Clinical trials: Anginal Pain
Multi Vessel Coronary Artery Disease, Non-ST Elevation Myocardial Infarction
PRospective Evaluation of Complete Revascularization in Patients With multiveSsel Disease Excluding chroNic Total Occlusions
This prospective, multicenter, non-randomized, single arm, objective performance goal (OPG) study is designed to evaluate clinical outcomes after complete revascularization by PCI and imaging guidance (OCT) in patients with…
- Conditions
- Multi Vessel Coronary Artery Disease, Non-ST Elevation Myocardial Infarction, Unstable Angina, Stable Angina
- Trial name
- PRESENT (NCT05230446)
- Testing
- PCI with OCT guidance
- Where
- Netherlands
- Volunteers
- 609 people
- Sponsor
- Erasmus Medical Center
Major Adverse Cardiac Events, Acute Myocardial Infarction (AMI)
Preoperative Cardiology Consultation and the Incidence of Major Adverse Cardiac Events（MACE）
This cohort study aims to determine when preoperative cardiology consultation is needed to reduce the incidence of major adverse cardiac events (MACE) in elderly patients undergoing non-cardiac surgery.
- Conditions
- Major Adverse Cardiac Events, Acute Myocardial Infarction (AMI), Cardiac Death, Sudden, Cardiac Arrest (CA)
- Trial name
- MACE (NCT06884436)
- Where
- China
- Volunteers
- 22,000 people
- Sponsor
- Chinese PLA General Hospital
Ventricular Tachycardia, Coronary Artery Disease
Coronary Flow During Rapid Heart Rates
The goal of this observational study is to learn about the factors which determine how well ventricular tachycardia (VT) is tolerated. The main questions it aims to answer are: 1.
- Conditions
- Ventricular Tachycardia, Coronary Artery Disease, Heart Failure, Coronary Microvascular Dysfunction
- Trial name
- VT flow (NCT05841199)
- Testing
- Pressure and flow measurement during simulated VT
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Imperial College London
Coronary Artery Disease Premature, Angina, Stable
Influence of Air Quality on the Development and Progression of Premature Coronary Artery Disease
The new global guidelines from the World Health Organization on air quality provide evidence of the damage that air pollution inflicts on human health at even lower concentrations than previously thought.
- Conditions
- Coronary Artery Disease Premature, Angina, Stable, Acute Coronary Syndrome, MINOCA
- Trial name
- AIRHEART (NCT06464042)
- Where
- Spain
- Volunteers
- 4,272 people
- Sponsor
- pablo Juan-Salvadores
Coronary Artery Disease, Angina Pectoris
Personalized Risk Evaluation and Diagnosis (Using Corus CAD or ASGES) in the Coronary Tree
The PREDICT study is to develop and validate a diagnostic blood ASGES (age, sex, gene expression score) or Corus CAD for atherosclerotic coronary artery disease (CAD).
- Conditions
- Coronary Artery Disease, Angina Pectoris, Chest Pain, Cardiovascular Diseases
- Trial name
- PREDICT (NCT00500617)
- Testing
- Corus CAD (ASGES)
- Where
- 10 sites in United States
- Volunteers
- 4,350 people
- Sponsor
- CardioDx
Diabetes Mellitus, Angina, Unstable
Trimetazidine in Myocardial Injury After Percutaneous Coronary Intervention in Patients With Angina and Diabetes
Introduction: Recent studies have suggested that trimetazidine may help reduce myocardial damage following percutaneous coronary intervention.
- Trial name
- Trimeta (NCT03715582)
- Testing
- trimetazidine
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo General Hospital
Myocardial Infarction (MI)
Efficacy and Safety Study of Proposed Biosimilar Product Reveliza vs Actilise in Patients With ST-segment Elevation Myocardial Infarction
Thi is is a multi-center, randomized, single-blind, parallel group clinical trial to evaluate the efficacy and safety of the intravenious thrombolysis with Revelise® (GENERIUM, Russia) in comparosin with the Actilyse® (Boehringer…
- Trial name
- NCT07146360
- Testing
- Revelise (GENERIUM, Russia), Actilyse® (Boehringer Ingelheim Pharma GmbH and Co.KG, Germany)
- Where
- 22 sites in Russia
- Volunteers
- 180 people
- Sponsor
- AO GENERIUM
Diabete Type 2, Unstable Angina
Dapagliflozin Effects on Coronary Calcium and Epicardial Fat Assessed by Cardiotomography
Calcification of the coronary arteries is a direct sign of atherosclerotic disease of the coronary arteries and has been shown to be a strong predictor of the risk of cardiovascular diseases, including myocardial infarction…
- Conditions
- Diabete Type 2, Unstable Angina, Myocardial Infarction, Diabetes Mellitus, Type 2
- Trial name
- NCT05998525
- Testing
- Dapagliflozin 10Mg Tab
- Where
- Mexico
- Volunteers
- 54 people
- Sponsor
- Hilda Elizabeth Macías Cervantes
Coronary Microvascular Dysfunction (CMD), Angina Pectoris With Normal Coronary Arteriogram
Endothelin Role In COronary Microcirculation
Coronary microvascular dysfunction is an important cause of angina in patients who do not have significant blockages in the major coronary arteries.
- Conditions
- Coronary Microvascular Dysfunction (CMD), Angina Pectoris With Normal Coronary Arteriogram, Microvascular Angina
- Trial name
- ERICOM (NCT07670091)
- Testing
- Cardiac MRI, Invasive Coronary Angiogram, Endothelin Receptor Antagonist
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Ischemic Heart Disease
Multicenter Registry for Angiography-Derived Quantitative Flow Ratio
1. to investigate the feasibility and diagnostic performance of contrast quantitative flow ratio (QFR) for identifying the functional significance of intermediate degree stenotic lesions in all-comer patients with coronary artery…
- Trial name
- QFRRegistry (NCT03791788)
- Testing
- QFR assessment
- Where
- 5 sites in South Korea
- Volunteers
- 524 people
- Sponsor
- Samsung Medical Center
Myocardial Ischemia(Implanted Drug-eluting Stents Because of Ischemic Heart Disease(Stable Angina, Acute Coronary Syndrome))
Impact of IntraVascular UltraSound Guidance on the Outcomes of Xience Prime Stents in Long Lesions (IVUS-XPL Study): Retrospective and Prospective Follow-up Study
The investigator aimed to evaluate the long-term (up to 10 years) follow-up of the patients who enrolled the IVUS-XPL study (Impact of IntraVascular UltraSound Guidance on the Outcomes of Xience Prime Stents in Long Lesions)…
- Trial name
- NCT03866486
- Where
- South Korea
- Volunteers
- 1,400 people
- Sponsor
- Yonsei University
Angina, Stable
Method of Clopidogrel Pre-treatment Undergoing Conventional Coronary Angiogram in Angina Patients
The study included 511 patients who underwent PCI because of angina during 2010-2011 at three Korean hospitals. Clopidogrel-naïve patients received either a loading dose (LD; 600 mg at 2-24 h before the procedure) or routine…
- Trial name
- MECCA (NCT03759067)
- Testing
- clopidogrel 75mg, Clopidogrel 300 mg, clopidogrel 600mg
- Volunteers
- 511 people
- Sponsor
- Korea University Anam Hospital
Refractory Angina Pectoris
CoROnary SinuS Reducer implantatiOn for ischemiA reDuction
Patients with refractory angina pectoris have low quality of life and reduced exertional capacity. Studies have shown that the coronary sinus reducer (CSR) implantation improves the quality of life.
- Trial name
- CrossRoad (NCT04121845)
- Testing
- Coronary Sinus Reducer device
- Where
- Slovenia
- Volunteers
- 25 people
- Sponsor
- University Medical Centre Ljubljana
Coronary Artery Disease, Angina Pectoris
Change in Exercise Capacity as Measured by Peak Oxygen Uptake After CTO PCI
The purpose of this project is to objectively assess the change (improvement) in exercise capacity in patients undergoing routine percutaneous coronary intervention (PCI) for chronic total occlusion (CTO)
- Trial name
- EXERTION (NCT02499666)
- Testing
- Percutaneous Coronary Intervention, Coronary stent, Clopidogrel
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Angina, Non-obstructive Coronary Artery Disease
Imaging Coronary Microvascular Dysfunction (CMD) Study
Angina is a common clinical symptom of ischemic heart disease, affecting up to 11 million people in the United States alone, and 112 million people globally.
- Trial name
- NCT05634031
- Testing
- PET imaging, Coronary CT angiogram, Functional Angiography
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Angina Pectoris
Angina, Physiology, Biology (ANgina, FIsiologia BIOlogia)
Relationship between invasive physiological assessment with FFR and IMR and biological markers as micro-RNA's according to coronary vascular compartiment affected (Group 1: Macrovasculature + / Microvasculature +; Group 2…
- Trial name
- ANFIBIO (NCT05374694)
- Testing
- Physiological invasive coronary evaluation
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Arnau de Vilanova
Refractory Angina, Chronic Stable Angina
Coronary Arteriogenetic Heparinized Exercise
This study evaluates the addition of heparin to a 2-week cycle of physical rehabilitation in the treatment of refractory angina.
- Trial name
- CARHEXA (NCT03350737)
- Testing
- Physical rehabilitation, Heparin
- Where
- Serbia
- Volunteers
- 32 people
- Sponsor
- Clinical Centre of Serbia
Angina Pectoris, Variant, Sudden Cardiac Death
Implantable Cardioverter Defibrillator Versus Optimal Medical Therapy In Patients With Variant Angina Manifesting as Aborted Sudden Cardiac Death
The purpose of this study is to determine whether ICD(Implantable Cardioverter Defibrillator) implantation on the top of optimal medical therapy in patients with variant angina manifesting as aborted sudden cardiac death reduces…
- Trial name
- VARIANT ICD (NCT02845531)
- Testing
- Implantable Cardioverter Defibrillator, Optimal Medical Therapy
- Where
- 26 sites in South Korea
- Volunteers
- 140 people
- Sponsor
- Kee-joon Choi
Myocardial Infarction, Unstable Angina
The Impact of Gratitude on Biology and Behavior in Persons With Heart Disease
Overall, the investigators aim to recruit 150 subjects during their hospitalization for an acute coronary syndrome (ACS). At two weeks post-ACS, the investigators will assess levels of gratitude and optimism, draw blood for…
- Trial name
- GRACE (NCT01709669)
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- Massachusetts General Hospital
Coronary Artery Disease, Ischemic Heart Disease
Volatilome and Single-Lead Electrocardiogram Optimize Ischemic Heart Disease Diagnosis Using Machine Learning Models
This is a prospective, case-control, single-center, observational, non-randomized study. It is designed to evaluate the diagnostic accuracy of functional tests involving physical exertion monitored via a 12-lead ECG, combined…
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease, Chronic Coronary Disease, Angina Pectoris
- Trial name
- NCT06181799
- Testing
- Mass spectrometry using the PTR TOF-1000 (IONICON PTR-TOF-MS - Trace VOC Analyzer, Eduard-Bodem-Gasse 3, 6020 Innsbruck, Austria (Europe).
- Where
- Russia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
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