Clinical trials: Anti-bacterial Agents
Diabetes Mellitus
Comparative Study of Antibacterial Effect on Silver Dressing of Negative Pressure Wound
The purpose of this study is to test therapeutic benefits of silver dressing compared with non-silver dressing in NPWT(Negative pressure wound therapy). Silver dressing may antibacterial effect on infected diabetes mellitus foot.
- Trial name
- NPWT-silver (NCT02274207)
- Testing
- NPWT application
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Severance Hospital
Hydrocephaly, CSF Shunts
Cefazolin Antibiotic Prophylaxis in Ventricular Shunt Surgery: Determination of Cerebrospinal Fluid Concentration During Valve Implantation
The objective is to determine the concentration of cefazolin in the cerebrospinal fluid after a recommended antiobiotic prophylaxis by 2g of cefazolin.
- Conditions
- Hydrocephaly, CSF Shunts, Antibiotic Prophylaxis
- Trial name
- CC -PIV (NCT07067736)
- Testing
- Cefazolin antibiotic prophylaxis
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Strasbourg, France
Beta Lactam Adverse Reaction
Optimization of Perioperative Antibiotic Prophylaxis in Patients Allergic to Beta-lactams in the Orthopedic Surgery and Trauma Departments
When surgery is required, a consultation with an anesthesiologist is mandatory. This preoperative consultation allows for the selection of the appropriate antibiotic prophylaxis tailored to the patient and the type of procedure.
- Trial name
- ORTHO-PEN (NCT07342647)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Methicillin-Resistant Staphylococcus Aureus, ESBL
Mastering Hospital Antimicrobial Resistance and Its Spread Into the Community-Healthcare Workers
Medical staff will be screened for MRSA and ESBL (including: doctors, nurses, nurse aids, physical therapists, dietitians, Janitors and other medical staff).
- Trial name
- MOSAR (NCT00773864)
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Dental Pulp Necrosis
Antimicrobial Efficacy of Four Different Irrigation Protocols
proper disinfection of root canal system before obturation is a must for long term success of endodontic treatment, therefore a proper irrigant is mandatory, therefore investigators are studying the antibacterial effects of 4…
- Trial name
- NCT03668899
- Testing
- irrigation
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Bronchopulmonary Infection
Clinical Course and Changes in the Respiratory Microbiota Based on Antibiotic Treatment in Patients With Cystic Fibrosis
Bronchopulmonary infection is the most common and serious complication in the evolutionary course of cystic fibrosis (CF). Administration of antibiotics adapted to infecting pathogens is one of the key issues for its management.
- Trial name
- NCT01693965
- Testing
- sputum samples
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cellulitis of Leg
Cellulitis Optimal Antibiotic Treatment
To determine whether a short course of oral flucloxacillin (5 days) is non-inferior to a standard course (7 days) in terms of pain over days 6-14 (indicative of persistence or recurrence associated with the symptoms of most…
- Trial name
- COAT (NCT05584007)
- Testing
- Flucloxacillin Only Product in Oral Dose Form
- Where
- United Kingdom
- Volunteers
- 334 people
- Sponsor
- University of Southampton
Beta Lactam Allergy in Patients With a Hematologic Malignancy
Allergy Delabeling in Antibiotic Stewardship - Evaluations
The goal of this RENEW-EVAL project is to understand the potential barriers to implementation of the RENEW intervention into the routine clinical care of patients with a hematological malignancy.
- Trial name
- RENEW-EVAL (NCT06967467)
- Testing
- Semi-structured interview, Survey, Ethnographic observation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Stress Urinary Incontinence, Postoperative Urinary Tract Infection
The Effectiveness of Prophylactic Antibiotics for Urethral Bulking
The goal of this clinical trial is to evaluate if prophylactic antibiotics in urethral bulking are effective in reducing postprocedural urinary tract infections.
- Conditions
- Stress Urinary Incontinence, Postoperative Urinary Tract Infection, Urethral Bulking
- Trial name
- NCT06261736
- Testing
- Prophylactic antibiotics, No antibiotics
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Atlantic Health System
Communication, Anti-Bacterial Agents
Resetting the Default: Improving Provider-patient Communication to Reduce Antibiotic Misuse
Antibiotic overuse and misuse contributes to the development of antibiotic resistant infections and adverse drug reactions. The majority of all antibiotic prescribing occurs in outpatient settings; most of which are for…
- Conditions
- Communication, Anti-Bacterial Agents, Decision Making, Personal Satisfaction
- Trial name
- NCT03037112
- Testing
- Education, Communication Skills
- Where
- 3 sites in United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Intensive Care Unit
Intestinal Microbiota and Their Antibiotic Resistance Genes of ICU Health Care Workers
In this study, metagenomic sequencing (10G) results of stool samples from health care workers in ICU and non-medical professionals were compared to observe whether there are significant differences in community diversity…
- Trial name
- NCT06524765
- Testing
- Living conditions
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Sinusitis
Antibiotics Versus Therapeutic Ultrasound for Sinusitis
Question: Is the effect of therapeutic ultrasound equally effective to antibiotic for treatment of sinusitis? Design: A randomized clinical trial with concealed allocation, self-assessment by the subjects and intention-to-treat…
- Trial name
- NCT00934830
- Testing
- Antibiotic (Amoxicillin), Therapeutic ultrasound
- Where
- Norway
- Volunteers
- 48 people
- Sponsor
- Norwegian University of Science and Technology
Lung Transplantation
Development a Method to Extract Antibiotic Concentration From Interstitial Lung and Epithelial Lining Fluid.
Infections are critical factors for the survival of critically ill patients. A serious problem is the high variability of antibiotic concentrations in critically ill patients.
- Trial name
- ALF (NCT03970265)
- Testing
- extraction of ELF and ILF from explanted lung tissue; meropenem concentration in ELF and ILF; ELF on postoperative day 1-5 when bronchoscopy is performed within clinical routine.
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Acute Appendicitis
Initial Antibiotics and Delayed Appendectomy for Acute Appendicitis
Several recent studies have examined the feasibility and benefits of nonoperative treatment of perforated appendicitis in children.
- Trial name
- NCT01697059
- Testing
- Piperacillin + Amoxicillin
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Rhode Island Hospital
Mastitis Acute Female
The Effect of Chinese Herbal Medicine for Reducing the Application of Antibiotics in the Treatment of Acute Mastitis
The object of the study is to evaluate the effect of Pugongying (Herba Taraxaci) Granules to reduce the application of antibiotics for women with acute mastitis.
- Trial name
- NCT03756324
- Testing
- CHPM (Chinese Herbal Patent Medicine ), Antibiotics Cefdinir Capsules, Education
- Where
- 3 sites in China
- Volunteers
- 306 people
- Sponsor
- Beijing University of Chinese Medicine
Early Ventilator Associated Pneumonia
Duration of Antibiotic Treatment for Early VAP (DATE) Trial
Hypothesis: 4 days of antibiotic therapy, as compared to 8 days, is equally effective and results in decreased antibiotic exposure among surgical ICU patients with early VAP.
- Trial name
- DATE (NCT01994980)
- Testing
- Default 4 days antibiotic therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Denver Health and Hospital Authority
Infections, Respiratory Tract
Evaluate Safety, Tolerability, and Pharmacokinetics of Single and Repeat IV Doses
GSK2140944 belongs to the Bacterial Type II Topoisomerase Inhibitor (BTI) class of antibiotics. GSK2140944 has demonstrated in vitro and in vivo activity against Gram positive pathogens including methicillin resistant…
- Trial name
- NCT01615796
- Testing
- Part A: GSK2140944 Drug single dose of 200mg, 600mg, 1200mg, 1800 mg, and dose to be determined, Part B: GSK2140944 Repeat Drug dose of 400mg, 750mg, 1000 mg, and dose to be determined
- Where
- Australia
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Intra-Abdominal Infections
Procalcitonin Guided Antibiotic Therapy
The overuse of antibiotics is an enormous problem facing the healthcare system both in the United States and across the world. The investigators plan to test the hypothesis that using procalcitonin levels (blood test) to guide…
- Trial name
- NCT04240288
- Testing
- Procalcitonin-guided antibiotic treatment, Standard of Care Antibiotic Treatment
- Sponsor
- Columbia University
Antimicrobial Resistance (AMR), Oral Microbiota
Salivary Microbiota and Antimicrobial Resistance in Relation to Chlorhexidine Use
This study evaluated the ecological effects of 0.06% chlorhexidine toothpaste on the salivary microbiota of healthy individuals, focusing on taxonomic composition, functional shifts, and prevalence of predicted antimicrobial…
- Conditions
- Antimicrobial Resistance (AMR), Oral Microbiota, Oral Microbiome Health, Chlorhexidine
- Trial name
- SMARCH (NCT07570927)
- Testing
- 0.06% Chlorhexidine Digluconate Toothpaste
- Where
- 2 sites in Czechia
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Syphilis, Congenital
Comprehensive Ambulatory Antibiotics for the Treatment of Congenital Syphilis
CARES-1 is a randomised, open-label, phase II pharmacokinetic (PK) and safety study of ambulatory antibiotics for the treatment of neonates with "all-risk" asymptomatic congenital syphilis.
- Trial name
- Cares-1 (NCT06921213)
- Testing
- Linezolid (LZD), Amoxicillin, Benzathine Penicillin G
- Where
- 3 sites in Indonesia, Malawi and 1 more
- Volunteers
- 90 people
- Sponsor
- London School of Hygiene and Tropical Medicine
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.