Clinical trials: Anti-Retroviral Agents
HIV-1-infection
Immune Activation Markers in HIV-infected Patients Switching to Long Acting Dual Therapy
The purpose of the study is to measure the impact on immune activation and inflammatory markers of switching from a triple combination antiretroviral therapy (cART) to a long acting dual therapy in HIV-infected patients
- Trial name
- LONGADAPT (NCT05433987)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier de Cannes Simone Veil
HIV
Rapid Initiation of Antiretroviral Therapy to Promote Early HIV/AIDS Treatment in South Africa (RapIT Study)
One of the most serious challenges facing antiretroviral therapy (ART) programs for HIV/AIDS in resource-constrained settings is the failure of ART-eligible patients to complete the steps required to initiate treatment.
- Trial name
- RapIT (NCT01710397)
- Testing
- Rapid ART initiation
- Where
- 2 sites in South Africa
- Volunteers
- 531 people
- Sponsor
- Boston University
Healthy, HIV
A Phase 1, Open Label, Dose-escalation Study of the Safety, Pharmacokinetics and Antiretroviral Activity of 3BNC117
The proposed study is a first-in-man phase I study that aims to evaluate the safety, tolerability and pharmacokinetics of 3BNC117 in HIV-infected and HIV-uninfected subjects, and its antiretroviral activity in HIV-infected…
- Trial name
- NCT02018510
- Testing
- 1 mg/kg, single dose IV administration of 3BNC117, 3 mg/kg, single dose IV administration of 3BNC117, 10 mg/kg, single dose IV administration of 3BNC117
- Where
- 4 sites in United States, Germany
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
HIV-1-infection
Safety of FMT Using Oral Encapsulated PRIM-DJ2727 in HIV
The purpose of this study is to determine whether oral fecal microbiota transplantation (FMT) is safe for people with human immunodeficiency virus (HIV) infection.
- Trial name
- NCT03329560
- Testing
- Oral fecal microbiota transplantation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The University of Texas Health Science Center, Houston
HIV Infections
Comparative Pharmacokinetics (PK) Study of Efavirenz or Lopinavir/Ritonavir Between Older and Younger HIV-Infected Adults
HIV infected patients, aged </= 35 years and aged >/= 55 years, who are regularly taking either efavirenz (EFV) or lopinavir/ritonavir (Lop/r) as part of their antiretroviral regimen are being asked to spend 12 hours at the…
- Trial name
- NCT00179335
- Testing
- Blood drawing to determine drug levels
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Albert Einstein College of Medicine
HIV-Associated Lipodystrophy Syndrome, HIV Infections
Effect of Pioglitazone on HIV-1 Related Lipoatrophy: a Randomized, Double Blind, Placebo-Controlled Trial in 130 Patients
The aim of this randomized study is to compare the effect of pioglitazone versus placebo on change in limb fat in HIV 1-infected patients treated with antiretroviral therapy for at least 6 months and with clinical lipoatrophy.
- Trial name
- NCT00148850
- Testing
- Pioglitazone
- Where
- France
- Volunteers
- 130 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
HIV-1-infection
An HIV Vaccine Trial in Individuals Who Started ART During Primary or Chronic Infection
EVHA T01 is an international, phase I/II, multicentre, multi-stage, double-blind study that will evaluate at least three experimental arms compared to placebo control in HIV-1 infected participants to see if one or more has a…
- Trial name
- EHVAT01 (NCT02972450)
- Testing
- GTU-MultiHIV B-clade vaccine + MVA HIV-B HIV vaccine, GTU-MultiHIV B-clade vaccine + MVA HIV-B HIV vaccine+ Vedolizumab, Vedolizumab 300 MG [Entyvio]
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 1 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV/AIDS, Medication Adherence
Adherence Through Home Education and Nursing Assessment, Indonesia
Adherence to antiretroviral therapy (ART) drops sharply after prison release. Effective medication adherence training immediately before and after prison release may improve health outcomes and limit transmission of Human…
- Conditions
- HIV/AIDS, Medication Adherence, Substance Use
- Trial name
- ATHENA-I (NCT03397576)
- Testing
- ATHENA
- Where
- Indonesia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
HIV Infections, Tuberculosis
Early Versus Standard Start of Anti-HIV Therapy for Treatment-Naive Adults in Haiti
Anti-HIV treatment consisting of lamivudine/zidovudine (3TC/ZDV) and efavirenz (EFV) is the current standard of care for initial treatment of HIV in most areas of the world.
- Trial name
- NCT00120510
- Testing
- Efavirenz, Lamivudine/Zidovudine
- Where
- Haiti
- Volunteers
- 816 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cytomegalovirus Infections, HIV Infections
A Study of HIV and Cytomegalovirus (CMV) in HIV-Infected Patients
To define relationships between 1) HIV load and risk of CMV disease, 2) CMV load and the risk of developing CMV disease, and 3) CMV load and HIV load.
- Trial name
- NCT00001089
- Where
- 36 sites in United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV
Increasing Motivation for Antiretroviral Therapy Initiation: A Pilot Intervention
In this 3-year study, the investigators will develop and pilot test an intervention called Personal Approaches to Treatment Choices for HIV (PATCH).
- Trial name
- NCT02055417
- Testing
- Personal Approaches to Treatment Choices for HIV, Stress Reduction Skills Program
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Maryland, Baltimore
HIV-1-infection
A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection
The purpose of this study is to evaluate the safety, tolerability, and efficacy of combination broadly neutralizing antibodies (bNAbs), to induce HIV-1 control during analytic treatment interruption (ATI).
- Trial name
- NCT06987318
- Testing
- VRC07-523LS, PGT121.414.LS
- Where
- 13 sites in United States, Brazil and 1 more
- Volunteers
- 40 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV-1
Early Access to Low-dose Ritonavir (TMC114/r) and Other Antiretrovirals (ARVs) for Treatment-naive or Early Treatment Experienced in HIV-1 Patients
The purpose of this study is to provide early access to TMC114 administered with low-dose ritonavir (TMC114/r) and other antiretrovirals (ARVs) for HIV-1-infected patients who have not received previous HIV treatment or have…
- Trial name
- NCT01702090
- Testing
- TMC114/ritonavir
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Janssen-Cilag Ltd.
HIV-1 Infection
Bone, Immunologic, and Virologic Effects of a Antiretroviral Regimen
The main purpose of this study was to compare the effects on bones of the following two drug combinations: maraviroc (MVC), emtricitabine (FTC), plus darunavir/ritonavir (DRV/r) tenofovir (TDF) plus emtricitabine (FTC) plus…
- Trial name
- NCT01400412
- Testing
- Darunavir, Ritonavir, Tenofovir disoproxil fumarate
- Where
- 38 sites in United States, Puerto Rico
- Volunteers
- 262 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
HIV Infections
A Comparison of Epivir Plus Crixivan Combined With Zerit or Retrovir in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs
To evaluate the tolerance, and comparative virologic and immunologic effects of the two combination regimens.
- Trial name
- NCT00002369
- Testing
- Indinavir sulfate, Lamivudine, Stavudine
- Where
- 11 sites in United States, Puerto Rico
- Volunteers
- 200 people
- Sponsor
- Bristol-Myers Squibb
Pregnant HIV Positive Women
Effect of Omega-3 Supplementation on Pregnant Outcomes and Inflammation Markers of Women Infected With HIV Using Antiretroviral Therapy
This clinical trial aims to determine the effect of PUFA-n3 supplementation on birth weight, gestational length, and plasma inflammatory markers in pregnant women with HIV who are on antiretroviral therapy.
- Trial name
- OM3HIVPROUTINF (NCT06971445)
- Testing
- omega-3 polyunsaturated fatty acids (PUFA n-3)
- Where
- Mexico
- Volunteers
- 92 people
- Sponsor
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
HIV Patients
Impact of Long-term Protease Inhibitors in Patients Living With HIV on the Incidence of COVID-19 ( COVIP )
This is a prospective multicenter cohort study. The question arises as to whether treatment with protease inhibitors (PIs) could have a preventive role for COVID-19 infection, especially since patients living with HIV (PLWHIV)…
- Trial name
- NCT04357639
- Testing
- No intervention
- Where
- 6 sites in France
- Volunteers
- 1,040 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Measles
Immune Reconstitution to Measles Virus of HIV Infected Children in Zambia
This is an observational study of HIV-1 infected children starting antiretroviral therapy to measure the magnitude and quality of general immune reconstitution and pathogen-specific immune reconstitution to measles virus.
- Trial name
- NCT02058927
- Testing
- Measles vaccine
- Where
- Zambia
- Volunteers
- 203 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infection
Improving Antiretroviral Medication Adherence Among HIV-infected Youth
HIV is increasing among adolescents and young adults in the US. Antiretroviral medications, when taken correctly (≥ 90% of prescribed doses taken), can vastly improve life expectancy.
- Trial name
- NCT01347437
- Testing
- Positive STEPS
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- Fenway Community Health
HIV-1-infection
IAP-086-1: A Phase 1 Single Ascending Dose First-Time in Human Study
Purpose: To assess the safety and tolerability of a single dose of IAP086 in persons with HIV suppressed on stable ART Participants: 30 people from UNC within 18 to 70years of age.
- Trial name
- NCT07596888
- Testing
- IAP086 0.3 mcg/kg, IAP086 1 mcg/kg, IAP086 3 mcg/kg
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
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