Clinical trials: Anti-bacterial Agents
Surgery
Preoperative CHG Cloth on Healthy Subjects
Evaluate the effects of CHG cloth on the reduction of bacteria on the skin.
- Trial name
- NCT02291601
- Testing
- Chlorhexidine Gluconate, Vehicle, DynaHex-2
- Where
- United States
- Volunteers
- 879 people, healthy volunteers welcome
- Sponsor
- Medline Industries
Infectious Disease, Influenza
Antibiotic Therapy in Viral Airway Infections
Antimicrobial resistance is one of the most urgent health threats of our time, and Norwegian hospitals were required to reduce the use of broad-spectrum antibiotics with 30% by the end of 2020.
- Conditions
- Infectious Disease, Influenza, Respiratory Syncytial Virus (RSV), Respiratory Tract Infections
- Trial name
- ATHENIAN (NCT05045612)
- Testing
- Stop antibiotic therapy
- Where
- 12 sites in Norway
- Volunteers
- 380 people
- Sponsor
- University Hospital, Akershus
Malignant Otitis Externa
Microbiological Screening Of Malignant Otitis Externa Patients Presenting at Sohag University Hospitals
This is a prospective study to identify the bacterial and fungal organisms causing Malignant Otitis Externa (MOE) in patients presenting to Sohag University Hospitals.
- Trial name
- MOE Screening (NCT07790679)
- Testing
- ear swab and susceptibility testing
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Fracture Femur, Fracture Tibia
Standard Versus Short Course Prophylactic Antibiotic in Femur and Tibia Shaft Fractures Managed With Intramedullary Interlocking Nail
Long-bone fractures, particularly of femur and tibia, are common following fall injury and road traffic accidents.1,2 The standard treatment is "intramedullary nailing," where a metal rod is inserted into the center of the bone…
- Conditions
- Fracture Femur, Fracture Tibia, Surgical Site Infection (SSI), Antibiotic
- Trial name
- NCT07554079
- Testing
- Short Course Antibiotics, Standard Course Antibiotics
- Where
- Nepal
- Volunteers
- 56 people
- Sponsor
- Kathmandu University School of Medical Sciences
Changes in the Gut Microbiota During an Antibiotic Treatment
Gut Microbiota and Antibiotics - Prevention of Side Effects by New Prebiotics
Antibiotics disturb the balance of gut microbiota causing dysbiosis. The purpose of this double-blind placebo controlled intervention study is to investigate whether a new prebiotic product could prevent the side effects of…
- Trial name
- NCT03523936
- Testing
- Prebiotic product
- Volunteers
- 30 people
- Sponsor
- Turku University Hospital
Bone and Joint Infection
Consitution Of A Biological Collection From Samples From The Gut Microbiote In Patients Having A Bone Or Joint Infection Treated By A Suppressive Subcutaneous Antibiotherapy With Betalactamine
Optimal surgical therapy (debridement in chronic osteomyelitis; device exchange in patients with chronic prosthetic joint infection [PJI]) could be sometimes non-feasible, especially in the elderly population.
- Trial name
- NCT03611634
- Testing
- BIOLOGICAL COLLECTION FROM THE GUT MICROBIOTE
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Chronic Obstructive Pulmonary Disease
Effectiveness of Antibiotic Therapy for Exacerbations of Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine the effectiveness of antibiotic therapy for patients with acute exacerbations of mild-to-moderate chronic obstructive pulmonary disease.
- Trial name
- TRANCE (NCT00495586)
- Testing
- Amoxicillin and clavulanic acid
- Where
- 13 sites in Spain
- Volunteers
- 318 people
- Sponsor
- Societat Catalana de Medicina Familiar i Comunitària, Assoc. (CAMFiC)
Gram-negative Bacteremia
Rapid Identification and Phenotypic Susceptibility Testing for Gram-Negative Bacteremia
RAPIDS-GN is a multi-center, prospective, randomized, controlled trial to evaluate the following strategies for patients with confirmed gram-negative bacillus bacteremia (GNB): 1.
- Trial name
- RAPIDS-GN (NCT03218397)
- Testing
- Accelerate PhenoTest™ BC Kit, Standard Culture and AST
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- Duke University
Antibiotic Resistant Infection
Strategy to Prevent Transmission of Multidrug-resistant Gram-negative Organisms in ICU
1. Objective of study The purpose of this study was to investigate whether the active surveillance and preemptive isolation of multidrug-resistant Gram-negative bacteria in the intensive care unit affected the reduction of the…
- Trial name
- NCT03980197
- Testing
- Active surveillance and preemptive isolation, Control
- Where
- South Korea
- Volunteers
- 2,500 people
- Sponsor
- Sung-Han Kim
Sjogren Syndrome, Xerostomia
Photodynamic Treatment as Part of Oral Healthcare on Persons With Sjögren's Syndrome
This thesis study will investigate whether the regular use of antibacterial photodynamic therapy can alleviate dry mouth symptoms in patients with Sjogren's syndrome and thus be a potential addition to regular oral self-care…
- Trial name
- NCT06877546
- Testing
- Lumoral treatment
- Where
- Finland
- Volunteers
- 16 people
- Sponsor
- Koite Health Oy
Probiotic
Heat-Inactivated Lactobacillus Salivarius HM-6 in Preschool Children With ECC
This study aims to evaluate whether a short, 14-day administration of chewable tablets containing heat-inactivated Lactobacillus salivarius HM-6 Paradens can influence selected salivary parameters related to oral health in…
- Trial name
- AEPRO (NCT07825324)
- Testing
- Children in the intervention group received commercially available chewable tablets containing 10 mg of heat-inactivated Lactobacillus salivarius HM-6 Paradens.
