Clinical trials: Anti-Infective Agents
Complicated Skin and Skin Structure Infections
Efficacy and Safety Study of JNJ-32729463 for Treating Complicated Skin and Skin Structure Infections Compared to Linezolid (Zyvox)
The purpose of this study is to determine the clinical efficacy, safety, and tolerability of a 250 mg BID oral dose of JNJ-32729463 compared with linezolid in subjects with complicated skin and skin structure infections (cSSSIs).
- Trial name
- NCT01128530
- Testing
- JNJ-32729463, linezolid
- Where
- 27 sites in United States
- Volunteers
- 161 people
- Sponsor
- Furiex Pharmaceuticals, Inc
Pseudomonas Infections, Pseudomonas Aeruginosa
Antimicrobial Therapy for Difficult-to-treat Pseudomonas Aeruginosa
The primary objective of the ADDICT study is to assess and compare the clinical efficacy of available options for antimicrobial therapy (new beta-lactam/beta-lactamase inhibitor combination, cefiderocol or older agents such as…
- Conditions
- Pseudomonas Infections, Pseudomonas Aeruginosa, Prognosis, Drug Resistance, Multiple, Bacterial
- Trial name
- ADDICT (NCT06738771)
- Where
- 48 sites in France, Reunion
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Fungal Infection, Acute Myelogenous Leukemia
Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115)
The purpose of this study is: to explore the potential for different dosing strategies of posaconazole oral suspension (POS) to increase plasma levels and to profile the pharmacokinetics of these dosing strategies in patients…
- Conditions
- Fungal Infection, Acute Myelogenous Leukemia, Neutropenia
- Trial name
- NCT00686543
- Testing
- Posaconazole
- Volunteers
- 75 people
- Sponsor
- Merck Sharp & Dohme LLC
COVID-19 SARS-CoV-2 Infection
A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease
The purpose of the study is to evaluate whether ibuzatrelvir is effective and safe in adults and adolescents with COVID-19 who do not need to be in the hospital but who are at high risk for progression to severe disease.
- Trial name
- NCT06679140
- Testing
- ibuzatrelvir
- Where
- 256 sites in United States, Argentina and 17 more
- Volunteers
- 2,330 people
- Sponsor
- Pfizer
Pregnancy, Malnutrition in Pregnancy
Nutritional and Anti-infective Interventions for Malnutrition in Pregnancy (Beleuman Welbodi)
Acute malnutrition in pregnancy is a risk factor for adverse outcomes in mothers and their unborn children. Undernutrition during pregnancy can result in maternal complications such as life-threatening hemorrhage and hypertensive…
- Conditions
- Pregnancy, Malnutrition in Pregnancy, Nutrition Disorders, Stunting
- Trial name
- NCT03079388
- Testing
- Ready-to-use-supplementary food, Corn-soy-blend, Monthly intermittent preventive treatment of malaria during pregnancy (IPTp)
- Where
- Sierra Leone
- Volunteers
- 1,489 people
- Sponsor
- Washington University School of Medicine
Hepatitis C, Chronic, Liver Diseases
Cellular Immune Responses in the Liver in Chronic Hepatitis C (CHC) Patients
In order to persist in the liver, HCV has numerous nonspecific and specific strategies to overcome the immunity of the host. The crucial step in the establishment of viral persistence and chronic hepatitis is the avoidance of…
- Conditions
- Hepatitis C, Chronic, Liver Diseases, Virus Diseases
- Trial name
- NCT01062659
- Where
- Germany
- Sponsor
- University of Ulm
Acute Kidney Insufficiency, Anti-Infective Agent Toxicity
Computer-based Dosage Calculation for Antibiotics
Adequate dosing of antiinfective therapy in critically ill patients with impaired or lost renal function or continuous renal replacement therapy is nearly impossible without measuring the drug concentration in blood samples.
- Trial name
- NCT03036826
- Testing
- Piperacillin/tazobactam, Meropenem
- Where
- Germany
- Sponsor
- University Hospital Tuebingen
Heart Failure, Implant Infection
Complications in Pediatric Mechanical Circulatory Assistance: Evaluation of Infection Management.
End-stage heart failure in children is a rare cause of infant mortality. The most frequent cause is dilated cardiomyopathy, often of undetermined origin, which can lead to cardiogenic shock refractory to standard medical…
- Trial name
- VADINFECT (NCT05983341)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Sepsis
To Evaluate the Treatment Effect of an Anti-Infective Agent for Complicated Infections (0826-053)
To collect clinical response data with the use of ertapenem in community acquired sepsis.
- Trial name
- NCT00397956
- Testing
- MK0826, ertapenem sodium / Duration of Treatment: 14 Days
- Volunteers
- 30 people
- Sponsor
- Merck Sharp & Dohme LLC
Halitosis
Clinical Evaluation of Some Local Antimicrobial Agents' Adjunctive Effects On Periodontal Parameters and Halitosis
The aim of this trial was to establish the clinical efficacy of Listerine and chlorhexidine (CHX) when used as a cooling agent with ultrasonic instrumentation, on periodontal parameters and halitosis.
