Clinical trials: Anesthetic, Inhalation
General Anesthetics
Effectiveness of Facial Mask NIV in Adults Under General Anesthesia: Two-Hand C-E vs V-E Techniques
This study aims to compare two different ways doctors hold a face mask to help the participant breathe during general anesthesia. The investigators are evaluating which method, the "C-E" or the "V-E" technique, works best.
- Trial name
- VENTMASK (NCT07179432)
- Testing
- V-E facial mask ventilation maneuver, C-E facial mask ventilation maneuver
- Where
- 2 sites in Colombia
- Volunteers
- 206 people
- Sponsor
- Universidad de Antioquia
Xenon, Sevoflurane
A Pre- and Post- Coronary Artery Bypass Graft Implantation Disposed Application of Xenon
The aim of this study is to determine whether xenon - as compared to sevoflurane - can be applied safely in patients for general anesthesia before and after CABG implantation.
- Conditions
- Xenon, Sevoflurane, Anesthetics, Inhalation, Coronary Disease
- Trial name
- CArDiAX (NCT01285271)
- Testing
- Xenon, Sevoflurane
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- RWTH Aachen University
Anesthesia, General, Sevoflurane
Frequency Analysis of Raw EEG During Sevoflurane Anesthesia in Children Younger Than 2 Years Old
The purpose of this study is to analyze raw electroencephalogram in infants younger than 2 years old undergoing general anesthesia using sevoflurane.
- Conditions
- Anesthesia, General, Sevoflurane, Infant
- Trial name
- NCT05148065
- Testing
- BIS, PSi
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Sang-Hwan Ji
Oropharyngeal Neoplasms
Isocapnic Hyperventilation - an Alternative Method
Isocapnic hyperventilation (IHV) is a method that shortens time to extubation after inhalation anaesthesia by increasing airway carbon dioxide (CO2) during hyperventilation (HV).
- Trial name
- NCT03074110
- Testing
- Isocapnic hyperventilation
- Where
- Sweden
- Volunteers
- 31 people
- Sponsor
- Sahlgrenska University Hospital
Mechanical Ventilation
Retrospective Study on Prolonged Sedation Effects With Inhaled Agents in PICU
The objective of the study is to evaluate the effects of halogenated gases on sedation and analgesia, to describe the tolerance and to determine the risk factors for failure, in pediatric intensive care patients during prolonged…
- Trial name
- RESPIRE (NCT05064592)
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Pain
The Role of Preoperative Melatonin in Reducing the Inhaled Isoflurane Requirements in Open Nephrectomy
Melatonin is a hormone that the pineal gland in the brain produces. Melatonin fulfills many functions in the body but it is mostly known for maintaining a circadian rhythm that is governed by the central circadian pacemaker…
- Trial name
- NCT04959825
- Testing
- Melatonin 5 mg, Sugar Coated Tablets
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Poisoning by Inhaled Anaesthetic, Fluoride Poisoning
Sevoflurane- Safety in Long-term Sedation Procedures
Patients needing intensive care often require sedative drugs to reduce anxiety and agitation during ventilator care and invasive therapeutic and diagnostic procedures.
- Conditions
- Poisoning by Inhaled Anaesthetic, Fluoride Poisoning, Recovery From Sedation, Renal Function
- Trial name
- NCT01802255
- Testing
- Sevoflurane, Midazolam
- Where
- Spain
- Sponsor
- F Javier Belda
ARDS, ARDS, Human
Effects of Sevoflurane on Extravascular Lung Water and Pulmonary Vascular Permeability in Patients With ARDS
The study will investigate the effects of inhaled sedation with sevoflurane using the AnaConDa device on extravascular lung water index (EVLWi) and the pulmonary vascular permeability index (PVPI) in patients with moderate to…
- Trial name
- NCT04530188
- Testing
- Sevoflurane, Propofol
- Volunteers
- 68 people
- Sponsor
- Bicetre Hospital
Diastolic Dysfunction, Coronary Artery Disease
Study of the Effect of Inhaled Anesthetics on Diastolic Heart Function Using a Doppler-derived Efficiency Index
The purpose of this study is to determine the effect of inhaled anesthetic drugs upon diastolic heart function (heart suction and filling performance) in patients who are undergoing coronary bypass surgery.
- Conditions
- Diastolic Dysfunction, Coronary Artery Disease, General Anesthesia
- Trial name
- NCT00907439
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Washington University School of Medicine
Anesthesia, General, Electroencephalography
Anesthesia and EEG Discontinuity in Infants
This study is a randomized controlled trial to evaluate whether EEG-guided calibration of inhalation agents can reduce occurrence of EEG discontinuity in infants during general anesthesia.
- Conditions
- Anesthesia, General, Electroencephalography, Infant, Anesthesia, Inhalation
- Trial name
- NCT05906225
- Testing
- EEG guided anesthesia, Conventional anesthesia
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Seoul National University Hospital
Lower Eyelid Bags
The Effect of Inhalation Aromatherapy on Intraoperative Fear in Patients Undergoing Lower Blepharoplasty Under Local Anesthesia: A Randomized Controlled Trial
This study is a single-center, randomized, controlled, open-label clinical trial designed to evaluate the intervention effect of inhaled aromatherapy on intraoperative fear in patients undergoing lower blepharoplasty (eyelid bag…
- Trial name
- NCT07766902
- Testing
- inhaled aromatherapy
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sevoflurane, Propofol
The Electroencephalogram Analysis in the Differences Between Inhalation Anesthetic and Propofol.
The investigators will record 120 patients who received general anesthesia, their EEG data recorded from Bispectral Index (BIS) machine for emperical mode decomposition (EMD) analysis, the investigators decomposed EEG signal to…
- Trial name
- NCT04431557
- Where
- Taiwan
- Volunteers
- 268 people
- Sponsor
- National Taiwan University Hospital
Inflammatory Response
Systemic Inflammatory Response Evaluation With the Use of Inhaled Anesthetic Sevoflurane During CPB
Cardiac surgery has evolved considerably after the advent of cardiopulmonary bypass (CPB), a feature that allowed more precision and tranquility to the heart surgeon.
- Trial name
- NCT02672345
- Testing
- Sevoflurane
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Anesthetics, Inhalation, Neuromuscular Blockade
Effect of Rocuronium and Sugammadex Under Sevoflurane and Desflurane Anesthesia in Children
Sugammadex is the first selective relaxant binding agent approved to reverse certain non-depolarizing neuromuscular drugs in patients 2 years old and above.
- Conditions
- Anesthetics, Inhalation, Neuromuscular Blockade, Anesthesia, General
- Trial name
- NCT03795259
- Testing
- Rocuronium, Sugammadex
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people
- Sponsor
- Istanbul University
Obstructive Sleep Apnea
Influence of Different Anesthetic Procedures on Sleep Disorder Breathing
Obstructive sleep apnea (OSA) is a common form of sleep disordered breathing characterized by partial or complete upper airway obstructions during sleep. OSA is associated with major comorbidities and perioperative complications.
- Trial name
- NCT03499132
- Testing
- anesthesia
- Where
- Czechia
- Volunteers
- 90 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Anesthetics, Inhalation
50% Effective Concentration of Sevoflurane for Immobility
Sevoflurane is as attractive inhalation agent fore deep sedation in children undergoing short invasive procedure because of lack of irritation to the respiratory tract, a pleasant odor and rapid clinical effect and recovery due…
- Trial name
- NCT03553446
- Testing
- children receiving sevoflurane
- Where
- South Korea
- Volunteers
- 23 people
- Sponsor
- Yeungnam University College of Medicine
Healthy Adults, Gynecological Disease
Sevoflurane, Propofol, Postoperative Pain
The impact of anaesthetic method (intravenous vs. inhalational) has been proposed, but not proven in a large-scale study. The researchers aim to provide an investigation that has sufficient power to clarify the potential effect…
- Trial name
- NCT01437462
- Testing
- Sevoflurane, Propofol
- Where
- Finland
- Volunteers
- 168 people
- Sponsor
- Tampere University Hospital
Neurocognitive Disorders, Inhalation; Vapor
Effect of Low Flow Anesthetics on Neurocognitive Decline in the Elderly
This study aims to investigate the effect of inhaled anesthetics with a low fresh gas flow on cognitive function of elderly patients undergoing elective surgery
- Trial name
- NCT05548998
- Testing
- General anesthesia with low fresh gas flow, General anesthesia with high fresh gas flow, Mini mental state examination
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Hypertension
Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics
It is controversial whether or not patients whose Renin Angiotensin System is blocked for the treatment of hypertension suffer increased risk when undergoing surgery and anaesthesia.
- Trial name
- NCT01715584
- Testing
- Sevoflurane/oxygen/air/nitrous oxide
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Respiratory Failure, Respiratory Infection
Avoiding Neuromuscular Blockers to Reduce Complications
The goal of this study to evaluate whether eliminating the use of non-depolarizing neuromuscular blocking agents (NMBA) for maintenance of general anesthesia reduces postoperative pulmonary complications in higher risk patients.
- Conditions
- Respiratory Failure, Respiratory Infection, Aspiration Pneumonia, Pneumonitis
- Trial name
- NCT03962725
- Testing
- Neuromuscular Blocking Agents, Anesthetic Adjuncts
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Beth Israel Deaconess Medical Center