Clinical trials: Anovulation
Infertility, Infertility Secondary
Sperm Preparation Prior to Intrauterine Insemination Study
This is a randomized controlled trial comparing density gradient centrifugation and microfluidic sperm sorting in patients undergoing intrauterine insemination to evaluate cumulative pregnancy outcomes.
- Conditions
- Infertility, Infertility Secondary, Infertility Unexplained, Anovulation
- Trial name
- PIoUS (NCT05693220)
- Testing
- Zymot Multi sperm separation device, Density gradient centrifugation
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of California, San Francisco
Polycystic Ovary Syndrome, Anovulation
The Effect of Metformin Added to Clomiphene Citrate on Pregnancy Rates in Hyperandrogenic, Chronic Oligoovulatory or Anovulatory Women
The purpose of our study was to conduct a placebo controlled, double-blind randomized trial in chronic oligoovulatory or anovulatory , hyperandrogenic, infertility patients comparing the effects of adjuvant metformin plus…
- Conditions
- Polycystic Ovary Syndrome, Anovulation, Oligoovulation, Infertility
- Trial name
- NCT00413179
- Testing
- Metformin, Clomiphene citrate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Infertility
Letrozole vs. Clomiphene Citrate in Patients With Anovulatory Infertility
OBJECTIVE: To compare the effectiveness of letrozole and clomiphene citrate (CC) in patients with anovulatory infertility. DESIGN: Open, prospective, randomized, parallel group, multicentric, comparative trial.
- Trial name
- NCT00610077
- Testing
- Letrozole, Clomiphene citrate
- Where
- India
- Volunteers
- 55 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Polycystic Ovary Syndrome, Infertility
Clomiphene Citrate in Infertile PCOS Patients
Anovulatory infertility is a common feature of the polycystic ovary syndrome (PCOS). Clomiphene citrate (CC) represents the first therapeutic option for treating the anovulatory infertility in PCOS patients because it is…
- Trial name
- NCT00501839
- Testing
- clomiphene citrate
- Where
- Italy
- Sponsor
- University Magna Graecia
InFertility
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Three Dosage Strengths of Pulsatile GnRH
This study will be performed in approximately 132 women with anovulatory/oligoovulatory infertility.
- Trial name
- NCT00296465
- Testing
- Pulsatile gonadotropin-releasing hormone (GnRH), Clomiphene Citrate
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Anovulation, Irregular Menses
Uterine and Endometrial Volume in PCOS and HPOD
Group II causes of anovulation according to the World Health Organization include polycystic ovary syndrome (PCOS) and the less common dysfunction of the hypothalamic-pituitary-ovarian axis (HPOD).
- Trial name
- NCT06211608
- Testing
- Two-dimensional and three-dimensional ultrasound of the female reproductive organ
- Where
- Poland
- Volunteers
- 648 people
- Sponsor
- Jagiellonian University
Amenorrhea, Dysmenorrhea
Reproductive Effects of Pesticide, PCB and Mercury Exposure in Laotian Immigrants
This project is examining the reproductive effects of exposure to certain compounds that are suspected to act on the endocrine system, e.g. they may act like or interfere with hormones such as estrogen.
- Conditions
- Amenorrhea, Dysmenorrhea, Oligomenorrhea, Anovulation
- Trial name
- NCT00011388
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Polycystic Ovary Syndrome (PCOS), Anovulatory Infertility
Clomiphene Citrate Alone Versus Clomiphene Plus Metformin as First Line Approach for the Treatment of Anovulation in Infertile Patients With Polycystic Ovary Syndrome
This study will compare the effectiveness of clomiphene citrate alone with clomiphene citrate combined with metformin for treating anovulation and infertility in women with polycystic ovary syndrome (PCOS).
- Trial name
- CC-MET PCOS T (NCT07872501)
- Testing
- Clomiphane citrate + Metformin, clomiphene citrate alone
- Where
- Pakistan
- Volunteers
- 218 people
- Sponsor
- Independent University Hospital, Pakistan
Anovulatory Infertility
Efficacy of Injectable Vitamin D Supplementation in Females With Polycystic Ovary Syndrome
Poly cystic Ovarian Syndrome (PCOS) is an endocrine disorder of reproductive age defined by "the presence of any two out of three criteria: oligo and/or anovulation, excess androgen activity and/or polycystic ovarian morphology…
- Trial name
- NCT06045351
- Testing
- Vitamin D, Active Comparator
- Where
- Pakistan
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Anovulation
Phase III Clinical Study of Domestic Recombinant Human Follitropin for Injection to Treat WHO Class II Anovulation
The purpose of this study is to evaluate the efficacy and safety of Domestic Recombinant Human Follitropin (Gonal-F) for Injection for treatment of WHO Ⅱ anovulation (including polycystic ovarian syndrome [PCOS] subjects).
- Trial name
- NCT02335879
- Testing
- Gonal-F
- Volunteers
- 534 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
PCOS, Infertility, Female
Effect of Acupuncture Plus Governor Vessel Moxibustion Combined With Letrozole on Live Birth in Anovulatory Infertile Women With Spleen-kidney Yang Deficiency PCOS
Investigators expected to verify this hypothesis through this study:acupuncture and moxibustion combined with LE induced ovulation in Chinese anovulatory PCOS women has a higher rate of live birth than LE induced ovulation alone.
- Trial name
- PCOS (NCT04987632)
- Testing
- Letrozole, acupuncture, Governor vessel moxibustion
- Volunteers
- 90 people
- Sponsor
- Qiu-ping Lin
Anovulation, Obesity
An RCT of Metformin Vs Orlistat in Obese Anovulatory Women
This study aims to investigate the role of the weight reduction agent, Orlistat compared to the Metformin for the management of women who are obese and do not ovulate or have difficulty conceiving.
- Trial name
- NCT00292799
- Testing
- Orlistat Vs Metformin
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
PCOS (Polycystic Ovary Syndrome), Infertility
Letrozole Extended vs Traditional Therapy for Ovulation Induction in Women With PCOS (PROLEx-PCOS)
This randomized clinical trial aims to compare the efficacy and safety of extended letrozole therapy (5 mg/day for 10 days) versus standard letrozole therapy (5 mg/day for 5 days) for ovulation induction in women with polycystic…
- Conditions
- PCOS (Polycystic Ovary Syndrome), Infertility, Anovulation
- Trial name
- PROLEx-PCOS (NCT07159880)
- Testing
- Traditional Letrozole Therapy, Extended Letrozole Therapy
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GABRIEL MONTEIRO PINHEIRO
Polycystic Ovary Syndrome, Anovulation
Structured Exercise Training Program Versus Hypocaloric Hyperproteic Diet in Obese Anovulatory Infertile Patients With PCOS
Lifestyle modifications are successfully employed in polycystic ovarian syndrome (PCOS) improving menstrual cycles and fertility. Unfortunately, the compliance over the time is very low.
- Conditions
- Polycystic Ovary Syndrome, Anovulation, Infertility
- Trial name
- NCT00473538
- Testing
- Structured exercise training, Hypocaloric hyperproteic diet
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University Magna Graecia
Ovulation Induction
AS900672-Enriched in Ovulation Induction
This is a Phase 2, interventional, multi-center, randomized, assessor-blind, active-comparator, dose-finding study to evaluate a new investigational long-acting follicle stimulating hormone (FSH) in oligo-anovulatory women…
- Trial name
- NCT00553514
- Testing
- AS900672-Enriched 10 microgram (mcg), AS900672-Enriched 20 mcg, AS900672-Enriched 30 mcg
- Where
- Switzerland
- Volunteers
- 71 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Female Infertility Associated With Anovulation
Amlodipine on Blood Flow of Preovulatory Follicle in Polycystic Ovarian Patients
On the basis of the current study, amlodipine seems to be a promising drug on improving uterine, ovarian blood flow, size of pre-ovulatory follicle, midluteal progesterone level and pregnancy outcome in patients with pco.
- Trial name
- NCT02544776
- Testing
- Clomifene citrate ( clomid 50 mg ), Amlodipine
- Volunteers
- 60 people
- Sponsor
- Ahmed Fathy Ali Mohamed Ghanem
Hypogonadotropic Hypogonadism
Clinical Outcomes in WHO Type I Anovulatory Women Using r-hFSH+r-hLH in a 2:1 Ratio or hMG-HP
The aim of the study is to compare the efficacy and safety of r-hFSH+r-hLH in a 2:1 ratio with human Menopausal Gonadotropin Highly Purified (hMG-HP), in WHO type I anovulation, HH women.
- Trial name
- NCT01623570
- Testing
- Pergoveris: 150IU r-hFSH + 75IU r-hLH, Menopur: HMG-HP (150 IU)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Centro Riproduzione e Andrologia
Anovulation, Polycystic Ovary Syndrome
Letrozole Versus Clomiphene Citrate for Ovulation Induction in Women With Poly Cystic Ovary Syndrome ( PCOS )
110 infertile women diagnosed as polycystic ovary syndrome (PCOS) at the age group of 20-35 distributed randomly : 55 women will receive letrozole 2.5mg twice daily orally from the 2nd day to the 6thday of the cycle for three…
- Trial name
- LVCCFOROI (NCT02551367)
- Testing
- Letrozole, Clomiphene citrate, hcg hormone
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- mostafa gomaa hamid halawa
Infertility, Monofollicular Development
Low-dose Gonal-f® in Ovulation Induction
This is a prospective, multicenter, open-label, comparative and parallel-group study of ovulation induction evaluating tailoring of Recombinant follicle stimulating hormone (FSH) treatment using the Gonal-f® prefilled pen in…
- Trial name
- LoGo (NCT01871532)
- Testing
- Gonal-f®
- Where
- 10 sites in Ireland, United Kingdom
- Volunteers
- 24 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Polycystic Ovary Syndrome, PCOS
Randomized Controlled Trial of Combined Letrozole and Clomid (CLC II) Versus Letrozole Alone for Women With Anovulation
This study evaluates the addition of clomiphene citrate (CC) to letrozole for the treatment of infertility in women with polycystic ovary syndrome across a course of two treatment cycles with stair step dosing of letrozole…
- Conditions
- Polycystic Ovary Syndrome, PCOS, Infertility
- Trial name
- CLC II (NCT05206448)
- Testing
- Letrozole, Clomiphene Citrate
- Where
- 4 sites in United States
- Volunteers
- 190 people
- Sponsor
- Rachel Mejia