Clinical trials: Anti-bacterial Agents
Infection
Pharmacokinetics of Small Spectrum Beta-lactam Antibiotics (Amoxicillin/Clavulanic Acid and Cefuroxime) in Patients on Intensive Care Units
Adequate antibiotic therapy is very important in the treatment of infections. Spectrum and dosing of the antibiotics are two factors of the therapy: the spectrum of an antibiotic can't be changed, but the dosing scheme can be…
- Trial name
- AMOCEF (NCT01581047)
- Where
- Belgium
- Volunteers
- 37 people
- Sponsor
- University Hospital, Ghent
Surgical Site Infection (SSI)
Prophylaxis Against Surgical Site Infections Using Local as Well as Systemic Antibiotic
Surgical site infections were defined as infections that developed in the area of an operation within 30 days after surgery. They remained a common problem after surgery and could increase pain, delay wound healing, prolong…
- Trial name
- NCT07478874
- Testing
- Cefazolin plus Gentamicin, Cefazolin
- Where
- Pakistan
- Volunteers
- 284 people
- Sponsor
- Lahore General Hospital
Pressure Ulcers, Pressure Ulcers Stage III
Efficacy of a Polyhexanide Biguanide-Based Gel in the Prevention of Biofilm Formation in Pressure Ulcers
INTRODUCTION: Pressure ulcers (PU) are one of the main challenges for nursing in our country. Wound bed preparation and the TIME algorithm provide essential tools for adequately treating these lesions.
- Conditions
- Pressure Ulcers, Pressure Ulcers Stage III, Pressure Ulcer Prevention, Pressure Ulcer ( Stage 2-3)
- Trial name
- EGELPUPP (NCT07391748)
- Testing
- To determine the efficacy of a gel containing polyhexanide and biguanide, alone or in combination with alginate with or without silver, in preventing biofilm in PU, in terms of healing at 4 weeks
- Volunteers
- 140 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Community-Acquired Pneumonia (CAP), Pneumonia
PromotIng Optimal Treatment for Community-acquired PNeumonia in EmErgency Rooms
In North America, up to 5% of preschoolers develop community-acquired pneumonia (CAP) every year. Pneumonia is the second-leading reason for paediatric hospitalization in both Canada and the US; approximately 20% of children…
- Trial name
- PIONEERS (NCT07099976)
- Testing
- The novel care pathway intervention, Usual Care Alone
- Where
- 6 sites in Canada
- Volunteers
- 698 people
- Sponsor
- Jeffrey Pernica
Surgical Site Infection
Dose Escalation Trial of Intrasite Vancomycin Pharmacokinetics
Surgical wound infections remain a serious problem despite aseptic techniques and the use of prophylactic systemic antibiotics. Such infections can occur at rates up to ~20% in high-risk patients receiving long segment…
- Trial name
- NCT01764750
- Testing
- Intrasite Vancomycin, IV Vancomycin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Washington University School of Medicine
Candidosis Vaginal
Safety and Tolerability Studies of CanProFem-AK, Vaginal Suppositories in Healthy Volunteers
The study object of this clinical trial is CanProFem-AK, 100 mg suppositories. The Pharmacological group - Antifungal drug for external use.
- Trial name
- NCT06535126
- Testing
- CanProFem-AK
- Where
- Kazakhstan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Industrial Microbiology LLP
Class II Dental Caries
Clinical Performance of Bulk-Fill Composite Using With Adhesives With or Without Chlorhexidine
This study aims to evaluate the clinical success of chlorhexidine-containing dentin bonding agent in primary molars with a 12-month follow-up.
- Trial name
- NCT06257108
- Testing
- Class II Cavity Restorations
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Uşak University
CABG-patients, Saphenectomy
Clinical Impact of Surgical Wound Morbidity According to the Type of Saphenous Vein Harvesting Technique (Endoscopic vs. Open) in Patients Undergoing Myocardial Revascularization Surgery
The goal of this clinical trial is to compare two different techniques: endoscopic saphenous vein harvesting versus conventional open harvesting in patients undergoing coronary artery bypass grafting, either alone or in…
- Conditions
- CABG-patients, Saphenectomy, Endoscopic Surgery, Wound Complications
- Trial name
- EndOSiC (NCT07002658)
- Testing
- Harvesting of the saphenous vein graft
- Where
- Spain
- Volunteers
- 356 people
- Sponsor
- Hospital San Carlos, Madrid
Gram Positive Infection, Concurrent Antibiotic Treatment
PK and Safety Evaluation of Daptomycin in Children Ages 2-6 With Proven or Suspected Gram-positive Infections
This is a research study designed to look at the pharmacokinetics (distribution, breakdown, and removal) and tolerability of a single dose of daptomycin in patients aged 2 to 6 years who have infections that are caused by a…
- Trial name
- NCT00679835
- Testing
- daptomycin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Breast Augmentation
Asian Outcomes of Primary Breast Augmentation
In 162 Asian patients, primary breast augmentations were performed by a single surgeon during 5 years. The purpose of this study evaluates Asian outcomes in primary breast augmentation using single antibiotic breast irrigation by…
- Trial name
- BA (NCT02235285)
- Testing
- primary breast augmentation
- Where
- South Korea
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Winners Clinic
Malnutrition
Optimising Antibiotic Treatment for Sick Malnourished Children
Children with severe malnutrition who are admitted sick to hospitals have a high mortality, usually because of infection. All children with severe malnutrition admitted to hospitals are treated with antibiotics.
- Trial name
- FLACSAM-PK (NCT02746276)
- Testing
- Ceftriaxone, Metronidazole
- Where
- Kenya
- Volunteers
- 81 people
- Sponsor
- University of Oxford
Burns
Comparison of Mepitel Ag vs Antibiotic Ointment Used With Soft Cast Technique for Treatment of Pediatric Burns
The aim of this study is to compare Mepitel Ag to Triple antibiotic ointment impregnated Adaptic gauze when used with the soft cast technique to assess overall time to healing, yeast infection rate and parents perception of pain…
- Trial name
- NCT02681757
- Testing
- triple antibiotic ointment dressing, Mepitel Ag
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Antibiotic Stewardship, Neonatal Sepsis, Late-Onset
Vancomycin Reduction Practices (VRP) in the NICU
This multi-center, cluster randomized study aimed at improving implementation of vancomycin reducing practices (VRP) in neonatal intensive care units (NICUs).
- Conditions
- Antibiotic Stewardship, Neonatal Sepsis, Late-Onset, Vancomycin
- Trial name
- NCT06772675
- Testing
- External Facilitation
- Where
- 13 sites in United States
- Volunteers
- 13 people
- Sponsor
- Children's Hospital of Philadelphia
Pneumonia, Bacterial, Extracorporeal Membrane Oxygenation
" Study of the Benefit of Nebulized Amikacin in the Treatment of Gram-negative Bacillus Pneumonia Acquired During Mechanical Ventilation in Patients Receiving Extracorporeal Membrane Veno-arterial Oxygenation "
Pneumonia are the most frequent infectious complication in patients on Extracorporeal Membrane Oxygenation Veno-arterial (ECMO-VA), with a treatment failure rate of around 40%, even though antibiotic therapy is tailored to the…
- Trial name
- NAVAP-ECMO (NCT06602557)
- Testing
- Amikacin, Standard of care
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Community-acquired Pneumonia
Impact of Comprehensive Molecular Tests on Antimicrobial Stewardship in Community-acquired Pneumonia
Background: Community-acquired pneumonia (CAP) continues to be a major health problem with significant mortality and it's one of the main causes of antibiotic prescription.
- Trial name
- RADICAP (NCT04158492)
- Testing
- real-time multiplex PCR, Standard diagnostic procedures
- Where
- 4 sites in Spain
- Volunteers
- 242 people
- Sponsor
- Hospital Universitari de Bellvitge
Tonsillectomy
Effect of Duration of Antibiotic Therapy on Recovery Following Tonsillectomy
To determine whether a 3-day course of postoperative antibiotics is effective as a 7-day course in reducing pain and reducing time to resumption of normal diet and activity following pediatric tonsillectomy
- Trial name
- NCT00662987
- Testing
- 7 days of amoxicillin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Frenectomy, Erbium YAG Laser
Retrospective Frenectomy Analysis: Techniques and Adjunctive Antimicrobials
The frenulum is a mucosal fold that connects the lips and cheeks to the alveolar mucosa or gingiva, with abnormal attachments-particularly papillary and papillary-penetrating types-linked to clinical issues such as gingival…
- Conditions
- Frenectomy, Erbium YAG Laser, Antimicrobial Agent
- Trial name
- NCT07054021
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Catheter-Related Infections
Impact of Prophylactic Antibiotics on Bloodstream Infections After Liberation From Extracorporeal Membrane Oxygenation
The goal of this prospective interventional study is to evaluate the impact of antibiotic prophylaxis on bloodstream infections after liberation of extracorporeal membrane oxygenation therapy.
- Trial name
- IPANEMA-ECMO (NCT05651464)
- Testing
- Vancomycine
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- Universität des Saarlandes
Acute Cholecystitis
Is it Fair to Use Antibiotics After Laparoscopic Cholecystectomy for the Patients With Acutely Inflamed Gallbladder?
During the laparoscopic cholecystectomy for acute cholecystitis, most surgeons routinely use the postoperative antibiotics after surgery.
- Trial name
- NCT02490293
- Testing
- Cephalosporin
- Where
- South Korea
- Volunteers
- 198 people
- Sponsor
- Taeho Hong
Cornea
Comparison of Oral Isotretinoin vs Ancomparison of Oral Isotretinoin vs Antibiotics on Corneal Thickness With AV
Comparison of Oral Isotretinoin versus comparison of Oral Isotretinoin versus Antibiotics on Corneal Thickness in Patients with Acne Vulgaris
- Trial name
- NCT06483971
- Testing
- Oral Isotretinoin, Antibiotics
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Superior University
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