Clinical trials: Anti-bacterial Agents
Open Fracture
Assessment of Severe Extremity Wound Bioburden at the Time of Definitive Wound Closure or Coverage
The purpose of this study is to characterize the bacteria in the wound "bioburden" at the time of definitive wound coverage/closure of severe tibia fractures in both the military and civilian populations.
- Trial name
- Bioburden (NCT01496014)
- Where
- 40 sites in United States
- Volunteers
- 646 people
- Sponsor
- Major Extremity Trauma Research Consortium
Gram-negative Bacterial Infections
Surveillance Study - Incidence of Antibiotic Resistance in Serial Gram-negative Bloodstream Isolates
This research is important because it allows for the determination of resistance rates to antibiotics that may not be frequently tested by the clinical microbiology laboratory at University of Pittsburgh Medical Center…
- Trial name
- NCT00394784
- Where
- United States
- Sponsor
- University of Pittsburgh
Endotoxemia
The Role of the Gut Microbiota in the Systemic Immune Response During Human Endotoxemia
The purpose of this study is to determine whether treatment with antibiotics, which harm the gut flora, causes the immune system to be less effective.
- Trial name
- MISSION-2 (NCT02127749)
- Testing
- Endotoxin, Vancomycin, Metronidazole, Ciprofloxacin
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Behavior Change, Bacterial Infections
Nurse Promotion of IV to PO Antimicrobial Conversion
This is a prospective, quasi-experimental, historically controlled study to evaluate if a behavioural change intervention informed by the COM-B model of behaviour change can improve nurses' self-perceived capability, opportunity…
- Trial name
- FERN-IPO (NCT03761043)
- Testing
- Professional Behavior Change Intervention
- Where
- Canada
- Volunteers
- 853 people
- Sponsor
- Kelowna General Hospital
Prevention
Phase 3 Multicenter Randomized Double Blind Placebo Controlled Study With Antibacterial Prophylaxis in Azacitidine Treated MDS Patients
Infections are a major and prevalent life-threatening complication among patients with myelodysplastic syndrome (MDS). Currently, the role of prophylactic antibacterial agents after chemotherapy in MDS patients remains…
- Trial name
- NCT02981615
- Testing
- Levofloxacin
- Where
- Israel
- Volunteers
- 67 people
- Sponsor
- Sheba Medical Center
Total Hip Arthroplasty (THA), Antibiotic Prophylaxis
Infection-related Revision Rates After Single-dose Versus Multiple-dose Antibiotic Prophylaxis in Primary Hip and Knee Arthroplasty: a Comparative Implementation Study.
Prosthetic Joint Infection (PJI) is a significant issue in joint replacement surgeries, causing additional surgeries and substantial healthcare costs.
- Conditions
- Total Hip Arthroplasty (THA), Antibiotic Prophylaxis, Revision Arthroplasty, Total Knee Arthroplasty
- Trial name
- REVISE (NCT07053943)
- Where
- Netherlands
- Volunteers
- 70,000 people
- Sponsor
- JointResearch
Implant Complication, Implant Infection
Local Antibiotics for Breast Implants
The BREAST-AB Trial is a multi-center, randomized, double blind, placebo-controlled trial investigating the efficacy of local application of gentamicin, vancomycin and cefazolin in decreasing all-cause implant explantation after…
- Conditions
- Implant Complication, Implant Infection, Implant Site Infection, Implant Capsular Contracture
- Trial name
- BREAST-AB (NCT04731025)
- Testing
- Gentamicin, Cefazolin and Vancomycin
- Where
- 8 sites in Denmark
- Volunteers
- 1,003 people, healthy volunteers welcome
- Sponsor
- Mikkel Herly
Chronic Lymphocytic Leukaemia (CLL)
CLL Empirical Antibiotic Regimen
The purpose of this study is to evaluate whether patients with previously untreated, early stage CLL respond to empirical broad spectrum antibiotics and therefore test the hypothesis that occult bacterial infections are involved…
- Trial name
- CLEAR (NCT01279252)
- Testing
- metronidazole, clarithromycin, ciprofloxacin and lansoprazole
- Where
- United Kingdom
- Volunteers
- 71 people
- Sponsor
- King's College Hospital NHS Trust
Antibiotic Use, Rural Healthcare-seeking Behaviour
Antibiotics and Activity Spaces: An Exploratory Study of Behaviour, Marginalisation, and Knowledge Diffusion
The investigators will conduct two rural surveys in Thailand and Lao PDR to improve the understanding of antibiotic-related health behaviour among the general population.
- Conditions
- Antibiotic Use, Rural Healthcare-seeking Behaviour, Marginalisation (Economic, Social, Spatial)
- Trial name
- ESRC (NCT03241316)
- Testing
- Observational study of behaviour
- Where
- 2 sites in Laos, Thailand
- Volunteers
- 5,885 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Ventilator Associated Pneumonia, Respiratory Infection
Aerosolized Antibiotics and Respiratory Tract Infection in Patients on Mechanical Ventilation
The purpose of this study was to determine the effect of aerosolized antibiotics on respiratory infection in mechanically ventilated patients.We hypothesize that aerosolized antibiotics , which achieve high drug concentrations in…
- Conditions
- Ventilator Associated Pneumonia, Respiratory Infection, Tracheobronchitis
- Trial name
- NCT00396578
- Testing
- aerosolized vancomycin or gentamicin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Stony Brook University
Antimicrobial Resistance, Attitude to Health
Testing New Ways to Name Antimicrobial Resistance
This study aims to investigate the public's views on antibiotics and the impact of different ways to name the potential consequences of antibiotics not working in the future.
- Trial name
- NCT06356285
- Testing
- Presentation of Antimicrobial Resistance
- Where
- United Kingdom
- Volunteers
- 4,296 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Neonatal Infection
Neonatal Antimicrobial Resistance and Outcome
This is a multicentre observational study involving NNUs across the UK. Study personnel (Neonatologists and research Nurses) from these NNUs will identify eligible babies in whom a positive culture has been obtained.
- Trial name
- neoAMRO (NCT05743816)
- Where
- United Kingdom
- Volunteers
- 800 people
- Sponsor
- St George's, University of London
Bacterial Vaginosis, Candida Vaginal
The LISA (Lactoferrin InStead of Antibiotics/Antifungals) Feasibility Study
Three-quarters of women have bacterial vaginosis (BV) or vaginal thrush/candida yeast infection at least once during their lifetime. Symptoms can include abnormal vaginal discharge, soreness, itching and an unpleasant smell.
- Trial name
- LISA (NCT05434104)
- Testing
- Vaginal lactoferrin, Usual care
- Where
- 2 sites in United Kingdom
- Volunteers
- 114 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Clostridium Difficile
Use of Recombinant Human Lactoferrin in Long-Term Care Patients With Feeding Tubes With Clostridium Difficile.
Primary objective of this pilot study is to evaluate the effect of recombinant human lactoferrin on the rate of infection with Clostridium difficile in long-term care patients supported by enteral feeding requiring broad spectrum…
- Trial name
- NCT00377078
- Testing
- recombinant human lactoferrin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Gingival Recession, Gingival Recession, Generalized
Evaluation of Root Coverage by Connective Graft and Different Root Conditioning Adjunctive Therapies
The aim of this study was to evaluate the effect of two different treatment agents used in conjunction with subepithelial connective graft technique on root coverage outcomes in multiple recession defects.
- Trial name
- NCT03462368
- Testing
- Control, antimicrobial photodynamic therapy, Photobiomodulation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
UTI
Randomized Trial of Culture Directed Versus Empiric Antibiotics for Urinary Tract Infections in Older Women
To evaluate the feasibility of recruiting eligible subjects into a randomized trial of a culture-directed versus empiric antibiotic strategy for patient-reported urinary tract infection symptoms in older women and the adherence…
- Trial name
- REDUCTION (NCT05726318)
- Testing
- Antibiotics
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Megan Bradley
Periapical Abscess
Comparison of Triple Antibiotic Paste With Combination of Chitosan and Calcium Hydroxide as a Root Canal Disinfectant
Investigators observed the clinical and radiographic healing of periapical lesion using Chitosan mixed with calcium hydroxide and compared it with triple antibiotic paste when used as intracanal medicament in 3months, 6 months…
- Trial name
- NCT04319575
- Testing
- root canal treatment and intracanal medicament
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Pulmonary Tuberculosis, Other Specified Pulmonary Tuberculosis
PanACEA - STEP2C -01
This is a phase 2B/C, open label platform study that will compare the efficacy, safety of experimental regimens with a standard control regimen in participants with newly diagnosed, drug sensitive pulmonary tuberculosis.
- Trial name
- NCT05807399
- Testing
- BTZ-043, Rifampicin, Isoniazid
- Where
- 10 sites in Gabon, Malawi and 4 more
- Volunteers
- 390 people
- Sponsor
- Michael Hoelscher
Biliary Infection, Antibiotic Resistant Strain
Predictive Factors Associated to Bile Cultures and Antibiogram Resistance in Patients with Laparoscopic Cholecystectomy
The BACILO study was designed with the objective of having robust data on local epidemiological bacterial colonisation information on bile cultures with patients taken to laparoscopic cholecystectomy in our institution to find…
- Trial name
- BACILO (NCT06314399)
- Testing
- Bile culture and phenotypic antibiogram resistance test
- Where
- 2 sites in Colombia
- Volunteers
- 703 people
- Sponsor
- Hospital Universitario Mayor Méderi
Sepsis
Procalcitonin as a Tool to Shorten Antibiotic Therapy in the ICU
Recently, biomarkers like procalcitonin have been studied in order to help physicians to decrease the duration of the antibiotic therapy.
- Trial name
- NCT01494675
- Testing
- procalcitonin measurement
- Where
- Brazil
- Volunteers
- 81 people
- Sponsor
- Hospital Israelita Albert Einstein
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