Clinical trials: Anesthetic
Anesthesia, Local, Pain
Clinical Trial Comparing Effectiveness of Buffered Versus Unbuffered Local Anesthetic in Children Ages 10-12 Years
Local anesthesia is an integral part of clinical pediatric dental practice, but it has challenges. It can be uncomfortable for children, and the risk of adverse events limits how much is used.
- Trial name
- NCT03562481
- Testing
- 1% Buffered Lidocaine 1:100,000 Epinephrine, 2% Unbuffered Lidocaine 1:100,000 Epinephrine
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Hypotension, Anesthesia
Methohexital v Propofol as General Anesthetic in Patients on ACEIs or ARBs
Patient undergoing general anesthesia in elective surgery will be assigned to receive either methohexital or propofol general anesthesia.
- Trial name
- NCT02624050
- Testing
- Methohexital, Propofol
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Opioid Pain Medication
Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation
This study is a prospective randomized trial examining the effect of topically combined antifibrinolytics (Tranexamic acid) with local anesthetics in all electively created surgical wound beds in hand surgery to provide long term…
- Trial name
- NCT04814433
- Testing
- Tranexamic acid, Aminocaproic acid, Recombinant Human Thrombin
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Pain
The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections
The inferior alveolar nerve block (shot) is the most frequently used injection technique for achieving local anesthesia (numbness) for the teeth in the lower jaw.
- Trial name
- NCT01574807
- Testing
- mepivacaine + lidocaine followed by lidocaine +lidocaine, lidocaine + lidocaine followed by mepivacaine + lidocaine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Anesthesia of Mucous Membrane
Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis
The efficacy of the topical anesthetics will be determined by how much pain the patient felt (using a Heft-Parker pain analog scale) upon needle penetration.
- Trial name
- NCT01951820
- Testing
- Pliaglis, Benzocaine, Articaine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Sleep
Implications of Anesthetics on Sleep Consolidation
Sleep leads to consolidation of learning in humans, restoring memories that were forgotten over a waking day and protecting memories against future forgetting.
- Trial name
- NCT04329091
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Symptomatic Irreversible Pulpitis
Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis
The purpose of this study is to determine whether one type of anesthetic (numbing medicine) will work better at numbing the nerve in a tooth than using a different type of anesthetic.
- Trial name
- NCT05227300
- Testing
- Onset Sodium Bicarbonate Inj., 8.4%, USP Neutralizing Additive Solution, 2% lidocaine with 1:100,000 epinephrine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Pain
Effectiveness Study of Different Local Anesthetic Mixtures
Purpose and Background The purpose of this research study is to investigate the benefits of mixing lidocaine and bupivacaine for numbing the skin.
- Trial name
- CA (NCT01243112)
- Testing
- 1% Lidocaine with Epinephrine (1:100,000), 0.25% Bupivacaine with Epinephrine (1:200,000), 0.5% Lidocaine, 0.125 Bupivacaine, and epi (1:150,000)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Scott and White Hospital & Clinic
Labor Pain, Complications; Cesarean Section
Outcomes of Neuraxial Anesthetic Technique on the Trial of Labor After Cesarean (TOLAC)
To compare the effects of epidural versus combined spinal and epidural (CSE) anesthesia on the success of Trial of Labor After Cesarean (TOLAC).
- Conditions
- Labor Pain, Complications; Cesarean Section, Pregnancy
- Trial name
- NCT02105558
- Testing
- Epidural anesthesia, Combined spinal and epidural anesthesia
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Healthy
Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes
This study involves 60 healthy volunteers aged between 18 and 50 recruited from the general community. It involves doing a set of simple memory tests while inside a fMRI machine.
- Trial name
- Amygdala (NCT00504894)
- Testing
- Propofol, Thiopental
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Achilles Tendon Pain
Achilles Pain Block
The purpose of this study is to better understand how the peripheral and central nervous system interact to produce the sensation of pain and motor patterns in patients with achilles tendinopathy (AT).
- Trial name
- APB (NCT03316378)
- Testing
- Ropivacaine injection
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Ruth Chimenti
Application Site Discomfort, Medical Device Discomfort
Control of Tourniquet Pain With an Axillary Ring of Subcutaneous Local Anesthetic
Purpose: Even with excellent regional anesthesia of the upper extremity, tourniquet (Tq) pain from an upper arm Tq can limit the ability to use regional anesthesia as the primary anesthetic for surgical procedures on the upper…
- Trial name
- NCT01829399
- Testing
- Bupivacaine with Epinephrine, Normal Saline
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Anesthesia
Experimental Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 Anesthetic Spray in Normal Volunteers
The purpose of this study is to determine if the topical application to cheek tissue of the combination of benzocaine and tetracaine has a longer duration of local anesthetic activity than benzocaine alone.
- Trial name
- NCT02908620
- Testing
- One spray CTY-5339-A, One spray CTY-5339-CB, Two sprays CTY-5339-A
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cetylite Industries
Local Anaesthetic Complication, Pain
Kinetic Anesthesia Device Study
Patients experience discomfort from lidocaine injections. Vibrating kinetic anesthesia devices (KAD) have been shown to reduce pain of injections in dentistry, pediatrics, and dermatology, though no studies of lidocaine…
- Trial name
- NCT03344510
- Testing
- Kinetic Anesthesia Device, Control
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Relatively Healthy Volunteers
Optimizing Local Anesthetic Concentration for Continuous Popliteal-Sciatic Nerve Blocks
A continuous peripheral nerve block-also termed "perineural local anesthetic infusion"-involves the insertion of a tiny tube (a "catheter") through the skin and adjacent to a peripheral nerve, followed by local anesthetic…
- Trial name
- NCT01898689
- Testing
- Ropivacaine 0.1%, Ropivacaine 0.4%
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Keloid, Alopecia Areata
Pain Outcomes Following Intralesional Corticosteroid Injections
Corticosteroid therapy, including intralesional and topical applications, has many indications within the fields of Dermatology, Plastic Surgery, and Orthopedics.
- Conditions
- Keloid, Alopecia Areata, Acne, Hypertrophic Scar
- Trial name
- NCT03630198
- Testing
- Corticosteroid with lidocaine, Corticosteroid with normal saline
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Pain
Tetracaine Versus Lidocaine Gel for Anesthetic Effect and Comfort in Patients Undergoing LASIK
In this study the investigators will be comparing two different types of anesthetic, a numbing eye drop and a numbing gel, to test if they are equally effective or if one has a better outcome in terms of the level of comfort you…
- Trial name
- NCT01383200
- Testing
- Tetracaine drop, Lidocaine gel
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Miami
Pain, Local Anesthesia for Peripheral Intravenous Catheterization
Local Anesthetics for Pain Reduction Prior to IV Line Placement
The purpose of this study is to compare the pain level felt by patients when receiving placement of a peripheral intravenous catheter (IV line) following the administration of a local anesthetic.
- Trial name
- NCT01759459
- Testing
- Lidocaine, Buffered Lidocaine, Bacteriostatic Normal Saline
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Allina Health System
Anesthesia
Improving Information Extraction From EEG on Cerebral Anesthetic Drug Effects
This is an interventional, randomized controlled study in health volunteers that involves collecting data on raw EEG waves measuring various combinations of anesthetic drugs during standardized drug titration.
- Trial name
- NCT02043938
- Testing
- SedLine EEG sensor
- Where
- Netherlands
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Masimo Corporation
Anesthesia
Evaluation of Bispectral Index (BIS™) and Levels of Sedation With Common Inhalational Anesthetics in Healthy Volunteers (OLIVER)
To investigate the relationship between BIS™ and inhaled anesthetics across a wide range of anesthetic concentration and hypnotic states, and to provide evidence to support BIS™ performance in use with Isoflurane, Sevoflurane and…
- Trial name
- OLIVER (NCT04602546)
- Testing
- BIS Complete Monitoring System
- Where
- 3 sites in United States
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG