstrated , but the threshold at which consequences for perfusion of one or more organs appear varies according to the mechanism of…
- Trial name
- DELTAPAMAG (NCT05803876)
- Testing
- Diagnostic test - monitoring
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Pain, Analgesic Consumption
Analgesic Consumption in the Early Postoperative Period: A Prospective Observational PACU Study
Postoperative pain remains a significant clinical challenge that directly affects patient recovery, functional outcomes, and overall quality of care.
- Conditions
- Postoperative Pain, Analgesic Consumption, Pain Management
- Trial name
- NCT07547618
- Testing
- Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 254 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Laryngeal Masks, Anesthesia, General
The Effect of Placement of Proseal Laryngeal Mask Airway With C-Mac Videolaryngoscopy
The ProSeal laryngeal mask airway (ProSeal LMA; Intavent Orthofix, Maidenhead, UK) is a device with a double cuff to improve the seal and a drain tube to help prevent aspiration and gastric insufflation, facilitate passage of a…
- Conditions
- Laryngeal Masks, Anesthesia, General, Videolaryngoscopy
- Trial name
- NCT03852589
- Testing
- C-MAC videolaryngoscope, Blind
- Where
- Turkey (Türkiye)
- Volunteers
- 115 people
- Sponsor
- Inonu University
Neurosurgery, Cardiovascular System
Fluid Challenge Infusion and Response
It is unclear if the rate of administration of the fluid challenge could affect the rate of fluid responsiveness. The role of this small-dose (the so called mini-FC) has been recently tested to assess if the infusion of a small…
- Conditions
- Neurosurgery, Cardiovascular System, Anesthesia, General
- Trial name
- REFILL (NCT03810118)
- Testing
- fluid challenge
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- Humanitas Clinical and Research Center
Pulpitis, Pain Management
Effects of Topical Anesthesia Approaches on Dental Pain During and After Restorative Management of Dental Caries
The purpose of the Research Study and Overview of Participation: This study will compare different approaches used to prevent pain when giving local anesthesia to numb the teeth while managing dental cavities and decay.
- Trial name
- NCT07379515
- Testing
- Photobiomodulation (PBM)-induced analgesia device using multi-wavelength LED, Medicated analgesia
- Volunteers
- 204 people
- Sponsor
- Dubai Health