Clinical trials: Anterior Cerebral Circulation
Cerebral Ischemia
Study on the Role of Human Serum Albumin in Large Acute Ischemic Stroke of Anterior Circulation After Thrombectomy
This project intends to explore the therapeutic efficacy of human serum albumin in mitigating postoperative cerebral edema and enhancing clinical outcomes following mechanical thrombectomy in patients with acute anterior…
- Trial name
- NCT06629116
- Testing
- Patients with AIS receive intravascular therapy, and within 10 minutes after the surgery, they are administered 100ml of 20% human albumin intravenously (infused within 30 minutes).
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tingyu-Yi
Stroke, Acute, Infarction, Middle Cerebral Artery
Autologous Bone Marrow Stem Cells in Ischemic Stroke.
The aim of the study is to determine the safety and tolerability of an autologous CD34+ subset bone marrow stem cell infusion into the middle cerebral artery in patients who have suffered acute total or partial anterior…
- Trial name
- NCT00535197
- Testing
- Infusion of autologous CD34+ stem cells into middle cerebral artery
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Imperial College London
Carotid Artery Diseases, Thrombectomy
Thrombectomy In TANdem Occlusion
Tandem occlusion is defined by an acute ischemic stroke (AIS) with concomitant steno-occlusive disease of the extra cranial carotid artery and concerned about 10% of AIS patients.
- Conditions
- Carotid Artery Diseases, Thrombectomy, Tandem Occlusion, Stroke
- Trial name
- TITAN (NCT03978988)
- Testing
- Carotid Stenting, Procedural Aspirin, Dual dual antiplatelet therapy after 24-hours imaging follow-up
- Where
- France
- Volunteers
- 432 people
- Sponsor
- Central Hospital, Nancy, France
Cerebrovascular Occlusion, Collateral Blood Circulation
The Impact of NBP on the Collateral Circulation in ICA/M1 Occlusion
Stroke is the first leading cause of death in China, and is responsible for almost 22.4% of deaths. In approximately 80% of cases stroke is ischaemic, i.e.
- Conditions
- Cerebrovascular Occlusion, Collateral Blood Circulation, Anterior Cerebral Circulation Infarction
- Trial name
- INCIMO (NCT02594995)
- Testing
- NBP
- Where
- China
- Volunteers
- 311 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Thrombectomy, Tandem Occlusion
Stent Implantation Versus Balloon Dilation for Acute Anterior Circulation Tandem Occlusion
1. To evaluate whether stent implantation on the ipsilateral extracranial segment, after intracranial thrombectomy successful recanalization compared with balloon angioplasty (eTICI≥2b_50) for acute anterior circulation tandem…
- Conditions
- Thrombectomy, Tandem Occlusion, Stroke
- Trial name
- START (NCT05902000)
- Testing
- Carotid Stenting, Thrombectomy, Dual antiplatelet treatment
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Xueli Cai
Ischemic Stroke, Large Vessel Occlusion
Direct Intra-arterial Thrombectomy in Order to Revascularize AIS Patients With Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals
Background: Intravenous thrombolysis (IVT) combined with mechanical thrombectomy (MT) has been proven safe and effective in patients with acute ischemic stroke (AIS) of anterior circulation large vessel occlusion (LVO).
- Conditions
- Ischemic Stroke, Large Vessel Occlusion, Thrombectomy, Thrombosis
- Trial name
- DIRECT-MT (NCT03469206)
- Testing
- intra-arterial thrombectomy, Intravenous thrombolysis
- Where
- China
- Volunteers
- 656 people
- Sponsor
- Changhai Hospital
Ischemic Stroke
Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion Study
Ischaemic stroke causes significant morbidity and mortality and is a leading cause of disability within an ageing United Kingdom (UK) population.
- Trial name
- RICE PAC (NCT03152799)
- Testing
- RIPC Remote Ischaemic Pre-Conditioning
- Volunteers
- 60 people
- Sponsor
- University College, London
Acute Ischemic Stroke, Large Vessel Occlusion
Tenecteplase Before Interhospital Transfer for EVT in Acute Anterior Circulation LVO at 4.5-24 Hours
This study will address the efficacy and safety of Tenecteplase administered in non-endovascular capable center (nECC) in patients with acute ischemic stroke (AIS) caused by anterior circulation large vessel occlusion (acLVO) who…
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Transportation of Patients
- Trial name
- TREASURE (NCT07253181)
- Testing
- Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg)
- Where
- 2 sites in China
- Volunteers
- 572 people
- Sponsor
- Xuanwu Hospital, Beijing
Cerebral Edema, Ischemic Stroke, Acute
A Trial of Adacolumn on Cerebral Edema After Anterior Circulation Ischemic Stroke
The primary objective is to investigate whether treatment with Adacolumn can ameliorate the progression of cerebral edema within 72 hours in patients with anterior circulation ischemic stroke.
- Conditions
- Cerebral Edema, Ischemic Stroke, Acute, Malignant Cerebral Edema, Anterior Circulation Brain Infarction
- Trial name
- NCT07386262
- Testing
- Adacolumn®, Standard Reperfusion Therapy, Standard Medical Management
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Randomized Controlled Trial, Intracranial Aneurysm
Comparison of Clipping Via Keyhole Versus Traditional Approaches and Coiling for Ruptured Aneurysms
Endovascular coiling has become a strategy of choice of intracranial aneurysms due to its minimally invasiveness. However, there has few prospective randomized controlled studies on the comparison of therapeutic effect between…
- Conditions
- Randomized Controlled Trial, Intracranial Aneurysm, Microsurgery, Endovascular Procedures
- Trial name
- NCT05049564
- Testing
- keyhole microneurosurgery, conventional microneurosurgery, endovascular coiling
- Volunteers
- 150 people
- Sponsor
- ZhuQing
Acute Ischemic Stroke, Large Vessel Occlusion
Tenecteplase or Reteplase as Bridging Thrombolysis Before Thrombectomy in Acute Ischemic Cerebrovascular Events
Acute ischemic stroke caused by large vessel occlusion (LVO) is a major cause of disability, and mechanical thrombectomy (MT) has become the standard treatment for eligible patients.
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Anterior Circulation Brain Infarction
- Trial name
- TRACE- BRIDGE (NCT07748039)
- Testing
- rhTNK-tPA (0.25mg/kg), Reteplase 10 Units (U) plus a second dose of reteplase 10 U, No thrombolysis (thrombectomy alone)
- Where
- 5 sites in China
- Volunteers
- 1,440 people
- Sponsor
- Yongjun Wang
Acute Ischemic Stroke, Large Vessel Occlusion
Sivelestat Sodium as an Adjunct to Endovascular Thrombectomy for Acute Anterior Circulation Large-Vessel Occlusion
Stroke remains a major global health burden, with acute ischemic stroke (AIS) accounting for more than 65% of all cases. Endovascular thrombectomy (EVT) has been established as a standard treatment for large vessel occlusion…
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Thrombectomy, Neutrophil Extracellular Trap Formation
- Trial name
- NCT07552610
- Testing
- Sivelestat sodium, Endovascular Thrombectomy
- Where
- 2 sites in China
- Volunteers
- 868 people
- Sponsor
- Xuanwu Hospital, Beijing
Ischemic Stroke, Anterior Cerebral Circulation
Anesthesia Management in Endovascular Therapy for Ischemic Stroke - 2
The goal of this clinical trial is to learn what is the best anesthetic management in participants with severe stroke that require a medical intervention called mechanical thrombectomy (MT) done to open the occluded brain vessel.
- Conditions
- Ischemic Stroke, Anterior Cerebral Circulation, General Anesthesia, Procedural Sedation
- Trial name
- AMETIS 2 (NCT07235514)
- Testing
- General Anesthesia, Procedural sedation
- Where
- 16 sites in France
- Volunteers
- 958 people
- Sponsor
- University Hospital, Clermont-Ferrand
Ischemic Stroke
Change in Serum Biomarkers After Endovascular Treatment for Acute Anterior Circulation Large Vessel Occlusion
Acute ischaemic stroke (AIS) results in high rates of neurological morbidity and mortality, especially in patients with large vessel occlusion (LVO).
- Trial name
- NCT06383182
- Testing
- endovascular treatment
- Where
- China
- Volunteers
- 800 people
- Sponsor
- General Hospital of Shenyang Military Region
Ischemia Stroke, Thrombectomy
Intra-arterial Methylprednisolone After Endovascular Thrombectomy
The purpose of IMPACT-LVO trial is to investigate the efficacy and safety of early adjunctive intra-arterial combined with intravenous administration methylprednisolone sodium succinate after successful endovascular thrombectomy…
- Conditions
- Ischemia Stroke, Thrombectomy, Large Vessel Occlusion
- Trial name
- IMPACT-LVO (NCT07516522)
- Testing
- The methylprednisolone sodium succinate group
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Tang-Du Hospital
Acute Stroke, Blood Pressure
Blood Pressure Target in Acute Stroke to Reduce hemorrhaGe After Endovascular Therapy
A randomized, multicenter study comparing two strategies: 1 / standard management of systolic blood pressure according to international recommendations (systolic blood pressure <185 mm Hg) versus 2 / intensive blood pressure…
- Conditions
- Acute Stroke, Blood Pressure, Cerebral Hemorrhage
- Trial name
- BP-TARGET (NCT03160677)
- Testing
- Systolic blood pressure target < 130 mm Hg, Systolic blood pressure target < 185 mm Hg
- Where
- 7 sites in France
- Volunteers
- 320 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild