Clinical trials: Anthracyclines
Breast Cancer
Vinorelbine and Gemcitabine Versus Capecitabine in Pretreated Metastatic Breast Cancer
The combination of vinorelbine and gemcitabine seems to be an important part of the chemotherapy regimens used in metastatic breast cancer patients following treatment failure with the combination of a taxane and an…
- Trial name
- NCT00431106
- Testing
- Gemcitabine, Capecitabine, Vinorelbine
- Where
- 10 sites in Greece
- Volunteers
- 144 people
- Sponsor
- Hellenic Oncology Research Group
Triple-negative Breast Cancer
A Phase II Study of Chiauranib in Combine With Capecitabine in TNBC
This study is to evaluate the preliminary efficacy and safety of chiauranib in combine with capecitabine in advanced triple-negative breast cancer failed to prior anthracyclines and taxanes therapy
- Trial name
- NCT05336721
- Testing
- Chiauranib, capecitabine
- Where
- 4 sites in China
- Volunteers
- 9 people
- Sponsor
- Chipscreen Biosciences, Ltd.
Acute Myeloid Leukemia
Study of Dendrogenin A / Oxysterols Balance Between Healthy Volunteers and Acute Myeloid Leukemia Patients
Dendrogenin A is present in mammals normal tissues and fluids, notably blood. It is down-represented or absent in cancer cell lines and tumors.
- Trial name
- OXYLAM (NCT02602587)
- Testing
- Blood sample, Bone marrow sample
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Endometrial Carcinoma
Combination Chemotherapy of Paclitaxel and Carboplatin With or Without Anthracycline as Aneo Adjuvant Treatment in Advanced Endometrial Carcinoma
Endometrial cancer, the most common gynecologic cancer worldwide, is steadily increasing in developed countries.The early-stage forms of endometrial cancer are usually highly curable by surgical treatment alone, whereas advanced…
- Trial name
- NCT06102252
- Testing
- Paclitaxel/epirubcin/carboplatin, Paclitaxel/carboplatin
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sohag University
Breast Cancer
Capecitabine Compared With Vinorelbine in Treating Women With Metastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known if capecitabine is more effective than vinorelbine in treating metastatic breast cancer.
- Trial name
- NCT00049660
- Testing
- capecitabine, vinorelbine tartrate
- Where
- 12 sites in Belgium, France and 3 more
- Volunteers
- 47 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Non-Muscle Invasive Bladder Urothelial Carcinoma
Irinotecan Liposomes Combined with Epirubicin in Recurrent Non-muscle Invasive Bladder Urothelium Carcinoma After Anthracyclines Treatment
The goal of this clinical trial is to learn the dose-limiting toxicity of the new combined treatment with irinotecan liposomes (intravenous injection) and epirubicin (intravesical instillation) in anthracyclines treatment-failed…
- Trial name
- NCT06766266
- Testing
- Irinotecan liposome II combination therapy regimen
- Where
- China
- Volunteers
- 18 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Advanced Breast Cancer
A Randomised,Multi-Center Study of Docetaxol Plus Capecitabine or Cisplatin in Anthracycline-Pretreated Patients With Advanced Breast Cancer
Docetaxol plus capecitabine regimen is the standard treatment for the anthracycline-pretreated patients with advanced breast cancer.
- Trial name
- NCT00717951
- Testing
- docetaxol, cisplatin, capecitabine
- Volunteers
- 120 people
- Sponsor
- Academy Military Medical Science, China
Breast Cancer
Irinotecan and Cetuximab in Treating Patients With Metastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00275041
- Testing
- cetuximab, irinotecan hydrochloride
- Volunteers
- 21 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Cancer
Trastuzumab Administered Concurrently or Sequentially to Anthracycline-containing Adjuvant Regimen for Breast Cancer
Most of the published data support the preferential use of an anthracycline-containing adjuvant regimen for individuals with HER2-positive tumors.
- Trial name
- NCT01413828
- Testing
- concurrent, sequential
- Where
- China
- Volunteers
- 201 people
- Sponsor
- Peking Union Medical College Hospital
Neoplasms
Low-dose CT-based Method for Detection of Subclinical Anthracycline-induced Cardiotoxicity
Prospective single arm study to evaluate a low-dose CT-based protocol for early detection of myocardial dysfunction in 50 cancer patients undergoing anthracycline-based chemotherapy.
- Trial name
- NCT03553654
- Testing
- low dose CT
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of California, San Diego
Breast Cancer
Developing a Diagnostic Tool to Predict Response to Chemotherapy
Every year nearly 62,000 people are diagnosed with breast cancer in the UK. One in eight women in the UK will develop breast cancer in their lifetime.
