Clinical trials: Anesthetic
Contraception
Ethyl Chloride Spray Versus Subcutaneous Lidocaine Anaesthetic Prior to Contraceptive Implant Insertion
Study to look at the acceptability of local anaesthetic spray versus injection, prior to contraceptive implant insertion
- Trial name
- NCT02651207
- Testing
- Questionnaire based study looking at pain scores felt by patients either having a lidocaine injection or ethyl chloride spray prior to insertion of a contraceptive implant
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tayside Medical Science Centre
Intercostal Nerve Block, Pulmonary Ventilation
EIT Evaluation of Pulmonary Ventilation With Different Ropivacaine Concentrations in Intercostal Nerve Blockade
This study aims to find out how different strengths of the anesthetic drug ropivacaine affect lung breathing function when used in intercostal nerve block (a type of local anesthesia) for breast quadrantectomy surgery.
- Conditions
- Intercostal Nerve Block, Pulmonary Ventilation, Anesthesia, Local, Breast Neoplasms
- Trial name
- EIT (NCT07079436)
- Testing
- 0.25% ropivacaine, 0.375% Ropivacaine, 0.5% Ropivacaine
- Where
- China
- Volunteers
- 67 people
- Sponsor
- Fudan University
Symptomatic Irreversible Pulpitis
Assessment of Local Anaesthesia Effectiveness in Symptomatic Irreversible Pulpitis
This study aims to evaluate the comparative efficacy of two different local anaesthetic agents for supplemental buccal infiltration after a failed inferior alveolar nerve block in achieving profound pulpal anaesthesia for…
- Trial name
- LA AGENTS (NCT06862570)
- Testing
- 2% lignocaine with epinephrine 1.8 ml(36mg/ml lignocaine HCL, epinephrine bitartrate 0.0324mg/ml), 4% Articaine with epinephrine 1.7 ml (40mg/ml Articaine HCL, epinephrine bitartrate 0.018 mg/ml)
- Where
- Pakistan
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- 28 Military Dental Centre Lahore
Postoperative Pain, Abdominal Surgery
Bupivacaine Effectiveness and Safety in SABER® Trial
This is a research study testing SABER-Bupivacaine (an experimental pain-relieving medication). SABER-Bupivacaine is designed to continuously deliver bupivacaine, a common local anesthetic, for a few days in order to treat local…
- Trial name
- BESST (NCT01052012)
- Testing
- SABER-Bupivacaine, Bupivacaine HCl
- Where
- 26 sites in United States, Australia and 1 more
- Volunteers
- 331 people
- Sponsor
- Durect
Anesthesia
Anesthetic Efficacy in Irreversible Pulpitis
The purpose of this study was to compare the anesthetic efficacy of articaine, lidocaine and mepivacaine in patients with irreversible pulpitis of mandibular molar.
- Trial name
- NCT02054767
- Testing
- Intervention: inferior alveolar nerve block injection
- Where
- Brazil
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Hyperparathyroidism
Interaction Between Anaesthetics and Methylene Blue
We hypothesized that pre-treatment with methylene blue could potentiate the effects of general anaesthetic agents in patients undergoing parathyroidectomy
- Trial name
- NCT00513032
- Testing
- methylene blue
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- University Hospital, Geneva
Neurocognitive Disorders, Inhalation; Vapor
Effect of Low Flow Anesthetics on Neurocognitive Decline in the Elderly
This study aims to investigate the effect of inhaled anesthetics with a low fresh gas flow on cognitive function of elderly patients undergoing elective surgery
- Trial name
- NCT05548998
- Testing
- General anesthesia with low fresh gas flow, General anesthesia with high fresh gas flow, Mini mental state examination
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Sleep Apnea, Obstructive, Sleep Apnea
Comparison Between Natural Sleep Endoscopy and Drug-induced Sleep Endoscopy in Patients With Obstructive Sleep Apnea
Drug-induced sleep endoscopy (DISE) is the most used technique for identifying the obstruction site associated with obstructive sleep apnea (OSA).
- Conditions
- Sleep Apnea, Obstructive, Sleep Apnea, Sleep Apnea Syndromes, Apnea
- Trial name
- NCT04729478
- Testing
- Drug-induced sleep endoscopy, Natural sleep endoscopy
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- ethisch.comite@uza.be
Anesthesia, Gastric Ultrasound
Gastric Emptying Time in Traumatic Injuries
The investigators plan to do serial sonographic examinations of the gastric antrum (quantity, quality) to estimate the gastric emptying time and dependant factors after traumatic injurys.
- Conditions
- Anesthesia, Gastric Ultrasound, Sonography, Point of Care Ultrasound (POCUS)
- Trial name
- NCT06643325
- Testing
- Gastric ultrasound
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Kantonsspital Winterthur KSW
Neuromuscular Blockade
Interaction of Volatile Anesthetics With Magnesium
Magnesium and volatiles anesthetics both have an effect on the neuromuscular transmission. The primary objective of the study is to quantify the effect of a perfusion of intravenous magnesium on neuromuscular transmission…
- Trial name
- Volmag (NCT05261516)
- Testing
- Magnesium Sulfate
- Where
- Switzerland
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Christoph Czarnetzki
Injection Pain, Local Anesthesia Infiltration
Sweet-Tasting Solution Versus Placebo to Reduce Pain During Local Anesthetic Injection in Children
The goal of this clinical trial is to learn whether applying a sugar-free flavored sweet solution (SFSS) before local anesthesia helps reduce injection pain in children.
- Conditions
- Injection Pain, Local Anesthesia Infiltration, Pain, Injection Pain Prevention
- Trial name
- NCT07279285
- Testing
- Sugar-free-flavored sweet tasting solution
- Where
- Jordan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Jordan
General Anesthetic, Positive Expiratory Pressure
Impact of Body Mass Index on Positive End-expiratory Pressure Guided by Electrical Impedance Tomography for Patients Under General Anaesthesia
The induction of general anaesthesia is associated with a fall in lung volume due in particular to a decrease in muscle tone and the formation of denitrogenation atelectasis.
- Conditions
- General Anesthetic, Positive Expiratory Pressure, Obesity
- Trial name
- PEPTI (NCT04439604)
- Testing
- regional ventilation monitoring
- Where
- France
- Volunteers
- 59 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Anesthesia, Spinal Puncture
Intravenous Fentanyl or Local Anesthetic Infiltration for Pain Reducing During Spinal Needle Insertion
Background and Objectives: Spinal puncture is painful procedure which may cause patient refusal of spinal anesthesia in future surgery.
- Trial name
- NCT01157247
- Testing
- Comparison of intravenous fentanyl and local anesthetic infiltration in pain reducing during spinal needle puncture
- Where
- Croatia
- Volunteers
- 88 people
- Sponsor
- Croatian Society of Regional Anesthesia and Analgesia
Myocardial Ischemia
Optimization of Cardioprotection in Diabetic Patients Undergoing Cardiac Surgery
This study evaluates the myocardial protection against perioperative ischemia comparing two standard anesthetic regimes in diabetic patients undergoing elective cardiac surgery.
- Trial name
- OPT (NCT02407626)
- Testing
- Propofol, Sevoflurane
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- Triemli Hospital
Labour Analgesia
Prediction of Local Anaesthetic Dosing During Labour Epidural Analgesia
Epidural analgesia is the gold standard for controlling labour pain. However, labour pain happens during neuraxial analgesia, due to anaesthetic, obstetric, maternal factors.
- Trial name
- DIANA (NCT07614516)
- Testing
- Machine-learning prediction model
- Where
- Italy
- Volunteers
- 12,500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pain Management, Laparascopic Sleeve Gastrectomy
Ketamine for Shoulder Pain Following Laparoscopic Gastric Sleeve Surgery
Shoulder pain is a well-recognized complaint following laparoscopic surgery. It is underlying mechanism has various causes, therefore, modalities in management and prevention of this sort of pain are numerous with different…
- Trial name
- NCT07429916
- Testing
- Intraoperative ketamine
- Where
- Jordan
- Volunteers
- 50 people
- Sponsor
- King Abdullah University Hospital
Biliary Atresia
Laparoscopic Kasai Has Similar Anesthetic Outcomes to Open Kasai
Biliary atresia (BA) is a rare biliary tree disease with a high incidence in eastern Asia. Kasai operation is a standard treatment for BA, and studies have shown that timely Kasai operation is crucial for better outcomes.
- Trial name
- NCT06163417
- Testing
- laparoscopic
- Volunteers
- 28 people
- Sponsor
- Taichung Veterans General Hospital
Anesthesia, Sleep
Acupoint Stimulation and Postoperative Sleep
Sleeping model can be affected after surgery. Anesthetics may be involved in the change. The changing of sleeping mode may exert adverse effect on postoperative recovery.
- Trial name
- ASIS (NCT04632576)
- Testing
- transcutaneous electrical acupoint stimulation
- Where
- 4 sites in China
- Volunteers
- 274 people
- Sponsor
- Air Force Military Medical University, China
Endotracheal Tube Wrongly Placed During Anesthetic Procedure
Modified Magill Forceps Facilitating Nasal Intubation for Children Undergoing Dental Operations
compare between Magill forceps and modified pediatric Magill forceps for nasotracheal intubation (which method is easier and better?).
- Trial name
- NCT05513989
- Testing
- modified Magill forceps, Magill forceps
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ain Shams University
Hemodynamic Changes, Music Therapy
Effects of Music Therapy on Anesthetic Requirements and Hemodynamic Parameters
Music therapy has been reported to reduce analgesic and anesthetic requirements, but evidence in thoracic surgery remains limited.
- Conditions
- Hemodynamic Changes, Music Therapy, Thoracic Surgery, Anesthetic Consumption
- Trial name
- NCT07322562
- Testing
- music therapy during surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Cukurova University
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