Clinical trials: Anesthetics, Intravenous
Anesthesia
Effect of Gender on Propofol Requirement
Total intravenous anaesthesia (TIVA) has emerged as a viable alternative to inhalational general anaesthesia (GA). Propofol is the preferred drug for providing TIVA due to its favorable pharmacokinetic profile, such as, rapid…
- Trial name
- NCT05725135
- Testing
- Propofol
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Sir Ganga Ram Hospital
Postoperative Nausea and Vomiting, Postoperative Pain
Postoperative Nausea, Vomiting and Pain After Bariatric Surgery - a National Registry Study
Around 4,000-5,000 bariatric (weight-loss) operations are performed in Sweden every year. Nausea, vomiting and pain are common immediately after these operations, cause considerable suffering and increase the intensity and length…
- Conditions
- Postoperative Nausea and Vomiting, Postoperative Pain, Obesity, Morbid, Bariatric Surgery
- Trial name
- BAROSPOR (NCT07797374)
- Where
- 2 sites in Sweden
- Volunteers
- 30,000 people
- Sponsor
- Umeå University
Pain
Multimodal Analgesia With Interfascial Continuous Wound Infiltration: A Randomized Clinical Trial
Objectives: For major laparoscopic surgery, as with open surgery a multimodal analgesia plan can help control postoperative pain.
- Trial name
- NCT02223533
- Testing
- 19Gx500-mm Pajunk InfiltraLong® catheter, morphine
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Hospital Galdakao-Usansolo
Healthy
Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD3043
The primary purpose of this study is to assess the safety and tolerability of AZD3043 following administration of single ascending bolus doses (Part A) and single ascending bolus doses followed by infusion (Part B).
- Trial name
- NCT00984880
- Testing
- AZD3043
- Where
- Sweden
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Lower Limb Fracture
Comparison of Postoperative Analgesia Between Intravenous Paracetamol and Intranasal Tapentadol
The aim of the study was to compare the analgesic efficacy of intranasal tapentadol nasal spray 44.5mg and intravenous paracetamol 1gm during the postoperative period by Visual analog scale(VAS)in patients undergoing lower…
- Trial name
- NCT05999890
- Testing
- Tapentadol Hydrochloride
- Where
- India
- Volunteers
- 74 people
- Sponsor
- Kempegowda Institute of Medical Sciences, Bangalore
Caudal Block for Postoperative Analgesia
Comparison of Optic Nerve Sheath Diameter in Children Receiving Caudal Block According to Anesthetic Agents: Total Intravenous Anesthesia vs. Volatile Anesthesia
Caudal block is commonly used for postoperative analgesia in paediatric patients. A higher volume (1.5 ml/kg) of local anaesthetic for caudal block has been reported to not only increase the level of cranial spread but also…
- Trial name
- NCT04415905
- Testing
- Propofol, Sevoflurane
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Pain, Infant, Newborn
Intravenous and Topical Analgesics for Procedural Pain in Neonates
This study will test which type of pain medication is best for the management of pain in newborn preterm and full-term infants having a deep intravenous cannula inserted.
- Trial name
- NCT00213200
- Testing
- morphine, amethocaine
- Where
- 2 sites in Canada
- Volunteers
- 108 people
- Sponsor
- The Hospital for Sick Children
Peripheral Intravenous Cannulation, Pain Management
Is Pain Ease (New Formula) Safe and Effective in Reducing Pain Associated With Peripheral Intravenous Cannulation (PIV)?
The goal of this clinical trial is to learn if Pain Ease (new formula) is more effective than Nature's Tears in reducing pain associated with Peripheral Intravenous Cannulation (PIV), also known as an IV.
- Trial name
- NCT07821476
- Testing
- Sterile water, Vapocoolant spray
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gebauer Company
Depression, Unipolar
Repeated Neurocognitive Measurements in Depressed Patients
In this project, we will A) track the functioning of a collection of potential neurobiological targets for depression over time, B) examine how fluctuations in the functioning of those targets relates to real-world functioning…
- Trial name
- NCT05991232
- Testing
- Intravenous Ketamine
- Where
- United States
- Sponsor
- Jay Fournier
Lung Volume Reduction Surgery
Effects of Desflurane and Propofol During Lung Volume Reduction Surgery
Patients presenting for lung volume reduction are very high risk patients and it is important they receive the best anesthetic available. This study aims to answer which is the best anesthetic for managing such cases.
