Clinical trials: Anesthesia and Analgesia
Anesthesia, Surgery
Association Between Clinical Effect of Continuous Morphine Administration After Surgery and Pharmacogenetics
Identification of the genetic polymorphisms that could be correlated either with a better clinical response or with a major predisposition of patients to develop tolerance and/or side effects to the treatment with morphine.
- Trial name
- NCT01233219
- Testing
- morphine chlorhydrate
- Where
- Italy
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Postoperative Pain
Bilateral Continuous Erector Spinae Blocks for Post-Sternotomy Pain Management
To evaluate the efficacy of bilateral continuous erector spinae blocks (BESB) for postoperative analgesia in children and adolescents undergoing cardiac surgical procedures via sternotomy in the Early Recovery After Surgery…
- Trial name
- NCT04567407
- Testing
- Bilateral erector spinae blocks using ropivacaine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Elderly, Malignant Tumor
Epidural Anesthesia-analgesia and Long-term Outcome
Surgical resection is one of the most important treatments for resectable cancer; on the other hand, cancer recurrence and/or metastasis are the major reasons of treatment failure.
- Conditions
- Elderly, Malignant Tumor, Surgical Resection, Epidural Anesthesia
- Trial name
- NCT03012945
- Testing
- Combined epidural-general anesthesia, General anesthesia
- Where
- 5 sites in China
- Volunteers
- 1,802 people
- Sponsor
- Peking University First Hospital
Pain, Acute
Vibration Analgesia in Propofol Infusion During Anesthesia Induction
In this study, the investigators seek to evaluate the role of vibration in the reduction of discomfort associated with painful stimulus associated with anesthesia induction.
- Trial name
- VAPI (NCT03509857)
- Testing
- BUZZY(tm), No Intervention
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Pain Management, Anesthesia , Analgesia
Comparison Between External Oblique Intercostal Plane Block and Rectus Sheath Block Combined With Transversus Abdominis Plane Block
Effective perioperative pain management remains a cornerstone in enhancing recovery and improving patient outcomes in laparoscopic cholecystectomy.
- Conditions
- Pain Management, Anesthesia , Analgesia, Nerve Block
- Trial name
- NCT07384000
- Testing
- External intercostal plane puncture, control group (nalbuphine), the single-puncture technique of (rectus sheath block) combined with (Transversus abdominis plane block)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Pain
ADVANCE: Assessment for Defining Variability in Anesthesia Through Novel Clinical EEG
The present study is designed to compare prospectively whether sBIS, sEMG, or CVI variability (brain monitoring) can be used to predict unwanted intraoperative responses (high blood pressure, fast heart rate, tearing, etc.) to…
- Trial name
- CVI (NCT00689130)
- Where
- 4 sites in United States, Spain
- Volunteers
- 120 people
- Sponsor
- Medtronic - MITG
Anesthesia, Conduction, Arthroplasty, Replacement, Knee
Concentration Effect of Local Anesthetics on Femoral Nerve Block Efficiency
US-guided femoral nerve block is used effectively in post-operative pain management in the surgical treatment of the lower extremity.
- Conditions
- Anesthesia, Conduction, Arthroplasty, Replacement, Knee, Pain, Postoperative, Anesthesia and Analgesia
- Trial name
- NCT03623230
- Testing
- Ultrasound Guided Femoral Nerve Block, Dressing, Bupivacaine 0.25% Injectable Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Bozyaka Training and Research Hospital
Thoracic Paravertebral Block
Thoracic Paravertebral Catheters
Thoracic operations are known to be painful and requiring an adequate postoperative pain therapy. A well documented technique to achieve postoperative analgesia is the use of paravertebral catheters.
- Trial name
- NCT01009398
- Testing
- Fluoroscopic examination
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Knee Osteoarthritis (OA), Postoperative Pain
Effect of Adding a Biceps Femoris Short Head Block to Adductor Canal Block for Analgesia After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is frequently associated with moderate to severe postoperative pain, which may delay mobilization, increase opioid consumption, and impair functional recovery.
- Trial name
- BiFeS-TKA (NCT07803887)
- Testing
- Ultrasound-Guided Adductor Canal Block, Ultrasound-Guided Biceps Femoris Short Head Block
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Antalya Training and Research Hospital
Analgesia, Patient-Controlled, Epidural Analgesia
Intrathecal Morphine Analgesia vs. Continuous Epidural Analgesia vs. Systemic Analgesia in Colorectal Surgery.
The purpose of this study is to determine which postoperative analgesia is optimal after colorectal surgery. The investigators will compare intrathecal morphine, continuous epidural analgesia and standard systemic analgesia.
- Conditions
- Analgesia, Patient-Controlled, Epidural Analgesia, Anesthesia; Spinal, Morphine
- Trial name
- KOLORIT (NCT03007121)
- Testing
- Morphine intrathecal, Bupivacaine + Sufentanil epidural, Morphine intravenous
- Where
- Czechia
- Volunteers
- 75 people
- Sponsor
- Charles University, Czech Republic
Anesthesia, Anxiety
Buzzy Bee for Pain and Anxiety Control During Pediatric Dental Local Anesthesia
The present study will evaluate the effectiveness of Buzzy Bee in reducing pain and physiological responses during maxillary buccal infiltration in children aged 5-7 years compared with a conventional injection protocol.
- Conditions
- Anesthesia, Anxiety, Pain, Children
- Trial name
- NCT07886333
- Testing
- Intervention A: Buzzy® Bee-Assisted Local Anesthesia, Intervention B: Conventional Local Anesthesia Technique
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Postoperative Analgesia, Anesthesia; Functional
Comparison of Two Regional Technics In Knee Artroplasty
Purpose: This prospective, randomised, controlled, single-blind, multicentre study was designed to investigate the effects of peripheral nerve block methods (applied using unilateral spinal anaesthesia [USA] on elderly patients…
- Trial name
- CTRTIKA (NCT03021421)
- Testing
- intratechal (subarachnoidal )injection, lombar plexus and sciatic nerve injection
- Volunteers
- 60 people
- Sponsor
- Ordu University
Pain, Postoperative, Developmental Dysplasia of the Hip
Intravenous Dexamethasone to Prolong Caudal Block Analgesia in Children Undergoing Hip Surgery
The goal of this clinical trial is to learn whether a single intravenous dose of dexamethasone prolongs postoperative analgesia after a caudal block in children aged 6 months to 9 years undergoing surgery for developmental…
- Trial name
- DEXA-CAUDAL (NCT07896304)
- Testing
- Dexamethasone, Normal Saline, Caudal Block Anesthesia
- Where
- Tunisia
- Volunteers
- 54 people
- Sponsor
- National Institute of Neurology, Tunisia
Spondylolisthesis, Lumbar Disc Herniation
Erector Spinae Plane Block as Pain Management After Lumbar Fusion Surgery
Rationale: Lumbar spine surgery is associated with high postoperative pain scores and analgesic use, despite use of multimodal analgesia.
- Conditions
- Spondylolisthesis, Lumbar Disc Herniation, Lumbar Spinal Stenosis, Lumbar Disc Disease
- Trial name
- RCT-ESPB (NCT05345249)
- Testing
- Ropivacaine Hydrochloride Injection, Sodium chloride
- Where
- Netherlands
- Volunteers
- 76 people
- Sponsor
- Ilse van de Wijgert
Cancer
Regional Anesthesia and Endometrial Cancer Recurrence
The purpose of this study is to determine whether recurrence of local and metastatic cancer after open hysterectomy for stage 1 or 2 endometrial cancer is reduced when patients receive epidural anesthesia/analgesia combined with…
- Trial name
- ECA/R (NCT00531349)
- Testing
- propofol general anesthesia, Sevoflurane
- Where
- United States
- Sponsor
- The Cleveland Clinic
Femoral Neck Fracture
Fascia Iliaca Block in the Emergency Department for Analgesia After Femoral Neck Fracture
Femoral neck fracture is very common in the elderly and can produce severe to moderate pain. As this pathology is not life-threatening, waiting time in the emergency department may be prolonged due to the high number of…
- Trial name
- NCT02433548
- Testing
- Fascia iliaca block
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Pregnancy Termination in First Trimester
Patient Preferences in Anesthesia for Abortion Care
This study will use semi-structured interviews with participants in a prospective cohort study to explore women's experiences of pain and preferences in pain management during first trimester surgical abortion to create a more…
- Trial name
- PAC (NCT03030443)
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Regional Anaesthesia
Comparison Between Ultrasound Guided Femoral 3 in 1 Block Versus Blind Fascia Iliaca Block Before Spinal Anaesthesia
This study aimed to evaluate the efficacy of ultrasound guided femoral 3 in 1 block versus the blind technique single shot fascia iliaca compartment block as an analgesia method in patients prior positioning for spinal…
- Trial name
- IKH (NCT03139617)
- Testing
- Fascia Iliaca Compartment Block (FICB), 3 in 1 femoral block (FNB)
- Where
- Malaysia
- Volunteers
- 60 people
- Sponsor
- Universiti Sains Malaysia
Pain, Postoperative, Lumbar Spine Degeneration
Epidural PCA on Pain Relief After L-spine Surgery
This study aimed to evaluate the effect of epidural patient-controlled analgesia (PCA) on postoperative pain relief after lumbar spine surgeries.
- Conditions
- Pain, Postoperative, Lumbar Spine Degeneration, Analgesia, Patient-Controlled, Epidural Anesthesia
- Trial name
- NCT06316921
- Testing
- Epidural patient-controlled analgesia, Standard postoperative pain management
- Where
- Taiwan
- Volunteers
- 209 people
- Sponsor
- Taipei City Hospital
Breast Neoplasm Female, Postoperative Pain Management
PECS II vs. MTP for Analgesia After MRM
This randomized controlled study aims to compare the analgesic efficacy of the ultrasound-guided modified pectoral nerve block (PECS II) and the midpoint transverse process to pleura (MTP) block in female patients undergoing…
- Trial name
- NCT06187909
- Testing
- PECS II BLOCK, MTP BLOCK
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Ain Shams University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.