Clinical trials: Anterior Segment Diseases
Uveitis
PANDA-ASOCT: Paediatric Anterior Uveitis Detection With Automated Image Analysis Using ASOCT
Uveitis is an inflammation inside the eye. Although rare, it is an important auto-inflammatory eye condition that affect children and young people (CYP).
- Trial name
- PANDA (NCT07813598)
- Testing
- Slit Lamp Examination, Anterior segment ocular coherence tomography (ASOCT)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Diabetes, Proteinuria
The Effect of Renin Angiotensin System Blockage (RAS) Blockade On PTX3 Levels In Diabetic Patients With Proteinuria
Long pentraxin 3 (PTX3) is a recently discovered multimeric inflammatory mediator structurally linked to CRP and serum amyloid P-component.
- Conditions
- Diabetes, Proteinuria, Renin Angiotensin System
- Trial name
- NCT00674596
- Testing
- ramipril
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Anophthalmia, Microphthalmia
National Cohort on Congenital Defects of the Eye
Congenital malformations of the eye comprise various developmental defects including microphthalmia, anophthalmia, aniridia, and anterior segment anomalies (such as Peters and Axenfeld-Rieger anomalies).
- Conditions
- Anophthalmia, Microphthalmia, Aniridia, Anterior Segment Dysgenesis 6, Peters Anomaly Subtype
- Trial name
- RaDiCoACOEIL (NCT05954403)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cataract Extraction
Comparison of Acular LS With Lotemax to Prevent Inflammation After Cataract Surgery and Intraocular Lens Implantation
The purpose of this study is to compare the effectiveness of Acular LS® and Lotemax® in the prevention of inflammation in the eye after cataract surgery. Acular LS is made by Allergan, Inc.
- Trial name
- NCT00366691
- Testing
- Acular LS, Lotemax
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Inflammation Eye
Evaluation of Inflammation of the Anterior Segment by Laser Flashmeter in Patients Having Undergone Surgery of the Posterior Segment (Vitrectomy or Preindentation) During the First Postoperative Year. (FLAVIC)
Observational study, monocentric, prospective, descriptive and comparative (eye operated vs fellow eye).
- Trial name
- FLAVIC (NCT03677700)
- Testing
- Laser Flare Meter
- Volunteers
- 100 people
- Sponsor
- Rennes University Hospital
Strabismus, Tomography, Optical Coherence
Measurement of Insertion of Extraocular Muscles Using Anterior Segment Optical Coherence Tomography
Study designed to determine the ability and accuracy of anterior segment optical coherence tomography (AS-OCT) to measure the distance between the corneoscleral limbus and the insertion site of the extraocular muscles (EOM) in…
- Trial name
- NCT02454920
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Miami
Pseudoexfoliation Syndrome, Biomechanical Parameters
Corneal Biomechanics, Optical Properties and Anterior Segment Structural Features in Patients With Pseudoexfoliation
The purpose of this study is to assess the effect of pseudoexfoliation syndrome on corneal biomechanics, optical clarity of the cornea, and anterior segment structural features.
- Conditions
- Pseudoexfoliation Syndrome, Biomechanical Parameters, Corneal Densitometry
- Trial name
- CorPEX (NCT06731530)
- Testing
- Pentacam-AXL, HD Analyzer, Corvis ST
- Where
- Greece
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Vitrectomy, Cataract
Triamcinolone Assisted Anterior Vitrectomy
Injecting Triamcinolone acetenoide for visualizing and removing vitreous from the anterior chamber.
- Trial name
- NCT01051648
- Testing
- Intra ocular injection of triamcinolone acetonide
- Where
- 2 sites in Egypt
- Volunteers
- 10 people
- Sponsor
- Cairo University
Diabetes Mellitus
AS-OCT Study in Diabetic Retinopathy
This study evaluates the corneal features using anterior segment - optical coherence tomography in patients affected by type 2 diabetes mellitus
- Trial name
- NCT04992325
- Testing
- Anterior segment-optical coherence tomography
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Federico II University
Cataract
A Clinical Investigation of MINIVISC® PLUS 14 mg/ml Fermented Ophthalmic Viscosurgical Device (OVD-F), Used for Cataract Surgery and Implantation of Intraocular Lenses, Glaucoma Surgery, Anterior Segment Surgery and Corneal Transplantation (CGAC)
A clinical investigation to confirm the clinical safety and performance of OVD-F device MINIVISC® PLUS 1.4 % for cataract surgery and implantation of intraocular lenses, glaucoma surgery, anterior segment surgery and corneal…
- Trial name
- Minivisc01 (NCT07184437)
- Testing
- OVD-F device Minivisc®PLUS 14 mg/ml
- Where
- 6 sites in Belgium, Sweden
- Volunteers
- 134 people
- Sponsor
- Bohus Biotech AB
Keratoconus
Assessment of Corneal Stiffness in Keratoconus After Crosslinking by Corvis ST and OCT.
Objectives: Measurement of corneal stiffness parameters { Deformation Amlitude (DAR1), Integrated radius, Stress parameter (SP A1), Stress strain index (SSI) and Corvis biomechanical index (CBI) } in keratoconic corneas before…
- Trial name
- NCT05161052
- Testing
- Corvis ST (dynamic Scheimpflug technology)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cataract
A Cataract Surgery Clinical Trial
The purpose of the study is to compare the efficiency and safety of UNITY™ Vitreoretinal Cataract System (UNITY VCS) to CENTURION® Vision System with Active Sentry (CAS) in adult subjects with grade 2 or greater nuclear sclerotic…
- Trial name
- NCT07044674
- Testing
- UNITY Vitreoretinal Cataract System, CENTURION Vision System with Active Sentry, Anterior segment ophthalmic surgery
- Where
- 5 sites in United States
- Sponsor
- Alcon Research
Dry Eye
Cyclosporine 0.1% / Loteprednol 0.2% Effect on Anterior Segment Normalization
The CLEAN Study: Cyclosporine 0.1% / Loteprednol 0.2% Effect on Anterior Segment Normalization-A Prospective Cohort Study of Combination Therapy in the Treatment of Dry Eye
- Trial name
- CLEAN (NCT05322148)
- Testing
- Klarity CL, Cylcosporine 0.1%/Loteprednol Etabonate 0.2% Preservative Free
- Where
- 3 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Research Insight LLC
Neurotrophic Keratitis, Neurotrophic Keratopathy
Open-label Trial to Evaluate Efficacy and Safety of rhNGF on Corneal Thickness Via AS-OCT in Neurotrophic Keratitis
Primary Objective: To assess the efficacy of cenegermin-bkbj (20 mcg/mL) ophthalmic solution on overall corneal thickness via AS-OCT in patients with stage 3 neurotrophic keratitis with respect to change from baseline at weeks 4…
- Conditions
- Neurotrophic Keratitis, Neurotrophic Keratopathy, Corneal Ulcer
- Trial name
- IMAGO (NCT06411145)
- Testing
- OXERVATE® 0.002%
- Sponsor
- Dompé Farmaceutici S.p.A
Congenital Cataract, Microphthalmos
Biometric Characteristics of the Eye With Microcornea/Microphthalmia and Congenital Cataract Before And After Cataract Extraction
Early cataract surgery in microcornea/microphthalmia eyes is essential to prevent amblyopia and improve visual outcomes, including stereopsis.
- Conditions
- Congenital Cataract, Microphthalmos, Microcornea
- Trial name
- NCT04759560
- Where
- Egypt
- Volunteers
- 133 people
- Sponsor
- Alexandria University
Angle Glaucoma Open
Incidence of Descemet Membrane Detachment Post GATT by AS OCT
detection of Incidence of Descemet membrane detachment post gonioscopy-assisted transluminal trabeculotomy by anterior segment optical coherence tomography in patients with open angle glaucoma.
- Trial name
- NCT05932940
- Testing
- Gonioscopy-Assisted Transluminal Trabeculotomy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Dry Eyes
Reproducibility of Anterior Segment Optical Coherence Tomography (AS-OCT) for Imaging Conjunctivochalasis
Conjunctivochalasis refers to loose redundant, non-edematous inferior conjunctiva that is situated between the globe and lower eyelid, and usually it occurs bilaterally.
- Trial name
- NCT01933178
- Testing
- Cirrus AS-OCT
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Myocardial Infarction
AMI-DC in Patients With Anterior Wall Myocardial Infarction
The purpose of this trial is to assess the safety of AMI-DC treatment. The participants who voluntarily sign the consent form will be screened according to the inclusion/exclusion criteria then allocated either to the…
- Trial name
- AMI-DC (NCT05554484)
- Testing
- Autologous peripheral blood-derived tolerogenic dendritic cells
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- The Catholic University of Korea
Intraoperative Floppy Iris Syndrome, Cataract
Pupillary Dilator Muscle Thickness as a Potential Predictor of Intraoperative Floppy Iris Syndrome
Intraoperative Floppy Iris Syndrome (IFIS) is a potencial complication encountered during cataract surgery in patients treated with α1-adrenergic receptor antagonists (α1-ARAs) for lower urinary tract symptoms.
- Conditions
- Intraoperative Floppy Iris Syndrome, Cataract, Age-related Cataract, Adrenergic Receptor Antagonist Adverse Reaction
- Trial name
- NCT07517094
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital Olomouc
Keratoconus, Forme Fruste Keratoconus
Corneal Biomechanical Properties and Anterior Segment Parameters, in Forme Fruste Keratoconus
The present study attempts to evaluate the diagnostic capacity of a) anterior segment parameters b) biomechanical metrics and c) a combination model, in differentiating Forme Fruste Keratoconus (FFK) from healthy corneas.
- Trial name
- NCT01448408
- Where
- Greece
- Sponsor
- Democritus University of Thrace