Clinical trials: Angina, Stable, open to volunteers
Angina, Stable
Effects of Acupuncture on Symptoms of Stable Angina
The goal of this clinical trial is to determine if a standardized 12-point acupuncture protocol will reduce pain in participants with stable angina. This study addresses the critical need to reduce persistent pain for angina.
- Trial name
- EASE (NCT06311461)
- Testing
- Acupuncture, Attention control
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of California, Los Angeles
Coronary Disease, Coronary Artery Disease
COMPLEX Registry - a Prospective COhort Study to Describe the Management and Outcomes of Patients Presenting with CompLEX and Calcified Coronary Artery Disease
The purpose of the COMPLEX Registry is to prospectively and retrospectively collect baseline, clinical and procedural data of patients who have undergone PCI or CABG for complex and/ or calcified chronic CAD, irrespective of…
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Restenosis, Coronary Arteriosclerosis
- Trial name
- COMPLEX (NCT06075602)
- Testing
- Impact of current PCI techniques/ devices in complex coronary artery lesions
- Where
- Switzerland
- Volunteers
- 5,000 people
- Sponsor
- Luzerner Kantonsspital
Angina (Stable), Coronary Occlusion
Drug-Coated Balloon Only Strategy After Recanalization of Chronic Total Coronary Occlusions
Chronic total occlusions (CTO) of the coronary arteries are usually treated with drug-eluting stents (DES) after successful recanalization.
- Conditions
- Angina (Stable), Coronary Occlusion, Coronary Artery Disease, Chronic Total Occlusion
- Trial name
- NoTrace-CTO (NCT07817719)
- Testing
- Paclitaxel-coated balloon (AGENT Paclitaxel-Coated PTCA Balloon Catheter), Serial intravascular ultrasound and protocol-mandated nine-month angiographic reassessment
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- University of Sao Paulo General Hospital
Peri-procedural Myocardial Infarction, Heart Failure Hospitalization
Clinical Evidence With Biomarker Confirmation for PPMI in PCI Clinical Trials Study
The goal of this prospective, multicenter, non-randomized observational study is to better identify and understand periprocedural myocardial injury among adults undergoing percutaneous coronary intervention (PCI) for stable…
- Conditions
- Peri-procedural Myocardial Infarction, Heart Failure Hospitalization, Mortality, Stable Angina Pectoris
- Trial name
- CEC-PPMI (NCT07848529)
- Testing
- Biomarker testing
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Baim Institute for Clinical Research
Counterpulsation, Angina Pectoris
Effectiveness of ECP Therapy in Stable Angina Pectoris Patients
External Counterpulsation (ECP) is a non-invasive therapy using pressured cuff that is performed on patients with refractory stable angina pectoris to relieve symptoms and increase quality of life.
- Trial name
- NCT04873687
- Testing
- External Counter Pulsation (ECP) therapy
- Where
- Indonesia
- Volunteers
- 84 people
- Sponsor
- Universitas Padjadjaran
Chronic Coronary Syndrome, Chronic Coronary Total Occlusion
Association of Plasma N-terminal Pro-Brain Natriuretic Peptide Levels With the Burden of Coronary Artery Disease
This study aim to investigate the association between plasma NT-proBNP levels and the presence, extent and severity of stenosis in patients with suspected coronary artery disease.
- Conditions
- Chronic Coronary Syndrome, Chronic Coronary Total Occlusion, Coronary Arterial Disease (CAD), Stable Chronic Angina
- Trial name
- BNP-CAD (NCT07013344)
- Testing
- BNP
- Where
- 2 sites in Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS Ospedale San Raffaele
Transthorcic Echocardiography, Stable Angina Pectoris
TTE Improves Clinical Management of Stable Chest Pain
The investigator aims to prospectively enroll patients who were referred for transthorcic echocardiography (TTE) for the assessment of stable chest pain (SCP) suspected of obstructive coronary artery disease (CAD).
- Conditions
- Transthorcic Echocardiography, Stable Angina Pectoris, Coronary Artery Disease, Major Adverse Cardiac Events
- Trial name
- TICM-SCP (NCT07063147)
- Testing
- TTE
- Where
- China
- Volunteers
- 50,000 people
- Sponsor
- Tianjin Chest Hospital
Stable Angina, Multivessel Coronary Artery Disease
Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina
ORBITA-MOON is a double-blinded, placebo-controlled experimental study that aims to understand how the different coronary artery stenoses contribute to overall clinical angina in patients with multi-vessel coronary artery…
- Trial name
- ORBITA-MOON (NCT06400290)
- Testing
- Percutaneous coronary intervention (PCI), Symptom assessment during experimentally induced ischaemia
- Where
- 8 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Chronic Coronary Syndrome, Myocardial Ischemia
Perfusion Estimation For Optimal Treatment Strategy in Chronic Coronary Syndrome
We will establish a cohort of 570 symptomatic chronic coronary syndrome patients undergoing 15O-water PET and assess their symptoms through repeated questionnaires.
- Conditions
- Chronic Coronary Syndrome, Myocardial Ischemia, Stable Angina, Coronary Artery Disease
- Trial name
- PERFORM-CCS (NCT05865600)
- Testing
- Optimization of guideline-directed medical therapy, Immediate referral for invasive coronary angiography, 3-months delayed referral for invasive coronary angiography
- Where
- Denmark
- Volunteers
- 570 people
- Sponsor
- Gødstrup Hospital
Chronic Stable Angina Pectoris
Outcome Research to Confirm the Anti-anginal Effect of T89 in Patients With Stable Angina
This is a multi-center, double-blind, randomized, placebo-controlled, parallel-group phase 3 clinical study to confirm the safety and efficacy of T89 in patients with stable angina pectoris, with an extended open-label period to…
- Trial name
- NCT03789552
- Testing
- T89 capsule
- Where
- United States
- Volunteers
- 765 people
- Sponsor
- Tasly Pharmaceuticals, Inc.
Coronary Disease, Coronary Artery Disease
SIROOP Registry - A Prospective Registry Study to Evaluate the Outcomes of Coronary Artery Disease Patients Treated With SIROlimus Or Paclitaxel Eluting Balloon Catheters
The purpose of the SIROOP Registry is to retrospectively and prospectively collect baseline, clinical and procedural characteristics of patients who have undergone PCI and are treated with either currently available sirolimus or…
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Restenosis, Coronary Arteriosclerosis
- Trial name
- SIROOP (NCT04988685)
- Testing
- Sirolimus Eluting Balloon
- Where
- Switzerland
- Volunteers
- 2,000 people
- Sponsor
- Luzerner Kantonsspital
Coronary Artery Disease
A Prospective muLticEnter Registry in chrONic coronARy synDrOme
In patients with chronic coronary syndrome (CCS), clopidogrel has a class I/A indication in patients undergoing elective percutaneous coronary intervention (PCI).
- Trial name
- LEONARDO (NCT06198673)
- Testing
- Antiplatelet Agents
- Volunteers
- 1,000 people
- Sponsor
- University of Roma La Sapienza
Stable Angina, Coronary Artery Disease
OCT-Guided Stent Optimization for Short-Duration Dual Antiplatelet Therapy in Stable Angina
This study aims to evaluate whether the use of optical coherence tomography (OCT), an advanced intravascular imaging tool, can improve stent implantation results and make it possible to shorten the duration of dual antiplatelet…
- Trial name
- COMFORT-SHORT (NCT07198529)
- Testing
- Short DAPT, Standard DAPT, Extended DAPT
- Where
- South Korea
- Volunteers
- 130 people
- Sponsor
- Korea University Guro Hospital
Microvascular Angina, Angina, Stable
iCorMicA - Stratified Medicine in Angina
The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry.
- Conditions
- Microvascular Angina, Angina, Stable, Ischemia With No Obstructive Coronary Arteries (INOCA), Coronary Microvascular Dysfunction (CMD)
- Trial name
- iCorMicA (NCT04674449)
- Testing
- Disclosure of IDP results, IDP performed but results not disclosed
- Where
- 39 sites in Ireland, Netherlands and 2 more
- Volunteers
- 1,500 people
- Sponsor
- NHS Greater Glasgow and Clyde
Angina (Stable), Coronary Artery Disease(CAD)
Study of Lesion-Specific Invasive Haemodynamic Angina Thresholds
ORBITA-SOLAR is an invasive physiological cardiac catheterisation study that aims to determine whether different coronary stenoses have different angina thresholds.
- Conditions
- Angina (Stable), Coronary Artery Disease(CAD), Ischaemic Heart Disease (IHD)
- Trial name
- ORBITA-SOLAR (NCT07386418)
- Testing
- Percutaneous coronary intervention (PCI), Measurement of the angina threshold
- Where
- 7 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- Imperial College London
Angina, Stable
Artificial Intelligence in ANOCA
Angina pectoris is diagnosed in >180.000 people in the Netherlands each year. Diagnosis in angina pectoris focuses on epicardial coronary stenosis, the identification of which may lead to guideline-directed medical therapy or…
- Trial name
- (AI)NOCA (NCT06387693)
- Testing
- Holter monitoring, intracoronary ECG
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- UMC Utrecht
Myocardial Infarction, Percutaneous Transluminal Coronary Angioplasty
Integration of Telemedicine and Home-Based Cardiac Rehabilitation: Feasibility, Efficacy, and Adherence
The aim of this study is to evaluate feasibility, efficacy, and adherence of home-based cardiac rehabilitation with the integration of telemedicine.
- Conditions
- Myocardial Infarction, Percutaneous Transluminal Coronary Angioplasty, Coronary Artery Bypass, Stable Angina
- Trial name
- NCT05972070
- Testing
- ROMTech Portable Connect
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- ROM Technologies, INC
Percutaneous Coronary Intervention (PCI), Acute Myocardial Infarction
Aerobic Exercise-induced Effect on Endothelial Function in Patients With Ischaemic Heart Disease
Endothelial dysfunction is one of the aetiological factors in ischaemic heart disease (IHD). Aerobic exercise is effective in improving endothelial function, as measured by flow-mediated dilation (FMD), in patients with IHD.
- Conditions
- Percutaneous Coronary Intervention (PCI), Acute Myocardial Infarction, Angina (Stable), Unstable Angina Pectoris
- Trial name
- ENDO-R (NCT06788275)
- Testing
- Aerobic exercise (MIT), Aerobic exercise (Short HIIT), Aerobic exercise (Long HIIT)
- Where
- 2 sites in Spain
- Volunteers
- 132 people
- Sponsor
- Instituto de Investigación Sanitaria y Biomédica de Alicante
Coronary Arterial Disease (CAD), Angina (Stable)
Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA
The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA).
- Conditions
- Coronary Arterial Disease (CAD), Angina (Stable), Microvascular Circulation
- Trial name
- BEACON (NCT06864234)
- Testing
- Saline (NaCl), Metoprolol Tartrate
- Where
- Belgium
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- VZW Cardiovascular Research Center Aalst
Angina, Stable, Coronary Artery Disease
Clinical Outcomes of CT-FFR Versus QFR-guided Strategy for Decision-Making in Patients With Stable Chest Pain
This study is a multicenter, prospective, blinded (blinding of clinical evaluators), randomized controlled, event-driven non-inferiority clinical trial.
- Trial name
- CONFIDENT (NCT05857904)
- Testing
- CT-FFR, QFR
- Where
- China
- Volunteers
- 4,648 people
- Sponsor
- Shanghai Zhongshan Hospital