Clinical trials: Anti-bacterial Agents
Denture Stomatitis
Clinical and Microbial Study of Reinforced 3D Printed Maxillary Denture Base Resin
Statement of problem: 3D printed denture base resin is needed to reinforce Purpose: To evaluate the effects of adding nano-ZrO2 and nano-TiO2 on microbial colonization and patient satisfaction with 3D-printed maxillary complete…
- Trial name
- dimensions (NCT06921577)
- Testing
- antimicrobial agent
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Tanta University
Antibiotic-associated Diarrhea
Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics
The focus of the study is to better understand the mechanisms causing antibiotic-associated diarrhea (AAD) and how probiotics may prevent some of the iatrogenic effects of antibiotic medications.
- Trial name
- YOBIOTIC (NCT03755765)
- Testing
- Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet, BB-12, Control
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Ventilator Associated Tracheobronchitis, Tracheobronchitis
Ventilator-associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation
The Ventilator Associated tracheobronchitis Initiative to Conduct Antibiotic evaluation (VATICAN) trial is a national, multicenter, non-inferiority trial in ICU patients comparing antibiotic treatment for 7 days versus clinical…
- Trial name
- VATICAN (NCT05266066)
- Testing
- Clinical observation without antibiotic therapy for VAT, 7 day antibiotic course for VAT
- Where
- 16 sites in Brazil
- Volunteers
- 590 people
- Sponsor
- Hospital Sirio-Libanes
Liver Transplant, Carbapenem-resistant Enterobacterales
Targeted Versus Standard Peri-operative Antibiotic Prophylaxis in Patients Colonized With Carbapenemase Producing Enterobacterales Undergoing Liver Transplantation
This is a multicenter stepped-wedge cluster randomized trial, conducted over a 2-year period at three hospitals. The trial is structured into four phases, each lasting six months.
- Conditions
- Liver Transplant, Carbapenem-resistant Enterobacterales, CRE Colonization
- Trial name
- TAILOR (NCT07759453)
- Testing
- Ceftazidime - Avibactam ( CAZ-AVI), Meropenem-Vaborbactam, Imipenem+Relebactam
- Where
- 3 sites in Italy
- Volunteers
- 168 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Neonatal Sepsis
Treatment Outcome With Antibiotic Use and Its Resistance Pattern Among Patient With Neonatal Sepsis
Determine Treatment outcome with antibiotic use and its resistance pattern among neonatal sepsis patients
- Trial name
- NCT05742477
- Testing
- Antibiotic
- Volunteers
- 100 people
- Sponsor
- Assiut University
Prostate Infections
Impact of Antibiotic Treatment on Prostate-Specific Antigen (PSA) Variability
Ciprofloxacin hydrochloride has been approved by the Food and Drug Administration (FDA) for the treatment of mild to moderate infections, including prostate infections.
- Trial name
- NCT00596453
- Testing
- Ciprofloxacin hydrochloride
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Johns Hopkins University
Bacterial Infections
Hospital Wide Roll-Out of Antimicrobial Stewardship
Dramatic increases in antibiotic utilization in hospitals continue to drive antibiotic resistance among hospital-acquired pathogens. However, 30-50% of the antibiotic use in hospitals is unnecessary or inappropriate.
- Trial name
- NCT01587937
- Testing
- Antibiotic stewardship audit-and-feedback to prescribers of patients receiving 3rd or 10th day of targeted broadspectrum antibiotics
- Where
- Canada
- Volunteers
- 19,220 people
- Sponsor
- Sunnybrook Health Sciences Centre
Hemodialysis Complication, Hemodialysis Catheter Infection
Mupirocin 2% Ointment Vs Spray Antibiotics on Temporary Hemodialysis Catheter
In dialysis centers, many patients are undergoing hemodialysis simultaneously, which facilitates the spread of microorganisms by direct or indirect contact through the devices, equipment, surface contact, and hands of health…
- Trial name
- NCT05874219
- Testing
- Local antibiotic spray Neomycin sulphate 165,000 IU + Bacitracin zinc 12,500 IU, Mupirocin 2% ointment
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Future University in Egypt
Patients at High Risk of Antibacterial Treatment Upon Admission
Impact of Prescription Quality, Infection Control and Antimicrobial Stewardship on Gut Microbiota Domination by Healthcare-Associated Pathogens
Extended-spectrum beta-lactamase producing Enterobacteriaceae (EPE), vancomycin-resistant enterococci (VRE) and Clostridium difficile have become a major threat to hospitalised patients worldwide.
- Trial name
- PILGRIM (NCT03765528)
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- University Hospital of Cologne
Methicillin-Resistant Staphylococcus Aureus, Recurrence
Patient-Centered Comparative Effectiveness Research (CER) Study of Home-based Interventions to Prevent CA-MRSA Infection Recurrence
The overall goal of the project is to develop and evaluate a home-based intervention to prevent re-infection and transmission of Community-Acquired Methicillin-resistant Staphylococcus aureus (CA-MRSA) in patients presenting to…
- Conditions
- Methicillin-Resistant Staphylococcus Aureus, Recurrence, Staphylococcal Skin Infections, Antibiotic Resistance
- Trial name
- CAMP-2 (NCT02566928)
- Testing
- 2% mupirocin ointment, Chlorhexidine wash, Hygiene protocol
- Where
- 6 sites in United States
- Volunteers
- 278 people
- Sponsor
- Clinical Directors Network
Diarrhea., Pneumonia.
The Effectiveness of Co-packaging With Zinc to Improve Treatment of Diarrhea and Pneumonia in Guatemala
This project applies a randomized community design to test the effectiveness of health center level co-packaging and counseling messages to improve provider and caregiver behavior in the treatment of diarrhea with zinc \& oral…
- Trial name
- Zinc10 (NCT02044107)
- Testing
- Co-packaging and counseling messages
- Where
- Guatemala
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Center for Studies of Sensory Impairment, Aging and Metabolism
Induced Abortion, Postaboral Pelvic Inflammatory Disease
To Compare the Strategies of Universal Antibiotic Prophylaxis Versus Screen-and-treat in Reducing Infective Complications and Re-infection in Women Who Undergo Termination of Pregnancy
Screen-and-treat approach reduces postabortal pelvic inflammatory disease after induced abortion, and at the same time alters women's sexual behavior and prevents further re-infection by sexually transmitted infections when…
- Conditions
- Induced Abortion, Postaboral Pelvic Inflammatory Disease, Sexually Transmitted Infections
- Trial name
- NCT01842100
- Testing
- Universal antibiotic prophylaxis, Screen-and-treat
- Where
- China
- Volunteers
- 2,193 people
- Sponsor
- The University of Hong Kong
Gastritis, Indigestion, Helicobacter Pylori Infection, Gastric Cancer, Peptic Ulcer
Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial
This study aims to evaluate the efficacy of vonoprazan combined with different antibiotics in dual therapy for Helicobacter pylori eradication treatment.
- Trial name
- NCT07068607
- Testing
- Vonoprazan, Tetracycline 500mg tid, Minocycline
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Yongquan Shi
Surgical Site Infections
Continuous v Bolus Infusion of Cefazolin During Ventral Hernia Repair
Patients undergoing an elective ventral hernia repair will be randomly assigned to receive either bolus infusion or continuous infusion of the cefazolin as the prophylactic antibiotic.
- Trial name
- NCT02666365
- Testing
- Bolus infusion of Cefazolin, Continuous infusion of Cefazolin
- Sponsor
- Milton S. Hershey Medical Center
Postoperative Complications, Antibiotic Reaction
Complications After Lower Third Molar Surgery
Surgical removal of impacted mandibular wisdom teeth is a frequent intervention, usually accompanied by unpleasant sequelae (pain, swelling and trismus) in the postoperative period, sometimes even with possibly serious…
- Conditions
- Postoperative Complications, Antibiotic Reaction, Antibiotic Side Effect, Antibiotic Resistant Infection
- Trial name
- NCT05027893
- Testing
- Moxifloxacin 400 mg Oral Tablet, Cefixime 400 mg Oral Tablet
- Where
- Serbia
- Volunteers
- 157 people
- Sponsor
- University of Novi Sad
Otitis Media Acute
Otitis Treatment With OtoSight™ - Modification of Antibiotic Treatment Intervention in Children
A pragmatic, mixed-method trial is to show the ability of OtoSight to change management of the pediatric patient presenting with ear pain in a way that improves patient outcomes and reduces costs.
- Trial name
- OTO-MATIC (NCT06285812)
- Testing
- OtoSight Middle Ear Scope
- Where
- 7 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- PhotoniCare, Inc.
Antibiotic-Associated Diarrhea
Comparison of Two Formulations of Bio-K
Main research Question: The investigators would like to find out if both the Bio-K (lactobacillus acidophilus and lactobacillus casei) drink and capsule are equally effective in the prevention of diarrhea associated with…
- Trial name
- NCT00792844
- Testing
- Bio-K capsule formulation, Bio-K drink
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- McMaster University
Wound Infection
Daptomycin as Antibiotic Prophylaxis of Sternal Wound Infections
The purpose of this study is to show that the incidence of sternal wound infections at day 30 after cardiac surgery is 50% lower with the additional use of Daptomycin on top of a standard antibiotic prophylaxis as compared to the…
- Trial name
- DaPro (NCT01080963)
- Testing
- Daptomycin, Cefuroxime
- Where
- Germany
- Volunteers
- 650 people
- Sponsor
- Hannover Medical School
Resistance Bacterial
T2Resistance - Detection of Resistance Related Genes
The purpose of this study is to evaluate the safety and effectiveness of the T2Resistance Panel by validating clinical performance in three study arms: 1.
- Trial name
- NCT05231187
- Testing
- T2Resistance Panel
- Where
- 10 sites in United States
- Volunteers
- 1,566 people
- Sponsor
- T2 Biosystems
Septic Abortion
Prolonged Treatment for Infected Abortion After Hospital Discharge.
Patients with infected abortion will be treated with dilatation and curettage, intravenous antibiotics. The purpose of this study is to verify if it is necessary to keep the use of oral antibiotics after hospital discharge.
- Trial name
- APA (NCT00376493)
- Testing
- metronidazole and doxycycline
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.