- Trial name
- NCT03468595
- Testing
- ultrasonic (Piezon Master 700) performed with Listerine, ultrasonic (Piezon Master 700) performed with CHX, ultrasonic (Piezon Master 700) performed with serum
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey
Infection
Pharmaceutical Consultation at Hospital Discharge and Adherence to Anti-infective Treatment
The main objective of this study is to evaluate the impact of a pharmaceutical consultation at the time of hospital discharge on the adherence of patients ; non-adherence is determined by the following criteria: As concerns…
- Trial name
- CPS-INFECTIO (NCT02126930)
- Testing
- Pharma consult, Routine care
- Where
- France
- Volunteers
- 174 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Normal Physiology
Volunteer Screening for Vaccine and Antivirals Clinical Trials
Background: Vaccines and antiviral therapies are critical for preventing and treating viral diseases. Testing these vaccines and drugs often requires healthy volunteers.
- Trial name
- NCT01593709
- Where
- United States
- Volunteers
- 359 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Phase I Study of Safety and Persistence of UC-781 Vaginal Microbicide
Vaginal microbicides are compounds that may protect women from HIV and other sexually transmitted infections (STIs). This study will determine the safety of the microbicide UC-781 by comparing the effects of keeping the…
- Trial name
- NCT00441909
- Testing
- UC-781
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Population Modeling of Anti-infective Drugs
Translational PKPD Modeling of Anti-infective Drugs Used in Pediatric Units.
Pharmacokinetic and pharmacodynamic modeling (PKPD) is becoming an essential tool for optimizing pharmacotherapy. Building mechanistic models allows determining the relationship between the dose, concentration, pharmacological…
- Trial name
- NCT05426499
- Testing
- Patients requiring cefotaxime treatment, Patients requiring meropenem treatment, Patients requiring fluconazole treatment
- Where
- 4 sites in Poland
- Volunteers
- 150 people
- Sponsor
- Poznan University of Medical Sciences
Pancreaticoduodenectomy, Antibiotherapy
Postoperative Anti-infective Strategy Following Pancreaticoduodenectomy in Patients With Preoperative Biliary Stent
The main objective of the study is to compare 2 broad-spectrum antibiotic (Piperacillin / Tazobactam) treatment modalities, following pancreaticoduodenectomy in patients with preoperative biliary stent, to demonstrate the…
- Trial name
- FRENCH24 ANIS (NCT06123169)
- Testing
- Antibioprophylaxis (Piperacillin-tazobactam), 5 days Antibiotherapy (Piperacillin-tazobactam)
- Where
- France
- Volunteers
- 326 people
- Sponsor
- University Hospital, Rouen
Gonorrhea
Comparison of Delafloxacin Versus Ceftriaxone for the Treatment of Uncomplicated Gonorrhea
The purpose of this study is to evaluate the effects of a single oral dose of delafloxacin versus a single intramuscular injection of ceftriaxone in subjects with uncomplicated cervical, urethral, rectal, or pharyngeal gonorrhea.
- Trial name
- NCT02015637
- Testing
- Delafloxacin, Ceftriaxone
- Where
- 25 sites in United States
- Volunteers
- 460 people
- Sponsor
- Melinta Therapeutics, Inc.
Urinary Tract Infection, Prostatitis
FOsfomycin for Male Urinary Tract Infection
Male urinary tract infections (MUTI) are often less recognised compared to those in women. French clinical guidelines practices recommend the use of antibiotics called fluoroquinolones, which are highly effective in treating…
- Conditions
- Urinary Tract Infection, Prostatitis, Cystitis
- Trial name
- FOMUTI (NCT06822751)
- Testing
- Fosfomycun-trometamol
- Where
- France
- Volunteers
- 138 people
- Sponsor
- University Hospital, Rouen
Infectious Disease
Antibiotic Outbreak, Risk Factors for Never Event, Prediction of Inappropriate Use
In order to decrease inappropriate antibiotic use, drivers of inappropriate use must be identified locally. This study will focus on the MOST inappropriate use, which are defined as 'never events'.
- Trial name
- NCT03489330
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Midwestern University
Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis
Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections)
The purpose of this study is to evaluate the effects of Ceftazidime Avibactam compared to Doripenem for treating hospitalized patients with complicated urinary tract infections, including acute pyelonephritis
- Trial name
- NCT01595438
- Testing
- Ceftazidime - Avibactam ( CAZ-AVI), Doripenem, Either switch to oral therapy: 500 mg of Ciprofloxacin (oral)
- Where
- 80 sites in United States, Argentina and 20 more
- Volunteers
- 598 people
- Sponsor
- Pfizer
HIV Infections, Anti-Infective Agents
Acceptability Study of Vaginal Films for HIV Prevention
This study is being done to find out what women would want in a film vaginal product for human immunodeficiency virus (HIV) prevention, especially what it should look like and how to apply it.
- Trial name
- FACE (NCT01231763)
- Testing
- No intervention (not applicable)
- Where
- 2 sites in United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh