Clinical trials: Anti-inflammatory Agents
Breast Cancer
UCLA Breast Cancer Survivor Health Promotion Research Study
Pilot randomized controlled parallel group behavior change comparative effectiveness trial involves 30 breast cancer survivors interested in losing excess body fat.
- Trial name
- NCT05113485
- Testing
- Diabetes Prevention Program-based lifestyle change intervention (DPP), Highly Microbiota-Accessible Foods (HMAFs) intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Rotator Cuff Syndrome
Exercise vs. Supplements in Rotator Cuff-Related Shoulder Pain
Rotator cuff-related shoulder pain is a pathology characterized by pain and functional impairment originating from one or more rotator cuff tendons.
- Trial name
- NCT05976035
- Testing
- Exercise, Supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Istanbul University - Cerrahpasa
Asthma, Asthma, Bronchial
Mechanistic Study of Anti-inflammatory Effects of Fevipiprant in Patients With Eosinophilic Asthma.
This is an exploratory, randomized, subject- and investigator-blinded, placebo-controlled mode-of-action study to demonstrate the anti-inflammatory effects of fevipiprant compared to placebo after 12 weeks of treatment in 48…
- Conditions
- Asthma, Asthma, Bronchial, Bronchial Asthma, Eosinophilia
- Trial name
- NCT03989635
- Testing
- QAW039
- Sponsor
- Novartis Pharmaceuticals
Target Drug-related Adverse Events
Standard of Care Versus Urine Testing With Selective PHarmacogenomics for Effective Drug and Dosing REgimens
The purpose of this study is to determine whether the addition of selective pharmacogenomic (PGx) testing as determined by Urine Drug Testing (UDT) adds a clinical benefit as evidenced by a reduction in Target Drug-related…
- Trial name
- SPHERE (NCT02625155)
- Testing
- Urine diagnostic testing as SOC, drug regimen changes per SOC, Urine diagnostic testing with selective PGx testing, drug regimen changes based on PGx test results
- Where
- United States
- Volunteers
- 14,000 people, healthy volunteers welcome
- Sponsor
- InSource Diagnostics
Septic Shock
Pilot Phase II Study: Hemodynamic Tolerance and Anti-inflammatory Effects of Esmolol During the Treatment of Septic Shock
The purpose of this study is : to evaluate the hemodynamic tolerance of esmolol titrated to obtain a lowering of heart rate of 10% or 20%.
- Trial name
- THANE (NCT02120404)
- Testing
- Esmolol administration
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Familial Adenomatous Polyposis, Duodenal Neoplasms
Prevention of Progression of Duodenal Adenomas in Patients With Familial Adenomatous Polyposis
Duodenal carcinomas are the leading cause of mortality in patients with Familial Adenomatous Polyposis (FAP) who underwent prophylactic colorectal surgery.
- Conditions
- Familial Adenomatous Polyposis, Duodenal Neoplasms, Duodenal Polyps
- Trial name
- PreDuoFAP (NCT00808743)
- Testing
- Celecoxib, Ursodeoxycholic acid
- Where
- 5 sites in Netherlands
- Volunteers
- 37 people
- Sponsor
- Radboud University Medical Center
Periodontitis
Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy
This study aimed to determine the effect of anti-inflammatory nutrition on non-surgical periodontal treatment in individuals with periodontitis by evaluating gingival crevicular fluid (GCF) and serum biomarkers and clinical…
- Trial name
- NCT07287540
- Testing
- non surgical periodontal trearment, anti-inflammatory nutrition education
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Cystic Fibrosis
SD Cystic Fibrosis Study
Subject with Cystic Fibrosis have increased clearance of many drugs. Based on pre-clinical data SB656933 was found to have low clearance and high bio-availability.
- Trial name
- NCT00605761
- Testing
- SB656933
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- GlaxoSmithKline
Spondylarthropathies, Magnetic Resonance Imaging
Effects of Nonsteroidal Anti-inflammatory Drug (NSAID) on Inflammatory Lesion of Axial Spondyloarthritis
Axial Spondyloarthritis (SpA) is a kind of inflammatory arthritis which includes ankylosing spondylitis. Common symptoms of axial SpA are inflammatory back pain, morning stiffness, peripheral arthritis, enthesitis.
- Trial name
- NCT03190603
- Testing
- Celecoxib
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Armed Forces Capital Hospital, Republic of Korea
Pulpitis - Irreversible
The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo
Aim. To compare the outcome of preoperative administration of single-dose ketorolac, non-steroidal anti-inflammatory drug and placebo on postoperative pain in teeth with irreversible pulpitis and apical periodontitis.
- Trial name
- PreOp (NCT03116672)
- Testing
- one dose ketorolac 10 mg, One dose Diclofenac
- Where
- Mexico
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Spinal Fusion Acquired, Spinal Stenosis
Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion
Major lumbar spine surgery causes inflammation, soreness and swelling that can delay discharge from the hospital. Dexmedetomidine (DEX) has been shown to have anti-inflammatory effects.
- Conditions
- Spinal Fusion Acquired, Spinal Stenosis, Lesions of Lumbosacral Intervertebral Disc, Spinal Diseases
- Trial name
- DEXREDLOS (NCT00808665)
- Testing
- Dexmedetomidine, 0.9% Saline
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Vanderbilt University Medical Center
Metabolic Syndrome X
High Density Lipoprotein (HDL) Functionality in Metabolic Syndrome
The aim of the study is to examine the kinetic, anti-oxidant, anti-inflammatory and cellular cholesterol efflux properties of high-density lipoprotein (HDL) in subjects with the metabolic syndrome (MetS) and lean individuals.
- Trial name
- NCT00716300
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Western Australia
HIV Infections
A Phase I Study of Methotrexate for HIV Infection
To determine the safety and tolerance of methotrexate in HIV-infected patients. To determine the dose effective in modulating key markers of immune activation.
- Trial name
- NCT00000834
- Testing
- Lamivudine, Methotrexate, Zidovudine
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Gaucher Disease Type 1
Role of Oxidative Stress and Inflammation in Type 1 Gaucher Disease (GD1)
The purpose of this study is to measure levels of blood and brain chemicals related to oxidative stress and inflammation in healthy volunteers and individuals with Type 1 Gaucher disease (GD1) to see if these levels are altered…
- Trial name
- NCT02583672
- Testing
- N-acetylcysteine
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Eosinophilic Esophagitis
Efficacy and Safety APT-1011 in Adolescent Subjects With Eosinophilic Esophagitis (EoE) - A Sub-Study of the FLUTE-2 Trial
This is a randomized, double-blind, placebo-controlled study of APT-1011, followed by an open-label extension (OLE) in adolescents (≥12 to <18 years) with EoE.
- Trial name
- FLUTEEN (NCT05083312)
- Testing
- APT-1011
- Where
- 3 sites in United States, Australia
- Volunteers
- 6 people
- Sponsor
- Ellodi Pharmaceuticals, LP
Gastric Ulcer, Duodenal Ulcer
Long Term Study to Investigate the Efficacy & Safety of D961H (Esomeprazole) for the Prevention of NSAIDs-induced Ulcer
The purpose of this study is to assess the Safety and tolerability of D961H (Esomeprazole) 20 mg once daily for up to 52 weeks of treatment involving patients with a history of gastric and/or duodenal ulcers receiving daily…
- Conditions
- Gastric Ulcer, Duodenal Ulcer, Rheumatoid Arthritis, Osteoarthritis
- Trial name
- NCT00595517
- Testing
- Esomeprazole 20 mg
- Where
- 3 sites in Japan
- Volunteers
- 395 people
- Sponsor
- AstraZeneca
Respiratory Distress Syndrome, Adult
Roflumilast as add-on Therapy in Early Cases of ARDS
Mild cases of ARDS will be included in a two-arm protocol, to receive 500 mcg of roflumilast daily up to 28 days (FDA approved dose for COPD) plus standard of care versus standard of care alone.
- Trial name
- NCT04744090
- Testing
- Roflumilast
- Where
- 2 sites in Egypt
- Volunteers
- 76 people
- Sponsor
- Cairo University
Trauma
Combined Analgesia to Control Pain in Children Seen in Emergency Department (ED) for a Trauma of a Limb
Prospective study to evaluate the additive value of codeine on ibuprofen in the management of pediatric patient with a trauma of a limb.
- Trial name
- NCT01189773
- Testing
- ibuprofen and codeine
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- St. Justine's Hospital
Bone Resorption, Stress Fracture
The Effects of NSAIDs on Bone Metabolism Following Exercise
The purpose of this study is to determine the effects of a single dose of non-steroidal anti-inflammatory drugs on post-exercise markers of bone and muscle metabolism.
- Conditions
- Bone Resorption, Stress Fracture, Bone Injury
- Trial name
- NCT05512013
- Testing
- Ibuprofen 800 mg, Celecoxib 200mg, Flurbiprofen 100 mg
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Allergic Rhinitis, Allergic Rhinitis (AR)
Effect of Combined Probiotics and Vitamin D on Symptoms of Allergic Rhinitis
The goal of this clinical trial is to learn if taking probiotics, vitamin D, or both together can help lower symptoms of allergic rhinitis (AR) and improve quality of life in adults.
- Trial name
- NCT07115342
- Testing
- Standard Allergic Rhinitis Treatment, Combined Vitamin D and Probiotics Supplementation
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
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