Clinical trials: Anti-bacterial Agents
Sepsis
Procalcitonin to Shorten Antibiotics Duration in ICU Patients
The trial is aimed to show that implementation of a procalcitonin-guided antibiotics algorithm may result in shortened antibiotics course in ICU sepsis patients without inferior outcome as compared to the conventional therapy
- Trial name
- ProShort (NCT01379547)
- Testing
- Procalcitonin guided antibiotics treatment algorithm, Conventional treatment
- Where
- 8 sites in China, Hong Kong and 1 more
- Volunteers
- 1,700 people
- Sponsor
- National Taiwan University Hospital
Drug-Related Side Effects and Adverse Reactions, Treatment Adherence and Compliance
Compliance and Tolerance to Oral AntiBiotherapy in Osteoarticular Infections (OTABIO)
Bone and joint infections (BJI) are most often bacterial infections that can occur after surgery or de novo. They are rarely fatal in the short term, but are associated with significant morbidity, impaired quality of life and…
- Trial name
- OTABIO (NCT05202964)
- Testing
- Tolerance and adherence to oral antibiotics in patients managed for BJI
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Sickle Cell Disease, Acute Chest Syndrome
Use of Macrolides in Acute Chest Syndrome: A Multicenter Retrospective Study
This study looks at whether using macrolide antibiotics is helpful and safe in treating acute chest syndrome, a serious complication in people with sickle cell disease.
- Conditions
- Sickle Cell Disease, Acute Chest Syndrome, Glucose-6-Phosphate Dehydrogenase Deficiency, Anti-Bacterial Agents
- Trial name
- NCT07037706
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Infection, Surgical Site
Efficacy of Antimicrobial Coating Suture Coated Vicryl Plus Compared With Vicryl in Reduced Surgical Site Infection of Dental Implant Surgeries: A Uni-Blind Randomized Clinical Trial Study
Patients randomly aligned in 2 groups.Vicryl plus sutures were used in group 1 for closing subperiostal flaps after dental implant surgeries and vicryl sutures were used in group 2.
- Trial name
- NCT03659344
- Testing
- Vicryl plus
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Shiraz University of Medical Sciences
Chronic Periodontitis
Role of Infected Blood Dendritic Cells in Heart Disease Risk
The investigators hypothesize that blood dendritic cells harbor pathogens from the oral cavity in chronic periodontitis and disseminate these pathogens to atherosclerotic plaques.
- Trial name
- NCT01568944
- Testing
- Oral Antibiotic and Oral Rinse, Standard Treatment
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Augusta University
Bacteremia, Healthcare-associated Pneumonia
Randomized-controlled Trial (RCT) on Combination Antibiotic for Infections Caused by Gram-negative Bacteria
Background and rationale: Antimicrobial resistance is a global public health threat. An increasing number of Gram-negative bacteria isolates worldwide are resistant to virtually all antibiotics including carbapenems.
- Conditions
- Bacteremia, Healthcare-associated Pneumonia, Ventilator-associated Pneumonia
- Trial name
- XDR-GNB (NCT02134106)
- Testing
- Polymyxin B, Polymyxin B + Doripenem
- Where
- 2 sites in Singapore
- Sponsor
- Tan Tock Seng Hospital
Paediatric Antimicrobial Pharmacokinetics
Neonatal and Paediatric Pharmacokinetics of Antimicrobials Study
The aim of NAPPA is to develop new models to improve our understanding of how children process ('metabolise') penicillins, to help us discover if we can improve the dosing regimens used for children in the future.
- Trial name
- NAPPA (NCT01975493)
- Where
- 9 sites in United Kingdom
- Volunteers
- 428 people
- Sponsor
- St George's, University of London
Comparing Antibiotic Duration of Therapy
Procalcitonin Protocol Use to Guide Antibiotic Therapy Duration in the Intensive Care Unit
To compare and contrast antibiotic use and its effects on patient outcomes before and after the implementation of a PCT protocol in the ICU at Methodist Richardson Medical Center (MRMC).
- Trial name
- NCT05756049
- Testing
- compare antibiotic duration of therapy
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Methodist Health System
Cystic Fibrosis
Comparison of Antibiotics for Pseudomonas in Early CF
This is a prospective, randomized clinical trial comparing the effects of these 2 modes of antibiotic treatment on BALF inflammation in young, P. aeruginosa-positive CF patients.
- Trial name
- CAPEC (NCT00823238)
- Testing
- ceftazidime and tobramycin, inhaled tobramycin
- Volunteers
- 21 people
- Sponsor
- University of North Carolina, Chapel Hill
Surgical Site Infection
Prophylactic Antibiotics After Cesarean
The purpose of this study is to determine if the addition of a 48-hour course of post-operative antibiotics to the recommended course of pre-operative antibiotics improves surgical site infection rate in patients who are obese…
- Trial name
- PACT (NCT03187106)
- Testing
- Cephalexin, Metronidazole
- Where
- 2 sites in United States
- Volunteers
- 321 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Postpartum Infectious Morbidity in Cesarean Section Delivery
Role of Skin Cleansing and Prophylactic Antibiotic in Preventing Infectious Morbidity After Cesarean Section Delivery
This study aims to determine the effectiveness of skin cleansing and prophylactic antibiotics given to women undergoing a cesarean section for reducing the incidence of postpartum infectious morbidity and to assess potential…
- Trial name
- NCT03007706
- Testing
- Women undergo cesarean section delivery
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Raghda Gamal Mohamed
Clinical Pharmacists, Electronic Medical Record
Relationship Between the Clinical Pharmacist & Antibiotic Use by Using the Electronic Program
A retrospective cohort study to explore the association between clinical pharmacists' interventions and antibiotic consumption through the use of the medical electronic reports and to identify mortality and cost savings in…
- Trial name
- NCT05002647
- Testing
- NO intervention
- Where
- Egypt
- Volunteers
- 2,601 people
- Sponsor
- Alexandria University
Fungal Infection
The Assessment of Antimicrobial Peptides Against Fungal Infection
Identification of different types of fungi. Determine sensitivity the profile and the resistance pattern of the clinical isolates against antifungal.
- Trial name
- NCT05368948
- Volunteers
- 100 people
- Sponsor
- Assiut University
STI, Mycoplasma Genitalium Infection
Mycoplasma Genitalium Infection and Associated Antimicrobial Resistance Among HIV-infected Male in Hong Kong
Worldwide, Mycoplasma genitalium (MG) is increasingly reported as an emerging cause of sexually transmitted infections. Internationally, the prevalence of MG is higher in male with urethritis and community groups especially among…
- Trial name
- NCT05789134
- Testing
- self-sampling kits for STI testing in the laboratory
- Where
- Hong Kong
- Volunteers
- 573 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Infection Secondary to Surgical Procedure
Antibiotic Prophylaxis in Gynecologic Laparoscopy
Laparoscopy is a surgical procedure indicated for most gynecological pathologies and presents numerous advantages over laparotomy, among them lower rates of surgical site infection and less comorbidity feverish.
- Trial name
- NCT01991834
- Testing
- gynecologic laparoscopy, Cefazolin
- Where
- 2 sites in Brazil
- Volunteers
- 114 people
- Sponsor
- Universidade do Vale do Sapucai
Cirrhosis, Liver, Hypertension, Portal
Prophylactic Antibiotics in Endoscopic Secondary Prevention of Gastroesophageal Variceal Bleeding
Whether prophylactic antibiotics should be administered in the endoscopic secondary prevention of GVB or not is unclear. In this non-inferiority trial, we are aimed to evaluate whether prophylactic antibiotics are essential in…
- Conditions
- Cirrhosis, Liver, Hypertension, Portal, Variceal Hemorrhage
- Trial name
- NCT06437964
- Testing
- No use of prophylactic antibiotics, Prophylactic Antibiotics
- Where
- China
- Volunteers
- 226 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Helicobacter Pylori Infection, Antimicrobial Susceptibility Testing
Antimicrobial Susceptibility Testing Guided Antibiotic Selection Strategies in Salvage Helicobacter Pylori Treatment
Helicobacter pylori (H. pylori), which infects about 50% of the global population, has been recognized as a main risk factor of multiple gastric pathologies, especially non-cardiac gastric cancer.
- Trial name
- NCT02988089
- Testing
- Clarithromycin susceptibility dependant strategy, 2 susceptible antibiotics (amoxicillin, clarithromycin, metronidazole, tinidazole,levofloxacin, furazolidone and tetracycline ), proton pump inhibitor (PPI) and Colloidal Bismuth Pectin
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Shandong University
Complicated Urinary Infection
Urinary Tract Infection Study With the Antibiotic Levofloxacin Given at a Higher Dose Over a Shorter Period of Time
The purpose of the study is to compare the safety and effectiveness of the antibiotic levofloxacin by administering a higher dose of levofloxacin and using a shorter course of therapy.
- Trial name
- NCT00245791
- Testing
- Levofloxacin
- Where
- 3 sites in Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Tuberculous Meningitis, HIV
BPaLMZ for TB Meningitis
This two-stage study will compare consented research participants with tuberculous meningitis receiving experimental Bedaquiline (B), Pretomanid (Pa), Linezolid (L); Moxifloxacin (M), Pyrazinamide (Z) known as (BPaLMZ) to…
- Conditions
- Tuberculous Meningitis, HIV, Meningitis, TB - Tuberculosis
- Trial name
- BPaLMZ (NCT07227779)
- Testing
- BPaLMZ Regimen
- Where
- 2 sites in Uganda
- Volunteers
- 312 people
- Sponsor
- David Boulware
Ventilator Associated Pneumonia, Critical Care
Delayed Antibiotic Therapy in Non-severe Ventilator Acquired Pneumonia (VAP)
This retro-prospective monocentric observational study compare the impact of the implementation of a restrictive (delayed) versus aggressive (immediate) antibiotic strategy for Ventilator Acquired Pneumonia suspicion without…
- Conditions
- Ventilator Associated Pneumonia, Critical Care, Antibiotic Therapy
- Trial name
- DELAVAP (NCT05205525)
- Testing
- Restrictive antibiotic strategy, Aggressive antibiotic strategy
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Nantes University Hospital
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