Clinical trials: Anti-Infective Agents
Sinusitis
Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children
The investigators objective is to compare short course (5 days) to long course (14 days)antibiotics for the treatment of acute bacterial sinusitis in children.
- Trial name
- NCT01166945
- Testing
- Amoxicillin-Potassium Clavulanate Combination
- Where
- 2 sites in United States
- Volunteers
- 98 people
- Sponsor
- University of Wisconsin, Madison
Communicable Diseases, Infection
Probiotics to Promote Intestinal Health
The purpose of this study is to evaluate the effectiveness of bacteria called Lactobacillus GG, a Probiotic, in preventing the growth of resistant bacteria in the digestive tract in patients on broad spectrum antimicrobials.
- Conditions
- Communicable Diseases, Infection, Anti-Infective Agents, Therapeutic Uses
- Trial name
- NCT02046512
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Washington University School of Medicine
HIV Infections
A Double-Blind Study to Evaluate the Safety and Pharmacokinetics of L-Ofloxacin (RWJ 25213) in Subjects With HIV Infection
To determine the safety and pharmacokinetics of L-ofloxacin (RWJ 25213) in patients with HIV infection.
- Trial name
- NCT00002249
- Testing
- Levofloxacin
- Where
- United States
- Sponsor
- R W Johnson Pharmaceutical Research Institute
Infection, Pneumonia
To Evaluate the Treatment Effect of an Anti-Infective Agent for Different Kinds of Infections (0826-052)
To collect clinical response data with the use of ertapenem in approved indications.
- Conditions
- Infection, Pneumonia, Urinary Tract Infection
- Trial name
- NCT00398099
- Testing
- MK0826, ertapenem sodium / Duration of Treatment: 14 Days
- Volunteers
- 30 people
- Sponsor
- Merck Sharp & Dohme LLC
Urinary Tract Infections, Acute Pyelonephritis
Safety and Efficacy Study of Cefepime/VNRX-5133 in Patients With Complicated Urinary Tract Infections
This study will assess the safety and efficacy of cefepime/VNRX-5133 compared with meropenem in both eradication of bacteria and in symptomatic response in patients with cUTIs.
- Trial name
- CERTAIN-1 (NCT03840148)
- Testing
- Cefepime/VNRX-5133 (taniborbactam), Meropenem
- Where
- 78 sites in United States, Argentina and 13 more
- Volunteers
- 661 people
- Sponsor
- Venatorx Pharmaceuticals, Inc.
Dental Caries
The Use of Antimicrobial Agents in the Inhibition of Mutans Streptococci in Children With Dental Caries
The aim of the present study was to compare salivary MS levels in four different groups of children with caries, that have been submitted to intraoral topical treatment with either 1,23% sodium fluoride, 1% chlorhexidine, 3% or…
- Trial name
- NCT00612469
- Testing
- Sodium Fluoride, vancomycin hydrochloride, chlorhexidine digluconate
- Where
- Brazil
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Ceara
Hematological Neoplasms
Dose Individualization of Antineoplastic Drugs and Anti-Infective Drug in Children With Hematoplastic Disease
The investigators' purpose was to assess the feasibility of dosage individualization of the commonly used antineoplastic drugs and anti-infective drugs in children with hematoplastic disease.
- Trial name
- NCT03844360
- Testing
- Bortezomib, Eltrombopag, Imatinib
- Where
- 2 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Wei Zhao
Sepsis, Acute Kidney Injury
A Pharmacokinetics Study of Meropenem and Piperacillin in Patients With Sepsis
This study was a single-center, open clinical study in Chinese septic patients with or without acute kidney injury. The aims of this study were to obtain the blood concentration and pharmacokinetic parameters of meropenem and…
- Trial name
- APSOMAPIPWS (NCT05807217)
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Shen Ning
Antimicrobials, Subcutaneous Injection
Pharmacokinetics and Safety of Antimicrobial Agents Administered by Subcutaneous Route in Patients AGEd Over 65 Years
Elderly people are more prone to develop infection with a poorer prognosis compared to young people. Physicians may encounter difficulties regarding antimicrobial agents administration route.
- Conditions
- Antimicrobials, Subcutaneous Injection, Antibiotic, Older People
- Trial name
- PhASAge (NCT03583749)
- Testing
- Subcutaneous (SC) route for antibiotic treatment, Intravenous (IV) route for antibiotic treatment
- Where
- 5 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Bordeaux
Infection, Surgery
Topical Vancomycin for Neurosurgery Wound Prophylaxis
This study is a collaboration between New York Presbyterian (NYP)-Columbia and NYP-Cornell that seeks to evaluate the use of topical vancomycin and its reduction on surgical site infection (SSI) in neurosurgical procedures.
- Conditions
- Infection, Surgery, Nervous System Diseases
- Trial name
- Vanguard (NCT02284126)
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 1,103 people
- Sponsor
- Columbia University
Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis
Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections)
The purpose of this study is to evaluate the effects of Ceftazidime Avibactam compared to Doripenem for treating hospitalized patients with complicated urinary tract infections, including acute pyelonephritis
- Trial name
- NCT01595438
- Testing
- Ceftazidime - Avibactam ( CAZ-AVI), Doripenem, Either switch to oral therapy: 500 mg of Ciprofloxacin (oral)
- Where
- 80 sites in United States, Argentina and 20 more
- Volunteers
- 598 people
- Sponsor
- Pfizer
Anti-Infective Agents
Cross-over Study to Prove Bioequivalence Between Two Brands of Cefalexin Suspension
A single dose, two treatments (two cephalexin suspension brands), two sequences, cross-over design was used with a washout of 7 days between the two study periods.
- Trial name
- NCT01073540
- Testing
- Cephalexin suspension (Optocef, BAYO5448), Cephalexin suspension (Keflex)
- Where
- Mexico
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Bayer
Periimplantitis, Dental Plaque
Antimicrobial Activity of Two Mouthwashes
This is a three arm randomized trial. The aim is to evaluate the antimicrobial activity of chlorhexidine and polyhexamethylene biguanide oral antiseptics on the microorganisms of the oral cavity.
- Conditions
- Periimplantitis, Dental Plaque, Periodontal Diseases, Caries
- Trial name
- NCT02375178
- Testing
- chlorhexidine, Polyhexamethylene biguanide, Sterile saline solution
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade do Vale do Sapucai
Infectious Diseases of Spine
Model-informed Individualized Treatment of Anti-Infective Drugs in Patients With Spinal Infections
The purpose of this study is to describe the population pharmacokinetic characteristics in patients with suspected/confirmed spinal infections who are undergoing anti-infective drug therapy, and to evaluate effectiveness and…
- Trial name
- NCT06711575
- Testing
- Anti-Infective Drugs
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shandong University
Infectious Disease
Antibiotic Outbreak, Risk Factors for Never Event, Prediction of Inappropriate Use
In order to decrease inappropriate antibiotic use, drivers of inappropriate use must be identified locally. This study will focus on the MOST inappropriate use, which are defined as 'never events'.
- Trial name
- NCT03489330
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Midwestern University
Phythoterapy, Venipuncture Site Numbness
Antiseptic and Analgesic Action Acmella Oleracea Skin: Randomized Clinical Trial
Context: Research on natural products with therapeutic, analgesic or antimicrobial purpose should be encouraged to create new drugs.
- Conditions
- Phythoterapy, Venipuncture Site Numbness, Antimicrobial, Analgesic
- Trial name
- NCT02792972
- Testing
- A. oleracea, 70% alcohol
- Volunteers
- 60 people
- Sponsor
- Ana Beatriz Alkimim Teixeira Loyola
Anti Infective, Pediatric Population
Evaluation of the Prevalence of Anti-infective Drug Compliance in Pediatric Patients Hospitalized at Nimes University Hospital After Return Home
Nowadays, resistance to anti-infectives has become a global public health problem and its increased prevalence threatens human health.
- Trial name
- PEDIAOBST (NCT04009785)
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Urinary Tract Infections, Pyelonephritis
Safety, Tolerability, and Efficacy of MK-7655 (Relebactam) + Imipenem/Cilastatin Versus Imipenem/Cilastatin Alone for Treating Complicated Urinary Tract Infection (cUTI) (MK-7655-003)
The purpose of this study is to evaluate the efficacy, safety and tolerability of adding 125 mg or 250 mg doses of MK-7655 (relebactam) to imipenem/cilastatin in adults 18 years or older with complicated urinary tract infection…
- Trial name
- NCT01505634
- Testing
- Relebactam 250 mg, Relebactam 125 mg, imipenem/cilastatin 500 mg
- Volunteers
- 302 people
- Sponsor
- Merck Sharp & Dohme LLC
Urinary Tract Infections
INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI
Women have problems with oral antibiotics, including vagina and bowel infections. Also, bacteria causing urinary infections are becoming more resistant to oral antibiotis.
- Trial name
- INSTANT (NCT03299387)
- Testing
- Nitrofurantoin, Gentamicin
- Sponsor
- Mayo Clinic
Anti-Bacterial Agents, Respiratory Tract Infections
Improving Antimicrobial-Prescribing in Emergency Departments
Antimicrobial resistance is one of today's most urgent public health problems. One of the most important strategies to slow the spread of antimicrobial resistance is the promotion of judicious antimicrobial use.
- Trial name
- NCT03349567
- Testing
- Audit-and-feedback
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Iowa City Veterans Affairs Medical Center