Clinical trials: Anterior Cruciate Ligament (ACL)
ACL Tears
BioBrace® Augmentation in Anterior Cruciate Ligament Reconstruction Procedures
This research study will evaluate mid-term clinical safety and performance outcomes of the BioBrace® Reinforced Implant when used to augment a tissue graft during anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT06948591
- Testing
- Anterior cruciate ligament reconstruction with BioBrace® augmentation, Arthroscopic anterior cruciate ligament reconstruction
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- CONMED Corporation
Healthy Adult Participants, Anterior Cruciate Ligament (ACL)
Three-dimensional Biomechanics of the Lower Limbs in Healthy Volunteers: Establishment of a Reference Database Using the MERItest® System
Anterior cruciate ligament (ACL) reconstruction is frequently associated with persistent biomechanical impairments despite clinically satisfactory recovery.
- Trial name
- MERITEST TS (NCT07886411)
- Testing
- MERITest
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Clinique du Sport, Bordeaux Mérignac
Osteoarthritis, Knee, Post-traumatic Osteoarthritis
Preventing Injured Knees From osteoArthritis: Severity Outcomes
This study is being done to find out if metformin is effective at reducing pain by delaying the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) reconstruction.
- Conditions
- Osteoarthritis, Knee, Post-traumatic Osteoarthritis, ACL Tear
- Trial name
- PIKASO (NCT06096259)
- Testing
- Metformin
- Where
- 9 sites in United States
- Volunteers
- 512 people
- Sponsor
- Brigham and Women's Hospital
ACL Tear
Quadriceps Strengthening ACL Reconstruction
The purpose of this study is to characterize quadriceps function and squat biomechanics during the early strengthening phase in adolescent patients undergoing a standardized combined neuromuscular electrical stimulation (NMES)…
- Trial name
- ACL (NCT07015541)
- Testing
- NMES and BFR, Standard physical therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Ligamentoplasty, Anterior Cruciate Ligament (ACL)
A Study Aiming to Demonstrate That the Addition of Intravenous (IV) Tranexamic Acid-Compared to Placebo-During Anterior Cruciate Ligament (ACL) Reconstruction Results in Reduced Blood Loss and Postoperative Pain.
Various reconstruction and graft harvesting techniques are used for ACL reconstruction. The most common techniques involve harvesting one or more hamstring tendons.
- Trial name
- EXACYLCA (NCT07753161)
- Testing
- ACL reconstruction
- Where
- France
- Volunteers
- 100 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Anterior Cruciate Ligament Reconstruction (ACLR), Anterior Cruciate Ligament Reconstruction Rehabilitation
The Effect of Isokinetic Vs Plyometric Training in Post-ACLR Surgery
The primary goal of this RCT is to evaluate the effects of isokinetic training compared to plyometric training in patients aged 18-40 years who have undergone ACLR surgery.
- Conditions
- Anterior Cruciate Ligament Reconstruction (ACLR), Anterior Cruciate Ligament Reconstruction Rehabilitation, Anterior Cruciate Ligament/Surgery, Anterior Cruciate Ligament (ACL) Reconstruction Surgery
- Trial name
- NCT07862868
- Testing
- Isokinetic Training, Plyometrics Training
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Anterior Cruciate Ligament Reconstruction (ACLR), Anterior Cruciate Ligament Reconstruction Rehabilitation
The Effect of Plyometric Training in Post-ACLR Surgery
The primary goal of this RCT is to evaluate the effect of adding plyometric training on standard program intervention in patients aged 18-40 years who have undergone ACLR surgery.
- Conditions
- Anterior Cruciate Ligament Reconstruction (ACLR), Anterior Cruciate Ligament Reconstruction Rehabilitation, Anterior Cruciate Ligament/Surgery, Anterior Cruciate Ligament (ACL) Reconstruction Surgery
- Trial name
- NCT07862881
- Testing
- Standard program, Plyometrics Training
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
ACL Injury, Meniscal Injuries
Intraoperative Energy Expenditure During ACL Reconstruction Surgery
This prospective observational study evaluates the intraoperative energy expenditure of the surgeon during anterior cruciate ligament reconstruction procedures.
- Trial name
- NCT07683247
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- ASL Lecce
ACL - Anterior Cruciate Ligament Rupture
Soft-tissue Quadriceps Autograft ACL-reconstruction in the Skeletally-immature vs. Hamstrings
To date, the use of the quadriceps tendon as an autograft option in primary paediatric Anterior Cruciate Ligament (ACL) reconstruction has not been well studied.
- Trial name
- SQuASH (NCT03896464)
- Testing
- Soft tissue hamstring autograft, Quadriceps tendon autograft
- Where
- 6 sites in Canada, Japan
- Volunteers
- 352 people
- Sponsor
- McMaster University
Anterior Cruciate Ligament (ACL) Tear
Bone-Patellar Tendon-Bone Versus Quadriceps Tendon Autograft for Anterior Cruciate Ligament Reconstruction: A Non-Inferiority Trial Regarding Anterior Knee Pain
This prospective, randomized, single-center, non-inferiority clinical trial will compare anterior knee pain (AKP) after primary anterior cruciate ligament (ACL) reconstruction using either a bone-patellar tendon-bone autograft…
- Trial name
- BTB vs QT (NCT07846709)
- Testing
- Bone-Patellar Tendon-Bone Autograft ACL Reconstruction, Quadriceps Tendon Autograft ACL Reconstruction
- Volunteers
- 150 people
- Sponsor
- Hospital del Mar
ACL - Anterior Cruciate Ligament Rupture
SharkScrew ACL RCT
This prospective, randomized controlled trial will compare three tibial interference screw types used for graft fixation during primary anterior cruciate ligament (ACL) reconstruction: a polyetheretherketone (PEEK) screw, a…
- Trial name
- NCT07830953
- Testing
- ACL Reconstruction with a Biocomposite Screw, ACL Reconstruction using a PEEK Screw, ACL Reconstruction using an Allograft Screw
- Where
- Austria
- Volunteers
- 33 people
- Sponsor
- Austrian Workers Compensation Board Styria
ACL Injury
Functional Movement Training Versus Functional Stability Training in Post-ACL Surgery
This randomized controlled trial study will include 32 athletes aged 18-35 who had ACL surgery. After surgery, participants will be selected and assigned randomly to the Functional Movement Training or Functional Stability…
- Trial name
- NCT07725016
- Testing
- Functional Movement training, Functional stability training
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Knee Osteoarthristis, ACL Injuries
Treatment of Post Traumatic Knee Osteoarthritis With Extracorporeal Shockwave Therapy
This study is recruiting current or former athletes who had ACL reconstruction surgery over a year ago and have been diagnosed with knee osteoarthritis (OA).
- Conditions
- Knee Osteoarthristis, ACL Injuries, Post-Traumatic
- Trial name
- PTOA Knee (NCT06686680)
- Testing
- extracorporeal shockwave therapy (ESWT)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Spaulding Rehabilitation Hospital
ACL Injury
Motor Imagery-Enhanced Rehabilitation Modulates Cortical Plasticity and Functional Recovery After ACL Reconstruction
Part 1: Neural Correlates of Motor Imagery in ACLR Patients This cross-sectional study aims to systematically compare differences in electroencephalographic (EEG) activity between patients who have returned to sport one year…
- Trial name
- NCT07833189
- Testing
- Motor Imagery Therapy (i.e., "mentally practicing movement"), conventional rehabilitation"
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
ACL - Anterior Cruciate Ligament Deficiency
AI-Based Video Assessment of Anterior Knee Laxity
This prospective observational validation study aims to evaluate the accuracy and reliability of artificial intelligence-based video analysis for quantifying anterior knee laxity.
- Trial name
- AI-LAX (NCT07833605)
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- ASL Lecce
ACL Tear
Anterior Cruciate Ligament (ACL) Reconstruction With Bone Tendon Bone Autograft With Versus Without Internal Bracing
There is no consensus regarding the best surgical management of primary ACL tears. Recent evidence suggests that internal brace augmentation may increase load failure and therefore stabilize the graft in-situ at the time of ACL…
- Trial name
- NCT05532189
- Testing
- ACL reconstruction with BTB autograft with internal brace augmentation (suture tape), ACL reconstruction with BTB autograft without internal brace augmentation (suture tape), Standardized Rehabilitation Protocol
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
ACL-injury
Comparison of Low-Level Laser Therapy Versus Infrared Therapy in Grade II ACL Injury Rehabilitation
This study is being conducted to compare two commonly used physical therapy treatments, low-level laser therapy (LLLT) and infrared therapy, for people with a Grade II anterior cruciate ligament (ACL) injury of the knee.
- Trial name
- NCT07829835
- Testing
- Low-Level Laser Therapy (LLLT), Infrared Therapy (IRT), Standard Physiotherapy
- Where
- 3 sites in Pakistan
- Volunteers
- 30 people
- Sponsor
- Superior University
ACL, Anterior Cruciate Ligament
Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction
The goal of this study is to gather pilot data to help inform a future clinical trial. As such, the investigators will employ a randomized clinical trial design, but data will only be collected on 9 total subjects.
- Conditions
- ACL, Anterior Cruciate Ligament, ACL Injury
- Trial name
- Mi-SPA (NCT06529692)
- Testing
- Split-Belt Training
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Michigan
ACL Injury, Hemodynamics
A Paradigm Shift in Musculoskeletal Rehabilitation Assessment After ACL Reconstruction Using Near-Infrared Spectroscopy
This study aims to establish and compare muscle haemodynamic response patterns in physically active subjects with anterior cruciate ligament (ACL) reconstruction, at different time points after surgery, against healthy controls…
- Conditions
- ACL Injury, Hemodynamics, Oxygen Consumption Based Assessment of Hemodynamics, Exercise
- Trial name
- HemoNIRS-LCA (NCT06621355)
- Testing
- Incremental Interval Test on a Cycle Ergometer
- Where
- Spain
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Universitat de Lleida
Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament (ACL) Tear
Active Noise-Cancelling Headphones With Closed-Loop Communication During Arthroscopic ACL Reconstruction
Operating room noise may interfere with communication, concentration, and surgical workflow. Active noise-cancelling (ANC) headphones can reduce background auditory distractions; however, their potential benefit during surgery…
- Conditions
- Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament (ACL) Tear, Anterior Cruciate Ligament Injury
- Trial name
- ANC-ACL-2026 (NCT07589582)
- Testing
- Active Noise-Cancelling Headphones With Closed-Loop Communication, Standard Operating Room Communication
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital