Clinical trials: Anterior Myocardial Infarction
Myocardial Infarction, Left Ventricular Systolic Dysfunction
Objective Systolic Function Recuperation Assessed by Echocardiography
The purpose of this study is to evaluate left ventricular systolic ejection fraction and anterior or apical akinesis 1 month and 3 months after a myocardial infarction treated with primary PCI to determine whether improvement at…
- Conditions
- Myocardial Infarction, Left Ventricular Systolic Dysfunction, Anterior Akinesis, Apical Akinesis
- Trial name
- ROSE (NCT01086124)
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Paul Farand
Myocardial Infarction, Myocardial Reperfusion Injury
Efficacy of Endovascular Catheter Cooling Combined With Cold Saline for the Treatment of Acute Myocardial Infarction
The purpose of this study is to determine whether treatment of patients suffering from ST-elevation myocardial infarction (STEMI) with 1-2 liters of cold saline and central venous catheter cooling with Philips InnerCool RTx…
- Conditions
- Myocardial Infarction, Myocardial Reperfusion Injury, Anterior Wall Myocardial Infarction, Inferior Wall Myocardial Infarction
- Trial name
- CHILL-MI (NCT01379261)
- Testing
- Cooling
- Where
- 10 sites in Austria, Denmark and 2 more
- Volunteers
- 120 people
- Sponsor
- Region Skane
Acute Myocardial Infarction, STEMI
Delivery SSO2 Therapy for 60 Min in Anterior MI Patients With PCI ≤ 6 Hours of Symptoms Onset Compared to Standard.
A multi-center randomized post-approval evaluation of delivery of intracoronary hyperoxemic supersaturated Oxygen therapy for 60 minutes in anterior AMI patients with successful reperfusion (via PCI) within 6 hours after onset of…
- Trial name
- NCT04743245
- Testing
- TherOx DownStream System, PCI
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- TherOx
Acute Myocardial Infarction With ST Segment Elevation
3 Nehb Precordial Leads Anterior, Dorsalis and Inferior Allow Accurate Diagnostics of Different Heart Conditions
The method of ECG recording with the use of three bipolar leads A (anterior), D dorsalis) and J (or I - inferior) was introduced in 1938 by German electrophysiologist W. Nehb.
- Trial name
- Nehb-STEMI (NCT00623896)
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Coronary Artery Disease, Acute Myocardial Infarction
LV Thrombus Pilot Study for Comparing Enoxaparin Vs. Warfarin
To prospectively evaluate the utility of enoxaparin vs. oral warfarin in reduction of echocardiographic indices of LV mural thrombus. The primary outcome is the presence of LV mural thrombus at 3.5 months.
- Trial name
- NCT00321009
- Testing
- Enoxaparin
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Corewell Health East
Anterior Myocardial Infarction
TACTIC Coronary Thrombus Aspiration With Cath Rx In Anterior Myocardial Infarction: A Randomized Control Trial.
The aim of this study is to evaluate the impact of sustained thrombectomy with INDIGO ASPIRATION SYSTEM using CAT RX versus no thrombectomy during primary percutaneous coronary intervention (PPCI) on microvascular obstruction and…
- Trial name
- TACTIC (NCT06887413)
- Testing
- THROMBOASPIRATION WITH INDIGO SYSTEM
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Ceric Sàrl
Myocardial Infarction
The Effect of Granulocyte Colony Stimulating Factor (G-CSF) on Myocardial Function After Acute Anterior Myocardial Infarction, a Prospective Double Blind Randomized Placebo Controlled Study
The investigators applied G-CSF to patients 2 weeks after acute anterior MI and successful PCI to evaluate the efficacy and safety of G-CSF in improving myocardial function as cytokine which improve inflammation and mobilize stem…
- Trial name
- NCT00756756
- Testing
- G-CSF
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Shiraz University of Medical Sciences
Anterior Wall Acute Myocardial Infarction
Evaluation of the Delivery of Optimized Supersaturated Oxygen Therapy to Treat Patients With an Acute Heart Attack
The purpose of this study is to evaluate the feasibility of the delivery of SuperSaturated Oxygen (SSO2) Therapy for 60 minutes selectively into the left main coronary artery (LMCA).
- Trial name
- NCT01630707
- Testing
- SuperSaturated Oxygen (SS02) Therapy
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- TherOx
ST Elevation Myocardial Infarction (STEMI)
Effect of Very Early and Rapid Lowering Cholesterol With Evolocumab on Left Ventricular Remodeling in Patients With Anterior STEMI Undergoing Primary PCI
For patients with anterior ST elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI), whether early application of proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors to…
- Trial name
- EVALUATE-STEMI (NCT05613426)
- Testing
- Rosuvastatin 20 mg, Evolocumab 140 mg/1 ml Subcutaneous Solution [REPATHA]
- Where
- 6 sites in China
- Volunteers
- 119 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
STEMI
Short and Intermediate Term Effect of Dapagliflozin on Left Ventricular Remodeling in Anterior STEMI Patients
Methodology This study will enroll (120) patients presenting with acute anterior STEMI who will undergo early reperfusion presenting at Helwan University Hospitals and Ain Shams University Hospitals.
- Trial name
- NCT05957887
- Testing
- Dapagliflozin
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mohamed Nabil Elkholy
Anterior STEMI
The RECOVERY Study: Using Supersaturated Oxygen Therapy To Treat Small Vessel Blockages After a Heart Attack
The study tests whether adding supersaturated oxygen (SSO₂) therapy to standard stent treatment can improve heart recovery after a major heart attack (anterior STEMI).
- Trial name
- NCT07000266
- Testing
- Percutaneous Coronary Intervention (PCI), Diagnostic Imaging, Device Treatment
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundacio Privada Mon Clinic Barcelona
Acute Anterior Myocardial Infarction
Rapid Intravascular Cooling in Myocardial Infarction as Adjunctive to Percutaneous Coronary Intervention
Rapid MI-ICE-Pilot is designed to demonstrate the safety and efficacy of the Celsius Control™ System (CCS) endovascular catheter to reduce the infarct size resulting from acute anterior myocardial infarction when used in…
- Trial name
- NCT00417638
- Testing
- Endovascular cooling by the Celsius Control System, Standard of care
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- ZOLL Circulation, Inc., USA
Anterior Myocardial Infarction
Effects of Pressure-controlled Intermittent Coronary Sinus Occlusion (PiCSO) Therapy on miRNAs Expression and Absolute Microvascular Resistance by Continuous Thermodilution in ST-segment Elevation Myocardial Infarction (STEMI) Patients: PiCSO-STEMI TRIAL
In this study we pretend to determine the molecular (miRNAs expression, angiogenic and inflammatory biomarkers) and microcirculatory (assessed by the innovative continuous intracoronary thermodilution technique) effects of PiCSO…
- Trial name
- PiCSO-STEMI (NCT05644925)
- Testing
- PiCSO Impulse System, Percutaneous Coronary Intervention (PCI)
- Sponsor
- Fundacio Privada Mon Clinic Barcelona
Myocardial Infarction, Acute, Myocardial Infarction First
MSCs for Prevention of MI-induced HF
Results from recent clinical trials on bone marrow mononuclear cell (BM-MNC) transplantation show that this intervention can help reduce the incidence of heart failure (HF) after acute myocardial infarction (AMI).
- Conditions
- Myocardial Infarction, Acute, Myocardial Infarction First, Myocardial Infarction, Anterior Wall, Cardiac Remodeling, Ventricular
- Trial name
- PREVENT-TAHA8 (NCT05043610)
- Testing
- Umbilical Cord-Derived Wharton's Jelly Mesenchymal Stem Cells (WJ-MSCs), Conventional Treatment
- Where
- 3 sites in Iran
- Volunteers
- 420 people
- Sponsor
- Shiraz University of Medical Sciences
Left Ventricular Dysfunction, Coronary Artery Disease
Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function
The purpose of this study is to assess if using the Impella® CP (or Impella® 2.5) device during high-risk PCI in patients with reduced left-sided heart function will result in an improvement in symptoms, heart function and health…
- Trial name
- PROTECT IV (NCT04763200)
- Testing
- Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®, IABP Intra-aortic balloon pump
- Where
- 110 sites in United States, Canada and 5 more
- Volunteers
- 1,252 people
- Sponsor
- Abiomed Inc.
Anterior Wall Acute Myocardial Infarction
Evaluation of Intracoronary Hyperoxemic Oxygen Therapy in Anterior Acute Myocardial Infarction Patients (IC-HOT)
The primary objective of the study is to collect confirmatory data supporting the safety and effectiveness of SSO2 Therapy in treatment of anterior acute myocardial infarction (AMI) patients who have undergone successful…
- Trial name
- IC-HOT (NCT02603835)
- Testing
- SSO2 Therapy
- Where
- 15 sites in United States
- Volunteers
- 100 people
- Sponsor
- TherOx
Anterior Acute Myocardial Infarction (AMI)
A Prospective Real-World Multi-Center Post-Market Observational Evaluation of Supersaturated O2 Therapy Using the TherOx® Downstream® System
The purpose of this study is to collect real-world data on the TherOx DownStream System® to assess the effectiveness and cost- effectiveness of SSO2 Therapy, compared with PCI alone for treatment of patients with acute anterior…
- Trial name
- REAL (NCT05156996)
- Testing
- Supersaturated O2 Therapy of the Therox Downstream System®, PCI alone
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- TherOx
Acute Myocardial Infarction With ST Elevation, Anterior Wall Myocardial Infarction
Deferred Stenting in Patients With Anterior Wall STEMI
Trial Name) Impact of Immediate SteNt ImplaNtatiOn Versus Deferred Stent ImplAntaTION on Clinical Outcomes in Patients with AnteRior Wall ST-segment Elevation Myocardial Infarction (INNOVATION-CORE) Objectives) To evaluate the…
- Trial name
- INNOVATIONCORE (NCT03744000)
- Testing
- Immediate stenting, Deferred stenting
- Where
- South Korea
- Volunteers
- 185 people
- Sponsor
- Korea University Anam Hospital
ST Elevated Myocardial Infarction
Rituximab in Patients With ST-elevation Myocardial Infarction
The main objective is to compare the effect of a single injection of two doses of rituximab versus placebo on 6 months left ventricular systolic function, using CMR, in patients who have had an acute anterior STEMI.
- Trial name
- RITA-MI2 (NCT05211401)
- Testing
- Active arm 1000 mg
- Where
- France
- Volunteers
- 372 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anterior Wall Myocardial Infarction
The Enhanced Angiogenic Cell Therapy - Acute Myocardial Infarction Trial
This will be the first clinical trial to include a strategy designed to enhance the function of autologous progenitor cells by overexpressing eNOS, and the first to use combination gene and cell therapy for the treatment of…
- Trial name
- ENACT-AMI (NCT00936819)
- Testing
- Plasma-Lyte A and 25% Autologous Plasma, Autologous EPCs, Autologous EPCs Transfected with human eNOS
- Where
- 3 sites in Canada
- Volunteers
- 47 people
- Sponsor
- Ottawa Hospital Research Institute