Clinical trials: Anesthetics
Pain
Methadone in Pediatric Anesthesiology II
Three arm randomized controlled trial to evaluate the efficacy of a single dose of intraoperative methadone in reducing post-operative pain and opioid consumption in adolescents undergoing posterior spinal fusion.
- Trial name
- MEPAII (NCT01990573)
- Testing
- 0.3mg/kg IV methadone HCl, 0.4mg/kg IV methadon HCl, control no methadone
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Washington University School of Medicine
Postoperative Pain, Abdominal Surgery
Bupivacaine Effectiveness and Safety in SABER® Trial
This is a research study testing SABER-Bupivacaine (an experimental pain-relieving medication). SABER-Bupivacaine is designed to continuously deliver bupivacaine, a common local anesthetic, for a few days in order to treat local…
- Trial name
- BESST (NCT01052012)
- Testing
- SABER-Bupivacaine, Bupivacaine HCl
- Where
- 26 sites in United States, Australia and 1 more
- Volunteers
- 331 people
- Sponsor
- Durect
Informed Consent
A Survey of Patient's Attitudes Towards Consent For Clinical Research In Anesthesiology
In most current academic anesthesia groups, it appears that consent for research is acquired on the day of surgery. This practice raises concerns because the hospital may be regarded as a coercive environment and there may be the…
- Trial name
- NCT01546194
- Testing
- Phone call explaining the research project
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Endeavor Health
Pain Control for Intrauterine Device Insertions
Paracervical Block Before Intrauterine Device (IUD) Insertion
The purpose of this study is to evaluate if a paracervical block containing 1% lidocaine administered prior to IUD insertion reduces insertion pain.
- Trial name
- NCT01207401
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Delirium, Emergence Delirium
EEG - Guided Anesthetic Care and Postoperative Delirium
The study is a prospective, double blinded, randomized and controlled parallel trial to investigate the effect of the anesthetic care guided by EEG monitor (SedLine) on postoperative delirium.
- Conditions
- Delirium, Emergence Delirium, Anesthesia, General, Electroencephalography
- Trial name
- EMODIPOD (NCT03330236)
- Testing
- Anesthetic "depth" management
- Where
- China
- Volunteers
- 1,560 people
- Sponsor
- Yale University
Traumatic Femur Fracture
Femoral Nerve Block for Femur Fracture Repair in Pediatrics
The purpose of this study is to prospectively compare post-operative pain relief in pediatric patients undergoing traumatic femur fracture repair who have received either a femoral nerve block with a lateral femoral cutaneous…
- Trial name
- NCT01759407
- Testing
- Ropivicaine, Epinephrine
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Nationwide Children's Hospital
Chronic Pain
Bacteriostatic Normal Saline Versus Lidocaine for Intradermal Anesthesia
The purpose of this study is to determine if creation of a skin wheel with bacteriostatic normal saline, which includes 0.9% benzyl alcohol, is less painful and provides a similar level of anesthesia compared to 1% lidocaine.
- Trial name
- NCT04495868
- Testing
- Bacteriostatic Normal Saline, 1% Lidocaine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Emory University
Local Anesthetics
Clinical Study to Evaluate the Effect of pH on Pain Upon Local Anesthetic Administration.
When one receives a local anesthetic, such as novocaine for a dental procedure, there is a burning painful sensation experienced upon injection of the local anesthetic.
- Trial name
- NCT01304082
- Testing
- Lidocaine, normal saline, alkalinized lidocaine
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Massachusetts General Hospital
Patient Care
Efficacy of Cotton as a Dampener for Vibration Anesthetic Device
The study aims to determine the effectiveness of cotton as a dampener for vibratory anesthetic devices (VADs) for dermatologic patients.
- Trial name
- NCT06916468
- Testing
- VAD with Cotton Dampener, Vibratory Anesthetic Device (VAD)
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Waste Anesthetic Gas (WAG) Emanating From Patients Post-operative Recovery
Evaluation and Control of WAG in PACU Within Patient and Caregiver Breathing Zone
The purpose of this study is to evaluate anesthetic gas in the PACU within patient and caregiver breathing zones.
- Trial name
- NCT02428413
- Testing
- ISO-Gard Mask, Standard oxygen mask
- Volunteers
- 125 people
- Sponsor
- Teleflex
Surgery
Brain Function Monitoring During Surgery
The purpose of this research is to gather information on the effectiveness of the Sedline Brain Function Monitor, and its use in this study to determine whether monitoring the brain activity during anesthesia will improve…
- Trial name
- NCT06619730
- Testing
- Sedline Brain Function Monitor
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Submental Fat
Evaluation the Effects of Various Treatments on RZL-012-Induced Adverse Events
This is a Phase 2, open-label, 2-stage, adaptive-design study in which subjects will be randomized into one of 5 treatment groups comprised of RZL-012 with or without additional study treatments:
- Trial name
- NCT05476679
- Testing
- RZL-012, RZL-012+Lidacaine injection prior treatment, RZL-012+Medrol
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Raziel Therapeutics Ltd.
Postoperative Pain
Transversus Abdominis Plane Block Versus Local Anesthetic Infiltration for Pain Control in the Abdominal Surgery
Postoperative analgesia is an important part of the anesthetic care. According to the recent studies, multimodal analgesia can provide better analgesia \& patient satisfaction with fewer side effect.
- Trial name
- TAP (NCT02029755)
- Testing
- transversus abdominis plane block, local infiltration, Patient controlled analgesia
- Where
- Taiwan
- Volunteers
- 108 people
- Sponsor
- Taipei Medical University Hospital
Opioid Pain Medication
Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation
This study is a prospective randomized trial examining the effect of topically combined antifibrinolytics (Tranexamic acid) with local anesthetics in all electively created surgical wound beds in hand surgery to provide long term…
- Trial name
- NCT04814433
- Testing
- Tranexamic acid, Aminocaproic acid, Recombinant Human Thrombin
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Dental Pain
Buffered Local Anesthetic
The purpose of this research study is to compare responses in children during dental injections of local anesthetic (used for numbing), while children are under deep sedation (breathing on their own, often with a loss of…
- Trial name
- NCT05757648
- Testing
- Non-buffered Anesthetic, Buffered Anesthetic, Onset
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Tibial Fractures
Intra-articular Local Anesthetic Injection and Hematoma Aspiration
The primary objective of this study is to determine whether a patient with a tibial plateau fracture (non-displaced, displaced, or depression type) will have decreased pain and narcotic analgesia requirements following an…
- Trial name
- NCT02951884
- Testing
- Aspiration, Bupivacaine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Loyola University
Lung Diseases, Ultrasonography
Lung Ultrasonography vs Fiberoptic Bronchoscopy for Aiding Lung Collapse in Patient Using Double Lumen Tube
The study contains the result from a comparison of diagnostic outcomes about lung collapse by using lung ultrasonography as a new diagnostic test compares to fiberoptic bronchoscopy as the standard test.
- Conditions
- Lung Diseases, Ultrasonography, Fiberoptic Bronchoscopy, One Lung Ventilation
- Trial name
- NCT03314519
- Testing
- Lung ultrasonography by experienced anaesthesiologist, Fiberoptic bronchoscopy for double lumen tube's position
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Mahidol University
Osteoarthritis
General or Regional Anesthesia for Hip Surgery
The purpose of this study is to determine whether general anaesthesia or regional anaesthesia is best for patients undergoing Total Hip Arthroplasty.
- Trial name
- NCT01733472
- Testing
- GA-arm, remifentanil, RA-arm
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Region Skane
Premedication, Endotracheal Intubation
Premedication Trial for Tracheal Intubation of the NEOnate
Multicenter double blind randomized controlled trial comparing "atropine+propofol" vs "atropine+atracurium+sufentanil" as a premedication prior to endotracheal intubation of the neonate.
- Trial name
- PRETTINEO (NCT01490580)
- Testing
- atropine+ propofol, atropine + atracurium + sufentanil
- Where
- 6 sites in France
- Volunteers
- 173 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Anaesthesia
The Laryngeal Mask Airway in Edentulous Geriatric Patients
With an aging population a prevalence of edentulous patients increased above 60 % among individuals aged ≥65 yr. Face mask ventilation of these edentulous patients is often difficult because of the inadequate fitting of the…
- Trial name
- NCT02197377
- Testing
- Group LMA Unique™, Group LMA Supreme™
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Dokuz Eylul University