Clinical trials: Ankle Surgery
Ankle Surgery
High Ankle Block Versus Regional Block for Acute Pain Control After Ankle Surgery
Researchers are trying to determine if a high ankle block during ankle surgery provides the same pain relief as the standard regional block.
- Trial name
- NCT03894098
- Testing
- Nerve block
- Where
- United States
- Sponsor
- Mayo Clinic
Patients Undergoing Ankle Surgery
Duration of Analgesia After Popliteal Fossa Nerve Blockade: Effects of Dexamethasone and Buprenorphine
Patients scheduled to go home after ankle surgery at HSS typically receive a sciatic nerve block in the popliteal fossa and oral analgesic tablets (such as Percocet).
- Trial name
- NCT01277159
- Testing
- A. Control Nerve Block. IV Dexamethasone (4 mg)., B. Nerve Block with Dexamethasone (4 mg). IV saline., C. Control Nerve Block. IV Dexamethasone (4 mg). IV Buprenorphine (0.3 mg)
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Hospital for Special Surgery, New York
Opioid Use, Post-operative Pain
Standardization of Post-operative Opiate Prescriptions for Same-day Ankle and Wrist Fracture Surgeries
The purpose of this prospective cohort study is to evaluate the opiate prescribing patterns post open reduction and internal fixation (ORIF) of wrist and ankle fractures at the Ottawa Hospital.
- Conditions
- Opioid Use, Post-operative Pain, Prescription Opioid Abuse, Fracture, Ankle
- Trial name
- NCT05322564
- Testing
- Standardized opiate prescription
- Volunteers
- 100 people
- Sponsor
- The Ottawa Hospital
Foot and Ankle Surgery
Immediate Weight-bearing Verses Non-Weight-bearing After Foot & Ankle Surgery
The primary objective of this study is to determine whether immediate weight-bearing following foot and ankle surgery provides similar or superior results to the traditional non-weight-bearing post-operative course, while…
- Trial name
- NCT03996707
- Testing
- Weight Bearing, Strict non-weight bearing
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Chronic Pain, Ankle Fracture Surgery
Anesthesia for Pain After Ankle Fracture Surgery
This pilot study will test the hypothesis that prolonged regional peripheral nerve block will reduce development of chronic pain in patients undergoing surgery for ankle fracture compared to standard of care.
- Conditions
- Chronic Pain, Ankle Fracture Surgery, Regional Anesthesia
- Trial name
- NCT02950558
- Testing
- Ropivacaine, Nerve block
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Cincinnati
Popliteal Nerve Block, Foot Surgery
Effect of Ropivacaine During Popliteal Nerve Block in Foot and Ankle Surgery
With the increasing rise of outpatient surgery in orthopaedic procedures, the management of immediate postoperative pain has been a major topic investigated, with the use of a peripheral nerve block in combination with general…
- Conditions
- Popliteal Nerve Block, Foot Surgery, Ankle Surgery
- Trial name
- NCT04872322
- Testing
- Ropivacaine 0.5% Injectable Solution, Ropivacaine 0.25% Injectable Solution, Percocet Pill
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Ankle Fractures, Surgery
Immediate Weight-Bearing Ankle Study
This single-centre historical control group comparative study will compare outcomes of surgically-treated rotational ankle fractures and the current routine practice of early protected weightbearing and range of motion with…
- Trial name
- NCT03032653
- Testing
- Late Rehabilitation, Early Rehabilitation
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Fraser Orthopaedic Research Society
Arthrodesis Surgery Involving the Hindfoot or Ankle
AMPLEX Ankle Fusion and Hindfoot
To demonstrate that AMPLEX is non-inferior to autogenous bone graft (ABG) for bone fusion in a population indicated for single, double, or triple hindfoot arthrodesis or ankle arthrodesis surgery with supplemental graft material.
- Trial name
- NCT03028415
- Testing
- AMPLEX, Autogenous Bone Graft (ABG)
- Where
- 36 sites in United States, Canada
- Volunteers
- 56 people
- Sponsor
- Ferring Pharmaceuticals
Bunion, Metatarsophalangeal Fusion
Phase 3, Randomized, Double Blinded, Active Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL Admixed With Bupi vs. Bupi Only Administered as Combined Sciatic and Adductor Canal Nerve Block for Postsurgical Analgesia in Lower Extremity Surgeries
This is a Phase 3, multicenter, randomized, double blinded, active controlled study in approximately 81 subjects undergoing lower extremity surgeries with combined sciatic and adductor canal nerve block.
- Conditions
- Bunion, Metatarsophalangeal Fusion, Midfoot Fusion, Hindfoot Fusion
- Trial name
- STRIDE (NCT03954639)
- Testing
- EXPAREL 13.3Mg/mL Suspension for Injection, Bupivacaine Hydrochloride
- Sponsor
- Pacira Pharmaceuticals, Inc
Foot and Ankle Surgeries, Bunion
Efficacy of Tranexamic Acid in Foot and Ankle Surgeries
Epidemiology of foot and ankle surgeries that present to the hospitals in the US are often underestimated. However there has been growing emphasis on identification of these injuries and practice patterns.
- Trial name
- NCT03653429
- Testing
- Tranexamic Acid, Normal saline
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Foot and Ankle Surgery, Popliteal Nerve Block
Efficacy of Popliteal Block and Bupivacaine Concentration Used for Analgesia in Foot and Ankle Surgery
In the orthopedic foot and ankle surgeries, the effects of postoperative popliteal nerve block applied for palliation of pain and local anesthetic agent in two different concentrations (0.166 and 0.250) which were used in…
- Conditions
- Foot and Ankle Surgery, Popliteal Nerve Block, Peripheral Nerve Block
- Trial name
- NCT04294732
- Testing
- Bupivacaine, Only spinal anesthesia without peripheral nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Bozyaka Training and Research Hospital
Post-surgical Pain, Total Knee Arthroplasty
Effects of Catheter Location on Postoperative Analgesia for Continuous Adductor Canal and Popliteal-Sciatic Nerve Blocks
Currently, continuous adductor canal and popliteal-sciatic nerve blocks are used commonly for lower extremity post-operative pain control, specifically for total knee arthroplasty and foot/ankle surgery, respectively.
- Conditions
- Post-surgical Pain, Total Knee Arthroplasty, Foot/Ankle Surgery, Catheterization for Postop Analgesia
- Trial name
- NCT02523235
- Testing
- ropivacaine 0.2%
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of California, San Diego
Acute Fracture Surgery, Alcohol Cessation Intervention
Alcohol Cessation Intervention in an Acute Surgical Setting
Hazardous alcohol intake is an independent risk factor for postoperative complications after major and minor operations, elective and emergency procedures for men and women.
- Conditions
- Acute Fracture Surgery, Alcohol Cessation Intervention, Postoperative Complications, Infection
- Trial name
- NCT00986791
- Testing
- GSP-A
- Where
- 3 sites in Denmark
- Volunteers
- 70 people
- Sponsor
- Bispebjerg Hospital
Ankle/Foot Surgery
Ultrasound Guided Popliteal Fossa Block. Does Blockade Distal to Sciatic Nerve Bifurcation Speed Onset Time? A Prospective, Randomized Trial
Sciatic nerve block is used routinely in ankle and foot surgery. It is applied often by a posterior approach at the popliteal fossa, near where the nerve divides into the common peroneal and tibial nerves.
- Trial name
- NCT00803426
- Testing
- Sciatic nerve blockade for ankle/foot surgery
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- University Health Network, Toronto
Ankle Fractures, Surgery
Study of Re-operation Rate After Introduction of Evidence Based Algorithm for the Treatment of Ankle Fractures
There is a high incidence of re-operations after surgery for ankle fractures. According to the Danish Fracture Database (DFDB) the re-operation rate, excluding hardware removal, is almost 10%.
- Conditions
- Ankle Fractures, Surgery, Syndesmotic Injuries, Posterior Malleolus Fractures
- Trial name
- PRO-Malleol (NCT03107767)
- Testing
- PRO-malleol algorithm
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Hvidovre University Hospital
Popliteal Nerve Block, Foot Surgery
Continuous Popliteal Nerve Blocks: Effect of Perineural Catheter Tip Location Relative to the Sciatic Nerve Bifurcation on Postoperative Analgesia
Research study to determine the relationship between perineural catheter tip location relative to the sciatic nerve bifurcation and postoperative analgesia for continuous popliteal nerve blocks.
- Conditions
- Popliteal Nerve Block, Foot Surgery, Ankle Surgery, Popliteal Bifurcation
- Trial name
- NCT01229696
- Testing
- Catheter Placed At Bifurcation, Catheter Placed 5cm Above Bifurcation
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, San Diego
Elective Foot and Ankle Surgery.
Use of Platelet-Rich Plasma (PRP) and Platelet-Poor Plasma (PPP) to Prevent Infection and Delayed Wound Healing
The purpose of this study is to see if applying PRP and PPP to surgical sites and the closing incision helps prevent infection and slow wound healing.
- Trial name
- PRP (NCT01639144)
- Testing
- PRP and PPP
- Where
- United States
- Volunteers
- 515 people
- Sponsor
- Gary M. Kiebzak, Ph.D.
Lower Leg Surgery, e.g. Ankle Fractures
Ultrasound-guided Nerve Blocks for the Sciatic and Saphenous Nerves: Characteristics of the Single Penetration Dual Injection (SPEDI) Technique
Background and aims: Ultrasound-guided (USG) nerve blocks of the sciatic nerve (popliteal level = PL) and the saphenous nerve (mid-femoral level = MFL) provides analgesia following leg surgery.
- Trial name
- NCT01815372
- Testing
- Single penetration dual injection (SPEDI) block technique to block the sciatic and the saphenous nerve with one needle penetration of the skin, The classical popliteal sciatic nerve block combined with the mid-femoral saphenous nerve block
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Bispebjerg Hospital
Major Ankle Surgery
Saphenous Nerve Block: Single Shot Versus Continuous Infusion to Supplement a Continuous Sciatic Nerve Block After Major Ankle Surgery
The most useful method to manage pain after major ankle surgery is infusion of local analgesics with a catheter close to the sciatic nerve.
- Trial name
- NCT01445210
- Testing
- Continuous saphenous nerve block
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Foot Surgery, Ankle Surgery
Popliteal Sciatic Nerve Block Catheter Placement for Foot Surgery
Hypothesis: When performed under ultrasound guidance, there is improvement in the sensory and motor blockade obtained with stimulating popliteal catheters versus those placed without nerve stimulation.
- Trial name
- NCT01049906
- Testing
- Placement of nerve block catheter
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic