Clinical trials: Anti-inflammatory Agent
Postprandial Inflammation
Anti-inflammatory Effects of Fiber
The main objective of this research is to investigate the effect of addition of fiber on the high fat high carbohydrate (HFHC) meal induced inflammation and oxidative stress mechanisms at the molecular level in humans, in vivo.
- Trial name
- NCT02781350
- Testing
- HFHC meal, HFHC MEAL plus Fiber
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Obesity, Diabetes Mellitus, Type 2
Study of the Potential of a Macronutrient Balanced Normocaloric Diet to Treat Lifestyle Diseases
One of today's major health problem in the western world is related to lifestyle. Lifestyle diseases include obesity, type 2 diabetes, cardiovascular diseases and different types of cancers.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Cardiovascular Diseases
- Trial name
- NCT01278121
- Testing
- Diet A, Diet B
- Where
- Norway
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Assessment of the Trophic and Anti-inflammatory Effect of SVF Added With HPL
Evaluation of Enhanced Therapeutic Effect of Adipose Stromal Vascular Fraction Added With Human Platelet Lysate in Treatment of Osteoarthritis
Osteoarthritis (OA) is a highly progressive and debilitating joint disease. Recently, it was demonstrated the existence of an important link between OA inflammation and progression of structural changes.
- Trial name
- NCT04225481
- Testing
- isolation of waste material and culturing with different supplement culture media
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Multiple Sclerosis
Defining the Anti-inflammatory Role of Lipoic Acid in Multiple Sclerosis
The purpose of this study is to learn about how the antioxidant, lipoic acid, works in the body and how it may help in the management of relapsing remitting and secondary progressive multiple sclerosis.
- Trial name
- NCT00997438
- Testing
- Lipoic Acid
- Where
- 2 sites in United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Portland VA Medical Center
Hereditary Angioedema (HAE)
Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese Volunteers
This is a single-dose study to evaluate the pharmacokinetics, safety, and tolerability of icatibant administered to adult Japanese subjects.
- Trial name
- NCT02045264
- Testing
- Icatibant (30 mg)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Shire
Osteoarthritis, Knee
Parabens Flocculation on the Anti Inflammatory Effects of Corticosteroid Injections for Total Knee Arthroplasty
The purpose of this study is to identify whether corticosteroid use with anesthetics containing preservatives (parabens) reduces clinical effectiveness of the anti-inflammatory agent Up to 100 patients, both male and female…
- Trial name
- 5160373 (NCT03445611)
- Testing
- corticosteroid solution with lidocaine containing parabens., corticosteroid solution with lidocaine containing no paraben
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Ebola Virus Disease, Marburg Virus Disease
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
Primary Objective: To evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults.
- Trial name
- NCT04723602
- Testing
- cAd3-Marburg, cAd3-EBO-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Periodontitis
A Clinical Trial to Study the Effect of a Drug, Curcumin in Patients With Periodontitis
The study will follow a parallel arm, randomised, double blinded, placebo controlled design. There will be two groups Group 1 = receiving 1% curcumin chips after routine scaling and root planing (n=20) Group 2 = receiving placebo…
- Trial name
- NCT03790605
- Testing
- 1 % curcumin chip, Scaling and root planing
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- KLE Society's Institute of Dental Sciences
Cancer
Study to Assess the Safety and Tolerability of MBF-118 in Healthy Volunteers
This is a single center, randomised, double blind, placebo controlled clinical study to assess the safety and tolerability of MBF-118 in healthy volunteers.This clinical phase I trial is divided in two stages and involves, first…
- Trial name
- NCT05921916
- Testing
- MBF-118 oral capsules
- Where
- Spain
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Medibiofarma S.L.
Healthy
Tolerability, Safety and Pharmacokinetic Study Of Methosulide in Healthy Adult Subjects
The purpose of this study is to determine the safety and tolerability, and to evaluate the pharmacokinetic characteristics and food effect of Methosulide after oral administration in healthy adult subjects.
- Trial name
- NCT02374684
- Testing
- Methosulide
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Hubei Biological Medicine Industrial Technology Institute Co., Ltd.
Liver Transplant; Complications, Infections
Inflammatory and Anti-Inflammatory Gene Expressions in Liver Transplant Patients
In our study, some inflammatory Interleukin-2 , Interleukin-6, Interferon-γ, Tumor Necrosis Factor-α and anti-inflammatory Interleukin-4 and Interleukin-10 cytokine genes expressions and Triggering Receptor Expressed On Myeloid…
- Conditions
- Liver Transplant; Complications, Infections, Gene Amplification, Immune Response
- Trial name
- NCT05852964
- Testing
- Molecular Immunology , gene expressions
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Inonu University
Healthy
Effect of Brazilian Fruits Peel on Metabolic Regulation and Appetite in Healthy Subjects
The purpose of the study was to investigate how Brazilian fruits peel affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective…
- Trial name
- BRASIL-MET (NCT02245906)
- Testing
- Control drink, Brazilian fruit peel flour, Negative control drink
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Lund University
Bone Resorption, Stress Fracture
The Effects of NSAIDs on Bone Metabolism Following Exercise
The purpose of this study is to determine the effects of a single dose of non-steroidal anti-inflammatory drugs on post-exercise markers of bone and muscle metabolism.
- Conditions
- Bone Resorption, Stress Fracture, Bone Injury
- Trial name
- NCT05512013
- Testing
- Ibuprofen 800 mg, Celecoxib 200mg, Flurbiprofen 100 mg
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Clinical Effect of Preventive Use of Tylenol on Fever After Removal of Drainage Tube in Lumbar Fusion Surgery
This study evaluates the influence of Non-steroidal Anti-inflammatory Drugs on preventing fever after the removal of drainage tube in the patients who suffered lumbar fusion surgery, if the outcome turn out positive, the…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Radiculopathy
- Trial name
- NCT04042948
- Testing
- Tylenol
- Where
- China
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Lung Diseases
Analysis of Anti-inflammatory and Antioxidant Pathways in Lung Diseases by Haem Oxygenase-1 (HO-1) in Induced Sputum and Carbon Monoxide (CO) in Exhaled Air
This work will focus on the anti-inflammatory and antioxidant pathways in lung diseases by measuring HO-1 in induced sputum and CO in exhaled air in cases of four respiratory diseases, asthma, chronic obstructive pulmonary…
- Trial name
- NCT01140685
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Obesity
An Anti-inflammatory Diet Effect on Metabolic, Inflammatory and Immune Status of Obese Younger Adults
Diet has a major role in the etiology of obesity, and there is a growing body of evidence suggesting that a variety of dietary factors can modulate obesity-induced chronic low-grade inflammation and thus the course of…
- Trial name
- NCT03987776
- Testing
- Anti-inflammatory energy-restricted diet, Control energy-restricted diet
- Where
- Croatia
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Center Rijeka
PreDiabetes
Effects of Moringa Oleifera Leaves on Glycemia, Lipemia and Inflammatory Profile in Prediabetic Patients
Moringa oleifera (MO) is a traditional food in tropical and subtropical areas and has attained a growing interest for its medicinal properties. It's a nutrient-rich vegetable, high in protein and polyphenol content.
- Trial name
- NUTRIMOL-DB (NCT04734132)
- Testing
- Moringa
- Where
- Spain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Lung Inflammation
Evaluation of Rosiglitazone Anti-inflammatory Effect With FDG-PET Imaging
The purpose of this research study is to gain understanding of the basic responses of the lung to inflammation and specifically if a certain medication can reduce the inflammation alone or in combination with another.
- Trial name
- NCT01174056
- Testing
- Zileuton, Pioglitazone
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Overweight, Healthy
Maximizing the Anti-inflammatory Effects of Strawberry Bioavailability
Primary objective is to determine if the efficacy of strawberries delivering polyphenols to prevent metabolic inflammation will be influenced by timing of consumption relative to meal intake.
- Trial name
- NCT01856153
- Testing
- Before meal, With Meal, After meal
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Joint Pains
Anti-inflammatory Effects of Curcumin, Ginger and Piperine Supplementation in Ultra-trail Runners: a Double-blind Randomized Placebo-controlled Trial
ECUM-RUN is a randomized, double-blind, placebo-controlled phase 3 trial evaluating whether a 30-day oral supplementation with curcumin, ginger, and piperine (9-5-1 formulation) reduces exercise-induced joint pain and…
- Trial name
- ECUM-RUN (NCT07699575)
- Testing
- 9-5-1
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion