Clinical trials: Anti-Retroviral Agents
Contraception
Assessing Preference for 3 Female Condoms: A Comparative Evaluation of the PATH Woman's Condom, FC2 and the Reddy 6
Evaluation of preference for three female condoms (FC).
- Trial name
- NCT01452503
- Testing
- Path Women's Condom, FC2 female condom, Reddy 6 female condom (V-Amour)
- Where
- South Africa
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- FHI 360
HIV Infections
Open Label Extension (OLE) of the TDF2 Study, Botswana
This study is an open label and is an extension to the TDF2 study in which the investigators offered daily oral tenofovir/emtricitabine (TDF/FTC) for a maximum of 12 months to HIV uninfected former participants of the TDF2 study.
- Trial name
- TDF2-OLE (NCT04318210)
- Testing
- Tenofovir Disoproxil Fumarate 300 mg + Emtricitabine 200 mg
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Acquired Immunodeficiency Syndrome
Longitudinal Study of HAART, Social Networks, & Adherence
Our study is a randomized controlled trial that aims to evaluate the effectiveness of modified directly observed therapy (mDOT) to (1) increase both short and long term adherence to HAART treatment, and (2) improve clinical…
- Trial name
- NCT00272220
- Testing
- modified directly observed therapy (mDOT)
- Where
- Mozambique
- Volunteers
- 350 people
- Sponsor
- University of Washington
HIV Infections
Monitoring Highly Active Antiretroviral Therapy in HIV-infected Parents in Thailand
The purpose of this study is to determine if a decision to switch to a subsequent antiretroviral regimen based upon the CD4 cell count rather than the standard switching strategy based on viral load could ensure the same…
- Trial name
- NCT00162682
- Testing
- Antiretroviral Drug Combination Switching Criteria
- Where
- 20 sites in Thailand
- Volunteers
- 716 people
- Sponsor
- Institut de Recherche pour le Developpement
HIV Infections
A Comparison of Two Anti-HIV Triple-Drug Combinations in HIV-Infected Patients
The purpose of this study is to compare the safety and effectiveness of two anti-HIV drug combinations when given to HIV-infected patients who have never been treated with anti-HIV drugs.
- Trial name
- NCT00002168
- Testing
- Indinavir sulfate, Lamivudine, Stavudine
- Where
- 13 sites in United States, Puerto Rico
- Volunteers
- 200 people
- Sponsor
- Bristol-Myers Squibb
HIV Infections, Hepatitis C
Effect of a Change in HIV Therapy on Liver Steatosis, Inflammation, and Fibrosis
The purpose of this study is to look at how 2 different anti-HIV drug treatments affect the liver. The use of anti-HIV drugs like the nucleoside reverse transcriptase inhibitors (NRTIs) may be linked to liver problems like fatty…
- Trial name
- NCT00023218
- Testing
- Lopinavir/Ritonavir, Efavirenz
- Where
- 3 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Evaluation of Therapeutic Drug Monitoring of Protease Inhibitors on Virologic Success and Tolerance of Highly Active Antiretroviral Therapy (HAART)
This Cophar2 study is a trial which evaluates repeated early therapeutic drug monitoring, from weeks 2 to 24, after the initiation of HAART including either indinavir/r, lopinavir/r or the new 625 mg formulation of nelfinavir…
- Trial name
- NCT00122590
- Testing
- nelfinavir, lopinavir/r, indinavir
- Where
- France
- Volunteers
- 115 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
HIV Infections
A Study on Possible Interactions Between Protease Inhibitors (Anti-HIV Drugs) and Drugs Which Lower the Level of Fat in Your Blood
The purpose of this study is to find out whether taking protease inhibitors (anti-HIV drugs) together with lipid-lowering drugs (drugs which lower the amount of fat in the blood) has an effect on the level of drugs found in the…
- Trial name
- NCT00000941
- Testing
- Pravastatin sodium, Simvastatin, Atorvastatin calcium
- Where
- 13 sites in United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Evaluation of Low-dose Darunavir in a Switch Study
This is a switch study to assess the non-inferiority (in terms of efficacy and safety) of darunavir (boosted with ritonavir, DRV/r 400mg/100mg daily) when compared with lopinavir (boosted with ritonavir, LPV/r total dose…
- Trial name
- DRV (NCT02671383)
- Testing
- Darunavir, Lopinavir
- Where
- South Africa
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Willem Daniel Francois Venter
HIV Infection
Vitamin D Absorption in HIV Infected Young Adults Being Treated With Tenofovir Containing cART
This is a 48 week randomized double-blind, placebo-controlled prospective cohort study of adolescents and young adults with HIV infection in the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) who are…
- Trial name
- NCT01751646
- Testing
- Vitamin D3 50,000 IU
- Where
- 17 sites in United States, Puerto Rico
- Volunteers
- 214 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infection
Primary Resistance in HIV Patients in Colombia
The investigators' main objective is to determine the prevalence of pre-treatment of resistance-associated mutations (RAMs) in a naïve and recently diagnosed HIV infection in 18 centers from 12 cities in Colombia.
- Trial name
- NCT03957369
- Testing
- HIV-1 plasma RNA Genotyping secuencing by Sanger technique, HIV-1 plasma RNA Genotyping secuencing by Ultra-deep sequencing technique
- Where
- Colombia
- Volunteers
- 527 people
- Sponsor
- Fundacion REVIVA, Red de VIH del Valle del Cauca
HIV/AIDS
Risk of CV Events With EFV vs. EFV-free Regimens
The purpose of this study is to determine whether there is an increased risk of cardiovascular events (CV) with regimens containing efavirenz (EFV) versus other regimens in patients with HIV.
- Trial name
- NCT02426866
- Testing
- Efavirenz
- Volunteers
- 29,612 people
- Sponsor
- Bristol-Myers Squibb
HIV Infections
Regimen Switch to Dolutegravir + Rilpivirine From Current Antiretroviral Regimen in Human Immunodeficiency Virus Type 1 Infected and Virologically Suppressed Adults (SWORD-2)
The aim of this study was to determine if virologically suppressed, human immunodeficiency virus type 1 (HIV-1) infected adults on an antiretroviral regimen (including 2 nucleoside reverse transcriptase inhibitors [NRTIs] plus a…
- Trial name
- NCT02422797
- Testing
- DTG 50 mg, RPV 25 mg, CAR
- Where
- 61 sites in United States, Argentina and 9 more
- Volunteers
- 518 people
- Sponsor
- ViiV Healthcare
HIV-1 Infection
Effects of Losartan and Antiretroviral Regimen Containing Raltegravir in Fibrosis Inflammation Mediators, Cardiovascular Risk and Neurocognitive Disorders in HIV Infected Patients Previously Effectively Treated
This is a open controlled trial in which 48 HIV-1 patients successfully treated with EFV/FTC/TDF will be randomized to one of 4 groups in equal proportion between arms (1:1).
- Trial name
- NCT01529749
- Testing
- EFV/FTC/TDF + Losartan, EFV/FTC/TDF, FTC/TDF + MK-0518
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Felipe Garcia
HIV Seropositivity
Initiation of First-line Antiretroviral Treatment With TENOFOVIR ALAFENAMIDE - EMTRICITABINE - BICTEGRAVIR at the First Clinical Contact in France: Trial IMEA 055 - FAST
Evaluation of antiretroviral treatment adherence using determination of Bictegravir, Emtricitabine and Tenofovir with new HIV patients in France
- Trial name
- FAST (NCT03858478)
- Testing
- Biktarvy arm
- Where
- 17 sites in France
- Volunteers
- 110 people
- Sponsor
- Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba
HIV Infections
Efficacy of Using Interleukin-2 in Antiretroviral Naïve HIV Patients (ANRS119)
Interleukin-2 (IL-2) increases the number of CD4 cells in HIV-1 infected patients under highly active antiretroviral therapy (HAART) with a CD4 cell count over 200/mm3, but its activity in patients without antiretroviral therapy…
- Trial name
- NCT00120185
- Testing
- Interleukin-2
- Where
- France
- Volunteers
- 130 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Cryptococcal Meningitis, HIV/AIDS
Clinical Outcomes of Cryptococcal Meningitis Among HIV-infected Patients in the Era of Antiretroviral Therapy
Cryptococcal meningitis is one of the most common central nervous system infections among HIV-infected patients. The outcome is generally severe.
- Trial name
- NCT02098525
- Where
- Thailand
- Volunteers
- 195 people
- Sponsor
- Mahidol University
HIV-2 Infection
An Open Label Trial of Stribild for Antiretroviral (ARV)-naïve HIV-2 Infected Adults in Dakar, Senegal
There is a critical need for safe and effective antiretroviral treatment (ART) regimens for HIV-2 infection. This is especially true in West Africa, where the vast majority of the 1-2 million individuals infected with HIV-2 live…
- Trial name
- Stribild HIV-2 (NCT02180438)
- Testing
- Stribild (Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF) 1 tablet daily X 48 weeks
- Where
- Senegal
- Volunteers
- 30 people
- Sponsor
- University of Washington
Tuberculosis, Human Immunodeficiency Virus
Adequacy of the New Pediatric Isoniazid/Rifampin/Pyrazinamide (HRZ) Tablet
Lack of quality-assured pediatric formulations of the first-line antituberculosis (anti-TB) drugs is barrier to optimized tuberculosis (TB) treatment outcome in children.
- Conditions
- Tuberculosis, Human Immunodeficiency Virus, Coinfection
- Trial name
- NCT03800381
- Testing
- Observational PK study
- Where
- Ghana
- Volunteers
- 92 people
- Sponsor
- University of Florida
HIV-1
Fuzeon Viral Decay Pilot Study
In order to better understand the source(s) and the mechanism(s) of HIV persistence and to potentially lead to further suppression of HIV from viral reservoirs, we propose to examine the effect of co-administration of…
- Trial name
- NCT00334022
- Testing
- enfuvirtide
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Canadian Immunodeficiency Research Collaborative
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