Clinical trials: Anosmia
Dysosmia, Anosmia
Treatment of Pediatric Patients That Lost Sense of Smell Due to COVID-19
This research study is a randomized controlled trial in pediatric and young adult patients who have lost their sense of smell due to COVID-19 viral infection. The goals are: 1.
- Conditions
- Dysosmia, Anosmia, Covid19
- Trial name
- NCT04964414
- Testing
- Smell Retraining, Budesonide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Amanda Stapleton
Weight, Birth, Premature Birth
Effects of Olfactory and Gustatory Stimulus on the Nutrition of Premature Babies
The objective of this clinical trial is to test the effects of olfactory and taste stimulation with milk or water in premature newborns with a gestational age between 28 and 32 weeks.
- Trial name
- NCT06305052
- Testing
- Milk, Water
- Where
- Brazil
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Olfaction Disorders
Evaluation of Two Methods of Olfactory Rehabilitation in Post-viral Loss of Smell: Classic and Intensive
One of the most common causes of loss of smell is upper respiratory tract infection. These disorders can be quantitative (hyposmia or anosmia) or qualitative (parosmia or phantosmia).
- Trial name
- Odorat-Covid (NCT04598763)
- Testing
- smell the odors of the olfactory rehabilitation kit according to the classic or intensive method
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Central Hospital, Nancy, France
Post-viral Anosmia, Post-traumatic Anosmia
Self-assessment of Olfactory Disorders for French Speaking Patients
Sense of smell disorders are common and are said to affect up to 20% of the general population. They are often disabling and have a real impact on the quality of life.
- Conditions
- Post-viral Anosmia, Post-traumatic Anosmia, Chronic Rhinosinusitis, Idiopathic Anosmia
- Trial name
- VIF-DOR (NCT04705805)
- Testing
- Self-assessment of olfactory disorders through two questionnaires.
- Where
- France
- Volunteers
- 135 people
- Sponsor
- University Hospital, Strasbourg, France
Subjective Cognitive Concerns, Mild Cognitive Impairment
Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
The goal of this study is to objectively test one's sense of smell, called olfaction, in participants with Subjective Cognitive Concerns (SCC), Mild Cognitive Impairment, Mild Behavioral Impairment (MBI), and age-matched…
- Conditions
- Subjective Cognitive Concerns, Mild Cognitive Impairment, Mild Behavioral Impairment, Healthy Aging
- Trial name
- NCT05881239
- Testing
- AROMHA Brain Health Test
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Parkinson Disease (PD), REM Sleep Behavior Disorder (iRBD)
Artificial Intelligence-based Parkinson's Disease Risk Assessment (AI-PRA) Study
The study aims to provide initial proof-of-concept validation data of an artificial intelligence-based model to estimate individual Parkinson's disease risk using demographic, clinical, genetic information and digital biomarker…
- Conditions
- Parkinson Disease (PD), REM Sleep Behavior Disorder (iRBD), Neurogenic Orthostatic Hypotension, Hyposmia
- Trial name
- AI-PRA (NCT07706829)
- Testing
- Smartwatch and phone app
- Where
- 3 sites in France, Spain and 1 more
- Volunteers
- 60 people
- Sponsor
- Queen Mary University of London
Anosmia, Covid19
Visual-OLfactory Training in Participants With COVID-19 Resultant Loss of Smell
Olfactory dysfunction is a defining symptom of COVID-19 infection. As the number of total, confirmed COVID-19 cases approached 19 million in the United States, it is estimated that there will be 250,000 to 500,000 new cases of…
- Conditions
- Anosmia, Covid19, Ageusia, Hyposmia
- Trial name
- VOLT (NCT04710394)
- Testing
- Smell Training
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Washington University School of Medicine
Congenital Cytomegalovirus Infection
Assesment of Olfactory Disorders and Performance of a New Olfactory Test in Children With Congenital CMV
CMV lesions were found in the olfactory system of children with congenital CMV infection but no study has hitherto examined the impact of congenital CMV infection on olfaction.
- Trial name
- INFECSMELL (NCT02782988)
- Testing
- olfactory tests, otoacoustic emissions (OAE)
- Where
- 2 sites in France
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Obesity, Overweight
The Effects of GLP-1 Receptor Agonists on Chemosensory Function and Ingestive Behavior
The goal of this study is to explore whether of GLP-1 receptor agonist use is associated with differences in taste, smell, food preferences, appetite, food cravings, and responses to food cues in adults.
