Clinical trials: Aneurysmal Disease
Subarachnoid Hemorrhage
Constitution of Cerebrospinal Fluid and Blood Database/Specimen in Acute Stage of Subarachnoid Hemorrhage (aSAH) Patients
Neuropeptide Y (NPY) may play a major role in the pathophysiology of aneurysmal subarachnoid hemorrhage (aSAH). To investigate the correlation of NPY in cerebrospinal fluid (CSF) and blood (serum) and the neurological outcome in…
- Trial name
- NCT01292278
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Regensburg
Periodontitis, Vascular Disease
Vascular and Periodontal Disease - Microbial, Genetic and Histological Causalities
The purpose of this study is to analyze genetic polymorphisms in genes encoding pro-inflammatory cytokines, and study the genetic predisposition to chronic periodontitis (CP) in combination with atherosclerotic cardiovascular…
- Trial name
- NCT01358630
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Subarachnoid Hemorrhage
miRNA Profile in Aneurysmal Subarachnoid Haemorrhage
The investigators aim to investigate and understand the circulating miRNA profiles after acute aneurysmal subarachnoid haemorrhage and underlying pathological significance.
- Trial name
- miRNA (NCT03344744)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Subarachnoid Hemorrhage, Aneurysmal, Cerebral Vasospasm
Magnesium Treating Subarachnoid Hemorrhage Vasospasm
A randomized clinical trial investigating magnesium sulphate ability to reduce risk of cerebral vasospasm after acute subarachnoid hemorrhage hence improving outcome particularly in haptoglobin 2-2 patients who are highly…
- Trial name
- MATSH-SHapE (NCT04613960)
- Testing
- Magnesium sulfate, normal saline
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Brain Injury, Coma, Cardiac Arrest (CA)
Prediction for Coma Recovery With Comaweb
The general objective of the comaScore project is to provide an external validation of the accuracy of the comaScore, a score derived from magnetic resonance imaging (MRI), to predict 1 year outcome of patients unresponsive to…
- Conditions
- Brain Injury, Coma, Cardiac Arrest (CA), Traumatic Brain Injury (TBI), Aneurysmal Subarachnoid Hemorrhages (aSAH)
- Trial name
- COMASCORE (NCT03874208)
- Testing
- MRI sequence, MRI
- Where
- France
- Volunteers
- 611 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Subarachnoid Hemorrhage, Aneurysmal
Cerebral Nitrosative/Oxidative Stress in Aneurysmal Subarachnoid Haemorrhage
Aneurysmal subarachnoid haemorrhage (SAH) carries a high morbidity and mortality, which is in part due to the development of secondary brain injury.
- Trial name
- NOX2 (NCT05686265)
- Testing
- Oxygen
- Where
- Denmark
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Aneurysmal Subarachnoid Hemorrhage
Aneurysmal Subarachnoid Hemorrhage Multi-Omics Research Program
Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening cerebrovascular emergency with high mortality and disability rates.
- Trial name
- aSAH-Omics (NCT07270419)
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Xiaolin Chen, MD
Cognitive Dysfunction
Cognitive Dysfunction After Aneurysmal Subarachnoid Haemorrhage
This is a longitudinal, multi-center, prospective study of aneurysmal subarachnoid haemorrhage patients in neurosurgical units in Hong Kong.
- Trial name
- NCT01038193
- Testing
- Cognitive assessment
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Epigenome-wide DNA Methylation Profiling in Aneurysmal Subarachnoid Hemorrhage and Delayed Ischemic Neurologic Deficit
The goal of this observational study is to investigate DNA methylation changes in adults with bleeding from brain aneurysm, which is called aneurysmal subarachnoid hemorrhage (aSAH), and their association with delayed ischemic…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Cerebral Vasospasm After Subarachnoid Hemorrhage, Intracranial Aneurysm
- Trial name
- NCT06881329
- Where
- Poland
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Pomeranian Medical University Szczecin
Aneurysmal Subarachnoid Hemorrhage
Relative Bioavailability of Intravenous GTX-104 Compared to Oral Nimodipine Capsules in Healthy Subjects
This is a Phase 1, single center, randomized, two-period crossover study in healthy male and female subjects designed to evaluate the relative bioavailability (BA) and safety at steady state of two formulations of nimodipine: GTX…
- Trial name
- NCT05418348
- Testing
- GTX-104, Nimodipine Capsules
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Grace Therapeutics Inc.
Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome
Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage
Intracranial hemorrhage is a condition characterized by high mortality rates and suboptimal functional outcomes. It precipitates both direct brain injury and subsequent secondary injuries, including delayed cerebral ischemia…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome, Mass Spectrometry, Heart Failure
- Trial name
- NCT06906432
- Testing
- Multi-disciplinary assessment
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Subarachnoid Hemorrhage, Aneurysmal
Evaluation of Neuroinflamation of SAH
The investigators are planning that can these markers be used a predictive marker at SAH and for this aim we will study both patiens' blood sample and their CT image.
- Trial name
- BAP (NCT03822260)
- Testing
- Bezmialem VAkif Unv. Ethical board
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Subarachnoid Hemorrhage, Aneurysmal
Cerebral Autoregulation in Patients With Aneurysmal SubArachnoid Haemorrhage
The purpose is, in patients with aneurysmal subarachnoid haemorrhage in the early phase after ictus, to examine the following: 1.
- Trial name
- CASAH (NCT03987139)
- Testing
- Hypertension, Hyper- and hypoxia, Hyper- and hypocapnia
- Where
- Denmark
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Aneurysmal Subarachnoid Hemorrhage
Human Albumin for Clinical Outcome in Aneurysmal Subarachnoid Hemorrhages
Aneurysmal subarachnoid hemorrhage (aSAH) is a dreadful acute neurological condition with overwhelmingly high rate of associated morbidities and mortality.
- Trial name
- HASH (NCT06548477)
- Testing
- Human albumin
- Where
- Qatar
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Acute Kidney Injury
Cystatin c: a Biomarker of AKI in Aneurysmal Subarachnoid Haemorrhage Patients
The goal of this observational study is to assess cystatin c as a predictive biomarker of early acute kidney injury in aneurysmal subarachnoid hemorrhage patients.
- Trial name
- NCT06635408
- Testing
- cystatin c
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Aneurysmal Subarachnoid Hemorrhage
Early Brain Damage Assessment in Aneurysmal Subarachnoid Haemorrhage in Predicting Cognitive Impairment
the goal of this type of study : observation study is to learn about cerebral edema and hematoma in aneurysmal subarachnoid hemorrhage the main questions it aims to answer are current clinical practices lack predictive models to…
- Trial name
- NCT06172556
- Testing
- Endovascular coiling, Surgical clipping, Mix
- Where
- China
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Hebei Medical University
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage
The goal of this observational study is to understand if angiographic cerebral vasospasm (CV) can be predicted by levels of nitric oxide (NO) consumption in patients with aneurysmal subarachnoid hemorrhage (SAH).
- Trial name
- NCT07614906
- Where
- 2 sites in United States, Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Intracranial Aneurysm, Subarachnoid Hemorrhage, Aneurysmal
Epidemiological Insights Into the Formation, Progression, and Rupture of Intracranial Aneurysms: A Retrospective, Multi-Center Hospital-Based Study in China
This is a retrospective, hospital-based and multi-center study aiming at investigating the potential exposures associated with the formation, progression, and rupture of intracranial aneurysms in Chinese population.
- Conditions
- Intracranial Aneurysm, Subarachnoid Hemorrhage, Aneurysmal, Cerebral Aneurysm, Brain Aneurysm
- Trial name
- NCT06456814
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Subarachnoid Hemorrhage, Aneurysmal
Investigate the Relationship Between Inflammatory and Coagulation in SAH CSF
Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage.
- Trial name
- NCT04938414
- Testing
- Lumbar puncture
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Subarachnoid Hemorrhage, Aneurysmal
Predictive Values of Serum Adiponectin Levels in Aneurysmal Subarachnoid Hemorrhage.
The purpose of this study is to evaluate the predictive value of serum adiponectin levels in aneurysmal subarachnoid hemorrhage patients.
- Trial name
- NCT02814162
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital