Clinical trials: Anesthesia for Cesarean Delivery
Spinal Anesthesia, Pregnancy
Ephedrine vs Phenylephrine - ECG Changes
ECG changes during caesarean section are common. Incidence of ST depression on the ECG is up to 81% in some studies. Although this may indicate inadequate oxygen supply to the heart muscle (myocardial ischaemia) many other…
- Trial name
- NCT01243970
- Testing
- Phenylephrine, Ephedrine
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Pregnant People, Anxiety
Remimazolam Versus Dexmedetomidine for Sedation During Neuraxial
Patients presenting for a scheduled cesarean delivery who require a neuraxial anesthetic will be randomized to receive intravenous remimazolam or dexmedetomidine for procedural sedation during the placement of their spinal or…
- Trial name
- NCT07651956
- Testing
- Remimazolam, Dexmedetomidine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cesarean Section
Heart Rate Variability to Predict Hypotension Following Spinal Anesthesia in Cesarean Delivery
Based on the patient's heart rate variability, the analgesia nociception index (ANI) measures the activity of the autonomic nervous system and the sympathetic/parasympathetic nervous system and expresses it as a numerical value…
- Trial name
- NCT04979039
- Testing
- analgesia nociception index (ANI) monitoring
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Bundang Hospital
Cesarean Section, Anesthesia, Spinal
Intrathecal Dexmedetomidine vs Epinephrine
Several studies have shown that adding dexmedetomidine or epinephrine to single-dose spinal analgesia preparations improves the length and/or speed of onset of the sensory block and post-operative pain management without…
- Trial name
- NCT06418308
- Testing
- Dexmedetomidine, Epinephrine, Standardized Spinal Mixture
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Anesthesia Morbidity, Cesarean Section Complications
Effect of General Anesthesia on Early Postoperative Cognitive Function in Cesarean Section
Cognitive dysfunction is the impairment of the mental process of perception, memory and information processing. The preoperative cognitive state is important, as mild cognitive impairment may be worsened following a cesarean…
- Trial name
- NCT03818009
- Testing
- Assessment document
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Beni-Suef University
Ultrasound
Ultrasound Versus Palpation for Spinal Anesthesia Success
Aim is to investigate the difference in number of attempts to place neuraxial block comparing handheld ultrasound versus use of palpation alone for women with impalpable bony landmarks undergoing spinal anesthesia for elective…
- Trial name
- Accuro (NCT03679663)
- Testing
- Ultrasound
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Hypotension During Surgery
Epinephrine Infusion for Prophylaxis Against Maternal Hypotension After Spinal Anesthesia for Cesarean Delivery
Subarachnoid block is the common route of anesthesia for cesarean delivery. Maternal hypotension after subarachnoid block is very common despite the vigorous methods for its prevention.
- Trial name
- NCT05881915
- Testing
- Phenylephrine, Epinephrine
- Where
- Egypt
- Volunteers
- 196 people
- Sponsor
- Cairo University
Pain, Postoperative, Anesthesia, Local
Wound Infiltration as Part of an Opioid Free Pain Management Pathway Following Cesarean Delivery
This study will investigate the effect of three types of wound infiltration on post Cesarean opioid analgesia consumption when used in conjunction with an opioid free postoperative analgesia pathway.
- Conditions
- Pain, Postoperative, Anesthesia, Local, Opioid Use
- Trial name
- NCT03545516
- Testing
- Bupivacaine, Dexmedetomidine
- Where
- United States
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Richmond University Medical Center
Anesthesia, Spinal, Nonemergency Cesarean Section
Spinal Anaesthesia for Caesarean Section: Descriptive Multicentre Study
Most of caesarean sections can be performed under spinal anaesthesia. Its major advantages are reliability and fast onset. However, dose of hyperbaric bupivacaine used, combination with adjuvants, hemodynamic management, and…
- Trial name
- CesAR (NCT04719819)
- Testing
- Spinal anaesthesia for caesarean section
- Where
- 11 sites in France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Anxiety, Hypotension
Impact of Music on Satisfaction, Anxiety, and Hemodynamics During Spinal Anesthesia for Cesarean Delivery
The aim of this study is to evaluate the effect of perioperative music on maternal anxiety, hemodynamic response to spinal anesthesia, postoperative pain medication requirement, and overall maternal satisfaction.
- Trial name
- NCT02732964
- Testing
- Pandora Music, Mozart Music
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Postoperative Pain After Cesarean Section, Postoperative Pain
Abdominal Ice Application After Cesarean Section
Cesarean section is one of the most commonly performed surgical procedures worldwide, and effective postoperative pain control is important for maternal recovery and patient comfort.