- Conditions
- Obesity, Overweight, Taste Perception, Olfaction
- Trial name
- NCT07611201
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Purdue University
Traumatic Olfactory Nerve Injury With Anosmia (Diagnosis), Effect of Drug
The Effect of Platelet-rich Plasma Nasal Injection in the Treatment of Traumatic Olfactory Dysfunction
The purpose of this study is to explore the efficacy of injecting high-concentration platelet plasma combined with hyaluronic acid into the nasal olfactory mucosa in the treatment of traumatic anosmia.
- Trial name
- PRP (NCT06290219)
- Testing
- platelet-rich plasma combined with hyaluronic acid, Zinc Gluconate 10 MG Oral Tablet, 4 bottles of phenyl ethyl alcohol, lemon, eucalyptus, and clove oil
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taichung Veterans General Hospital
End Stage Renal Disease, Olfactory Disorders
Helping Olfaction and Nutrition On Renal Replacement
This clinical trial examines whether nasal theophylline administration can improve olfaction and nutrition in hemodialysis patients.
- Trial name
- HONORR (NCT02479451)
- Testing
- Theophylline
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Mild Cognitive Impairment
Olfactory Training in Mild Cognitive Impairment
Sense of smell tends to decline in individuals with early Alzheimer's disease, typically earlier than when other senses and thinking abilities begin to decline.
- Trial name
- OTMCI (NCT06825403)
- Testing
- Olfactory Memory Training, Visual Memory Training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Jeffrey Motter
Parkinson Disease
Role of Nasal Dysbiosis in Parkinson Disease
Olfactory dysfunction is frequent in Parkinson Disease (PD) and may be present years before the motor symptoms appear. The early olfactory dysfunction could result from environmental factors acting through the nasal cavity such…
- Trial name
- SMELLPARK (NCT04249245)
- Testing
- Nasal Swab
- Where
- 2 sites in France, Guadeloupe
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Specific Anosmias
Experiments to Test How and Why the Sense of Smell Differs Between People
The ability to smell varies greatly between different individuals. Some people are unable to detect an odor that most people can smell. It is not known what causes these individual differences.
- Trial name
- NCT00220038
- Testing
- smell tests
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Drug Abuse
The Effects of Expectation on Natural and Drug -Induced Rewards
Background: Environmental cues frequently induce expectancies in individuals that may strongly influence the actual experience associated with the cue.
- Trial name
- NCT01036230
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Surgery, Gallbladder
Smell Memory Method for Patients Before Surgery
The research is planned as a randomized controlled experimental at Erzurum Atatürk University Health Application and Research Center.
- Conditions
- Surgery, Gallbladder, Smell
- Trial name
- NCT06414980
- Testing
- Experimental
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Anosmia, Covid19
Olfactory Disfunction and Co-ultraPEALut
Olfactory dysfunction is common among patients with Corona-Virus-Infection-Disease (COVID)-19, and up to 30% of patients may report persistent disorders of smell or taste as a long-term sequelae.
- Conditions
- Anosmia, Covid19, Hyposmia, Parosmia
- Trial name
- NCT04853836
- Testing
- co-ultraPEALut, Olfactory Rehab, PEA-LUT 1 sachet
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Olfactory Dysfunction, Post-traumatic Olfactory Dysfunction
PANDORA: Evaluation of Platelet-rich Plasma in Non-tumoural Odour Disorders: a Descriptive Pilot Study.
This is a prospective, single-center, single-arm, non-comparative descriptive pilot study evaluating autologous platelet-rich plasma (PRP) injections in adults with persistent (>6 months) non-tumoural olfactory dysfunction…
- Conditions
- Olfactory Dysfunction, Post-traumatic Olfactory Dysfunction, Age-related Degenerative Olfactory Dysfunction
- Trial name
- PANDORA (NCT07473830)
- Testing
- Autologous Platelet-Rich Plasma (PRP) Injection
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Anosmia, COVID-19
Characteristics of the Anosmic Olfactory Mucosa
The present study aims to describe the structural tissue and cell characteristics of the olfactory mucosa in patients with persistent anosmia (≥2 years) due to COVID-19 or head-trauma, in comparison to healthy individuals with…
- Conditions
- Anosmia, COVID-19, Head Injury
- Trial name
- NCT05562050
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Nicolai Nielsen
Body Schema
Body-environment Relationship Related Modified Gravity
The overall objective of this study is to better understand the relationship between the body and its environment, including cognitive performance, following repeated changes in gravity, including microgravity (0G) and modified…
- Trial name
- ENACT (NCT05531162)
- Testing
- Cognition and emotional neuropsychologicl evaluations
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Caen