Clinical trials: Anti-bacterial Agents
Clostridium Difficile Infection
Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile - Associated Diarrhea
This clinical study is conducted to assess the efficacy of cadazolid compared to vancomycin in subjects with Clostridium difficile-associated diarrhea (CDAD).
- Trial name
- NCT01987895
- Testing
- Cadazolid, Vancomycin
- Volunteers
- 632 people
- Sponsor
- Actelion
Prescribing, Off-Label
CMO Letter to Reduce Unnecessary Antibiotic Prescribing March 2018
This trial aims to reduce unnecessary prescription of antibiotics by general practitioners (GPs) in England. Unnecessary prescriptions are defined as those that do not improve patient health outcomes.
- Trial name
- NCT03582072
- Testing
- letter from the CMO
- Where
- United Kingdom
- Volunteers
- 4,796 people
- Sponsor
- Public Health England
Sepsis, Antimicrobial Resistance (AMR)
Implementation of a Sepsis Chart and Its Effects on Mortality Rate in Indonesian Primary Referral Hospitals
The goal of this observational study is to evaluate the effectiveness of implementing Koran Sepsis, or sepsis chart, a paper-based order set designed to guide the implementation of the One-hour Sepsis Bundle, in improving…
- Trial name
- NCT07843277
- Testing
- Sepsis chart (koran sepsis), Usual care
- Where
- 2 sites in Indonesia
- Volunteers
- 304 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Urinary Tract Infections
Fosfomycin Versus Standard of Care in Children With Antibiotic-resistant Urinary Tract Infections
Urinary tract infections (UTIs) are among the most common bacterial infections in children. Up to 50% of UTI's are caused by multi-drug resistant ESBL-producing gram negative bacteria that do not respond to treatment with oral…
- Trial name
- FosUTI (NCT05709028)
- Testing
- Fosfomycin, Standard of care antibiotics
- Where
- 5 sites in Australia
- Volunteers
- 300 people
- Sponsor
- University of Sydney
Bacterial Infections, Gram-Positive Bacterial Infections
Antibiotic Treatment for Infections of Short Term In-dwelling Vascular Catheters Due to Gram Positive Bacteria
This study will treat patients who have a short term central catheter that is thought to be infected with a specific bacteria (gram positive bacteria)
- Conditions
- Bacterial Infections, Gram-Positive Bacterial Infections, Bacteremia
- Trial name
- NCT00037050
- Testing
- Linezolid, Vancomycin, Oxacillin
- Volunteers
- 739 people
- Sponsor
- Pfizer
Microbial Colonization, Periodontal Diseases
Impact of Non-surgical Periodontal Therapy on Oral and Gut Microbiome
Periodontitis is an inflammatory disease characterized by a dysbiotic microbiome which can lead to bone destruction and tooth loss.
- Conditions
- Microbial Colonization, Periodontal Diseases, Periodontal Inflammation
- Trial name
- NCT04580355
- Testing
- One-Stage Full Mouth Debridement, Amoxicillin 500mg, Metronidazole 400mg
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Campinas, Brazil
Appendicitis, Children
Randomized Controlled Trial of a Patient Activation Tool in Pediatric Appendicitis (Antibiotics Alone vs. Appendectomy)
The purpose of this study is to determine if a patient activation tool (PAT) can improve decision making and patient centered outcomes in pediatric patients with appendicitis and their caregivers choosing between antibiotics…
- Trial name
- Appy-PAT (NCT02110485)
- Testing
- Patient Activation Tool
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Peter Minneci
Antibiotic-Associated Diarrhea, Clostridium Difficile-Associated Diarrhea
Efficacy and Safety Study in the Prevention of Antibiotic-Associated Diarrhea (AAD) and Clostridium Difficile-Associated Diarrhea (CDAD) in Hospitalized Adult Patients Exposed to Nosocomial Infection
The purpose of this study is to evaluate the efficacy and safety of Bio-K+ CL-1285 in the prevention of Antibiotic-Associated Diarrhea (AAD) and Clostridum difficile-Associated Diarrhea (CDAD) in hospitalized patients exposed to…
- Trial name
- NCT00958308
- Testing
- BIO-K+ CL-1285®
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Bio-K Plus International Inc.
Cellulitis, Skin Disease, Infectious
Naproxen Versus Placebo as Adjunct Treatment of Cellulitis
Cellulitis is a painful bacterial skin infection commonly seen in Canadian emergency departments. Cellulitis has a negative impact on patients' quality of life and productivity.
- Conditions
- Cellulitis, Skin Disease, Infectious, Infection, Skin and Soft Tissue Infections (SSTIs)
- Trial name
- NVP (NCT07665476)
- Testing
- enteric-coated naproxen, Cephalexin Tablets
- Where
- Canada
- Volunteers
- 884 people
- Sponsor
- Ottawa Hospital Research Institute
Surgery Complications, Surgery
SurgWeek-2: Identifying the Global Burden of Post Operative Complications: an International Prospective Cohort Study Protocol
This study aims to assess and improve the global outcomes following surgery. Every year approximately 313 million operations are performed, with 50 million people experiencing a complication and unfortunately 3.5 million people…
- Conditions
- Surgery Complications, Surgery, Global Surgery, Robotic
- Trial name
- SurgWeek-2 (NCT07785076)
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
UTI
Randomized Trial of Culture Directed Versus Empiric Antibiotics for Urinary Tract Infections in Older Women
To evaluate the feasibility of recruiting eligible subjects into a randomized trial of a culture-directed versus empiric antibiotic strategy for patient-reported urinary tract infection symptoms in older women and the adherence…
- Trial name
- REDUCTION (NCT05726318)
- Testing
- Antibiotics
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Megan Bradley
Gastric Cancer, Complication of Surgical Procedure
Study About no Antimicrobial Prophylaxis in Totally Laparoscopic Distal Gastrectomy
Laparoscopic gastrectomy has fewer infectious complications compared to open surgery. Recently, the incidence of postoperative infectious complications was greatly reduced due to the development of surgical techniques and…
- Trial name
- KSWEET-03 (NCT03802097)
- Testing
- No use of antimicrobial prophylaxis, Use of antimicrobial prophylaxis
- Where
- South Korea
- Volunteers
- 260 people
- Sponsor
- Korean South West East Gastric Surgery Group
Pneumonia, Bronchoalveolar Lavage
HCAPPED I: HCAP-Pcr in Emergency Department
Prospective Observational Study (on Diagnostic Procedure) - Single-Center, Non-Profit. A pilot study will be conducted on a prospective cohort of patients with HCAP (Healthcare-Associated Pneumonia).
- Conditions
- Pneumonia, Bronchoalveolar Lavage, Antimicrobial Treatment, Sputum
- Trial name
- HCAPPED-I (NCT06506617)
- Where
- Italy
- Volunteers
- 93 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Atopic Dermatitis
Validation of the Short-term Antimicrobial Action of Transplanted Bacteria
Unlike healthy control skin, the skin of patients with atopic dermatitis (AD) is frequently colonized by Staphylococcus aureus (S. aureus), putting these patients at increased risk of S. aureus skin infections.
- Trial name
- NCT01959113
- Testing
- Autologous Microbiome Transplant
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, San Diego
Bowel Cleansing Prior to Clinical Procedures, Colorectal Anastomosis
Oral Antibiotics vs. No Antibiotics in Pediatric Colorectal Surgery
This study aims to evaluate whether giving oral antibiotics before elective colorectal surgery can improve recovery and reduce complications in children.
- Trial name
- PEACO (NCT07713433)
- Testing
- oral antibiotics, No Oral Antibiotics
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- Muhammad Zubair Shoukat
Colorectal Cancer
Does Administration of Antibiotics in Patients Undergoing Surgery for Colorectal Cancer Result in Less Complications and Better Prognosis?
The primary objectives of this randomized clinical trial are to evaluate if perioperative SDD can reduce clinical anastomotic leakage rate and its septic consequences as well as other infectious complications.
- Trial name
- SELECT (NCT01740947)
- Testing
- Selective decontamination of the digestive tract (SDD) (colistin sulfate, tobramycin, amphotericin B)
- Where
- 5 sites in Netherlands
- Volunteers
- 485 people
- Sponsor
- H. Jaap Bonjer, PhD
Clostridium Enterocolitis, Pseudomembranous Colitis
Vancomycin vs. Nitazoxanide to Treat Recurrent C. Difficile Colitis
The purpose of this study is to compare the outcome of treatment with nitazoxanide vs. vancomycin for diarrheal disease due to Clostridium difficile in patients who have failed previous treatment with metronidazole.
- Conditions
- Clostridium Enterocolitis, Pseudomembranous Colitis, Antibiotic-Associated Colitis
- Trial name
- NCT00304889
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Febrile Neutropenia
Procalcitonin Protocol to Shorten the Antibiotic Therapy in Febrile Neutropenia
In this study the investigators aim to test if a procalcitonin (PCT) - guided strategy allows to reduce the antibiotic use in patients with febrile neutropenia hospitalized in a Brazilian tertiary university hospital, causing no…
- Trial name
- NCT00928291
- Testing
- procalcitonin, antibiotic therapy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Minas Gerais
Clostridium Difficile Infection, VRE Infection
Antibiotic Stewardship and Infection Control in Patients at High Risk of Developing Infection by Clostridium Difficile, Vancomycin-Resistant Enterococci or Multi-Resistant Gram-Negatives
Throughout project, the investigators design, evaluate and disseminate infection control and antibiotic stewardship (ABS) measures aimed at reducing the incidence of Clostridium difficile infection (CDI).
- Conditions
- Clostridium Difficile Infection, VRE Infection, Nosocomial Infection, MRGN Bacteria
- Trial name
- ABSOLUTE (NCT03250104)
- Testing
- Infection Control, Antibiotic Stewardship
- Where
- Germany
- Volunteers
- 80,000 people
- Sponsor
- University Hospital of Cologne
Antibiotic-associated Diarrhea
Antibiotic-Associated Diarrhea and the Role of Microorganisms in the Gut
Amoxicillin-clavulanate is an antibiotic commonly prescribed to treat a myriad of community-acquired infections. One of the most common adverse effects of amoxicillin-clavulanate is antibiotic-associated diarrhea (AAD).
- Trial name
- NCT04156555
- Testing
- Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet
- Where
- Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
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