Clinical trials: Anesthetics, Inhalation
Healthy Adults, Gynecological Disease
Sevoflurane, Propofol, Postoperative Pain
The impact of anaesthetic method (intravenous vs. inhalational) has been proposed, but not proven in a large-scale study. The researchers aim to provide an investigation that has sufficient power to clarify the potential effect…
- Trial name
- NCT01437462
- Testing
- Sevoflurane, Propofol
- Where
- Finland
- Volunteers
- 168 people
- Sponsor
- Tampere University Hospital
Neurocognitive Disorders, Inhalation; Vapor
Effect of Low Flow Anesthetics on Neurocognitive Decline in the Elderly
This study aims to investigate the effect of inhaled anesthetics with a low fresh gas flow on cognitive function of elderly patients undergoing elective surgery
- Trial name
- NCT05548998
- Testing
- General anesthesia with low fresh gas flow, General anesthesia with high fresh gas flow, Mini mental state examination
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Hypertension
Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics
It is controversial whether or not patients whose Renin Angiotensin System is blocked for the treatment of hypertension suffer increased risk when undergoing surgery and anaesthesia.
- Trial name
- NCT01715584
- Testing
- Sevoflurane/oxygen/air/nitrous oxide
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Respiratory Failure, Respiratory Infection
Avoiding Neuromuscular Blockers to Reduce Complications
The goal of this study to evaluate whether eliminating the use of non-depolarizing neuromuscular blocking agents (NMBA) for maintenance of general anesthesia reduces postoperative pulmonary complications in higher risk patients.
- Conditions
- Respiratory Failure, Respiratory Infection, Aspiration Pneumonia, Pneumonitis
- Trial name
- NCT03962725
- Testing
- Neuromuscular Blocking Agents, Anesthetic Adjuncts
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Beth Israel Deaconess Medical Center
Anesthesia, General
Effect of Binaural Beats for Maintenance of General Anesthesia
The goal of this clinical trial is to learn about the effects of binaural beats on maintenance of general anesthesia in patients undergoing thyroidectomy without intraoperative neuromonitoring.
- Trial name
- BB (NCT06002568)
- Testing
- Silent, Binaural beats
- Where
- South Korea
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Pharmacokinetics of Inhaled Anesthetics
Ventilatory Effect on Speed of Anesthesia Under Various Inhaled Anesthetics
Three groups of patients are going to have minor surgery under general anesthesia with inhaled anesthetics and different ventilatory setting (Tidal volume: 8, 10, 12 ml/kg, respiratory rate: 10/min each).
- Trial name
- NCT01171833
- Testing
- Sevoflurane, Desflurane, Isoflurane
- Volunteers
- 36 people
- Sponsor
- DongGuk University
Elective Surgical Procedures, Laparoscopy
Nitrous Oxide Added at the End of Sevoflurane Anesthesia and Recovery
Addition of nitrous oxide N2O towards the end of prolonged isoflurane anesthesia hastens patients recovery. The hypothesis is that the addition of N2O at the end of prolonged sevoflurane anaesthesia also hastens early recovery…
- Conditions
- Elective Surgical Procedures, Laparoscopy, Laparotomy, Anesthesia, General
- Trial name
- SEVONATE (NCT03420586)
- Testing
- Nitrous Oxide
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- General Hospital Zadar
Pulmonary Aspiration of Gastric Contents
Gastric Content After 6 vs 4 Hours of Preoperative Fasting in Children
The primary objective of the study is to compare the risk of increased stomach contents after tube feeding (Enteral feeding) 6 and 4 hours before anesthesia using antrum measured by ultrasound.
- Trial name
- ENGUS (NCT05695066)
- Testing
- Preoperative fasting instruction
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- Uppsala University Hospital
Liver Function After Partial Liver Resection
Xenon-anesthesia on Patients Undergoing Major Liver-resection
The aim of this study is to compare the postoperative outcome of patients undergoing major liver resection under xenon- compared to desflurane-anesthesia.
- Trial name
- XeLiv (NCT03504033)
- Testing
- Xenon, Desflurane
- Where
- Germany
- Sponsor
- RWTH Aachen University
Solid Tumor, Carcinoma
Propofol vs Sevo for Paediatric Tumor Surgery
Background: Retrospective studies and meta-analyses have shown a reduction in 5-year survival following inhalational based compared to propofol based total intravenous (TIVA) anaesthesia for cancer surgery.
