Clinical trials: Anesthesia for Cesarean Delivery
Pregnancy, Cesarean Section
The Effect of Low-dose Atropine on Sympathetic Blockade in Spinal Cesarean Section Patients
The most common side effect in cesarean section surgeries performed under spinal anesthesia is hypotension, which is seen in over 80% and can cause significant morbidity for the mother and fetus.
- Conditions
- Pregnancy, Cesarean Section, Anesthesia, Spinal
- Trial name
- NCT05892913
- Testing
- Slow dose preemptive Atropine, Ephedrine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Abant Izzet Baysal University
Sevoflurane, Propofol
Comparison of Propofol and Sevoflurane as Maintaining Anesthetics During General Anesthesia of Cesarean Section
Sevoflurane and propofol are the most popular drug choices for maintenance of general anaesthesia for caesarean section. However, effects of these two anesthetics on maternal and fetal outcomes after caesarean section haven't…
- Conditions
- Sevoflurane, Propofol, Cesarean Section
- Trial name
- NCT03149588
- Testing
- propofol, sevoflurane
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tao Zhang
Hemodynamic Instability and Shivering
Comparative Study Between Intravenous Granisetron and Ondansetron on Their Effect on Hemodynamics and Shivering After Spinal Anesthesia in Elective Cesarean Delivery
Spinal anesthesia is commonly used in cesarean section surgeries . The most important adverse effects of spinal anesthesia are hypotension and bradycardia caused by sympathetic blockade, with an incidence of about 55-100% .
- Trial name
- NCT06437236
- Testing
- ondansetron, granisetron
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Cesarean Section, Hypotension Drug-Induced
Bupivacaine 5 mg vs 7.5 mg for Spinal Anesthesia in Cesarean Delivery in Indonesian Population
This study aims to evaluate the efficacy of hyperbaric 5 mg bupivacaine + fentanyl 25 mcg versus hyperbaric 7.5 mg bupivacaine + fentanyl 25 mcg to lower incidence of hypotension
- Conditions
- Cesarean Section, Hypotension Drug-Induced, Spinal Anesthesia, Postoperative Complications
- Trial name
- NCT03834454
- Testing
- Bupivacaine
- Where
- Indonesia
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Cesarean Section
Presence of the Father During Hyperacute Cesarean Section in General Anesthesia
This study concerns cesarean sections, category 1, meaning those cases where the life of mother and/or fetus is in immedeate danger and the child must be delivered within 15 minutes from activating the cesarean section team.
- Trial name
- NCT04948892
- Testing
- Prescence of the father during cesarean section in general anesthesia
- Where
- 2 sites in Denmark
- Volunteers
- 26 people
- Sponsor
- Sygehus Lillebaelt
Cesarean Section, Spinal Anesthesia
Comparison of Three Different Doses of Intrathecal Morphine for Analgesia After Cesarean Section
In our study, It was aimed to determine the dose of morphine that provides the most effective analgesia with the least incidence of side effects in the postoperative period.
- Conditions
- Cesarean Section, Spinal Anesthesia, Postoperative Analgesia
- Trial name
- NCT05317572
- Testing
- 80 mcg intrathecal morphine, 120 mcg intrathecal morphine, 160 mcg intrathecal morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Cesarean Section Complications, Spinal Anesthesia
Ultrasound Guided Fluid Loading Before Spinal Anesthesia
Perioperative hypotension is a common complication of spinal anesthesia during cesarean sections. The aim of this study was to evaluate the effectiveness of echoguided correction of hypovolemia through crystalloid preloading on…
- Conditions
- Cesarean Section Complications, Spinal Anesthesia, Hypotension, Hypovolemia
- Trial name
- EHCOPRESPA (NCT07108881)
- Testing
- C, T
- Where
- Tunisia
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Hypotension
Management Arterial Hypotension During Planned Caesarean Section, Intravenous Ephedrine/Phenylephrine Mixture Versus Intravenous Baby Noradrenaline
Comparison of two practices of obstetrical services between the CHU of Clermont Ferrand and the HFME Lyon-Bron in the management of arterial hypotension during an elective cesarean section
- Trial name
- ARTEMIS (NCT05513066)
- Where
- 2 sites in France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Full Term Pregnant Patients, Undergoing Lower Segment Caesarian Section
Comparison of Different Doses of Clonidine to Fentanyl as an Adjuvant to Bupivacaine 0.5% for Spinal Anesthesia
The purpose of this study is to evaluate the safety, quality and duration of block with the addition of Clonidine in different doses to 0.5% heavy bupivacaine, and to compare it with addition of Fentanyl to 0.5% heavy bupivacaine…
- Trial name
- NCT01205204
- Testing
- Fentanyl, Clonidine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pravara Institute of Medical Sciences University
Spinal Anesthesia
Large Volume Bupivacaine 0.5% Versus Small Volume in Elective Caesarean Section
To test the safety of high dose spinal in elective CS after prolonged sitting position.
- Trial name
- NCT02937792
- Testing
- intrathecal 15 mg bupivacaine
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Cesarean Section, Analgesia
IV and Intrathecal Ketamine in Cesarean Section
In the current study, the investigators will compare the effects of low-dose intravenous (i.v.) ketamine versus intrathecal Ketamine added to spinal anesthesia on the time to first request for analgesia and maternal pain scores…
- Trial name
- NCT05679375
- Testing
- Intrathecal ketamine, Intravenous ketamine
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Adverse Effect
ED90 of Norepinephrine and Phenylephrine Boluses Under Intensive Treatment
The objective of this study is to investigate the ED90 of norepinephrine and phenylephrine boluses for treating postspinal anesthesia hypotension under intensive treatment during cesarean section
- Trial name
- NCT06158009
- Testing
- Norepinephrine, Phenylephrine
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
Anticoagulation, Minimally Invasive
Minimally Invasive Lumbar Aneasthesia Used for Cesarean Section
Spinal canal anesthesia is marked the most commonly used method of cesarean section. Traditional spinal anesthesia may cause post-dural puncture headache and low back pain.Plenty of parturients are undergoing anticoagulation…
- Conditions
- Anticoagulation, Minimally Invasive, Spinal Anesthesia
- Trial name
- NCT02987192
- Testing
- pen type 27 gauge needles, cutting type 22 gauge needles
- Where
- China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Husband Attendance, Maternal-Neonatal Outcomes
Effect of Husband Attendance on Anesthesia Performance and Maternal-Neonatal Outcomes During Elective Cesarean Section Under Spinal Anesthesia
Family-centered perinatal care has become an integral component of modern obstetric practice, emphasizing emotional support and shared parental experiences during childbirth.
- Trial name
- NCT07641751
- Testing
- Husbands will be allowed to attend the cesarean section procedure, providing emotional support to their partners., Husbands will not be permitted to attend the cesarean section procedure
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Hypotension Drug-Induced
Norepinephrine Addition in Spinal Anesthesia of Caesarean Section
The objective is to compare efficacy of prophylactic norepinephrine bolus versus Infusion in prevention of hypotension which occurs frequently after spinal anesthesia for caesarean section.
- Trial name
- NASA (NCT03626454)
- Testing
- Norepinephrine Bolus, Norepinephrine infusion, Normal Saline Flush, 0.9% Injectable Solution
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Spinal Anesthesia Evaluation, Cesarean Delivery
Preoperative Data and the Spinal Spread of Local Anesthetic in Cesarean Section
This study is designed to assess possible relation between the anthropometric data of pregnant women at term, as well as their babies, and the maximal level of sensory blockade following spinal anesthesia for cesarean section.
- Trial name
- NCT07197398
- Testing
- Spinal block level analysis, Data collection, Sub-group analysis
- Where
- Poland
- Volunteers
- 183 people
- Sponsor
- Centre of Postgraduate Medical Education
Anesthesia, Spinal and Epidural, Adverse Effect
Intravenous Bolus of Phenylephrine vs. Norepinephrine in Preventing Hypotension After Spinal Anesthesia
The purpose of the study is to determine if an intravenous bolus of phenylephrine is more effective compared to an intravenous bolus of norepinephrine associated with crystalloid loading for maintaining blood pressure during a…
- Conditions
- Anesthesia, Spinal and Epidural, Adverse Effect, Hypotension, Complications, Cesarean Section
- Trial name
- NorPN (NCT02854787)
- Testing
- Phenylephrine, Norepinephrine
- Where
- Tunisia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Caesarean Section
Ropivacaine 0.75% Versus Levobupivacaine 0.5% for Conversion of Labour Epidural
The aim of this trial is to compare the local anaesthetic ropivacaine to local anaesthetic levobupivacaine in converting the standard patient controlled labour epidural to provide anaesthesia for an emergency Caesarean section.
- Trial name
- RoLe (NCT01160965)
- Testing
- 0.5% levobupivacaine, 0.75% Ropivacaine
- Where
- United Kingdom
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Granisetron
Role of Granisetron in Preventing Hypotension After Spinal Anesthesia With Levobupivacaine in Rheumatic Patients Undergoing Elective Cesarean Section
Cardiac disease in pregnancy is a high-risk condition and a major cause of maternal mortality and morbidity. Although direct or immediate death due to cardiovascular disease is rare, it is an important indirect cause of maternal…
- Trial name
- NCT05314257
- Testing
- Granisetron Hydrochloride, 0.9% normal saline
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Assiut University
Pregnant Women, Cesarean Birth
QTc Interval in Cesarean Section Patients
The aim of this clinical study is to determine which type of anesthesia has the least effect on the electrical activity of the heart in pregnant women undergoing cesarean section.
- Trial name
- NCT07524296
- Testing
- QT and QTc interval
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Haseki Training and Research Hospital