- Trial name
- SPAG5 (NCT04277195)
- Testing
- SPAG5 Assay
- Where
- United Kingdom
- Volunteers
- 4,750 people
- Sponsor
- Nottingham University Hospitals NHS Trust
0.5-14 Year Old Children With Nephroblastoma
Combination Therapy of Anthracyclines for Children With Nephroblastoma
This study aims to estimate the efficacy and side effects of study drugs in children with nephroblastoma who are treated with combination therapy.
- Trial name
- NCT03892330
- Testing
- Vincristine, Oxytetracycline/ Cyclophosphamide, Liposomal doxorubicin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shengjing Hospital
Breast Cancer
An All-Oral Combination of Capecitabine and Cyclophosphamide in Patients With Metastatic Breast Cancer (MBC)
The primary objective of this study is to evaluate the time to progression. Secondary objectives are safety, OS and pharmacogenetic analysis. Sixty patients will be enrolled into this study.
- Trial name
- NCT00589901
- Testing
- capecitabine and cyclophosphamide
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fudan University
Metastatic Breast Cancer
Gemcitabine Plus Cisplatin Single Dose Versus Split Dose in the Treatment of Patients With Locally Advanced or Metastatic Breast Cancer After Failure of Anthracyclines and/or Taxanes
This is an open label, two arms, randomized, unblinded phase 2 study in patients with locally advanced or metastatic breast cancer who have been previously treated with anthracycline with/without taxane based regimen in the…
- Trial name
- NCT00192101
- Testing
- gemcitabine, cisplatin
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- Eli Lilly and Company
Glioblastoma
Evaluate the Role of Anthracycline After Radio Therapy in Patients With Glioblastoma (pGBM).
Glioblastoma (GBM) and diffuse intrinsic bridge gliomas (DIPG) only the most aggressive forms of cancer, and their prognosis remains bleak.
- Trial name
- NCT06297512
- Testing
- Radiotherapy, Temozolomide, Doxorubicin
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Iacopo Sardi
Breast Neoplasm
Safety Study of CAELYX in Patients With Metastatic Breast Cancer Previously Treated With Anthracyclines (Study P04057)(TERMINATED)
The purpose of this study is to evaluate the cardiac safety of Caelyx in patients with metastatic breast cancer who have previously received chemotherapy with anthracyclines.
- Trial name
- NCT00779285
- Testing
- Pegylated Liposomal Doxorubicin
- Volunteers
- 1 people
- Sponsor
- Merck Sharp & Dohme LLC
Breast Cancer, Neoplasm Metastasis
Vinorelbine Versus Gemcitabine Plus Vinorelbine in Metastatic Breast Cancer Patients
This is a multicenter, randomized, prospective, Phase III study in which patients with advanced breast carcinoma previously treated with anthracyclines and taxanes will be randomly assigned to receive one of two treatment…
- Trial name
- NCT00128310
- Testing
- Vinorelbine, Gemcitabine
- Where
- 2 sites in Spain, Venezuela
- Volunteers
- 252 people
- Sponsor
- Spanish Breast Cancer Research Group
Soft Tissue Sarcoma
Study in Patients With Advanced Soft Tissue Sarcoma (STS) After Failure of Anthracyclines and/or Ifosfamide
This is an observational, non-randomized, open label, multicenter, phase IV study, which aims to reflect a real-life practice routinely used for the management of advanced soft tissue sarcoma after failure of anthracyclines…
- Trial name
- NCT01299506
- Where
- 5 sites in Netherlands
- Volunteers
- 102 people
- Sponsor
- PharmaMar
Heart Failure
Ability of L-carnitine to Prevent Heart Damage in Breast Cancer Patients Receiving Anthracycline Chemotherapy
Breast cancer is very common and afflicts 1 in 9 North American women. The treatment of breast cancer often requires the use of chemotherapy including "anthracyclines".
- Trial name
- NCT00247975
- Testing
- L-carnitine
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Cardiac Toxicity, Unspecified Childhood Solid Tumor, Protocol Specific
Enalapril in Treating Heart Damage Patients Who Received Anthracycline Chemotherapy for Childhood Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs, such as enalapril, may protect normal cells from the toxic effects of chemotherapy.
- Trial name
- NCT00003070
- Testing
- enalapril maleate, quality-of-life assessment
- Where
- 61 sites in United States, Canada and 1 more
- Volunteers
- 13 people
- Sponsor
- Children's Oncology Group