Clinical trials: Angiogenesis
Aging, Sarcopenia
Effect of L-arginine on Microcirculation, Myogenesis and Angiogenesis Associated With Aging, Sarcopenia and Diabetes
This study aims was evaluated the effect of L-arginine on microcirculation, vasoreactivity / endothelial function and vascular smooth muscle of young and old women with Sarcopenia or Type 2 Diabetes Mellitus measured by Nailfold…
- Conditions
- Aging, Sarcopenia, Type 2 Diabetes, Microcirculation
- Trial name
- NCT04112875
- Testing
- L-arginine, Maltodextrin
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Pregnancy Related
ANgiogenic Function at NOrmal TErm on Placenta
In vivo and ex vivo study of trophoblastic angiogenic trophoblastic function in placentas from normal pregnancies, at term
- Trial name
- ANNOTEP (NCT03981653)
- Where
- France
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Pregnancy, Pre Eclampsia
Pre-Eclampsia Prediction By Doppler Screening Of Uterine Arteries And Angiogenic Factors In Second Trimester Of Pregnancy
BACKGROUND: Pre-eclampsia complicates about 2% of pregnancies. It accounts for at least 50 000 maternal deaths per year worldwide and is the second most common cause of maternal death in the developing world.
- Trial name
- NCT00725660
- Where
- Israel
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Macular Degeneration
Study Of The Repeat Dosing Of Ketoconazole On The Pharmacokinetics Of A Single Dose Of Pazopanib (GW786034) Eye Drops
This is a two-period study to evaluate the effect of repeat oral dosing of ketoconazole on the pharmacokinetics of single dose pazopanib administered as an eye drop
- Trial name
- NCT00659555
- Testing
- pazopanib eye drops, Ketoconozole tablets
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bladder Cancer
Antiangiogenic Effects of BCG on Urinary Concentration of Angiogenic Factors
To determine if there is an association between basic fibroblast growth factor,vascular endothelial growth factor, and interleukin levels and a patients response to BCG treatment ( as standard treatment)in the urine of patients…
- Trial name
- NCT00216814
- Where
- Canada
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Healthy Volunteer
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MRG-110 Following Intradermal Injection in Healthy Volunteers
MRG-110 is intended to promote the growth of new blood vessels by inhibiting a molecule called miR-92a. MRG-110 is being studied to determine if it can accelerate healing of wounds by improving blood flow into the wound area.
- Trial name
- NCT03603431
- Testing
- MRG-110
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- miRagen Therapeutics, Inc.
Hepatocellular Carcinoma
Biomarker Analyses in Hepatocellular Carcinoma (HCC) Patients Treated With TheraSphere®
To analyze specific angiogenic, inflammatory and immune profiles in hepatocellular carcinoma patients who undergo radioembolization.
- Trial name
- NCT03203837
- Testing
- Plasma collection
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Larynx Cancer, Larynx Carcinoma
An Investigation of Biomarker Candidate Molecules in Laryngeal Carcinoma
The aim of this study was to determine serum levels of VEGF, sVEGFR1, VEGFR2, IGFBP-3, angiogenin and endoglin in patients with larynx squamous cell carcinoma; investigate their association with clinical parameters and determine…
- Trial name
- NCT05217147
- Testing
- Obtaining blood samples
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Preeclampsia, Gestational Hypertension
Evaluation of sFlt-1/PlGF Ratio ,OPG and sEng as Predictive Biomarkers in the Diagnosis and Treatment Evaluation of Preeclampsia
his study investigates the effectiveness of three specific biological markers (biomarkers) in the blood-the sFlt-1/PlGF ratio, soluble endoglin (sEng), and osteoprotegerin (OPG)-to better diagnose and monitor preeclampsia.
- Conditions
- Preeclampsia, Gestational Hypertension, Hypertensive Disorders of Pregnancy
- Trial name
- PE-POSS (NCT07349277)
- Where
- Iraq
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ammar Jassim Abed
Pregnancy Disease, Preeclampsia
Dietary Salicylates and Preeclampsia
Preeclampsia (PE) is an important pregnancy complication and cause of maternal and perinatal mortality and morbidity. The underlying etiology and pathophysiology of preeclampsia is incompletely understood but it involves…
- Conditions
- Pregnancy Disease, Preeclampsia, Diet Habit
- Trial name
- PreSal (NCT06239363)
- Where
- Poland
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Healthy
A Research Pilot Study in Healthy Volunteers to Evaluate Biomarkers for Novel Anticancer Treatments
The overall goal of this study is to determine the feasibility and the variability of several biomarker assays in normal subjects that are relevant to tumor biology and novel anti-cancer treatments, with the goal of refining…
- Trial name
- NCT00586417
- Testing
- punch biopsy
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Duke University