- Trial name
- NCT04226625
- Testing
- Propofol, Desflurane
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Columbia University
Blood Pressure, Hypotension Drug-Induced
Comparison Between Inhalation and Intravenous Induction of Anaesthesia During Interventional Mitral Valve Repair
The induction of anaesthesia is one of the most critical situations for high-risk-patients undergoing interventions surgery. For several reasons, it is crucial to maintain adequate blood pressure and cardiac output during this…
- Trial name
- COMPETENT (NCT04865614)
- Testing
- Etomidate, Sevoflurane
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- Heidelberg University
Qt Interval, Variation in
The Effect of Anesthetic Agents Management on ECG Changes of Patients Who Were Operated Under RIVA
IVRA can be performed with many local anesthetics and adjuvant agents. Investigators planned to compare cardiac effects and ECG changes by IVRA with lidocaine and lidocaine plus ketamine.
- Trial name
- NCT02063620
- Testing
- Ketamine HCL
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duzce University
Intravenous Anesthesia, Cholelithiasis
Time to Loss of Consciousness With Remimazolam Versus Propofol for Anesthetic Induction in Laparoscopic Cholecystectomy
The goal of this clinical trial is to compare two medicines used to induce general anesthesia in adults undergoing elective laparoscopic cholecystectomy.
- Trial name
- REMIPROP-LOC (NCT07717684)
- Testing
- Remimazolam, Propofol
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Universidade Federal de Sergipe
Myocardial Ischemia
Optimization of Cardioprotection in Diabetic Patients Undergoing Cardiac Surgery
This study evaluates the myocardial protection against perioperative ischemia comparing two standard anesthetic regimes in diabetic patients undergoing elective cardiac surgery.
- Trial name
- OPT (NCT02407626)
- Testing
- Propofol, Sevoflurane
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- Triemli Hospital
Adult, Anesthesia, General
Anesthesia Induction With Intravenous Bolus or Continuous Infusion of Remimazolam
Bolus injection and continuous infusion are two widely used methods for intravenous administration of drugs. Bolus injection possibly leads to a rather high drug plasma concentration temporarily, however, it can induce a rapid…
- Trial name
- NCT05423080
- Testing
- Bolus injection of remimazolam, Infusion of remimazolam
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Korea University Guro Hospital
Shivering
Comparative Study Between the Efficacy of Intravenous Hydrocortisone and Intravenous Dexmedetomidine for Prevention of Postoperative Shivering After General Anaesthesia for Abdominal Surgeries
The aim and purpose of this study is to compare the efficacy of intravenous hydrocortisone and intravenous dexmedetomidine for prevention and treatment of postoperative shivering after general anesthesia for abdominal surgeries.
- Trial name
- NCT07154849
- Testing
- Hydrocortisone, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Acute Cholecystitis, Chronic Cholecystitis
Evaluation of Closed-loop TIVA Propofol, Sufentanil and Ketamine Guided by BIS Monitor
The purpose of this study is to compare a closed-loop intravenous anesthetic using Bispectral Index as a feedback loop and a controller based on reinforcement learning to titrate dose and intravenous anesthetic that is manually…
- Trial name
- NCT01942356
- Testing
- TIVA - Hypotension, TIVA - Hypertension, TIVA - Bradycardia
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Femoral Fracture
Analgesia For Positioning Patient With Femur Fracture For Spinal Anaesthesia
This study is performed to determine the efficacy of ultrasound-guided fascia iliaca compartment block during positioning for spinal anaesthesia in patient undergoing repair of proximal femur fracture surgery comparing with…
- Trial name
- NCT02983344
- Testing
- Ropivacaine, Fentanyl, Ultrasound
- Where
- Malaysia
- Volunteers
- 24 people
- Sponsor
- Kuala Lumpur General Hospital
Post-spinal Anesthesia Shivering
Comparison of Low-Dose Intravenous Ketamine and Tramadol for Prevention of Post-Spinal Anaesthesia Shivering in Orthopedic Surgical Patients
This randomized controlled trial will compare the prophylactic effectiveness of low-dose intravenous ketamine and tramadol in preventing post-spinal anesthesia shivering in patients undergoing orthopedic surgery at Shaheed…
- Trial name
- NCT07787702
- Testing
- Tramadol, Ketamin
- Where
- Pakistan
- Volunteers
- 106 people
- Sponsor
- Shaheed Mohtarma Benazir Bhutto Institue of Trauma
Total Intravenous Anesthesia, Desflurane
TIVA Versus Desfluran Anaesthesia in Patients Undergoing Bariatric Surgery
Many factors during laparascopic surgery leads to PONV (postoperative nausea and vomiting), such as C02 insufflations causing peritoneal stretch and irritation and type of anaesthesia given during surgery.
- Conditions
- Total Intravenous Anesthesia, Desflurane, Obesity, Pain, Postoperative
- Trial name
- NCT03727607
- Testing
- Desflurane
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ostfold Hospital Trust