Clinical trials: Anesthesia and Analgesia
Perioperative Care, Pediatric Anesthesia
Giving Children a Voice in Paediatric Anaesthesia
This project will identify the research priorities for paediatric anaesthesia and perioperative medicine in participating countries and highlight areas where further research and information can be provided to optimise the…
- Conditions
- Perioperative Care, Pediatric Anesthesia, Pain Management, Anxiety
- Trial name
- TR-VP26 (NCT07524049)
- Where
- 7 sites in Switzerland
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Contraception, Pain, Acute
Empathy Through Pain Control: Lidocaine Paracervical Block for IUD Placements
The goal of this research study is to learn more about how different uses of a numbing medication might affect pain levels while getting an IUD placed.
- Conditions
- Contraception, Pain, Acute, Anesthesia, Local
- Trial name
- EPIC (NCT06960317)
- Testing
- Buffered Lidocaine, Unbuffered lidocaine, Xylocaine jelly 2%
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Arthroplasty, Replacement, Knee, Anesthesia, Conduction
Femoral Triangle Block: Early Mobilization and Postoperative Analgesia After Total Knee Arthroplasty
The objective of this trial is to compare the efficacy of three different nerve blocks as an analgesic option after total knee arthroplasty (TKA), based on muscle strength, mobilization and pain.
- Conditions
- Arthroplasty, Replacement, Knee, Anesthesia, Conduction, Pain, Postoperative, Ultrasonography, Interventional
- Trial name
- NCT03518450
- Testing
- Apex Femoral Triangle Block, Femoral Nerve Block, Adductor Canal Block
- Where
- Spain
- Volunteers
- 78 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Biliary Disease
Unilateral TAP Block vs Trocar Insertion Sites Infiltration Anesthesia in Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy is a commonly performed operation in general surgery practice. Peripheral nerve block methods commonly used for analgesia after this operation are: transversus abdominis plane block (TAP) and trocar…
- Trial name
- NCT03543202
- Testing
- Transversus abdominis plane block, local infiltration anesthesia, Intravenous patient controlled analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Anesthesia
Oral Duloxetine as a Premedication for Postoperative Pain Control
The purpose of the study is to use duloxetine as premedication in Anterior cruciate ligament repair under spinal anesthesia and evaluate the effect on onset and duration of spinal anesthesia and postoperative pain control.
- Trial name
- NCT05050656
- Testing
- Duloxetine 60mg
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Laparoscopic Cholecystectomy
Kidney Function After Pneumoperitoneum and Analgesia
double blind study of kidney function of two groups of adult patients submitted to laparoscopic cholecystectomy and analgesia from tramadol associated to dipyrone or ketorolac
- Trial name
- NCT00914875
- Where
- Brazil
- Volunteers
- 126 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Electroencephalography, Craniotomy Surgery
Evaluation of Response to Pain From Skull Pin Fixation in Craniotomies
The goal of this observational study is to investigate the relationship between the response to skull pin fixation pain and the analysis of blood pressure, heart rate, and brain wave activity in adults undergoing brain surgery.
- Conditions
- Electroencephalography, Craniotomy Surgery, Pain Management
- Trial name
- NCT06811701
- Testing
- Scalp nerve block, Opioid Anesthetics, Local Anesthetic Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Diskapi Teaching and Research Hospital
Analgesia
NOL-Guided Superficial Parasternal Intercostal Plane Block Versus Erector Spinae Plane Block
This clinical trial focuses on an elaborate, propensity-matched, non-inferiority comparison of NOL-guided Superficial Parasternal Intercostal Plane Block (SPIPB) and Erector Spinae Plane Block (ESPB) within the context of…
- Trial name
- NESP-II (NCT06070701)
- Testing
- Superficial Parasternal Block (SIPB), Erector Spinae Plane Block (ESPB), General anesthetic
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
Postoperative Pain, Retinal Detachment
Postoperative Pain After Vitreoretinal Surgery
Postoperative pain (POP) is frequently underestimated in general and little data are available particularly for POP after vitreoretinal surgery (VRS).
- Trial name
- NCT03538847
- Testing
- Numerical rating scale
- Volunteers
- 800 people
- Sponsor
- University of Florence
Pain, Postoperative
Comaprison Between QLB and ESPB in Patients for PCNL Operation
comparing the subcostal oblique Quadratus Lumborum block and the Erector Spinae plane block in patients undergoing percutaneous nephrolithotomy operation to get the best and longest postoperative analgesic effect.
- Trial name
- NCT04277611
- Testing
- Subcostal Oblique Quadratus Lumborum Block and Erector Spinae Plain Block.
- Where
- Egypt
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Assiut University
Shoulder, Orthopedic Surgery
Ultrasound Guidance for Interscalene Brachial Plexus Block
This study has been designed to assess the possible advantages of using ultrasound imaging to block the brachial plexus (i.e., nerves of the upper limb) in patients undergoing shoulder surgery.
- Conditions
- Shoulder, Orthopedic Surgery, Nerve Block
- Trial name
- NCT00702416
- Testing
- Ultrasound-guided continuous interscalene brachial plexus block, Continuous interscalene brachial plexus block using electrical nerve stimulation, Ropivacaine
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Parma
Thyroid Diseases, Parathyroid Diseases
Ropivacaine Plus Magnesium Sulphate Infiltration
In the domain of endocrine gland surgery, thyroidectomy is the most common procedure. Patients report moderate to severe discomfort postoperatively, which is induced by a variety of mechanisms, the most common of which are…
- Conditions
- Thyroid Diseases, Parathyroid Diseases, Postoperative Pain, Anesthesia, Local
- Trial name
- NCT05294393
- Testing
- Ropivacaine 10%, Ropivacaine 10% plus magnesium sulphate 10mg/kg
- Where
- Greece
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Postoperative Pain, Analgesia
Comparison of Erector Spinae Plane Block and Penile Block in Hypospadias Surgery
In this study, we aimed to compare ultrasound-guided sacral erector spinae plane block and dorsal penile block on postoperative analgesic effect in hypospadias surgery.
- Trial name
- NCT04866368
- Testing
- The ultrasound-guided Sacral Erector spinae plane block, The dorsal penile block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kocaeli University
Pain Management
Adductor Canal Block After Total Knee Replacement - a Suture-method Catheter vs a Standard Catheter vs a Single Bolus
In this study we wish to investigate the analgesic effect of the administration of 0.2% ropivacaine for an adductor canal block as repeated boluses (20 ml every 8 hours) through a new suture-method catheter or a standard…
- Trial name
- NCT03142789
- Testing
- Initial bolus (Certa and standard catheter groups), Initial bolus (Single bolus group), Intermittent boluses (Certa and standard catheter groups)
- Where
- Denmark
- Volunteers
- 153 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Postoperative Pain
ESP vs QL for Total Abdominal Hysterectomy
Patients undergoing open total abdominal hysterectomy (n=82) at Parkland Memorial Hospital will be randomized into one of two groups to receive either ultrasound-guided bilateral ESP block with liposomal bupivacaine (Group 1) or…
- Trial name
- NCT04074226
- Testing
- Erector Spinae Plane block, Quadratus Lumborum Block
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Scheduled Laparoscopic Surgery
Pupillary Reflex Measurement to Guide Intraoperative Analgesia During Laparoscopic Surgery
The purpose of this study is to determine whether analgesia guided by pupillary reflex during laparoscopic surgery is effective in opioid sparing (intraoperative remifentanil and postoperative morphine).This is a prospective…
- Trial name
- NCT02116868
- Testing
- Pupillometry guided analgesia (PP), Tailored remifentanil controlled infusion, Tailored antihypertensive drug administration
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Paediatric, Surgery
Erector Spinae Plane Block for Paediatric Upper Abdominal Surgery
Upper abdominal surgeries are associated with severe postoperative pain. Thus, maintaining effective postoperative analgesia in the paediatric age group is very crucial in terms of future pain perception and chronic pain…
- Conditions
- Paediatric, Surgery, Analgesia, Anesthesia
- Trial name
- NCT04518215
- Testing
- Erector Spinae Plain Block, Intra-Venous Analgesia
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Nazmy Edward Seif
Anesthesia, Surgery
Association Between Clinical Effect of Morphine With PCA After Surgery and Pharmacogenetics
Identification of the genetic polymorphisms that could be correlated either with a better clinical response or with a major predisposition of patients to develop tolerance and/or side effects to the treatment with morphine.
- Trial name
- PCA-Gene (NCT01233752)
- Testing
- morphine chlorhydrate
- Where
- 2 sites in Italy
- Volunteers
- 224 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Regional Block
Quadratus Lumborum Block Type 2 Versus Posterior Transversus Abdominus Plane Block
This patient population are at risk of adverse effects secondary to inadequate pain management such as inadequate maternal bonding and late ambulation.
- Trial name
- quadratus (NCT04773730)
- Testing
- Posterior transversus abdominus plane block, Quadratus lumborum block type 2
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Obstetric Pain, Other Complications of Obstetric Anesthesia - Delivered
Epidural Dexamethasone for Labor Analgesia: the Effects on Ropivacaine Consumption and Labour Outcome
To assess the efficacy of epidural dexamethasone administration, compared to placebo, in reducing local anesthetics consumption during labor epidural analgesia in parturient women
- Trial name
- DEXAPER (NCT02857465)
- Testing
- Dexamethasone, Ropivacaine, Sufentanil
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
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