- Conditions
- Postoperative Pain After Cesarean Section, Postoperative Pain, Cesarean Section
- Trial name
- ICE-CS (NCT07626138)
- Testing
- Abdominal Ice Application, Standard Postoperative Care
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Nigde Omer Halisdemir University
Hypotension
The Effect of Ondansetron on Spinal Anesthesia in Caesarean Section
The purpose of this study is to compare the administration of two different doses of ondansetron to placebo to prevent hypotension and bradycardia following spinal anaesthesia.
- Trial name
- NCT03931863
- Testing
- Ondansetron 4mg, Ondansetron 8mg, 100ml normal saline 0.9 percent
- Where
- Greece
- Volunteers
- 180 people
- Sponsor
- Aretaieion University Hospital
Quality of Recovery, Anesthesia
Improving ObsQoR-11 With Continuous Wound Infusion Versus Intrathecal Morphine After Elective Cesarean Delivery
The purpose of this prospective randomized double-blinded and controlled study is to evaluate the quality of recovery after elective cesarean delivery using the Obstetric Quality-of-Recovery-11 (ObsQoR-11) score at 24 hours…
- Conditions
- Quality of Recovery, Anesthesia, Postoperative Pain, Cesarean Section
- Trial name
- CIVIMEC (NCT05696678)
- Testing
- Intrathecal Morphine, Ropivacaine 0.2%
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Hypotension
Evaluation of NEXFIN During Cesarean Delivery to Detect Hypotension
Hypotension after spinal anesthesia for cesarean delivery occurs frequently. Oscillometric measurement gives intermittent informations. Nexfin, a continuous noninvasive device, could help to detect hypotension.
- Trial name
- NEXFIN-CESAR (NCT01732133)
- Testing
- Nexfin
- Where
- 2 sites in France
- Volunteers
- 171 people
- Sponsor
- Hopital Foch
Anesthetic Complication Spinal
Variable Rate Phenylephrine Infusion for Prevention of Spinal-induced Hypotension for Cesarean Delivery
Rapid administration of crystalloid immediately after induction of spinal anesthesia (coload) to be more effective in terms of managing hypotension as compared to administering crystalloid before spinal anesthesia (preload).
- Trial name
- NCT01378325
- Testing
- Phenylephrine, saline
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Maternal Hypotension Associated With Spinal Anesthesia During Cesarean Section
The Effect of Compression Stockings and Leg Elevation on Hemodynamic Stability in Elective Cesarean Sections Under Spinal Anesthesia: A Single-Blind Randomized Controlled Trial
Aim: This study aimed to evaluate the effects of compression stockings and leg elevation on maternal intraoperative hypotension, vasopressor requirement, and neonatal well-being parameters in women undergoing elective cesarean…
- Trial name
- NCT07534891
- Testing
- compression stockings, Leg elevation
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Seçil Yavaş
Cardiac Output,Low, Hemodynamic Instability
Cardiac Output Changes in Cesarean Section
Since 2011, phenylephrine was recommended as the preferred drug to maintain blood pressure in obstetric anesthesia.Phenylephrine, an α adrenoceptor agonist, can induce peripheral vasoconstriction to maintain blood pressure, while…
- Conditions
- Cardiac Output,Low, Hemodynamic Instability, Obstetrical Complication of Anesthesia
- Trial name
- NCT02759510
- Testing
- Norepinephrine, Phenylephrine
- Volunteers
- 106 people
- Sponsor
- RenJi Hospital
Cesarean Section
Presence of the Father During Hyperacute Cesarean Section in General Anesthesia
This study concerns cesarean sections, category 1, meaning those cases where the life of mother and/or fetus is in immedeate danger and the child must be delivered within 15 minutes from activating the cesarean section team.
- Trial name
- NCT04948892
- Testing
- Prescence of the father during cesarean section in general anesthesia
- Where
- 2 sites in Denmark
- Volunteers
- 26 people
- Sponsor
- Sygehus Lillebaelt
Postoperative Pain Management, Obstetric Anesthesia
Effect of Bilateral Ultrasound-Guided TAP Block on Quality of Recovery in Cesarean Delivery Patients Receiving Intrathecal Morphine
This prospective, assessor-blinded observational cohort study will investigate the effect of adding bilateral ultrasound-guided transversus abdominis plane (TAP) block to standard intrathecal morphine (ITM) analgesia on the…
- Conditions
- Postoperative Pain Management, Obstetric Anesthesia, Recovery From Anesthesia
- Trial name
- QoR-TAP (NCT07145619)
- Testing
- Spinal Anesthesia with Intrathecal Morphine Only, Spinal Anesthesia with Intrathecal Morphine plus Bilateral TAP Block
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- MEHMET GÖKHAN TAFLAN
Anesthesia
Tachycardia as an Indication for Prophylactic Phenylephrine Injection in Caesarean Section Under Spinal Anesthesia; an Observational Study
The value of phenylephrine administration in response to tachycardia in preventing hypotension after spinal anesthesia in elective cesarean section.
- Trial name
- NCT06220942
- Testing
- Phenylephrine
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University