- Conditions
- Solid Tumor, Carcinoma, Malignancy, Cancer
- Trial name
- NCT04475705
- Testing
- propofol, sevoflurane
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Hong Kong Children's Hospital
Scrotum Disease, Hydrocele Male
Efficacy of Inhaled Methoxyflurane (Penthrox) as Adjunct for Urologic Procedures Under Local Anesthetic: A Pilot Study
We wish to perform a prospective randomized controlled pilot study at the Men's Health Clinic and Health Science's Centre to assess whether or not the use of Penthrox as an adjunct to LA is associated with improved pain tolerance…
- Conditions
- Scrotum Disease, Hydrocele Male, Spermatocele, Scrotal Hematocele
- Trial name
- NCT07192198
- Testing
- Methoxyflurane, Control
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Endotracheal Intubation, Deep Sedation
Inhaled Sedation Using the Anesthetic-conserving Device ( ANACONDA) in Prehospital Emergency Medecine.
Achieving the optimal sedation level for patient management is not always possible using our standard intravenous medications in Pre-hospital Emergency medicine.
- Trial name
- ANACONDA (NCT04141267)
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Anesthetics, Inhalation
Blood Levels of Sevoflurane and Desflurane
16 patients with American Society of AnesthesioIogy (ASA) physical status I-III will recruited to this study. Patients will divided to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D.
- Trial name
- NCT03015350
- Testing
- Sevoflurane, Desflurane
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Cukurova University
Colorectal Cancer Metastatic, Survival Rate
The Effects of General Anesthetics on Lymphocytes in Patients Undergoing Colorectal Cancer Resection and Mechanism Involved
The body immunity is important to the development of tumor. The immune system is in charge of monitoring and cleaning tumor cells in circulation. Anesthesia may alter the immune response and affect the elimination of tumor cells.
- Conditions
- Colorectal Cancer Metastatic, Survival Rate, General Anesthetics Toxicity, Lymphocyte Destruction
- Trial name
- NCT03193710
- Testing
- Propofol, Sevoflurane, Remifentanil
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Guizhi Du
ASA Class I/II Patients, General Anesthetic
PCV vs VCV in Low-Flow Anesthesia
The aim of this observational study is to investigate the effects of ventilation modes on intraoperative and postoperative lung functions in patients under general anesthesia.
- Conditions
- ASA Class I/II Patients, General Anesthetic, Low Flow Anesthesia
- Trial name
- NCT07305129
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- HULYA TOPCU, MD
Total Intravenous Anesthesia, Desflurane
TIVA Versus Desfluran Anaesthesia in Patients Undergoing Bariatric Surgery
Many factors during laparascopic surgery leads to PONV (postoperative nausea and vomiting), such as C02 insufflations causing peritoneal stretch and irritation and type of anaesthesia given during surgery.
- Conditions
- Total Intravenous Anesthesia, Desflurane, Obesity, Pain, Postoperative
- Trial name
- NCT03727607
- Testing
- Desflurane
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ostfold Hospital Trust
Sore Throat
Inhalation of Lidocaine Before Intubation
We investigate the potential benefits of ultrasound-driven lidocaine inhalation immediately before induction.
- Trial name
- NCT01838993
- Testing
- Lidocaine inhalation
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- New Taipei City Hospital
Oxidative Stress, Cardiac Surgery
The Comparison of Oxidative Stress Between Inhalation Anesthetics
Oxidative stress is an unavoidable event during cardiac surgery. Isoprostanes have been demonstrated to be a reliable biomarker for the evaluation of oxidative stress in vivo.The aims of this study are(1)to develop an accurate…
- Trial name
- NCT00965445
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Exposure to Environmental Pollution, Adverse Effect of Unspecified General Anesthetic
Anesthetic Gas Leakage in Children During Tonsillectomy: a Comparison of Cuffed and Uncuffed Tracheal Tubes
Fires and operating room pollution may occur when anesthesia gases leak into the oropharynx during airway surgery. Investigators sought to measure the concentrations of anesthetic gases that leak into the mouth of children…
- Trial name
- NCT02725164
- Testing
- oxygen concentration, nitrous oxide concentration, carbon dioxide concentration
- Volunteers
- 31 people
- Sponsor
- State University of New York at Buffalo
Intraoperative Hypotension
Bispectral Index Guided Sevoflurane Titration
Electroencephalographic-based monitoring systems such as the bispectral index (BIS) may reduce anaesthetic overdose rates. The investigators hypothesised that goal-directed sevoflurane administration (guided by BIS monitoring)…
- Trial name
- NCT02515019
- Testing
- Bispectral index Monitoring
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf