Clinical trials: Angioplasty
ICAS - Intracranial Atherosclerosis
IntraCranial Angiography-derived Fraction Flow-guided Percutaneous Transluminal Angioplasty and Stenting Versus Medical Therapy (ICAS-MT)
A multicenter, open-label, blinded-endpoint, prospective, randomized controlled clinical trial with an "all comers" design.
- Trial name
- NCT05974033
- Testing
- Stenting plus medical therapy, Medical therapy alone
- Volunteers
- 536 people
- Sponsor
- Changhai Hospital
Femoral Artery Stenosis, Popliteal Artery Stenosis
MDT-2113 Drug-Eluting Balloon vs. Standard PTA for the Treatment of Atherosclerotic Lesions in the Superficial Femoral Artery and/or Proximal Popliteal Artery
The purpose of this trial is to assess the safety and efficacy of MDT-2113 for the interventional treatment of de novo and non-stented restenotic lesions in the superficial femoral artery (SFA) and the proximal popliteal artery…
- Conditions
- Femoral Artery Stenosis, Popliteal Artery Stenosis, Femoral Artery Occlusion, Popliteal Artery Occlusion
- Trial name
- MDT-2113 SFA (NCT01947478)
- Testing
- MDT-2113 Drug-Eluting Balloon, Standard angioplasty balloon
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Medtronic Endovascular
Dialysis Access Dysfunction
Drug Eluting Balloon Angioplasty for Recurrent Cephalic Arch Stenosis in Dialysis Fistulas
This study is designed to compare the safety and efficacy of paclitaxel-eluting balloon (DEB) versus conventional percutaneous transluminal angioplasty (PTA) for the treatment of hemodynamically significant recurrent cephalic…
- Trial name
- NCT02368197
- Testing
- paclitaxel (Cardionovum Legflow drug eluting balloon), Balloon angioplasty (Bard Dorado)
- Where
- Israel
- Volunteers
- 13 people
- Sponsor
- Shaare Zedek Medical Center
Graft Occlusion, Vascular, Coronary Restenosis
A Blinded Study Conducted at Multiple Centers Evaluating Various Doses of an Investigational Agent (BO-653) Against Placebo, for Safety and Effectiveness in Preventing Post-Angioplasty Blood Vessel Re-Closure (Restenosis) in Stented Vessels.
This research study is intended to evaluate the safety and effectiveness of 3 different doses of BO-653, an investigational inhibitor of LDL cholesterol oxidation, when given orally twice a day compared to placebo (an inactive…
- Conditions
- Graft Occlusion, Vascular, Coronary Restenosis, Atherosclerosis
- Trial name
- NCT00055510
- Testing
- BO-653
- Where
- 29 sites in United States
- Sponsor
- Chugai Pharma USA
Chronic Coronary Occlusion, Vascular Disease
XIENCE V® Everolimus Eluting Coronary Stent System USA Post-Approval Study (XIENCE V® USA Long Term Follow-up Cohort)
XIENCE V USA is a prospective, multi-center, multi-cohort post-approval study. The objectives of this study are To evaluate XIENCE V EECSS continued safety and effectiveness during commercial use in real world settings, and To…
- Conditions
- Chronic Coronary Occlusion, Vascular Disease, Myocardial Ischemia, Coronary Artery Stenosis
- Trial name
- XVU-LTF (NCT01120379)
- Testing
- XIENCE V® EECSS
- Where
- United States
- Volunteers
- 5,034 people
- Sponsor
- Abbott Medical Devices
Myocardial Infarction
Coronary Anatomy Study and Times Since the Onset of Acute Myocardial Infarction Symptoms in Women Until the Opening of the Artery (TAPAC Study)
TAPAC study is an an investigator-driven, observational, prospective,cohort aimed at evaluating differences between men and women in patients undergoing primary angioplasty : hospital medical care, successful markers myocardial…
- Trial name
- TAPAC (NCT03152240)
- Testing
- Non intervention
- Where
- Spain
- Volunteers
- 800 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Coronary Artery Disease
Glasgow MRI and Rotablation Study
Percutaneous coronary intervention (PCI) with adjunctive high speed rotational atherectomy (HSRA) is commonly used to treat complex and calcified coronary artery stenoses.
- Trial name
- GlaMoRouS (NCT02857790)
- Volunteers
- 58 people
- Sponsor
- NHS National Waiting Times Centre Board
Carotid Artery Stenosis
Comparison of Staged Angioplasty and Routine Single-stage Stenting (CAS) in the Treatment of Carotid Artery Stenosis
The purpose of this study is to evaluate the efficacy and safety of staged carotid angioplasty v.s. routine single-stage carotid artery stenting in Chinese patients with carotid artery stenosis at high hyperperfusion risk in…
- Trial name
- STEP (NCT02224209)
- Testing
- Abbott EPD systems (Accunet/Emboshield), a balloon, stent, a balloon, stent
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Beijing Tiantan Hospital
Coronary Disease
Randomized Trial of Coronary Angioplasty for de Novo Lesions in sMall vesSElS With Drug Eluting Balloon.
Significant lesions in small coronary arteries are frequently found (35%-50%) in patients with coronary artery disease. Independently of the type of coronary angioplasty the restenosis and the need for repeat revascularization…
- Trial name
- RAMSES (NCT01722799)
- Testing
- Drug elluting Balloon (DEB), Drug elluting coronary stent (DES)
- Where
- Spain
- Volunteers
- 97 people
- Sponsor
- Andres Iñiguez Romo, MD, PhD
Arterial Occlusive Disease
Infrapopliteal Drug Eluting Angioplasty Versus Stenting
In total 50 patients diagnosed with long-segment infrapopliteal arterial disease will be randomized in two groups. The patients randomized in the Drug coated balloons (DCB) study arm will undergo a percutaneous transluminal…
- Trial name
- IDEAS-I (NCT01517997)
- Testing
- Paclitaxel coated balloon angioplasty., Infrapopliteal Primary Drug Eluting Stenting
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- University of Patras
Acute Coronary Syndromes
REal World Advanced Experience of BioResorbable ScaffolD by SMart Angioplasty Research Team (SMART REWARD)
Current drug-eluting stents (DES) has demonstrated excellent clinical outcomes in patients with coronary artery disease. However, a continued risk of clinical events even several years after the procedure is reported.
- Trial name
- NCT02601404
- Testing
- Bioresorbable scaffold (BRS)
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Samsung Medical Center
Myocardial Infarction, Angioplasty
Efficacy of High Dose atorvaSTATIN Loading Before Primary Percutaneous Coronary Intervention in ST Elevation Myocardial Infarction (STATIN STEMI)
Although statin prior to PCI has favorable effects in stable angina and ACS except ST elevation MI (STEMI), there have been few studies for STEMI. Celik T et al.
- Conditions
- Myocardial Infarction, Angioplasty, Percutaneous Coronary
- Trial name
- STATIN STEMI (NCT00808717)
- Testing
- Atorvastatin
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- Yonsei University
Acute Ischemic Stroke
Permanent Intracranial Stenting for Acute Ischemic Stroke Related to a Refractory Large Vessel Occlusion
Clot extraction failure during mechanical thrombectomy is a major concern in the management of acute ischemic stroke related to large vessel occlusions.
- Trial name
- PISTAR (NCT06071091)
- Testing
- Intracranial stenting, Optimal medical care, without additional endovascular procedures
- Where
- 13 sites in France
- Volunteers
- 346 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ST Elevation Myocardial Infarction, Coronary Stenting
Revascularization StrategIes for ST Elevation Myocardial Infarction Trial
This study is being conducted in patients with a major heart attack caused by a blocked artery undergoing Percutaneous Coronary Intervention (PCI) to open up the blockage.
- Conditions
- ST Elevation Myocardial Infarction, Coronary Stenting, Primary Angioplasty
- Trial name
- ASSIST-MI (NCT03263468)
- Testing
- Same sitting PCI with complete revascularization, Staged PCI with complete revsacularization >48 hours pf primary PCI
- Volunteers
- 3,520 people
- Sponsor
- Unity Health Toronto
ST-segment Elevation Myocardial Infarction
Henan STEMI Registry
ST-segment elevation myocardial infarction (STEMI) remains among the most acute and critical diseases, with primary percutaneous coronary intervention (pPCI) and thrombolysis as mainstay reperfusion treatments.
- Trial name
- NCT02641262
- Where
- China
- Volunteers
- 5,479 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Cardiovascular Diseases
Non-invasive Peri- and Postoperative Monitoring of Femoral Artery Balloon Angioplasty
This study evaluates a novel noninvasive method to dynamically monitor the effect of percutaneous transluminal angioplasty on arterial pulse wave
- Trial name
- NCT02725307
- Testing
- Noninvasive pulse wave analysis sensor, ECG-sensor
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Tampere University Hospital
Peripheral Artery Disease
AcoArt IV / SFA in China:Drug-eluting Balloon for SFA Angioplasty Evaluation in China
The registry is a prospective, multicenter, single arm post-market real-world registry in China assessing the clinical use, safety and outcomes of the Orchid 035 DCB Catheter in the Superficial Femoral Artery (SFA) and Popliteal…
- Trial name
- NCT03267056
- Testing
- drug eluting balloon catheter (trade name: Orchid)
- Where
- 10 sites in China
- Volunteers
- 120 people
- Sponsor
- Acotec Scientific Co., Ltd
Atherosclerosis, Ischemia Limb
Efficacy and Safety Comparison of the Open Surgical and Endovascular Methods for the Treatment of Long Atherosclerotic Lesions of the Femoral-popliteal Segment Above the Knee, TASC II, Type D.
Endovascular revascularization and open bypass grafting above the knee show comparable results in primary 2-year patency (about 65%) in medium-length lesions - TASC II, C (Pereira et al, 2006).
- Conditions
- Atherosclerosis, Ischemia Limb, Superficial Femoral Artery Occlusion, Popliteal Artery Occlusion
- Trial name
- NCT04588571
- Testing
- Endovascular recanalization with angioplasty and stenting with the biomimetic interwoven nitinol stent, Femoropopliteal proximal bypass
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
In-stent Restenosis
CVT-ISR First in Human Trial for Coronary In-Stent Restenosis
The goal of this first in human study is to assess the safety and inhibition of restenosis of the CVT Everolimus-coated PTCA Catheter in the treatment of subjects presenting in-stent restenotic lesions in native coronary arteries.
- Trial name
- NCT05731700
- Testing
- Drug Eluting Balloon
- Where
- 9 sites in France, Georgia and 2 more
- Volunteers
- 51 people
- Sponsor
- Abbott Medical Devices
Ischemic Reperfusion Injury
Single-cycle Remote Ischemic Preconditioning and Postconditioning (SCRIP) Trial
This trial is a 2 x 2 factorial design, double-blinded, randomized controlled trial to evaluate efficacy and safety of remote ischemic preconditioning and postconditioning in patient undergoing coronary angioplasty.
- Trial name
- SCRIP (NCT02649309)
- Testing
- RIPre, RIPost
- Where
- Thailand
- Volunteers
- 370 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital