Clinical trials: Anti-Retroviral Agents
HIV Infections
HIV Resistance and Treatment Strategies
The purpose of this observational study is to characterize which immune system cells hide the latent reservoir of HIV by counting the number of latent HIV in different subsets of CD4 cells.
- Trial name
- NCT00581802
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Insulin Resistance, HIV Infections
Use of a Nutritional Supplement to Treat Diabetic Symptoms in HIV-Infected Adults
The purpose of this study is to determine the effectiveness of the nutritional supplement chromium picolinate in improving insulin resistance, a symptom of diabetes, in HIV-infected patients.
- Trial name
- NT (NCT00109746)
- Testing
- chromium picolinate
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
AIDS-related Lymphoma, HIV Infection
Optimization of Antiretroviral Therapy in Patients With AIDS-Related Lymphoma
The goal of this clinical trial is to evaluate the efficacy and safety of different antiretroviral therapy (ART) strategies in adults with AIDS-related lymphoma (ARL) receiving anti-lymphoma treatment.
- Trial name
- OPT-ARL (NCT07727642)
- Testing
- Oral Antiretroviral Therapy, albuvirtide, Cabotegravir/Rilpivirine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Public Health Clinical Center
Pharmacogenetics, HIV
Individualized Antiretroviral Therapy
The efficacy and safety of antiretroviral therapy and the damage caused by chronic inflammation in the presence of the virus has recently lead to the consideration of initiating antiretroviral therapy earlier than what is…
- Conditions
- Pharmacogenetics, HIV, Drug Monitoring
- Trial name
- IAT (NCT03385473)
- Testing
- Pharmacogenomic index, Therapeutic drug monitoring
- Where
- Argentina
- Volunteers
- 190 people
- Sponsor
- Hospital Italiano de Buenos Aires
Mother-to-child HIV Transmission
The Kabeho Study: Kigali Antiretroviral and Breastfeeding Assessment for the Elimination of HIV
The study design includes an observational prospective cohort of HIV-positive pregnant/postpartum women and their infants enrolled during antenatal clinics (or immediately postpartum) from prevention of mother-to-child…
- Trial name
- Kabeho (NCT02295800)
- Testing
- Standard of care, Semi-structured interviews
- Where
- Rwanda
- Volunteers
- 1,216 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
HIV1 Infection, HIV Infections
Prospective Evaluation Among Patients Infected by HIV 1 in Virological Failure Owing to Lack of Compliance, of the Benefit in Terms of Compliance of an Optimised Antiretroviral Treatment With Enfuvirtide (Fuzeon) Associated With Two Active Molecules
In case of lack of compliance in HIV1 patients, the investigators hope to prove that enfuvirtide injection during almost 3 months, with nurse help at home and therapeutic education may contribute to obtain a good compliance more…
- Trial name
- AMPHORE (NCT00937729)
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Rouen
HIV
Structured Treatment Interruption for HIV Patients With Virologic Failure
The purpose of this study is to assess the virologic impact of switching treatment-experienced HIV-infected patients with virologic failure to a salvage regimen with or without a 12 week STI prior to the switch.
- Trial name
- NCT00188851
- Testing
- therapeutic management strategy
- Volunteers
- 196 people
- Sponsor
- University Health Network, Toronto
HIV
Outcomes for Antiretroviral Therapy Patients Receiving Palliative Care
Despite overwhelming need for effective HIV palliative care in sub-Saharan Africa, a systematic appraisal of the literature found almost no outcome or evaluative evidence.
- Trial name
- TOPCare (NCT01608802)
- Testing
- Palliative care, Standard care
- Where
- 2 sites in Kenya, South Africa
- Volunteers
- 240 people
- Sponsor
- King's College London
HIV Infections
Evaluate the Efficacy and Security of Darunavir/Ritonavir 900/100 mg Once a Day as an Antiretroviral Treatment Simplification Strategy
Basing in studies which have related the darunavir (DRV) virtual inhibitory quotient (vIQ) with the virological response, it is possible to think in the possibility of simplifying the rescue treatment with DRV/ritonavir to…
- Trial name
- DRV900100QD (NCT00611039)
- Testing
- Darunavir 900mg + ritonavir 100 mg once a day, Darunavir 600mg + ritonavir 100mg twice day
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Germans Trias i Pujol Hospital
HIV (Human Immunodeficiency Virus)
Optimizing the Efficiency and Implementation of Cash Transfers to Improve Adherence to Antiretroviral Therapy Phase II
This protocol describes a 2-arm cluster, randomized controlled trial designed to test the effectiveness of a conditional cash transfer on viral suppression at 12 months post-ART initiation among PHWHIV who have initiated ART…
- Trial name
- Afya 2 Phase2 (NCT04201353)
- Testing
- Conditional Cash Transfer
- Where
- Tanzania
- Volunteers
- 1,984 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Tuberculosis, Aids
Comparison of Nevirapine and Efavirenz for the Treatment of HIV-TB Co-infected Patients (ANRS 12146 CARINEMO)
The purpose of this study is to determine whether the use of Nevirapine in HIV patients already treated against tuberculosis by Rifampicin is as efficient and as well tolerated as Efavirenz.
- Conditions
- Tuberculosis, Aids, Hiv Infections
- Trial name
- CARINEMO (NCT00495326)
- Testing
- Nevirapine based therapy, Efavirenz based therapy, Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z)
- Where
- 3 sites in Mozambique
- Volunteers
- 570 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Tuberculosis, Human Immunodeficiency Virus
Contributing Factors for Poor HIV Treatment Response in Children With TB/HIV Coinfection
Efavirenz (EFV)-based antiretroviral therapy (ART) remains the preferred regimen in human immunodeficiency virus (HIV)-infected children aged 3 years or older on rifampin-containing antituberculosis (anti-TB) therapy.
- Conditions
- Tuberculosis, Human Immunodeficiency Virus, Coinfection
- Trial name
- NCT03800407
- Testing
- Observational study
- Where
- Ghana
- Volunteers
- 213 people
- Sponsor
- University of Florida
Infection, Human Immunodeficiency Virus, HIV Infections
ING200336, Pharmacokinetic and Safety Study in Pregnant Women With Human Immuno Virus Infection
In this study, the dolutegravir/abacavir/lamivudine (DTG/ABC/3TC) fixed dose combination (FDC) tablet is being made available to women who become pregnant while participating in study ING117172.
- Conditions
- Infection, Human Immunodeficiency Virus, HIV Infections, Arthralgia
- Trial name
- NCT02075593
- Testing
- DTG 50 mg /ABC 600 mg /3TC 300 mg FDC tablets
- Where
- 3 sites in Russia, Spain
- Volunteers
- 4 people
- Sponsor
- ViiV Healthcare
Human Immunodeficiency Virus
A Study of 2 Different Regimens of Tetravalent Ad26.Mos4.HIV Prime Followed by Boost With Modified Vaccinia Ankara (MVA)-Mosaic OR Ad26.Mos4.HIV Plus a Combination of Mosaic and Clade C gp140 Protein in Human Immunodeficiency Virus (HIV) Type 1 Infected Adults on Suppressive Antiretroviral Treatment
The primary purpose of this study is to assess safety/tolerability of 2 different prime/boost regimens containing adenovirus serotype 26 (Ad26).Mos4.HIV, Modified Vaccinia Ankara (MVA) -Mosaic or adjuvanted Mosaic and Clade C…
- Trial name
- NCT03307915
- Testing
- Ad26.Mos4.HIV, MVA-Mosaic, Clade C gp140 + Mosaic gp140
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Janssen Vaccines & Prevention B.V.
HIV
Validation of System for Monitoring the Effectiveness of Antiretroviral Therapy in HIV-Infected Patients in Africa
This study will evaluate a system for predicting the effectiveness of antiretroviral treatment in African HIV clinics where standard testing methods for measuring viral load, such as RNA polymerase chain reaction, are not…
- Trial name
- NCT00341393
- Where
- Uganda
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Lopinavir/r Monotherapy as Maintenance Therapy After Long Term Viral Suppression
1. Objectives Primary To investigate the possibility of maintaining virological suppression of HIV in infected patients, switching them to LPV/r as the only antiretroviral agent To assess the immunological response in patients…
- Trial name
- NCT00160849
- Testing
- Lopinavir/r
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- Universidade Federal do Rio de Janeiro
HIV Infections
A Comparison of Three Anti-HIV Drug Combinations Containing Saquinavir Soft Gelatin Capsules Used in HIV-1 Infected Patients
To determine the proportion of patients whose plasma HIV-1 RNA level falls below the level of detection (< 400 copies/ml) at week 24 of study therapy.
- Trial name
- NCT00002378
- Testing
- Ritonavir, Nelfinavir mesylate, Saquinavir
- Where
- 102 sites in United States, Germany and 4 more
- Volunteers
- 825 people
- Sponsor
- Hoffmann-La Roche
HIV Infection
Elvitegravir/Cobicistat/Tenofovir DF/Emtricitabine With Darunavir Treatment Simplification Strategy
The study aims to assess the safety and efficacy of darunavir 800mg plus the co-formulated elvitegravir/cobicistat/tenofovir disoproxil fumarate (DF)/emtricitabine (Stribild) tablet as a simplification strategy for the treatment…
- Trial name
- QuaDar (NCT02199613)
- Testing
- Treatment simplification
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of British Columbia
HIV Infections
The Safety and Effectiveness of Bis-POM PMEA in HIV-Infected Patients
To study the safety, tolerance, single and multiple dose pharmacokinetics, and anti-HIV activity of bis-POM PMEA ( adefovir dipivoxil ) versus placebo when administered orally on a daily basis for 2 weeks to HIV-infected patients.
- Trial name
- NCT00002346
- Testing
- Adefovir dipivoxil
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Gilead Sciences
HIV-1 Infection, Acquired Immunodeficiency Syndrome
Qiling Yiqi Tablets Plus Antiretroviral Therapy for HIV Immune Non-responders With Lung-Spleen Qi Deficiency
This pragmatic randomized controlled trial evaluates whether Qiling Yiqi Tablets combined with antiretroviral therapy (ART) improves immune reconstitution in people with HIV who meet criteria for immune reconstitution failure and…
- Conditions
- HIV-1 Infection, Acquired Immunodeficiency Syndrome, Immune Reconstitution Failure, Immunological Non-responder
- Trial name
- QLYQ-INR-pRCT (NCT07698574)
- Testing
- Qiling Yiqi Tablets plus ART, Antiretroviral Therapy (ART)
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing University of Chinese Medicine
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