Clinical trials: Anesthetic
Patient Care
Efficacy of Cotton as a Dampener for Vibration Anesthetic Device
The study aims to determine the effectiveness of cotton as a dampener for vibratory anesthetic devices (VADs) for dermatologic patients.
- Trial name
- NCT06916468
- Testing
- VAD with Cotton Dampener, Vibratory Anesthetic Device (VAD)
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Anesthesia, Local
A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution
This is a Phase 3, randomized, placebo-controlled, double masked, parallel design study in healthy subjects performed in the US.
- Trial name
- NCT04513652
- Testing
- AG-920
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Thoracic Surgery
Local Anesthetic as Single Shot Versus Catheter in Patients Undergoing Video Assisted Thoracoscopic Surgery
The purpose of this research is to compare a single shot long acting local anesthetic to catheter infusion of local anesthetic in patients undergoing video assisted thoracoscopic (VAT) surgery.
- Trial name
- NCT04559347
- Testing
- Liposomal Bupivacaine (EXPAREL®)/Bupivacaine, Ropivacaine (0.5% bolus followed by 0.2% infusion)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Poovendran Saththasivam
Traumatic Femur Fracture
Femoral Nerve Block for Femur Fracture Repair in Pediatrics
The purpose of this study is to prospectively compare post-operative pain relief in pediatric patients undergoing traumatic femur fracture repair who have received either a femoral nerve block with a lateral femoral cutaneous…
- Trial name
- NCT01759407
- Testing
- Ropivicaine, Epinephrine
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Nationwide Children's Hospital
Pain, Postoperative
Pre-incision Versus Post-incision Local Anesthetic During Robotic Sacrocolpopexy
Obtaining Likest-pain scale score on postoperative day one after injection of local anesthetic into incision sites of a laparoscopic/robotic-assisted sacrocolpopexy
- Trial name
- CLAPPS (NCT04996251)
- Testing
- Bupivacaine Injection
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Premature Ejaculation
Efficacy, Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment Premature Ejaculation
The purpose of this study is to evaluate the effectiveness, safety and tolerability of the investigational drug, PSD502 in subjects with premature ejaculation (PE) The study drug, PSD02, is a metered dose (measured dose), topical…
- Trial name
- NCT00556478
- Testing
- PSD502, contains a mixture of lidocaine and prilocaine
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Plethora Solutions Ltd
Lip Augmentation
A Multicenter, Double-blind, Randomized, Controlled, Roll-over Retreatment Study of the Safety and Pain Associated With Injections of PN40082, RV001 With Topical Anesthetic or RV001 for Lip Augmentation
The purpose of this study is to evaluate the safety of repeat injections and pain associated with injection of PN40082 and comparative pain associated with RV001 with a topical anesthetic and RV001 for lip augmentation.
- Trial name
- NCT04029545
- Testing
- PN40082
- Where
- 5 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Prollenium Medical Technologies Inc.
Chronic Low Back Pain
Comparison of Kinesio Taping and Local Injection in Chronic Low Back Pain
Low back pain can be seen in every period of life. More than 80 percent of the society complain of low back pain at any time of life.
- Trial name
- NCT03895307
- Testing
- kinesio tape, local anesthetic, local serum physiologic
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Regional Block for Pain Control, Supraclavicular Block
Duration of Analgesic Effect for Ultrasound Guided Supraclavicular Blocks With the Addition of Buprenorphine to Local Anesthetic Solution
The patients included will be those who have already agreed to have a brachial plexus nerve block for surgery. A flip of the coin will decide who gets and additive called buprenorphine in their block or not.
- Conditions
- Regional Block for Pain Control, Supraclavicular Block, Ultrasound Guided Block, Block Additive
- Trial name
- NCT01583179
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Wisconsin, Madison
Bariatric Surgery Candidate
The Use of Intraperitoneal Ropivacaine in Bariatric Bypass Surgery
This is a pilot study in a randomized, controlled, double-blinded format and will evaluate the ability of a local anesthetic, Ropivacaine, to decrease pain after gastric bypass surgery.
- Trial name
- INOPAIN (NCT02154763)
- Testing
- Ropivacaine, Normal Saline
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Ottawa Hospital Research Institute
Cervical Radiculopathy
Does Low-does Cervical Epidural Lidocaine Cause Transient Weakness?
"Does low-does cervical epidural lidocaine cause transient weakness?"
- Trial name
- NCT03382925
- Testing
- cervical interlaminar with lidocaine, cervical interlaminar with normal saline, Lidocaine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Utah
Liver Disease
Isoflurane Preconditioning for Liver Resections
The objective is to examine the efficacy of isoflurane (inhaled anesthetic gas) to induce clinically effective preconditioning in patients undergoing elective hepatic surgery.
- Trial name
- NCT01031550
- Testing
- isoflurane, propofol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rutgers, The State University of New Jersey
Keloid, Alopecia Areata
Pain Outcomes Following Intralesional Corticosteroid Injections
Corticosteroid therapy, including intralesional and topical applications, has many indications within the fields of Dermatology, Plastic Surgery, and Orthopedics.
- Conditions
- Keloid, Alopecia Areata, Acne, Hypertrophic Scar
- Trial name
- NCT03630198
- Testing
- Corticosteroid with lidocaine, Corticosteroid with normal saline
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Overactive Bladder
Local Anesthetic Treatments for Overactive Bladder
The purpose of this study is to determine whether alkalized lidocaine instilled into the bladder is effective in the treatment of overactive bladder (OAB).
- Trial name
- NCT00427648
- Testing
- alkalinized xylocaine
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Frank Tu
Pain
The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections
The inferior alveolar nerve block (shot) is the most frequently used injection technique for achieving local anesthesia (numbness) for the teeth in the lower jaw.
- Trial name
- NCT01574807
- Testing
- mepivacaine + lidocaine followed by lidocaine +lidocaine, lidocaine + lidocaine followed by mepivacaine + lidocaine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Healthy Volunteers
Anesthetic Effect Duration Assessment
The purpose of this study is to evaluate the duration of anesthetic effect produced , Lidocaine7% + Tetracaine 7% cream when applied with 2 different application times on the face and thigh.
- Trial name
- NCT01545765
- Testing
- Lidocaine 7% + Tetracaine 7% cream
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Epiphora, Dacryostenosis
Does Topical Ophthalmic Anesthetic Prior to Probing and Irrigation Decrease Pain?
Purpose: It is unknown whether instillation of a drop of anesthetic ophthalmic solution into the eye such as proparacaine hydrochloride 0.5% prior to probing and irrigation of the tear duct (lacrimal drainage) system improves…
- Conditions
- Epiphora, Dacryostenosis, Dacryocystitis
- Trial name
- NCT04229771
- Testing
- Proparacaine Hydrochloride ophthalmic solution, USP 0.5%, Balanced salt solution
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Corewell Health East
Arthroplasty, Replacement, Knee, Pain, Postoperative
Adductor Canal Block for Total Knee Arthroplasty
Total knee arthroplasty (TKA) can be associated with a large amount of postoperative pain. This pain can oftentimes be severe enough to limit participation in physical therapy and ultimately delay discharge resulting in increased…
- Trial name
- NCT02453360
- Testing
- Adductor Canal Block
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Wisconsin, Madison
Edentulous Jaw, Dental Implant
Comparing Two Anesthetic Techniques for Implant Placement
To evaluate in a comparative way the patient's perception in implant surgery in the posterior mandibular quadrants depending on whether the operation is performed under trunk anaesthesia or infiltrative anaesthesia, in both cases…
- Conditions
- Edentulous Jaw, Dental Implant, Anesthesia, Local
- Trial name
- NCT04395690
- Testing
- Dental Implant Placement in the posterior mandible
- Where
- 8 sites in Spain
- Volunteers
- 96 people
- Sponsor
- Aula Dental Avanzada
Breast Reconstruction, Anesthesia
Comparing Local Anesthetics for TAP Block During Abdominally-based Free Flap for Breast Reconstruction
This study will compare the efficiency of transversus abominus plane (TAP) block using liposomal bupivacaine versus plain bupivacaine that is administered in the operating room under ultrasound guidance prior to the in patients…
- Conditions
- Breast Reconstruction, Anesthesia, Transverse Abdominis Plane Block
- Trial name
- NCT03700970
- Testing
- Liposomal bupivacaine, Regular bupivacaine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center