Clinical trials: Anti-Retroviral Agents
Contraception
A Prospective Observational Study of the Clinical Performance of Femplant in Pakistan
This will be a non-comparative prospective observational study of women using Femplant as a primary method of contraception in Pakistan.
- Trial name
- NCT01463254
- Where
- Pakistan
- Volunteers
- 724 people, healthy volunteers welcome
- Sponsor
- FHI 360
HIV Infections
Pilot Study of Text Message Reminders to Improve HIV Medication Adherence in Botswana
While medication adherence is critical to successful treatment of HIV, there are few studies of interventions demonstrating improvements in adherence.
- Trial name
- NCT01001741
- Testing
- Cell phone text message
- Where
- Botswana
- Volunteers
- 128 people
- Sponsor
- University of Pennsylvania
HIV I Infection
Low Dose Nivolumab in Adults Living With HIV on Antiretroviral Therapy
The purpose of this study is to evaluate whether a single dose of Nivolumab in people living with HIV can reduce the latent reservoir.
- Trial name
- NIVO-LD (NCT05187429)
- Testing
- Nivolumab 10 MG/ML [Opdivo], Saline
- Where
- 2 sites in Australia, Singapore
- Volunteers
- 42 people
- Sponsor
- University of Melbourne
HIV Infections, Adherence
Adherence-Suppression-Resistance Relationships for Atripla Compared to Historical Antiretroviral Regimens
The study is recruiting 50 patients initiating or switching to Atripla and comparing them to 250 individuals previously followed in a prospective study of HIV+ low income individuals recruited from homeless shelters, single room…
- Trial name
- NCT01006005
- Volunteers
- 51 people
- Sponsor
- University of California, San Francisco
HIV Infections
Immune Response to a Therapeutic HIV Vaccine Followed by Treatment Interruption in Patients With Acute or Recent HIV Infection
The purpose of this study is to determine whether the HIV vaccine MRKAd5 HIV-1 gag/pol/nef followed by treatment interruption can increase immune system function in adults with acute or recent HIV infection who have started…
- Trial name
- NCT00183261
- Testing
- MRKAd5 HIV-1 gag/pol/nef
- Where
- 23 sites in United States, American Samoa and 1 more
- Volunteers
- 25 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infection
A Prospective, Observational Study of Pregnancy Outcomes Among Women Exposed to Truvada for PrEP Indication
This is a prospective, observational study to describe pregnancy outcomes among HIV-1 uninfected pregnant women who are taking emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF) (Truvada®) for a pre-exposure prophylaxis…
- Trial name
- NCT01865786
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Gilead Sciences
HIV Infections
Effectiveness of Adding Interleukin-2 to Anti-HIV Drugs in Patients Recently Infected With HIV
The purpose of this study is to see whether taking interleukin-2 (IL-2) and other anti-HIV drugs affects the course of HIV disease in patients with primary HIV infection (the time period that immediately follows infection with…
- Trial name
- NCT00006441
- Testing
- Lamivudine/Zidovudine, Nelfinavir mesylate, Aldesleukin
- Where
- 2 sites in United States
- Volunteers
- 398 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Study to Define Safety and Effectiveness of Dolutegravir (DTG) Use in Human Immunodeficiency Virus (HIV) Positive Pregnant Women
The purpose of this study is to assess the safety and effectiveness of DTG use in HIV positive pregnant women. This is a 3-year multi-site prospective observational study.
- Trial name
- NCT03564613
- Testing
- DTG
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- ViiV Healthcare
Alcohol Dependence, HIV/AIDS
Targeting Non-virally Suppressed Adults With Alcohol Use Disorder in HIV Primary Care
The proposed pilot study is a randomized feasibility trial of technology-enhanced brief intervention for drinking reduction and antiretroviral therapy (ART) adherence in 60 non-virally suppressed HIV participants who meet…
- Trial name
- NCT04280068
- Testing
- Clinician Guide (CG), Clinician Guide plus HealthCall
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
HIV-infection/AIDS
Vedolizumab Treatment in Antiretroviral Drug Treated Chronic HIV Infection
Background: In nearly all people with human immunodeficiency virus (HIV) infection, immunity cannot either control or eradicate the infection.
- Trial name
- HAVARTI (NCT03147859)
- Testing
- Vedolizumab (brand name Entyvio)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Ottawa Hospital Research Institute
Infection, Human Immunodeficiency Virus
A Prospective, Non-interventional Study of the Use of Dolutegravir as Part of Combination Antiretroviral Therapy in Routine Daily Practice in Germany
DOL-ART is a multi-center, prospective, non-interventional study of the use of doluetegravir as part of an antiretroviral combination therapy in routine daily practice in Germany.
- Trial name
- DOL-ART (NCT02076386)
- Testing
- Dolutegravir
- Where
- 38 sites in Germany
- Volunteers
- 411 people
- Sponsor
- ViiV Healthcare
HIV/AIDS, Depression
Collaborative Care for the Detection and Management of Depression Among Adults Receiving Antiretroviral Therapy in South Africa
With increasing access to antiretroviral therapy (ART) in South Africa, HIV has transitioned from a terminal illness to a long-term condition.
- Conditions
- HIV/AIDS, Depression, Chronic Diseases of Lifestyle
- Trial name
- COBALT (NCT02407691)
- Testing
- Primary care 101 plus mental health, Standard Primary Care 101
- Where
- 2 sites in South Africa
- Volunteers
- 2,002 people
- Sponsor
- University of Cape Town
Tuberculosis
Effect of Public Sector Antiretroviral Treatment Programme on Tuberculosis and Immunization Care
A scale-up of public sector antiretroviral treatment (ART) programmes may divert scarce resources from other priority primary care programmes like tuberculosis and childhood immunization.
- Trial name
- NCT00203762
- Testing
- Public sector antiretroviral treatment programmes
- Where
- South Africa
- Volunteers
- 39 people
- Sponsor
- University of Cape Town
Hiv
Study on PhArmacokinetics of First liNe Antiretrovirals in Healthy Breastfeeding Volunteers
No to little data exists on penetration of antiretroviral drugs in breastmilk. Too high concentrations may lead to infant toxicity and too low concentrations may lead to development of resistance in case the infant inadvertently…
- Trial name
- PANNA-B PK (NCT05648201)
- Testing
- Doravirine 100Mg Tab, Biktarvy 50/200/25 Tab
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Human Immunodeficiency Virus Infection, Diabetes Mellitus
Pilot Study of Bydureon to Treat Diabetes in HIV-infected Adults
This pilot study will evaluate the effects of the anti-diabetic drug Bydureon (exenatide extended-release formulation) on blood sugar levels and serum markers of inflammation in a cohort of 12 HIV-infected adults on combination…
- Trial name
- NCT01791465
- Testing
- extended-release exenatide
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Vanderbilt University
HIV Infections, Lipodystrophy
Effects of Treatment Changes on Fat Wasting in the Arms and Legs of HIV Patients
The goals of this study are to find out if fat wasting and weight loss in the arms and legs of HIV patients taking highly active antiretroviral therapy (HAART) are caused by nucleoside/nucleotide reverse transcriptase inhibitors…
- Conditions
- HIV Infections, Lipodystrophy, Wasting Disease
- Trial name
- NCT00028314
- Testing
- Abacavir sulfate, Atazanavir/Ritonavir, Lopinavir/Ritonavir
- Where
- 25 sites in United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
A Study of a Combination of Four Drugs in Patients With Recent HIV Infection
The purpose of this study is to see if it is safe to give a combination of four anti-HIV drugs to patients recently infected with HIV who have never received anti-HIV treatment.
- Trial name
- NCT00002233
- Testing
- Indinavir sulfate, Abacavir sulfate, Amprenavir
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Glaxo Wellcome
HIV
ACE Inhibitors to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Patients: A Pilot Study
The investigators propose a proof-of-concept, pathogenesis-oriented, randomized, placebo-controlled pilot study to assess whether the addition of an angiotensin converting enzyme (ACE) inhibitor to standard Highly Active…
- Trial name
- NCT01535235
- Testing
- Lisinopril
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of California, San Francisco
HIV Infection
Pharmacokinetics of Atazanavir/Ritonavir in HIV-1 Infected Pregnant Women
To determine what dosing regimen of atazanavir (ATV) / ritonavir (RTV) produces adequate drug exposure during pregnancy compared to drug exposure in historical data in human immunodeficiency virus (HIV) infected participants.
- Trial name
- NCT00326716
- Testing
- Atazanavir + Ritonavir + Combivir
- Where
- 6 sites in United States, Puerto Rico and 1 more
- Volunteers
- 69 people
- Sponsor
- Bristol-Myers Squibb
HIV-Infection
Immediate Versus Deferred Antiretroviral Therapy in HIV-infected Patients Presenting With Acute AIDS-defining Events
The purpose of this study is to compare the early versus deferred initiation of antiretroviral combination therapy consisting of tenofovir, emtricitabine and atazanavir/ritonavir in treatment naive patients who present with an…
- Trial name
- IDEAL (NCT01417949)
- Testing
- Time of starting antiretroviral therapy
- Where
- 17 sites in Germany
- Volunteers
- 61 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.