Clinical trials: Anti-bacterial Agents
Halitosis, Halitoses
Antimicrobial Photodynamic Therapy Or Lingual Scraper Associated With Periodontal Treatment In The Reduction Of Halitosis.
The aim of this study is to compare the effectiveness of two methods of treating bad breath. Patients are enrolled in the study based on an objective test using the Oral Chroma Device, which measures the concentration of volatile…
- Conditions
- Halitosis, Halitoses, Fetor Oris, Oral Malodor
- Trial name
- NCT07433816
- Testing
- Tongue scraper and oral rinse treatment, Tongue scraper and aPDT (photodynamic therapy), full mouth scaling
- Where
- Poland
- Volunteers
- 48 people
- Sponsor
- Medical University of Silesia
Cirrhosis
Empirical vs 2nd Line Antibiotic Therapy in Health-care Associated Infections in Cirrhosis
Bacterial infections are a frequent complication in liver cirrhosis with a bad prognosis. However, the clinical outcome of cirrhotic patients with serious infections is significantly improved over the last 30 years due to early…
- Trial name
- NCT01820026
- Testing
- Imipenem, Vancomycin, azithromycin
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- University of Roma La Sapienza
Infectious Diseases
Prescription Support System for Antimicrobial Use in Belgian Primary Care
Inappropriate antibiotic prescribing in primary care remains an important contributor to antimicrobial resistance. Despite the availability of evidence-based clinical guidelines, antibiotics are still frequently prescribed for…
- Trial name
- PaSSo (NCT07347015)
- Testing
- Prescription Support System (PSS)
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- KU Leuven
Leptospirosis
Study of Decreasing Kinetics of the Leptospiremia During Antibiotic Treatment of Leptospirosis in Martinique
The leptospirosis evolves on an endemic mode in French West Indies and its incidence in 2011 was de 61/100 000 inhabitants, 100 times more than the metropolitan France's incidence (0,47/100 000).
- Trial name
- Ciné LEPTO (NCT02000635)
- Testing
- Quantitative PCR performed at H0 , H24, H48 , H72, 7th day and 14th day
- Where
- Martinique
- Volunteers
- 50 people
- Sponsor
- University Hospital Center of Martinique
Irreversible Pulpitis
Effect of Temperature Elevation on the Antimicrobial Efficacy of Two Root Canal Irrigants in Primary Root Canal Infections: A Randomized Controlled Clinical Trial
evaluate the antimicrobial efficacy of preheated sodium hypochlorite and dexamethasone sodium phosphate and at room temperature in patients with primary root canal infection.
- Trial name
- NCT07906925
- Testing
- Dexamethasone Sodium Phosphate 10 MG/ML, Sodium Hypochlorite 2,5%
- Volunteers
- 40 people
- Sponsor
- Tanta University
Trichiasis
Study of Azithromycin to Prevent Recurrent Trichiasis Following Surgery in Ethiopia
Trachoma, an ocular infection caused by C. trachomatis, is the second leading cause of blindness worldwide.Years of repeated infection with C.
- Trial name
- STAR (NCT00347776)
- Testing
- azithromycin, topical tetracycline
- Where
- United States
- Volunteers
- 1,452 people
- Sponsor
- Johns Hopkins University
Pyelonephritis Acute
3-day IV Antibiotic Treatment Versus 3-day IV Followed by 7-day Oral Antibiotic Treatment for AP in Children
Antibiotic therapies currently recommended for the treatment of acute pyelonephritis (AP) in children, whether fully by the oral route or initially intravenous (IV, 3 days) followed by the oral route, have a duration of 7 to 14…
- Trial name
- PYELOCOURT (NCT05544565)
- Testing
- IV Antibacterial Agents, Orally antibacterial agents, Fecal/Rectal Swab
- Where
- 15 sites in France
- Volunteers
- 480 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infant, Premature, Diseases
Probiotics On Resistant Bacteria Colonization In Preterm Receiving Antibiotics
In this study, the investigators investigated the effect of probiotic use on colonization of resistant microorganisms in newborn preterm infants receiving antibiotics.
- Trial name
- NCT02178267
- Testing
- Lactobacillus reuteri (biogai AB, Sweden)
- Volunteers
- 51 people
- Sponsor
- Baskent University
Open Fracture
Placement of Antibiotic Powder in Wounds During the Emergency Room
This is the first prospective controlled study to determine whether the topical application of vancomycin powder reduces infection-related complications when applied to open fracture injuries in the acute emergency department…
- Trial name
- POWDER (NCT03765567)
- Testing
- Vancomycin
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Bacteriuria in Symptomatic Benign Prostate Hyperplasia, Antibiotic Susceptibility in Symptomatic Benign Prostate Hyperplasia
Prevalence of Bacteriuria, Antibiotic Susceptibility, and Treatment Response in Symptomatic Benign Prostatic Hyperplasia
The goal of this prospective observational study is to identify the common pathogens and antibiotic sensitivity pattern in urine samples of men with symptomatic BPH and to assess severity of LUTS in patients with symptomatic BPH…
- Conditions
- Bacteriuria in Symptomatic Benign Prostate Hyperplasia, Antibiotic Susceptibility in Symptomatic Benign Prostate Hyperplasia, Treatment Response to Antibiotics in Symptomatic Benign Prostate Hyperplasia
- Trial name
- BPH (NCT06520267)
- Testing
- Antibiotic therapy
- Where
- Nepal
- Volunteers
- 131 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Nosocomial Infection, Sepsis
Application of an Antimicrobial Stewardship Program in Brazilian ICUs Using Machine Learning Techniques and an Educational Model
Antimicrobial agents are frequently used empirically and include therapy for both Gram-positive and Gram-negative bacteria. In Brazil, multidrug-resistant Gram-negative pathogens are the cause of most nosocomial infections in…
- Trial name
- NCT05312034
- Testing
- Implementation of the predictive model for an antimicrobial management program
- Volunteers
- 100 people
- Sponsor
- D'Or Institute for Research and Education
Perianal Fistula, Perianal Abscess
Antibiotic Treatment foLlowing Surgical drAinage of Perianal abScess; the ATLAS Trial
Rationale: Perianal fistula is a burdening disease with an annual prevalence of 2/100.000 in the Dutch population. More than 90% of crypto-glandular fistulas originate from anorectal abscess.
- Conditions
- Perianal Fistula, Perianal Abscess, Drain Abscess
- Trial name
- ATLAS (NCT05385887)
- Testing
- Ciprofloxacin 500 mg, Metronidazole 500 mg
- Where
- 11 sites in Netherlands
- Volunteers
- 298 people
- Sponsor
- dr. IJM Han-Geurts
Open Fracture
Preventing Infections in Orthopaedic Patients
Determine if antibiotic prophylaxis with intravenous cephalosporin and aminoglycoside in patients with Type II and II open fractures is safe and effective.
- Trial name
- NCT02948387
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Olayemi Osiyemi MD
Postoperative Infection
Post-operative Antibiotics; Effects on Risk of Infection After Cochlear Implant Surgery
Currently there is little consensus regarding postoperative antibiotic prophylactic treatment and its effect on the postoperative infection rate after Cochlear implantation.
- Trial name
- NCT06177444
- Testing
- Antibiotic
- Where
- Denmark
- Volunteers
- 920 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Dysbiosis
A Pilot Study Assessing Intestinal Microbiota Diversification and Changes After Travel to South(East) Asia From the US
This prospective, observational pilot study is designed to assess feasibility, refine the target population, and quickly test qualitative and quantitative changes in the microbiome after short-term travel to South or Southeast…
- Trial name
- ABROAD (NCT03043300)
- Testing
- Screening Criteria Review, Pre-Travel Questionnaire, Pre-Travel Stool Specimen Collection
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Emory University
Laparotomy, Critical Illness
Are Standard Dosing Regimens of Piperacillin-Tazobactam Suitable in Critically Ill Patients With Open Abdomen and Negative Pressure Wound Therapy? A Population Pharmacokinetic Study.
For several years, open abdomen with temporary abdominal closure using Negative Pressure Therapy (OA/NPT) has become one of the leading strategies to treat or prevent intra-abdominal hypertension in critically ill surgical…
- Conditions
- Laparotomy, Critical Illness, Piperacillin, Tazobactam Drug Combination
- Trial name
- PK-LAP (NCT04915872)
- Testing
- Blood sampling (T0, inclusion), other samplings (T1)
- Where
- France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Bordeaux
Prescribing, Off-Label
CMO Letter to Reduce Inappropriate Antibiotic Prescribing Winter 2019/2020
This trial aims to reduce inappropriate prescription of antibiotics and broad spectrum antibiotics by general practitioners (GPs) in England.
- Trial name
- NCT04051281
- Testing
- Letter
- Where
- United Kingdom
- Volunteers
- 2,963 people
- Sponsor
- Public Health England
Patients Receiving Antimicrobial Therapy
Impact of Infectious Diseases Specialists on the Appropriateness of Antimicrobial Therapy in Surgical and Medical Wards
CONTEXT: Antibiotics are frequently used in hospital but the appropriateness of prescriptions ranged between 25-50%. The intervention of infectious disease specialists (IDS) could improve the appropriateness of prescriptions and…
- Trial name
- ATBREFSURMED (NCT01136200)
- Testing
- Infectious disease specialist advice
- Where
- France
- Volunteers
- 264 people
- Sponsor
- Henri Mondor University Hospital
Acute Otitis Media
Efficacy of Short-Course Antimicrobial Treatment for Children With Acute Otitis Media and Impact on Resistance
The investigators will study whether, in young children with acute otitis media (AOM), shortening length of antibiotic treatment as a strategy for reducing antimicrobial resistance provides satisfactory clinical outcome.
- Trial name
- NCT01511107
- Testing
- Amoxicillin-Clavulanate, 10 days, Amoxicillin-Clavulanate, 5 days
- Where
- 2 sites in United States
- Volunteers
- 520 people
- Sponsor
- Alejandro Hoberman
Pneumonia
Trial on the Ideal Duration of Oral Antibiotics in Children With Pneumonia
To determine, in children hospitalized with pneumonia, if an extended duration of oral antibiotics (10 days) will be superior to a shorter duration (3 days) of antibiotics in improving clinical outcomes. Secondary Aims: 1.
- Trial name
- NCT02258763
- Testing
- Amoxicillin-Potassium Clavulanate Combination
- Where
- Malaysia
- Volunteers
- 19 people
- Sponsor
- University of Malaya
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