- Where
- Poland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Infection
Expanding Antimicrobial Stewardship
Gold standard diagnostic criteria for diagnosing acute infection in older adult patients in the Emergency Department do not currently exist.
- Trial name
- NCT01746888
- Where
- United States
- Volunteers
- 437 people, healthy volunteers welcome
- Sponsor
- Jeffrey Caterino
Healthy Adults
Dietary Supplement With and Without a Probiotic and/or Antibiotic
Complex oligosaccharides can alter the gut microbiome by aiding in the growth of certain organisms, and possibly, inhibiting others. The synergy with a probiotic may enhance gastrointestinal colonization.
- Trial name
- NCT05141903
- Testing
- Antibiotic, HMO Concentrate, Probiotic
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Prolacta Bioscience
Influenza
Procalcitonin Role in Influenza Patients With Regard to Morbidity, Mortality and Antibiotic Use
The investigators intend to observe the inflammatory marker procalcitonin (PCT) in comparison with patient variables on morbidity, mortality and antibiotic treatment.
- Trial name
- NCT04171128
- Testing
- antibiotic stewardship efforts
- Where
- 2 sites in Norway
- Volunteers
- 119 people
- Sponsor
- Ostfold Hospital Trust
Aggressive Periodontitis
Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis
The aim of this study is to assess the clinical outcomes of full-mouth ultrasonic debridement combined with clarithromycin or amoxicillin + metronidazole association for the treatment of generalized aggressive periodontitis…
- Trial name
- NCT02969928
- Testing
- Full-mouth ultrasonic debridement, Clarithromycin, Amoxicillin
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Antibiotic Resistance
Impact on Antibiotic Prescriptions of a Bundle Intervention Conducted by Medical Representatives in General Practitioner Facilities, Based on Operational Demonstration of an Internet Decision Support Tool: Antibioclic
At the international level, several experiments have been conducted to modify antibiotic prescribing practices in GPs. The mere development of training or the mere provision of information on the internet do not seem to change…
- Trial name
- ACTION (NCT04028830)
- Testing
- Visit to GPs to promote good antibiotic prescription with the help internet tool for decision: ANTIBIOCLIC, Visit to GPs to promote good antibiotic prescription without presentation of the internet tool for decision support
- Where
- France
- Volunteers
- 2,501 people
- Sponsor
- Nantes University Hospital
Arthritis, Septic
Two Versus Four Weeks of Antibiotic Treatment in Native Joint Arthritis
The optimal duration of systemic antibiotic administration for native joint septic arthritis is unknown. The investigators perform a randomized study allowing up to 3 surgical lavages and allocating patients into a two-week's and…
- Trial name
- NCT03615781
- Testing
- Two week's arm - surgery, Four week's arm - surgery, Two week's arm - drugs
- Where
- Switzerland
- Volunteers
- 85 people
- Sponsor
- University Hospital, Geneva
Cystic Fibrosis
Outpatient Antibiotic Treatment for a Cystic Fibrosis Pulmonary Exacerbation
This study plans to learn more about the effect of oral antibiotics for an outpatient pulmonary exacerbation (respiratory illness) on sputum (mucus) bacterial infections, lung function, airway inflammation and quality of life.
- Trial name
- NCT02480270
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Colorado, Denver
Invasive Fungal Infections, Invasive Bacterial Infection
PATH Study: People With Injecting Related Infections: Assessing Treatment Outcomes for Those Who Are Hospitalised.
We seek to characterise the burden and outcomes of and understand the current experience of people who inject drugs admitted to hospital with invasive injecting-related infections, in order to implement and evaluate strategies to…
- Conditions
- Invasive Fungal Infections, Invasive Bacterial Infection, Injection Site Infection, Infection, Bacterial
- Trial name
- PATH (NCT06220370)
- Testing
- Observational
- Volunteers
- 300 people
- Sponsor
- Kirby Institute
Reversible Pulpitis, Pulpitis
Antibacterial Effect and Clinical Performance of Chitosan Modified Glass Ionomer
The study is a randomized clinical trial that assesses the clinical success and the antibacterial effect on carious dentine of glass ionomer when modified with Chitosan and/or Titanium dioxide nano particles vs the control group…
- Conditions
- Reversible Pulpitis, Pulpitis, Caries,Dental, Caries Class I
- Trial name
- NCT04365270
- Testing
- Glass Ionomer, Chitosan Low Molecular Weight (20-200 Mpa.S), Chlorhexidine Diacetate
- Where
- Egypt
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
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