Clinical trials: Anti-bacterial Agents
Appendicitis
A Study Comparing Safety and Efficacy of Levofloxacin and Metronidazole Versus Piperacillin/Tazobactam in Treating Complicated Appendicitis
The purpose of this study is to compare the efficacy and safety of two treatment regimens in treating patients with complicated appendicitis.
- Trial name
- NCT00236912
- Testing
- levofloxacin; metronidazole
- Volunteers
- 139 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Small Intestinal Bacterial Overgrowth
Antibiotic Treatment Trial for Small Intestinal Bacterial Overgrowth
This is a randomized, double-blind, placebo-controlled study to evaluate the efficacy of ciprofloxacin versus metronidazole versus placebo in eradication of small intestinal bacterial overgrowth (SIBO).
- Trial name
- NCT02458781
- Testing
- Metronidazole, Ciprofloxacin
- Volunteers
- 180 people
- Sponsor
- San Antonio Military Medical Center
Breastfeeding, Breastfeeding Education
Improved Child Nutrition and Development Through Social Transfers
The goal of this clinical trial is to learn if a conditional social transfer works to improve rates of complementary breastfeeding.
- Conditions
- Breastfeeding, Breastfeeding Education, Breastfeeding Duration, Breastfeeding Continuation
- Trial name
- TENDER (NCT07569172)
- Testing
- Social Transfer
- Where
- Côte d’Ivoire
- Volunteers
- 1,040 people
- Sponsor
- Swiss Tropical & Public Health Institute
Urinary Tract Infections
Fosfomycin Versus Standard of Care in Children With Antibiotic-resistant Urinary Tract Infections
Urinary tract infections (UTIs) are among the most common bacterial infections in children. Up to 50% of UTI's are caused by multi-drug resistant ESBL-producing gram negative bacteria that do not respond to treatment with oral…
- Trial name
- FosUTI (NCT05709028)
- Testing
- Fosfomycin, Standard of care antibiotics
- Where
- 5 sites in Australia
- Volunteers
- 300 people
- Sponsor
- University of Sydney
Drug Hypersensitivity, Penicillin Allergy
Drug Challenges Without Prior Skin Testing
The investigators are conducting a prospective study to determine the safety and outcomes of placebo-controlled graded drug challenges without prior skin testing in patients with a low-risk history of antibiotic hypersensitivity…
- Conditions
- Drug Hypersensitivity, Penicillin Allergy, Antibiotic Allergy
- Trial name
- NCT03158831
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Pouchitis
Stelara fOr ChRonic AntibioTic rEfractory pouchitiS
To evaluate the efficacy and safety of ustekinumab in the treatment of chronic antibiotic refractory and relapsing pouchitis.
- Trial name
- SOCRATES (NCT04089345)
- Testing
- Ustekinumab
- Where
- 3 sites in Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cystic Fibrosis
Virtual Care in CF (VIRTUAL-CF) Study
Cystic fibrosis (CF) is the most common fatal inherited condition in Caucasians, causing recurrent chest infections (pulmonary exacerbations).
- Trial name
- NCT03069651
- Testing
- Virtual Care
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Heart of England NHS Trust
Pneumonia, Bacterial
Five Versus Seven Day Antibiotic Course for the Treatment of Pneumonia in the Intensive Care Unit
The goal of the study is to determine if patients who are being treated for pneumonia in the intensive care unit can be safely treated with five days of antibiotics (the current standard is seven to eight days).
- Trial name
- NCT01554657
- Testing
- 5 Days of Antibiotics, 7 Days of Antibiotics therapy for pneumonia
- Volunteers
- 46 people
- Sponsor
- Washington University School of Medicine
Neonatal Sepsis, Sepsis
Simplified Antibiotic Therapy for Sepsis in Young Infants
This trial evaluates primary care clinic-based simplified antibiotic therapy options for young infants, 0-59 days old in high neonatal mortality settings in peri-urban Karachi where hospital referral is frequently refused by…
- Conditions
- Neonatal Sepsis, Sepsis, Infection
- Trial name
- SATT (NCT01027429)
- Testing
- procaine penicillin and gentamicin, amoxicillin and gentamicin, procaine penicillin, gentamicin, amoxicillin
- Where
- Pakistan
- Volunteers
- 2,543 people
- Sponsor
- Aga Khan University
Secondary or Tertiary Peritonitis
Procalcitonin as a Marker for the Length of Antibiotic Treatment in Peritonitis and Intra-abdominal Infections
Procalcitonin level used for determining length of antibiotic treatment in peritonitis and intra-abdominal infections. Hypothesis is that length of antibiotic use can be shortened by this method.
- Trial name
- NCT01155739
- Where
- Switzerland
- Volunteers
- 162 people
- Sponsor
- University of Lausanne Hospitals
Chorioamnionitis, Puerperal Endometritis
Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term
The aims of this study are to determine whether antibiotics administered routinely in women presenting with premature rupture of membranes later than the 37+0 weeks of gestation can alter the rate of maternal and neonatal…
- Conditions
- Chorioamnionitis, Puerperal Endometritis, Neonatal Early Onset Sepsis, Neonatal Meningitis
- Trial name
- NCT01633294
- Testing
- Ampicillin + gentamicin
- Where
- Portugal
- Volunteers
- 161 people
- Sponsor
- Hospital de Santa Maria, Portugal
Surgical Site Infection
Efficacy Study to Evaluate Antimicrobial Effectiveness of ZuraPrep™ (ZX-ZP-0055)
This is a randomized, paired-comparisons design where each subject receives two of the planned treatments.
- Trial name
- NCT02296645
- Testing
- ZuraPrep, ChloraPrep
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Zurex Pharma, Inc.
Anastomotic Leak, Microbial Colonization
SURGIcal COmplication and MIcrobiome ChangeS in Colorectal Surgery
The microbiome, the collection of microorganisms that live in our gut, plays an important role in maintaining our health, proper nutrient absorption, nutrient turnover and immunity.
- Trial name
- Surgi-Comics (NCT05779254)
- Testing
- Neomycin Sulfate
- Where
- 3 sites in Hungary
- Volunteers
- 100 people
- Sponsor
- Uzsoki Hospital
Prescribing, Off-Label
CMO Letter to Reduce Unnecessary Antibiotic Prescribing and Broad Spectrum Prescribing Winter 2018-9
This trial aims to reduce unnecessary prescription of antibiotics and broad spectrum antibiotics by general practitioners (GPs) in England.
- Trial name
- CMO2018-9 (NCT03862794)
- Testing
- new social norm feedback letter with bar chart, standard social norm feedback letter
- Where
- United Kingdom
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Public Health England
Liver Cirrhosis, Upper Gastrointestinal Bleeding
Prophylactic Antibiotics in Prevention of Spontaneous Bacterial Peritonitis in Compensated Liver Cirrhosis
timely short-term antibiotic prophylaxis is an essential step in the management of these patients . Prophylaxis must be instituted as early as variceal hemorrhage is suspected, and timely administration has been associated with a…
- Trial name
- NCT04711122
- Testing
- Third generation cephalosporin antibiotics
- Volunteers
- 80 people
- Sponsor
- Assiut University
Premature Rupture of Membrane
Comparison of Two Antibiotic Prophylactic Protocols in Preterm Premature Rupture of the Membranes
The objective of the study is to compare a new antibiotic protocol with the current prophylactic treatment in routine use and to evaluate obstetric and neonatal outcome: preterm labor, chorioamnionitis and early onset sepsis
- Trial name
- NCT02819570
- Testing
- I.V cefuroxime 750 mg*3/d for 2 days, I.V ampicillin 2 gram x4/d for 2 days, P.O cefuroxime 500 mgx2/d for 5 days
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- Western Galilee Hospital-Nahariya
Digestive System Disorders, Adverse Effects
The Treatment of Periodontal Diseases
The purpose of this study is to examine if the correct use of antibiotics, as well as the application of one-day-treatment, in the therapy of periodontal diseases.
- Trial name
- NCT01318928
- Testing
- Metronidazol
- Where
- Norway
- Volunteers
- 184 people
- Sponsor
- University of Oslo
Arrhythmia
Prevention of Arrhythmia Device Infection Trial (PADIT)
The goal of the pilot study is to compare whether a centre-wide policy of incremental antibiotic therapy will reduce pacemaker infection compared to a policy of conventional antibiotic prophylaxis in high-risk patients undergoing…
- Trial name
- NCT01613092
- Testing
- Incremental, Cefazolin
- Where
- 2 sites in Canada
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Cirrhosis, Liver
Prophylactic Antibiotics in Admitted Cirrhotics
In this pilot study, the investigators aim to assess feasibility of subject identification and data collection, including specimen processing, as well as the rate of enrollment for a future, larger study of the effect of empiric…
- Trial name
- NCT04218695
- Testing
- Ceftriaxone, Normal saline
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Beth Israel Deaconess Medical Center
Recurrent Urinary Tract Infection
Effect of Nanotechnology Structured Water Magnalife for the Prevention of Recurrent Urinary Tract Infections.
This study investigates nanotechnology structured water magnalife in urology and to test its effects against lower urinary tract infections (UTI) in females.
- Trial name
- NCT04306731
- Testing
- Nanotechnology Structured water Magnalife, Trimethoprim, Ordinary bottled drinking water
- Where
- Iraq
- Volunteers
- 437 people
- Sponsor
- University of Sulaimani
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